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Protein

C-X-C chemokine receptor type 6

Gene

Cxcr6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the C-X-C chemokine CXCL16.1 Publication

GO - Molecular functioni

  • coreceptor activity Source: InterPro
  • C-X-C chemokine binding Source: UniProtKB
  • C-X-C chemokine receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 6
Short name:
CXC-R6
Short name:
CXCR-6
Alternative name(s):
CD_antigen: CD186
Gene namesi
Name:Cxcr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1934582. Cxcr6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 68Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini69 – 77CytoplasmicSequence analysis9
Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini99 – 112ExtracellularSequence analysisAdd BLAST14
Transmembranei113 – 134Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini135 – 152CytoplasmicSequence analysisAdd BLAST18
Transmembranei153 – 173Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini174 – 196ExtracellularSequence analysisAdd BLAST23
Transmembranei197 – 224Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini225 – 240CytoplasmicSequence analysisAdd BLAST16
Transmembranei241 – 268Helical; Name=6Sequence analysisAdd BLAST28
Topological domaini269 – 284ExtracellularSequence analysisAdd BLAST16
Transmembranei285 – 302Helical; Name=7Sequence analysisAdd BLAST18
Topological domaini303 – 351CytoplasmicSequence analysisAdd BLAST49

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003032301 – 351C-X-C chemokine receptor type 6Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...)Sequence analysis1
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi111 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9EQ16.
PRIDEiQ9EQ16.

PTM databases

PhosphoSitePlusiQ9EQ16.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048521.
CleanExiMM_CXCR6.
GenevisibleiQ9EQ16. MM.

Interactioni

GO - Molecular functioni

  • C-X-C chemokine binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060776.

Structurei

3D structure databases

ProteinModelPortaliQ9EQ16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ9EQ16.
KOiK04191.
OMAiTPFNLVK.
OrthoDBiEOG091G0D3V.
PhylomeDBiQ9EQ16.
TreeFamiTF330966.

Family and domain databases

InterProiIPR002235. Chemokine_CXCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01105. CXCCHMKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EQ16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDGHQESAL YDGHYEGDFW LFNNSSDNSQ ENKRFLKFKE VFLPCVYLVV
60 70 80 90 100
FVFGLLGNSL VLIIYIFYQK LRTLTDVFLL NLPLADLVFV CTLPFWAYAG
110 120 130 140 150
TYEWVFGTVM CKTLRGMYTM NFYVSMLTLT CITVDRFIVV VQATKAFNRQ
160 170 180 190 200
AKWKIWGQVI CLLIWVVSLL VSLPQIIYGH VQDIDKLICQ YHSEEISTMV
210 220 230 240 250
LVIQMTLGFF LPLLTMILCY SGIIKTLLHA RNFQKHKSLK IIFLVVAVFL
260 270 280 290 300
LTQTPFNLAM LIQSTSWEYY TITSFKYAIV VTEAIAYFRA CLNPVLYAFV
310 320 330 340 350
GLKFRKNVWK LMKDIGCLSH LGVSSQWKSS EDSSKTCSAS HNVETTSMFQ

L
Length:351
Mass (Da):40,468
Last modified:March 1, 2001 - v1
Checksum:i5658788372B4C65A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119T → A in AAH96491 (PubMed:15489334).Curated1
Sequence conflicti207L → R in AAG31284 (Ref. 2) Curated1
Sequence conflicti305R → W in AAH96491 (PubMed:15489334).Curated1
Sequence conflicti321L → Q in AAH96491 (PubMed:15489334).Curated1
Sequence conflicti324S → P in AAH96491 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301018 mRNA. Translation: AAG34367.1.
AF305709 mRNA. Translation: AAG31284.1.
AK052901 mRNA. Translation: BAC35196.1.
AK137703 mRNA. Translation: BAE23469.1.
AK153914 mRNA. Translation: BAE32252.1.
BC096491 mRNA. Translation: AAH96491.1.
CCDSiCCDS23664.1.
RefSeqiNP_109637.3. NM_030712.4.
UniGeneiMm.124289.

Genome annotation databases

EnsembliENSMUST00000049810; ENSMUSP00000060776; ENSMUSG00000048521.
GeneIDi80901.
KEGGimmu:80901.
UCSCiuc009sgt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301018 mRNA. Translation: AAG34367.1.
AF305709 mRNA. Translation: AAG31284.1.
AK052901 mRNA. Translation: BAC35196.1.
AK137703 mRNA. Translation: BAE23469.1.
AK153914 mRNA. Translation: BAE32252.1.
BC096491 mRNA. Translation: AAH96491.1.
CCDSiCCDS23664.1.
RefSeqiNP_109637.3. NM_030712.4.
UniGeneiMm.124289.

3D structure databases

ProteinModelPortaliQ9EQ16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060776.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ9EQ16.

Proteomic databases

PaxDbiQ9EQ16.
PRIDEiQ9EQ16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049810; ENSMUSP00000060776; ENSMUSG00000048521.
GeneIDi80901.
KEGGimmu:80901.
UCSCiuc009sgt.2. mouse.

Organism-specific databases

CTDi10663.
MGIiMGI:1934582. Cxcr6.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ9EQ16.
KOiK04191.
OMAiTPFNLVK.
OrthoDBiEOG091G0D3V.
PhylomeDBiQ9EQ16.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ9EQ16.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048521.
CleanExiMM_CXCR6.
GenevisibleiQ9EQ16. MM.

Family and domain databases

InterProiIPR002235. Chemokine_CXCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01105. CXCCHMKINER6.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCR6_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ16
Secondary accession number(s): Q4VA95, Q9ERH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.