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Protein

C-X-C chemokine receptor type 6

Gene

Cxcr6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the C-X-C chemokine CXCL16.1 Publication

GO - Molecular functioni

  • coreceptor activity Source: InterPro
  • C-X-C chemokine binding Source: UniProtKB
  • C-X-C chemokine receptor activity Source: MGI

GO - Biological processi

  • chemokine-mediated signaling pathway Source: GOC
  • chemotaxis Source: InterPro
  • inflammatory response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 6
Short name:
CXC-R6
Short name:
CXCR-6
Alternative name(s):
CD_antigen: CD186
Gene namesi
Name:Cxcr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1934582. Cxcr6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence AnalysisAdd
BLAST
Transmembranei42 – 6827Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini69 – 779CytoplasmicSequence Analysis
Transmembranei78 – 9821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini99 – 11214ExtracellularSequence AnalysisAdd
BLAST
Transmembranei113 – 13422Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini135 – 15218CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei153 – 17321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini174 – 19623ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 22428Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini225 – 24016CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei241 – 26828Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini269 – 28416ExtracellularSequence AnalysisAdd
BLAST
Transmembranei285 – 30218Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini303 – 35149CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351C-X-C chemokine receptor type 6PRO_0000303230Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi111 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9EQ16.

PTM databases

PhosphoSiteiQ9EQ16.

Expressioni

Gene expression databases

BgeeiQ9EQ16.
CleanExiMM_CXCR6.
GenevisibleiQ9EQ16. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060776.

Structurei

3D structure databases

ProteinModelPortaliQ9EQ16.
SMRiQ9EQ16. Positions 38-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146723.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ9EQ16.
KOiK04191.
OMAiTPFNLVK.
OrthoDBiEOG7VX8W4.
PhylomeDBiQ9EQ16.
TreeFamiTF330966.

Family and domain databases

InterProiIPR002235. Chemokine_CXCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01105. CXCCHMKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQ16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDGHQESAL YDGHYEGDFW LFNNSSDNSQ ENKRFLKFKE VFLPCVYLVV
60 70 80 90 100
FVFGLLGNSL VLIIYIFYQK LRTLTDVFLL NLPLADLVFV CTLPFWAYAG
110 120 130 140 150
TYEWVFGTVM CKTLRGMYTM NFYVSMLTLT CITVDRFIVV VQATKAFNRQ
160 170 180 190 200
AKWKIWGQVI CLLIWVVSLL VSLPQIIYGH VQDIDKLICQ YHSEEISTMV
210 220 230 240 250
LVIQMTLGFF LPLLTMILCY SGIIKTLLHA RNFQKHKSLK IIFLVVAVFL
260 270 280 290 300
LTQTPFNLAM LIQSTSWEYY TITSFKYAIV VTEAIAYFRA CLNPVLYAFV
310 320 330 340 350
GLKFRKNVWK LMKDIGCLSH LGVSSQWKSS EDSSKTCSAS HNVETTSMFQ

L
Length:351
Mass (Da):40,468
Last modified:March 1, 2001 - v1
Checksum:i5658788372B4C65A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191T → A in AAH96491 (PubMed:15489334).Curated
Sequence conflicti207 – 2071L → R in AAG31284 (Ref. 2) Curated
Sequence conflicti305 – 3051R → W in AAH96491 (PubMed:15489334).Curated
Sequence conflicti321 – 3211L → Q in AAH96491 (PubMed:15489334).Curated
Sequence conflicti324 – 3241S → P in AAH96491 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301018 mRNA. Translation: AAG34367.1.
AF305709 mRNA. Translation: AAG31284.1.
AK052901 mRNA. Translation: BAC35196.1.
AK137703 mRNA. Translation: BAE23469.1.
AK153914 mRNA. Translation: BAE32252.1.
BC096491 mRNA. Translation: AAH96491.1.
CCDSiCCDS23664.1.
RefSeqiNP_109637.3. NM_030712.4.
UniGeneiMm.124289.

Genome annotation databases

EnsembliENSMUST00000049810; ENSMUSP00000060776; ENSMUSG00000048521.
GeneIDi80901.
KEGGimmu:80901.
UCSCiuc009sgt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301018 mRNA. Translation: AAG34367.1.
AF305709 mRNA. Translation: AAG31284.1.
AK052901 mRNA. Translation: BAC35196.1.
AK137703 mRNA. Translation: BAE23469.1.
AK153914 mRNA. Translation: BAE32252.1.
BC096491 mRNA. Translation: AAH96491.1.
CCDSiCCDS23664.1.
RefSeqiNP_109637.3. NM_030712.4.
UniGeneiMm.124289.

3D structure databases

ProteinModelPortaliQ9EQ16.
SMRiQ9EQ16. Positions 38-312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060776.

Chemistry

GuidetoPHARMACOLOGYi73.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9EQ16.

Proteomic databases

PRIDEiQ9EQ16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049810; ENSMUSP00000060776; ENSMUSG00000048521.
GeneIDi80901.
KEGGimmu:80901.
UCSCiuc009sgt.2. mouse.

Organism-specific databases

CTDi10663.
MGIiMGI:1934582. Cxcr6.

Phylogenomic databases

eggNOGiNOG146723.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ9EQ16.
KOiK04191.
OMAiTPFNLVK.
OrthoDBiEOG7VX8W4.
PhylomeDBiQ9EQ16.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Miscellaneous databases

NextBioi350238.
PROiQ9EQ16.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EQ16.
CleanExiMM_CXCR6.
GenevisibleiQ9EQ16. MM.

Family and domain databases

InterProiIPR002235. Chemokine_CXCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01105. CXCCHMKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo."
    Matloubian M., David A., Engel S., Ryan J.E., Cyster J.G.
    Nat. Immunol. 1:298-304(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: C57BL/6.
  2. "Molecular cloning of a putative chemokine receptor preferentially expressed in mouse lymphocytes."
    Sato H., Taniguchi M.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Spleen.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Heart, Thymus and Vagina.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6NCr.
    Tissue: Hematopoietic stem cell.
  5. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 116-145, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiCXCR6_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ16
Secondary accession number(s): Q4VA95, Q9ERH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2001
Last modified: June 24, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.