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Protein

Sodium-coupled neutral amino acid transporter 4

Gene

Slc38a4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by Ser, Gly, Cys, Asn, Thr, Pro and Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with lower transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5.1 Publication

GO - Molecular functioni

  • amino acid transmembrane transporter activity Source: RGD
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-RNO-352230. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.18.6.7. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 4
Alternative name(s):
Amino acid transporter A3
Na(+)-coupled neutral amino acid transporter 4
Solute carrier family 38 member 4
System A amino acid transporter 3
Gene namesi
Name:Slc38a4
Synonyms:Ata3, Snat4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621836. Slc38a4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 104ExtracellularSequence analysisAdd BLAST104
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 151CytoplasmicSequence analysisAdd BLAST26
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 195ExtracellularSequence analysisAdd BLAST23
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 220CytoplasmicSequence analysis4
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Topological domaini242 – 332ExtracellularSequence analysisAdd BLAST91
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Topological domaini354 – 369CytoplasmicSequence analysisAdd BLAST16
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391 – 411ExtracellularSequence analysisAdd BLAST21
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Topological domaini433 – 453CytoplasmicSequence analysisAdd BLAST21
Transmembranei454 – 474HelicalSequence analysisAdd BLAST21
Topological domaini475 – 476ExtracellularSequence analysis2
Transmembranei477 – 497HelicalSequence analysisAdd BLAST21
Topological domaini498 – 514CytoplasmicSequence analysisAdd BLAST17
Transmembranei515 – 535HelicalSequence analysisAdd BLAST21
Topological domaini536 – 547ExtracellularSequence analysisAdd BLAST12

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002478631 – 547Sodium-coupled neutral amino acid transporter 4Add BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineCombined sources1
Disulfide bondi249 ↔ 321By similarity
Glycosylationi260N-linked (GlcNAc...)Sequence analysis1
Glycosylationi264N-linked (GlcNAc...)Sequence analysis1
Glycosylationi276N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

The disulfide bond plays an important role in substrate transport, but has no effect on trafficking to the cell surface.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9EQ25.
PRIDEiQ9EQ25.

PTM databases

iPTMnetiQ9EQ25.
PhosphoSitePlusiQ9EQ25.

Expressioni

Tissue specificityi

Expressed predominantly in liver, and at lower level in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSRNOG00000006653.
GenevisibleiQ9EQ25. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009187.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ9EQ25.
KOiK14991.
OMAiNTLPMHV.
OrthoDBiEOG091G0GP8.
PhylomeDBiQ9EQ25.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQ25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPIELRSVN IEPYEDSCSV DSIQSCYTGM GNSEKGAMDS QFANEDAESQ
60 70 80 90 100
KFLTNGFLGK KTLTDYADEH HPGTTSFGMS SFNLSNAIMG SGILGLSYAM
110 120 130 140 150
ANTGIVLFVI MLLTVAILSL YSVHLLLKTA KEGGSLIYEK LGEKAFGWPG
160 170 180 190 200
KIGAFISITM QNIGAMSSYL FIIKYELPEV IRVFMGLEEN TGEWYLNGNY
210 220 230 240 250
LVLFVSVGII LPLSLLKNLG YLGYTSGFSL TCMVFFVSVV IYKKFQIPCP
260 270 280 290 300
LPVLDHNNGN LTFNNTLPMH VIMLPNNSES TGMNFMVDYT HRDPEGLDEK
310 320 330 340 350
PAAGPLHGSG VEYEAHSGDK CQPKYFVFNS RTAYAIPILA FAFVCHPEVL
360 370 380 390 400
PIYSELKDRS RRKMQTVSNI SITGMLVMYL LAALFGYLSF YGEVEDELLH
410 420 430 440 450
AYSKVYTFDT ALLMVRLAVL VAVTLTVPIV LFPIRTSVIT LLFPRRPFSW
460 470 480 490 500
VKHFGIAAII IALNNVLVIL VPTIKYIFGF IGASSATMLI FILPAAFYLK
510 520 530 540
LVKKEPLRSP QKIGALVFLV TGIIFMMGSM ALIIIDWIYN PPNPDHH
Length:547
Mass (Da):60,613
Last modified:March 1, 2001 - v1
Checksum:i28BFF2C0F2B74BF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295535 mRNA. Translation: AAG45335.1.
BC097292 mRNA. Translation: AAH97292.1.
RefSeqiNP_570104.1. NM_130748.1.
XP_008763885.1. XM_008765663.2.
UniGeneiRn.17990.

Genome annotation databases

EnsembliENSRNOT00000009187; ENSRNOP00000009187; ENSRNOG00000006653.
ENSRNOT00000085620; ENSRNOP00000068616; ENSRNOG00000006653.
GeneIDi170573.
KEGGirno:170573.
UCSCiRGD:621836. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295535 mRNA. Translation: AAG45335.1.
BC097292 mRNA. Translation: AAH97292.1.
RefSeqiNP_570104.1. NM_130748.1.
XP_008763885.1. XM_008765663.2.
UniGeneiRn.17990.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009187.

Protein family/group databases

TCDBi2.A.18.6.7. the amino acid/auxin permease (aaap) family.

PTM databases

iPTMnetiQ9EQ25.
PhosphoSitePlusiQ9EQ25.

Proteomic databases

PaxDbiQ9EQ25.
PRIDEiQ9EQ25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009187; ENSRNOP00000009187; ENSRNOG00000006653.
ENSRNOT00000085620; ENSRNOP00000068616; ENSRNOG00000006653.
GeneIDi170573.
KEGGirno:170573.
UCSCiRGD:621836. rat.

Organism-specific databases

CTDi55089.
RGDi621836. Slc38a4.

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ9EQ25.
KOiK14991.
OMAiNTLPMHV.
OrthoDBiEOG091G0GP8.
PhylomeDBiQ9EQ25.
TreeFamiTF328787.

Enzyme and pathway databases

ReactomeiR-RNO-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

PROiQ9EQ25.

Gene expression databases

BgeeiENSRNOG00000006653.
GenevisibleiQ9EQ25. RN.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS38A4_RAT
AccessioniPrimary (citable) accession number: Q9EQ25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.