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Protein

Guanine nucleotide-binding protein subunit beta-like protein 1

Gene

Gnb1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • social behavior Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit beta-like protein 1
Short name:
G protein subunit beta-like protein 1
Alternative name(s):
WD repeat-containing protein 14
WD40 repeat-containing protein deleted in VCFS
Short name:
WDVCF
Gene namesi
Name:Gnb1l
Synonyms:Estm55, Wdr14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1338057. Gnb1l.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510091 – 326Guanine nucleotide-binding protein subunit beta-like protein 1Add BLAST326

Proteomic databases

EPDiQ9EQ15.
PaxDbiQ9EQ15.
PRIDEiQ9EQ15.

PTM databases

iPTMnetiQ9EQ15.
PhosphoSitePlusiQ9EQ15.

Expressioni

Tissue specificityi

Expressed at low levels in most tissues and highly expressed in adult testis.

Gene expression databases

BgeeiENSMUSG00000000884.
ExpressionAtlasiQ9EQ15. baseline and differential.
GenevisibleiQ9EQ15. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087544.

Structurei

3D structure databases

ProteinModelPortaliQ9EQ15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati17 – 61WD 1Add BLAST45
Repeati64 – 104WD 2Add BLAST41
Repeati159 – 202WD 3Add BLAST44
Repeati205 – 244WD 4Add BLAST40
Repeati250 – 291WD 5Add BLAST42
Repeati292 – 325WD 6Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 11Poly-Pro6

Sequence similaritiesi

Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0322. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00390000018606.
HOGENOMiHOG000007056.
HOVERGENiHBG051745.
InParanoidiQ9EQ15.
OMAiCLELWQA.
OrthoDBiEOG091G0HHK.
TreeFamiTF344050.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9EQ15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALFPPPPG PRFVLRGTQS AVNTLHFCPP SQAAGNPLLF SGSQNGLVHI
60 70 80 90 100
WSLQTRRIVT TLNGHGGQGV IWLKTLPQGH QLLSQGRDLR LCLWDLEEGR
110 120 130 140 150
NTIMDSVQLD SVGFCRGSIL VRGQQCWMLA VPGKGSDEVQ ILEMPSKTSV
160 170 180 190 200
CTLKPEADAR PGMPMCLGLW QTNSSLRPLL LAGYEDGSVT LWDISERKVC
210 220 230 240 250
SQITCHEEPV MGLDFDSQKA KGISGSAGKV LAVWSLDDQQ SLQVKKTHEL
260 270 280 290 300
TNPGIAEVTI RPDHKILATA GWDHRIRVFH WRTMKPLAVL AFHSAPVYCV
310 320
AFAADGLLAA GSKDQRISIW SLYPCP
Length:326
Mass (Da):35,663
Last modified:December 13, 2002 - v2
Checksum:i64EB678A3EE72D89
GO
Isoform 2 (identifier: Q9EQ15-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     172-198: TNSSLRPLLLAGYEDGSVTLWDISERK → ESQKPQCPCLNWYRRGGGKVITGYCLF
     199-326: Missing.

Note: No experimental confirmation available.
Show »
Length:198
Mass (Da):21,712
Checksum:i4827B41832DA3E53
GO

Sequence cautioni

The sequence BAB26980 differs from that shown. Reason: Frameshift at positions 87, 90, 101 and 129.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2A → S in BAB26980 (PubMed:16141072).Curated1
Sequence conflicti33A → T in BAB26980 (PubMed:16141072).Curated1
Sequence conflicti59V → I in BAB26980 (PubMed:16141072).Curated1
Sequence conflicti66G → W in BAB26980 (PubMed:16141072).Curated1
Sequence conflicti80H → Q in BAB26980 (PubMed:16141072).Curated1
Sequence conflicti84S → T in BAB26980 (PubMed:16141072).Curated1
Sequence conflicti95D → Q in BAB26980 (PubMed:16141072).Curated1
Sequence conflicti133 – 135GKG → RKS in BAB26980 (PubMed:16141072).Curated3
Sequence conflicti139V → F in BAB26980 (PubMed:16141072).Curated1
Sequence conflicti150V → E in BAB26980 (PubMed:16141072).Curated1
Sequence conflicti236L → Q in AAG44996 (PubMed:11350118).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006769172 – 198TNSSL…ISERK → ESQKPQCPCLNWYRRGGGKV ITGYCLF in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_006770199 – 326Missing in isoform 2. 1 PublicationAdd BLAST128

