ID   CXCR6_MOUSE             Reviewed;         351 AA.
AC   Q9EQ16; Q4VA95; Q9ERH5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   24-JAN-2024, entry version 152.
DE   RecName: Full=C-X-C chemokine receptor type 6;
DE            Short=CXC-R6;
DE            Short=CXCR-6;
DE   AltName: CD_antigen=CD186;
GN   Name=Cxcr6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   STRAIN=C57BL/6J;
RX   PubMed=11017100; DOI=10.1038/79738;
RA   Matloubian M., David A., Engel S., Ryan J.E., Cyster J.G.;
RT   "A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo.";
RL   Nat. Immunol. 1:298-304(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Spleen;
RA   Sato H., Taniguchi M.;
RT   "Molecular cloning of a putative chemokine receptor preferentially
RT   expressed in mouse lymphocytes.";
RL   Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Heart, Thymus, and Vagina;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6NCr; TISSUE=Hematopoietic stem cell;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   PROTEIN SEQUENCE OF 116-145, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=OF1; TISSUE=Hippocampus;
RA   Lubec G., Sunyer B., Chen W.-Q.;
RL   Submitted (JAN-2009) to UniProtKB.
CC   -!- FUNCTION: Receptor for the C-X-C chemokine CXCL16.
CC       {ECO:0000269|PubMed:11017100}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF301018; AAG34367.1; -; mRNA.
DR   EMBL; AF305709; AAG31284.1; -; mRNA.
DR   EMBL; AK052901; BAC35196.1; -; mRNA.
DR   EMBL; AK137703; BAE23469.1; -; mRNA.
DR   EMBL; AK153914; BAE32252.1; -; mRNA.
DR   EMBL; BC096491; AAH96491.1; -; mRNA.
DR   CCDS; CCDS23664.1; -.
DR   RefSeq; NP_109637.3; NM_030712.4.
DR   AlphaFoldDB; Q9EQ16; -.
DR   SMR; Q9EQ16; -.
DR   BioGRID; 219838; 1.
DR   STRING; 10090.ENSMUSP00000060776; -.
DR   BindingDB; Q9EQ16; -.
DR   ChEMBL; CHEMBL4630853; -.
DR   GlyCosmos; Q9EQ16; 2 sites, No reported glycans.
DR   GlyGen; Q9EQ16; 2 sites.
DR   PhosphoSitePlus; Q9EQ16; -.
DR   EPD; Q9EQ16; -.
DR   PaxDb; 10090-ENSMUSP00000060776; -.
DR   ProteomicsDB; 277930; -.
DR   Antibodypedia; 12723; 754 antibodies from 44 providers.
DR   DNASU; 80901; -.
DR   Ensembl; ENSMUST00000049810.9; ENSMUSP00000060776.8; ENSMUSG00000048521.9.
DR   GeneID; 80901; -.
DR   KEGG; mmu:80901; -.
DR   UCSC; uc009sgt.2; mouse.
DR   AGR; MGI:1934582; -.
DR   CTD; 10663; -.
DR   MGI; MGI:1934582; Cxcr6.
DR   VEuPathDB; HostDB:ENSMUSG00000048521; -.
DR   eggNOG; ENOG502QSJQ; Eukaryota.
DR   GeneTree; ENSGT01030000234667; -.
DR   HOGENOM; CLU_009579_8_3_1; -.
DR   InParanoid; Q9EQ16; -.
DR   OrthoDB; 5322216at2759; -.
DR   PhylomeDB; Q9EQ16; -.
DR   TreeFam; TF330966; -.
DR   Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
DR   Reactome; R-MMU-418594; G alpha (i) signalling events.
DR   BioGRID-ORCS; 80901; 1 hit in 77 CRISPR screens.
DR   PRO; PR:Q9EQ16; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q9EQ16; Protein.
DR   Bgee; ENSMUSG00000048521; Expressed in peripheral lymph node and 66 other cell types or tissues.
DR   ExpressionAtlas; Q9EQ16; baseline and differential.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR   GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR   GO; GO:0019958; F:C-X-C chemokine binding; IPI:UniProtKB.
DR   GO; GO:0016494; F:C-X-C chemokine receptor activity; IDA:MGI.
DR   GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR   GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   CDD; cd15173; 7tmA_CXCR6; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR002235; Chemokine_CXCR6.
DR   InterPro; IPR000355; Chemokine_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR10489:SF705; C-X-C CHEMOKINE RECEPTOR TYPE 6; 1.
DR   PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00657; CCCHEMOKINER.
DR   PRINTS; PR01105; CXCCHMKINER6.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q9EQ16; MM.
PE   1: Evidence at protein level;
KW   Cell membrane; Direct protein sequencing; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..351
FT                   /note="C-X-C chemokine receptor type 6"
FT                   /id="PRO_0000303230"
FT   TOPO_DOM        1..41
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..68
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        69..77
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..112
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..134
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        135..152
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        174..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..224
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        225..240
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..268
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        269..284
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..302
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        303..351
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        23
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        24
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        111..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   CONFLICT        119
FT                   /note="T -> A (in Ref. 4; AAH96491)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        207
FT                   /note="L -> R (in Ref. 2; AAG31284)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        305
FT                   /note="R -> W (in Ref. 4; AAH96491)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        321
FT                   /note="L -> Q (in Ref. 4; AAH96491)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        324
FT                   /note="S -> P (in Ref. 4; AAH96491)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   351 AA;  40468 MW;  5658788372B4C65A CRC64;
     MDDGHQESAL YDGHYEGDFW LFNNSSDNSQ ENKRFLKFKE VFLPCVYLVV FVFGLLGNSL
     VLIIYIFYQK LRTLTDVFLL NLPLADLVFV CTLPFWAYAG TYEWVFGTVM CKTLRGMYTM
     NFYVSMLTLT CITVDRFIVV VQATKAFNRQ AKWKIWGQVI CLLIWVVSLL VSLPQIIYGH
     VQDIDKLICQ YHSEEISTMV LVIQMTLGFF LPLLTMILCY SGIIKTLLHA RNFQKHKSLK
     IIFLVVAVFL LTQTPFNLAM LIQSTSWEYY TITSFKYAIV VTEAIAYFRA CLNPVLYAFV
     GLKFRKNVWK LMKDIGCLSH LGVSSQWKSS EDSSKTCSAS HNVETTSMFQ L
//