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Q9EQ16 (CXCR6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C chemokine receptor type 6

Short name=CXC-R6
Short name=CXCR-6
Alternative name(s):
CD_antigen=CD186
Gene names
Name:Cxcr6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the C-X-C chemokine CXCL16. Ref.1

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351C-X-C chemokine receptor type 6
PRO_0000303230

Regions

Topological domain1 – 4141Extracellular Potential
Transmembrane42 – 6827Helical; Name=1; Potential
Topological domain69 – 779Cytoplasmic Potential
Transmembrane78 – 9821Helical; Name=2; Potential
Topological domain99 – 11214Extracellular Potential
Transmembrane113 – 13422Helical; Name=3; Potential
Topological domain135 – 15218Cytoplasmic Potential
Transmembrane153 – 17321Helical; Name=4; Potential
Topological domain174 – 19623Extracellular Potential
Transmembrane197 – 22428Helical; Name=5; Potential
Topological domain225 – 24016Cytoplasmic Potential
Transmembrane241 – 26828Helical; Name=6; Potential
Topological domain269 – 28416Extracellular Potential
Transmembrane285 – 30218Helical; Name=7; Potential
Topological domain303 – 35149Cytoplasmic Potential

Amino acid modifications

Glycosylation231N-linked (GlcNAc...) Potential
Glycosylation241N-linked (GlcNAc...) Potential
Disulfide bond111 ↔ 189 By similarity

Experimental info

Sequence conflict1191T → A in AAH96491. Ref.4
Sequence conflict2071L → R in AAG31284. Ref.2
Sequence conflict3051R → W in AAH96491. Ref.4
Sequence conflict3211L → Q in AAH96491. Ref.4
Sequence conflict3241S → P in AAH96491. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9EQ16 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 5658788372B4C65A

FASTA35140,468
        10         20         30         40         50         60 
MDDGHQESAL YDGHYEGDFW LFNNSSDNSQ ENKRFLKFKE VFLPCVYLVV FVFGLLGNSL 

        70         80         90        100        110        120 
VLIIYIFYQK LRTLTDVFLL NLPLADLVFV CTLPFWAYAG TYEWVFGTVM CKTLRGMYTM 

       130        140        150        160        170        180 
NFYVSMLTLT CITVDRFIVV VQATKAFNRQ AKWKIWGQVI CLLIWVVSLL VSLPQIIYGH 

       190        200        210        220        230        240 
VQDIDKLICQ YHSEEISTMV LVIQMTLGFF LPLLTMILCY SGIIKTLLHA RNFQKHKSLK 

       250        260        270        280        290        300 
IIFLVVAVFL LTQTPFNLAM LIQSTSWEYY TITSFKYAIV VTEAIAYFRA CLNPVLYAFV 

       310        320        330        340        350 
GLKFRKNVWK LMKDIGCLSH LGVSSQWKSS EDSSKTCSAS HNVETTSMFQ L 

« Hide

References

« Hide 'large scale' references
[1]"A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo."
Matloubian M., David A., Engel S., Ryan J.E., Cyster J.G.
Nat. Immunol. 1:298-304(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Strain: C57BL/6.
[2]"Molecular cloning of a putative chemokine receptor preferentially expressed in mouse lymphocytes."
Sato H., Taniguchi M.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Spleen.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Heart, Thymus and Vagina.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6NCr.
Tissue: Hematopoietic stem cell.
[5]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 116-145, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF301018 mRNA. Translation: AAG34367.1.
AF305709 mRNA. Translation: AAG31284.1.
AK052901 mRNA. Translation: BAC35196.1.
AK137703 mRNA. Translation: BAE23469.1.
AK153914 mRNA. Translation: BAE32252.1.
BC096491 mRNA. Translation: AAH96491.1.
RefSeqNP_109637.3. NM_030712.4.
UniGeneMm.124289.

3D structure databases

ProteinModelPortalQ9EQ16.
SMRQ9EQ16. Positions 38-312.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY73.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9EQ16.

Proteomic databases

PRIDEQ9EQ16.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049810; ENSMUSP00000060776; ENSMUSG00000048521.
GeneID80901.
KEGGmmu:80901.
UCSCuc009sgt.2. mouse.

Organism-specific databases

CTD10663.
MGIMGI:1934582. Cxcr6.

Phylogenomic databases

eggNOGNOG146723.
GeneTreeENSGT00730000110640.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidQ9EQ16.
KOK04191.
OMAARGFQKH.
OrthoDBEOG7VX8W4.
PhylomeDBQ9EQ16.
TreeFamTF330966.

Gene expression databases

BgeeQ9EQ16.
CleanExMM_CXCR6.
GenevestigatorQ9EQ16.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR002235. Chemokine_CXCR6.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR01105. CXCCHMKINER6.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio350238.
PROQ9EQ16.
SOURCESearch...

Entry information

Entry nameCXCR6_MOUSE
AccessionPrimary (citable) accession number: Q9EQ16
Secondary accession number(s): Q4VA95, Q9ERH5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries