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Q9EQ16

- CXCR6_MOUSE

UniProt

Q9EQ16 - CXCR6_MOUSE

Protein

C-X-C chemokine receptor type 6

Gene

Cxcr6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Receptor for the C-X-C chemokine CXCL16.1 Publication

    GO - Molecular functioni

    1. coreceptor activity Source: InterPro
    2. C-X-C chemokine receptor activity Source: MGI

    GO - Biological processi

    1. chemokine-mediated signaling pathway Source: GOC
    2. chemotaxis Source: InterPro
    3. inflammatory response Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C chemokine receptor type 6
    Short name:
    CXC-R6
    Short name:
    CXCR-6
    Alternative name(s):
    CD_antigen: CD186
    Gene namesi
    Name:Cxcr6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1934582. Cxcr6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351C-X-C chemokine receptor type 6PRO_0000303230Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi111 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9EQ16.

    PTM databases

    PhosphoSiteiQ9EQ16.

    Expressioni

    Gene expression databases

    BgeeiQ9EQ16.
    CleanExiMM_CXCR6.
    GenevestigatoriQ9EQ16.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EQ16.
    SMRiQ9EQ16. Positions 38-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini69 – 779CytoplasmicSequence Analysis
    Topological domaini99 – 11214ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini135 – 15218CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini174 – 19623ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini225 – 24016CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini269 – 28416ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini303 – 35149CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6827Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei113 – 13422Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 22428Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei241 – 26828Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei285 – 30218Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146723.
    GeneTreeiENSGT00730000110640.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiQ9EQ16.
    KOiK04191.
    OMAiARGFQKH.
    OrthoDBiEOG7VX8W4.
    PhylomeDBiQ9EQ16.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002235. Chemokine_CXCR6.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01105. CXCCHMKINER6.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9EQ16-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDGHQESAL YDGHYEGDFW LFNNSSDNSQ ENKRFLKFKE VFLPCVYLVV    50
    FVFGLLGNSL VLIIYIFYQK LRTLTDVFLL NLPLADLVFV CTLPFWAYAG 100
    TYEWVFGTVM CKTLRGMYTM NFYVSMLTLT CITVDRFIVV VQATKAFNRQ 150
    AKWKIWGQVI CLLIWVVSLL VSLPQIIYGH VQDIDKLICQ YHSEEISTMV 200
    LVIQMTLGFF LPLLTMILCY SGIIKTLLHA RNFQKHKSLK IIFLVVAVFL 250
    LTQTPFNLAM LIQSTSWEYY TITSFKYAIV VTEAIAYFRA CLNPVLYAFV 300
    GLKFRKNVWK LMKDIGCLSH LGVSSQWKSS EDSSKTCSAS HNVETTSMFQ 350
    L 351
    Length:351
    Mass (Da):40,468
    Last modified:March 1, 2001 - v1
    Checksum:i5658788372B4C65A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti119 – 1191T → A in AAH96491. (PubMed:15489334)Curated
    Sequence conflicti207 – 2071L → R in AAG31284. 1 PublicationCurated
    Sequence conflicti305 – 3051R → W in AAH96491. (PubMed:15489334)Curated
    Sequence conflicti321 – 3211L → Q in AAH96491. (PubMed:15489334)Curated
    Sequence conflicti324 – 3241S → P in AAH96491. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF301018 mRNA. Translation: AAG34367.1.
    AF305709 mRNA. Translation: AAG31284.1.
    AK052901 mRNA. Translation: BAC35196.1.
    AK137703 mRNA. Translation: BAE23469.1.
    AK153914 mRNA. Translation: BAE32252.1.
    BC096491 mRNA. Translation: AAH96491.1.
    CCDSiCCDS23664.1.
    RefSeqiNP_109637.3. NM_030712.4.
    UniGeneiMm.124289.

    Genome annotation databases

    EnsembliENSMUST00000049810; ENSMUSP00000060776; ENSMUSG00000048521.
    GeneIDi80901.
    KEGGimmu:80901.
    UCSCiuc009sgt.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF301018 mRNA. Translation: AAG34367.1 .
    AF305709 mRNA. Translation: AAG31284.1 .
    AK052901 mRNA. Translation: BAC35196.1 .
    AK137703 mRNA. Translation: BAE23469.1 .
    AK153914 mRNA. Translation: BAE32252.1 .
    BC096491 mRNA. Translation: AAH96491.1 .
    CCDSi CCDS23664.1.
    RefSeqi NP_109637.3. NM_030712.4.
    UniGenei Mm.124289.

    3D structure databases

    ProteinModelPortali Q9EQ16.
    SMRi Q9EQ16. Positions 38-312.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 73.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9EQ16.

    Proteomic databases

    PRIDEi Q9EQ16.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049810 ; ENSMUSP00000060776 ; ENSMUSG00000048521 .
    GeneIDi 80901.
    KEGGi mmu:80901.
    UCSCi uc009sgt.2. mouse.

    Organism-specific databases

    CTDi 10663.
    MGIi MGI:1934582. Cxcr6.

    Phylogenomic databases

    eggNOGi NOG146723.
    GeneTreei ENSGT00730000110640.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi Q9EQ16.
    KOi K04191.
    OMAi ARGFQKH.
    OrthoDBi EOG7VX8W4.
    PhylomeDBi Q9EQ16.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 350238.
    PROi Q9EQ16.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9EQ16.
    CleanExi MM_CXCR6.
    Genevestigatori Q9EQ16.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002235. Chemokine_CXCR6.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01105. CXCCHMKINER6.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo."
      Matloubian M., David A., Engel S., Ryan J.E., Cyster J.G.
      Nat. Immunol. 1:298-304(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: C57BL/6.
    2. "Molecular cloning of a putative chemokine receptor preferentially expressed in mouse lymphocytes."
      Sato H., Taniguchi M.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Spleen.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Heart, Thymus and Vagina.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6NCr.
      Tissue: Hematopoietic stem cell.
    5. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 116-145, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiCXCR6_MOUSE
    AccessioniPrimary (citable) accession number: Q9EQ16
    Secondary accession number(s): Q4VA95, Q9ERH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3