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301595 mRNA. Translation: AAG44996.1.
AK010489 mRNA. Translation: BAB26980.1. Frameshift.
AK016952 mRNA. No translation available.
BC024635 mRNA. Translation: AAH24635.1.
BC037676 mRNA. Translation: AAH37676.1.
CCDSiCCDS28022.1. [Q9EQ15-1]
RefSeqiNP_001075151.1. NM_001081682.2. [Q9EQ15-1]
NP_075609.2. NM_023120.5. [Q9EQ15-1]
XP_011244133.1. XM_011245831.1. [Q9EQ15-1]
UniGeneiMm.236139.

Genome annotation databases

EnsembliENSMUST00000090086; ENSMUSP00000087544; ENSMUSG00000000884. [Q9EQ15-1]
ENSMUST00000115600; ENSMUSP00000111263; ENSMUSG00000000884. [Q9EQ15-2]
ENSMUST00000167778; ENSMUSP00000130371; ENSMUSG00000000884. [Q9EQ15-1]
GeneIDi13972.
KEGGimmu:13972.
UCSCiuc007yoa.2. mouse. [Q9EQ15-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301595 mRNA. Translation: AAG44996.1.
AK010489 mRNA. Translation: BAB26980.1. Frameshift.
AK016952 mRNA. No translation available.
BC024635 mRNA. Translation: AAH24635.1.
BC037676 mRNA. Translation: AAH37676.1.
CCDSiCCDS28022.1. [Q9EQ15-1]
RefSeqiNP_001075151.1. NM_001081682.2. [Q9EQ15-1]
NP_075609.2. NM_023120.5. [Q9EQ15-1]
XP_011244133.1. XM_011245831.1. [Q9EQ15-1]
UniGeneiMm.236139.

3D structure databases

ProteinModelPortaliQ9EQ15.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087544.

PTM databases

iPTMnetiQ9EQ15.
PhosphoSitePlusiQ9EQ15.

Proteomic databases

EPDiQ9EQ15.
PaxDbiQ9EQ15.
PRIDEiQ9EQ15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090086; ENSMUSP00000087544; ENSMUSG00000000884. [Q9EQ15-1]
ENSMUST00000115600; ENSMUSP00000111263; ENSMUSG00000000884. [Q9EQ15-2]
ENSMUST00000167778; ENSMUSP00000130371; ENSMUSG00000000884. [Q9EQ15-1]
GeneIDi13972.
KEGGimmu:13972.
UCSCiuc007yoa.2. mouse. [Q9EQ15-1]

Organism-specific databases

CTDi54584.
MGIiMGI:1338057. Gnb1l.

Phylogenomic databases

eggNOGiKOG0322. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00390000018606.
HOGENOMiHOG000007056.
HOVERGENiHBG051745.
InParanoidiQ9EQ15.
OMAiCLELWQA.
OrthoDBiEOG091G0HHK.
TreeFamiTF344050.

Miscellaneous databases

ChiTaRSiGnb1l. mouse.
PROiQ9EQ15.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000884.
ExpressionAtlasiQ9EQ15. baseline and differential.
GenevisibleiQ9EQ15. MM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGNB1L_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ15
Secondary accession number(s): Q8R1F3, Q9CWP2, Q9D3Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: December 13, 2002
Last modified: November 2, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.