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Protein

Sodium-coupled neutral amino acid transporter 4

Gene

Slc38a4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by Ser, Gly, Cys, Asn, Thr, Pro and Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with lower transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5.1 Publication

GO - Molecular functioni

  • amino acid transmembrane transporter activity Source: RGD
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-RNO-352230. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.18.6.7. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 4
Alternative name(s):
Amino acid transporter A3
Na(+)-coupled neutral amino acid transporter 4
Solute carrier family 38 member 4
System A amino acid transporter 3
Gene namesi
Name:Slc38a4
Synonyms:Ata3, Snat4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621836. Slc38a4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 104104ExtracellularSequence analysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence analysisAdd
BLAST
Topological domaini126 – 15126CytoplasmicSequence analysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence analysisAdd
BLAST
Topological domaini173 – 19523ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21621HelicalSequence analysisAdd
BLAST
Topological domaini217 – 2204CytoplasmicSequence analysis
Transmembranei221 – 24121HelicalSequence analysisAdd
BLAST
Topological domaini242 – 33291ExtracellularSequence analysisAdd
BLAST
Transmembranei333 – 35321HelicalSequence analysisAdd
BLAST
Topological domaini354 – 36916CytoplasmicSequence analysisAdd
BLAST
Transmembranei370 – 39021HelicalSequence analysisAdd
BLAST
Topological domaini391 – 41121ExtracellularSequence analysisAdd
BLAST
Transmembranei412 – 43221HelicalSequence analysisAdd
BLAST
Topological domaini433 – 45321CytoplasmicSequence analysisAdd
BLAST
Transmembranei454 – 47421HelicalSequence analysisAdd
BLAST
Topological domaini475 – 4762ExtracellularSequence analysis
Transmembranei477 – 49721HelicalSequence analysisAdd
BLAST
Topological domaini498 – 51417CytoplasmicSequence analysisAdd
BLAST
Transmembranei515 – 53521HelicalSequence analysisAdd
BLAST
Topological domaini536 – 54712ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 547547Sodium-coupled neutral amino acid transporter 4PRO_0000247863Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491PhosphoserineCombined sources
Disulfide bondi249 ↔ 321By similarity
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence analysis
Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

The disulfide bond plays an important role in substrate transport, but has no effect on trafficking to the cell surface.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9EQ25.
PRIDEiQ9EQ25.

PTM databases

iPTMnetiQ9EQ25.
PhosphoSiteiQ9EQ25.

Expressioni

Tissue specificityi

Expressed predominantly in liver, and at lower level in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSRNOG00000006653.
GenevisibleiQ9EQ25. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009187.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ9EQ25.
KOiK14991.
OMAiNTLPMHV.
OrthoDBiEOG091G0GP8.
PhylomeDBiQ9EQ25.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQ25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPIELRSVN IEPYEDSCSV DSIQSCYTGM GNSEKGAMDS QFANEDAESQ
60 70 80 90 100
KFLTNGFLGK KTLTDYADEH HPGTTSFGMS SFNLSNAIMG SGILGLSYAM
110 120 130 140 150
ANTGIVLFVI MLLTVAILSL YSVHLLLKTA KEGGSLIYEK LGEKAFGWPG
160 170 180 190 200
KIGAFISITM QNIGAMSSYL FIIKYELPEV IRVFMGLEEN TGEWYLNGNY
210 220 230 240 250
LVLFVSVGII LPLSLLKNLG YLGYTSGFSL TCMVFFVSVV IYKKFQIPCP
260 270 280 290 300
LPVLDHNNGN LTFNNTLPMH VIMLPNNSES TGMNFMVDYT HRDPEGLDEK
310 320 330 340 350
PAAGPLHGSG VEYEAHSGDK CQPKYFVFNS RTAYAIPILA FAFVCHPEVL
360 370 380 390 400
PIYSELKDRS RRKMQTVSNI SITGMLVMYL LAALFGYLSF YGEVEDELLH
410 420 430 440 450
AYSKVYTFDT ALLMVRLAVL VAVTLTVPIV LFPIRTSVIT LLFPRRPFSW
460 470 480 490 500
VKHFGIAAII IALNNVLVIL VPTIKYIFGF IGASSATMLI FILPAAFYLK
510 520 530 540
LVKKEPLRSP QKIGALVFLV TGIIFMMGSM ALIIIDWIYN PPNPDHH
Length:547
Mass (Da):60,613
Last modified:March 1, 2001 - v1
Checksum:i28BFF2C0F2B74BF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295535 mRNA. Translation: AAG45335.1.
BC097292 mRNA. Translation: AAH97292.1.
RefSeqiNP_570104.1. NM_130748.1.
XP_008763885.1. XM_008765663.1.
UniGeneiRn.17990.

Genome annotation databases

EnsembliENSRNOT00000009187; ENSRNOP00000009187; ENSRNOG00000006653.
ENSRNOT00000085620; ENSRNOP00000068616; ENSRNOG00000006653.
GeneIDi170573.
KEGGirno:170573.
UCSCiRGD:621836. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295535 mRNA. Translation: AAG45335.1.
BC097292 mRNA. Translation: AAH97292.1.
RefSeqiNP_570104.1. NM_130748.1.
XP_008763885.1. XM_008765663.1.
UniGeneiRn.17990.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009187.

Protein family/group databases

TCDBi2.A.18.6.7. the amino acid/auxin permease (aaap) family.

PTM databases

iPTMnetiQ9EQ25.
PhosphoSiteiQ9EQ25.

Proteomic databases

PaxDbiQ9EQ25.
PRIDEiQ9EQ25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009187; ENSRNOP00000009187; ENSRNOG00000006653.
ENSRNOT00000085620; ENSRNOP00000068616; ENSRNOG00000006653.
GeneIDi170573.
KEGGirno:170573.
UCSCiRGD:621836. rat.

Organism-specific databases

CTDi55089.
RGDi621836. Slc38a4.

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ9EQ25.
KOiK14991.
OMAiNTLPMHV.
OrthoDBiEOG091G0GP8.
PhylomeDBiQ9EQ25.
TreeFamiTF328787.

Enzyme and pathway databases

ReactomeiR-RNO-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

PROiQ9EQ25.

Gene expression databases

BgeeiENSRNOG00000006653.
GenevisibleiQ9EQ25. RN.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS38A4_RAT
AccessioniPrimary (citable) accession number: Q9EQ25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.