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Protein

Hepcidin

Gene

Hamp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.2 Publications

GO - Molecular functioni

  • copper ion binding Source: MGI

GO - Biological processi

  • cellular iron ion homeostasis Source: UniProtKB
  • cellular response to extracellular stimulus Source: BHF-UCL
  • defense response to bacterium Source: MGI
  • defense response to fungus Source: MGI
  • iron ion homeostasis Source: MGI
  • JAK-STAT cascade Source: MGI
  • membrane protein proteolysis Source: CACAO
  • myeloid cell homeostasis Source: MGI
  • negative regulation of bone resorption Source: MGI
  • negative regulation of inflammatory response Source: MGI
  • negative regulation of iron ion transmembrane transport Source: CACAO
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of cellular protein catabolic process Source: MGI
  • positive regulation of macrophage activation Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Protein family/group databases

TCDBi8.A.37.1.1. the hepcidin (hepcidin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepcidin
Gene namesi
Name:Hamp
Synonyms:Hamp1, Hepc, Hepc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1933533. Hamp.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Propeptidei24 – 5330Sequence analysisPRO_0000013381Add
BLAST
Peptidei59 – 8325HepcidinPRO_0000013382Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi65 ↔ 81By similarity
Disulfide bondi68 ↔ 71By similarity
Disulfide bondi69 ↔ 77By similarity
Disulfide bondi72 ↔ 80By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ9EQ21.
PRIDEiQ9EQ21.

Expressioni

Tissue specificityi

Highly expressed in the liver and to a much lesser extent in the heart.2 Publications

Inductioni

Regulated in response to changes in circulating iron concentrations, iron stores or the development of inflammation and iron-restricted erythropoiesis. Down-regulated following anemia induced by hemorrhage or hemolysis: down-regulation is mediated by Fam132b/Erythroferrone hormone.2 Publications

Gene expression databases

BgeeiQ9EQ21.
CleanExiMM_HAMP.
GenevisibleiQ9EQ21. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055404.

Family & Domainsi

Sequence similaritiesi

Belongs to the hepcidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3JD. Eukaryota.
ENOG4111C2J. LUCA.
GeneTreeiENSGT00390000003154.
HOGENOMiHOG000008666.
HOVERGENiHBG003716.
InParanoidiQ9EQ21.
OMAiCGICCKT.
OrthoDBiEOG7N8ZZ3.
PhylomeDBiQ9EQ21.
TreeFamiTF330932.

Family and domain databases

InterProiIPR010500. Hepcidin.
[Graphical view]
PfamiPF06446. Hepcidin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQ21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSTRTQAA CLLLLLLASL SSTTYLHQQM RQTTELQPLH GEESRADIAI
60 70 80
PMQKRRKRDT NFPICIFCCK CCNNSQCGIC CKT
Length:83
Mass (Da):9,352
Last modified:March 1, 2001 - v1
Checksum:iC76423EA46260B18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297664 mRNA. Translation: AAG49293.1.
AF503444 mRNA. Translation: AAM27440.1.
BC021587 mRNA. Translation: AAH21587.1.
CCDSiCCDS39895.1.
RefSeqiNP_115930.1. NM_032541.1.
UniGeneiMm.439939.

Genome annotation databases

EnsembliENSMUST00000062620; ENSMUSP00000055404; ENSMUSG00000050440.
GeneIDi84506.
KEGGimmu:84506.
UCSCiuc009ghf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297664 mRNA. Translation: AAG49293.1.
AF503444 mRNA. Translation: AAM27440.1.
BC021587 mRNA. Translation: AAH21587.1.
CCDSiCCDS39895.1.
RefSeqiNP_115930.1. NM_032541.1.
UniGeneiMm.439939.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055404.

Protein family/group databases

TCDBi8.A.37.1.1. the hepcidin (hepcidin) family.

Proteomic databases

PaxDbiQ9EQ21.
PRIDEiQ9EQ21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062620; ENSMUSP00000055404; ENSMUSG00000050440.
GeneIDi84506.
KEGGimmu:84506.
UCSCiuc009ghf.1. mouse.

Organism-specific databases

CTDi57817.
MGIiMGI:1933533. Hamp.

Phylogenomic databases

eggNOGiENOG410J3JD. Eukaryota.
ENOG4111C2J. LUCA.
GeneTreeiENSGT00390000003154.
HOGENOMiHOG000008666.
HOVERGENiHBG003716.
InParanoidiQ9EQ21.
OMAiCGICCKT.
OrthoDBiEOG7N8ZZ3.
PhylomeDBiQ9EQ21.
TreeFamiTF330932.

Miscellaneous databases

NextBioi350906.
PROiQ9EQ21.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EQ21.
CleanExiMM_HAMP.
GenevisibleiQ9EQ21. MM.

Family and domain databases

InterProiIPR010500. Hepcidin.
[Graphical view]
PfamiPF06446. Hepcidin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload."
    Pigeon C., Ilyin G., Courselaud B., Leroyer P., Turlin B., Brissot P., Loreal O.
    J. Biol. Chem. 276:7811-7819(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  2. "Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice."
    Nicolas G., Bennoun M., Devaux I., Beaumont C., Grandchamp B., Kahn A., Vaulont S.
    Proc. Natl. Acad. Sci. U.S.A. 98:8780-8785(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: C57BL/6 X 129/Sv.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  4. "The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation."
    Nicolas G., Chauvet C., Viatte L., Danan J.L., Bigard X., Devaux I., Beaumont C., Kahn A., Vaulont S.
    J. Clin. Invest. 110:1037-1044(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. "Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co-inducibility during iron overload."
    Ilyin G., Courselaud B., Troadec M.-B., Pigeon C., Alizadeh M., Leroyer P., Brissot P., Loreal O.
    FEBS Lett. 542:22-26(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Identification of erythroferrone as an erythroid regulator of iron metabolism."
    Kautz L., Jung G., Valore E.V., Rivella S., Nemeth E., Ganz T.
    Nat. Genet. 46:678-684(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiHEPC_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.