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Protein

Hepcidin

Gene

Hamp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.2 Publications

GO - Molecular functioni

  • copper ion binding Source: MGI
  • hormone activity Source: UniProtKB-KW

GO - Biological processi

  • cellular iron ion homeostasis Source: UniProtKB
  • cellular response to extracellular stimulus Source: BHF-UCL
  • defense response to bacterium Source: MGI
  • defense response to fungus Source: MGI
  • iron ion homeostasis Source: MGI
  • JAK-STAT cascade Source: MGI
  • myeloid cell homeostasis Source: MGI
  • negative regulation of bone resorption Source: MGI
  • negative regulation of inflammatory response Source: MGI
  • negative regulation of iron ion transmembrane transport Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: BHF-UCL
  • positive regulation of cellular protein catabolic process Source: MGI
  • positive regulation of macrophage activation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionHormone

Protein family/group databases

TCDBi8.A.37.1.1 the hepcidin (hepcidin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Hepcidin
Gene namesi
Name:Hamp
Synonyms:Hamp1, Hepc, Hepc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1933533 Hamp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000001338124 – 53Sequence analysisAdd BLAST30
PeptideiPRO_000001338259 – 83HepcidinAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi65 ↔ 81By similarity
Disulfide bondi68 ↔ 71By similarity
Disulfide bondi69 ↔ 77By similarity
Disulfide bondi72 ↔ 80By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

MaxQBiQ9EQ21
PaxDbiQ9EQ21
PeptideAtlasiQ9EQ21
PRIDEiQ9EQ21

Expressioni

Tissue specificityi

Highly expressed in the liver and to a much lesser extent in the heart.2 Publications

Inductioni

Regulated in response to changes in circulating iron concentrations, iron stores or the development of inflammation and iron-restricted erythropoiesis. Down-regulated following anemia induced by hemorrhage or hemolysis: down-regulation is mediated by ERFE.2 Publications

Gene expression databases

BgeeiENSMUSG00000050440
CleanExiMM_HAMP
GenevisibleiQ9EQ21 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055404

Structurei

3D structure databases

SMRiQ9EQ21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hepcidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3JD Eukaryota
ENOG4111C2J LUCA
GeneTreeiENSGT00390000003154
HOGENOMiHOG000008666
HOVERGENiHBG003716
InParanoidiQ9EQ21
OMAiCGICCKT
OrthoDBiEOG091G1A4A
PhylomeDBiQ9EQ21
TreeFamiTF330932

Family and domain databases

InterProiView protein in InterPro
IPR010500 Hepcidin
PANTHERiPTHR16877 PTHR16877, 1 hit
PfamiView protein in Pfam
PF06446 Hepcidin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQ21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSTRTQAA CLLLLLLASL SSTTYLHQQM RQTTELQPLH GEESRADIAI
60 70 80
PMQKRRKRDT NFPICIFCCK CCNNSQCGIC CKT
Length:83
Mass (Da):9,352
Last modified:March 1, 2001 - v1
Checksum:iC76423EA46260B18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF297664 mRNA Translation: AAG49293.1
AF503444 mRNA Translation: AAM27440.1
BC021587 mRNA Translation: AAH21587.1
CCDSiCCDS39895.1
RefSeqiNP_115930.1, NM_032541.2
UniGeneiMm.439939

Genome annotation databases

EnsembliENSMUST00000062620; ENSMUSP00000055404; ENSMUSG00000050440
GeneIDi84506
KEGGimmu:84506
UCSCiuc009ghf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHEPC_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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