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Protein

Interleukin-23 subunit alpha

Gene

Il23a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.10 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense, Immunity, Inflammatory response, Innate immunity, Tissue remodeling

Enzyme and pathway databases

ReactomeiR-MMU-447115. Interleukin-12 family signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-23 subunit alpha
Short name:
IL-23 subunit alpha
Short name:
IL-23-A
Alternative name(s):
Interleukin-23 subunit p19
Short name:
IL-23p19
Gene namesi
Name:Il23a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1932410. Il23a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice have no overt phenotype but display compromised humoral and delayed-type hypersensitivity responses. They also have impaired secretion of IL17 and IL17F, higher succeptibility to Klebsiella pneumoniae and Citrobacter rodentium infection, do not develop experimentally-induced autoimmune encephalitis a mouse model of multiple sclerosis, collagen-induced arthritis a rodent model of rheumatoid arthritis and also spontaneous colitis induced by IL10 deficiency a rodent model of inflammatory bowel disease. Transgenic mice expressing Il23a ubiquitously display multiorgan inflammation and infertility, express acute phase genes, have impaired growth and dye prematurely.5 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000025948922 – 196Interleukin-23 subunit alphaAdd BLAST175

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9EQ14.
PRIDEiQ9EQ14.

Expressioni

Tissue specificityi

Secreted by activated dendritic cells (at protein level). Detected in various tissues with higher expression in polarized Th1 cells and activated macrophages.1 Publication

Inductioni

Up-regulated in trigeminal glanglia after herpes simplex virus type 1 infection, in the lung of mice infected with mycobacteria or Klebsiella pneumoniae. Up-regulated in microglia by combined LPS and IFNG stimulation. Up-regulated by FASLG.4 Publications

Gene expression databases

BgeeiENSMUSG00000025383.
CleanExiMM_IL23A.
GenevisibleiQ9EQ14. MM.

Interactioni

Subunit structurei

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9EQ14. 2 interactors.
STRINGi10090.ENSMUSP00000026449.

Structurei

3D structure databases

ProteinModelPortaliQ9EQ14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGBY. Eukaryota.
ENOG411142Q. LUCA.
GeneTreeiENSGT00390000006482.
HOGENOMiHOG000048728.
HOVERGENiHBG081786.
InParanoidiQ9EQ14.
KOiK05426.
OMAiPMGHVDL.
OrthoDBiEOG091G0Q9J.
PhylomeDBiQ9EQ14.
TreeFamiTF337234.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR010831. IL-23_alpha.
PANTHERiPTHR15947. PTHR15947. 1 hit.
PfamiView protein in Pfam
PF16649. IL23. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQ14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDCRAVIML WLLPWVTQGL AVPRSSSPDW AQCQQLSRNL CMLAWNAHAP
60 70 80 90 100
AGHMNLLREE EDEETKNNVP RIQCEDGCDP QGLKDNSQFC LQRIRQGLAF
110 120 130 140 150
YKHLLDSDIF KGEPALLPDS PMEQLHTSLL GLSQLLQPED HPRETQQMPS
160 170 180 190
LSSSQQWQRP LLRSKILRSL QAFLAIAARV FAHGAATLTE PLVPTA
Length:196
Mass (Da):22,071
Last modified:March 1, 2001 - v1
Checksum:iDAF4A318A2DD3B7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301619 mRNA. Translation: AAG37231.1.
BC019953 mRNA. Translation: AAH19953.1.
CCDSiCCDS24270.1.
RefSeqiNP_112542.1. NM_031252.2.
UniGeneiMm.125482.

Genome annotation databases

EnsembliENSMUST00000026449; ENSMUSP00000026449; ENSMUSG00000025383.
GeneIDi83430.
KEGGimmu:83430.
UCSCiuc007hmc.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiIL23A_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2001
Last modified: September 27, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families