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Q9EQ14

- IL23A_MOUSE

UniProt

Q9EQ14 - IL23A_MOUSE

Protein

Interleukin-23 subunit alpha

Gene

Il23a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.10 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. defense response to Gram-negative bacterium Source: Ensembl
    2. defense response to virus Source: UniProtKB-KW
    3. inflammatory response Source: UniProtKB-KW
    4. innate immune response Source: UniProtKB-KW
    5. negative regulation of interleukin-10 production Source: Ensembl
    6. positive regulation of activated T cell proliferation Source: Ensembl
    7. positive regulation of activation of JAK2 kinase activity Source: Ensembl
    8. positive regulation of defense response to virus by host Source: BHF-UCL
    9. positive regulation of granulocyte macrophage colony-stimulating factor production Source: Ensembl
    10. positive regulation of interferon-gamma production Source: Ensembl
    11. positive regulation of interleukin-10 production Source: Ensembl
    12. positive regulation of interleukin-12 production Source: Ensembl
    13. positive regulation of interleukin-17 production Source: Ensembl
    14. positive regulation of memory T cell differentiation Source: BHF-UCL
    15. positive regulation of natural killer cell proliferation Source: Ensembl
    16. positive regulation of neutrophil chemotaxis Source: BHF-UCL
    17. positive regulation of NK T cell activation Source: Ensembl
    18. positive regulation of NK T cell proliferation Source: Ensembl
    19. positive regulation of osteoclast differentiation Source: Ensembl
    20. positive regulation of T cell mediated cytotoxicity Source: BHF-UCL
    21. positive regulation of T-helper 17 cell lineage commitment Source: BHF-UCL
    22. positive regulation of T-helper 17 type immune response Source: BHF-UCL
    23. positive regulation of T-helper 1 type immune response Source: BHF-UCL
    24. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    25. positive regulation of tumor necrosis factor production Source: Ensembl
    26. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
    27. positive regulation of tyrosine phosphorylation of Stat4 protein Source: Ensembl
    28. positive regulation of tyrosine phosphorylation of Stat5 protein Source: Ensembl
    29. regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
    30. T cell proliferation Source: MGI
    31. tissue remodeling Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense, Immunity, Inflammatory response, Innate immunity, Tissue remodeling

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-23 subunit alpha
    Short name:
    IL-23 subunit alpha
    Short name:
    IL-23-A
    Alternative name(s):
    Interleukin-23 subunit p19
    Short name:
    IL-23p19
    Gene namesi
    Name:Il23a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1932410. Il23a.

    Subcellular locationi

    Secreted 1 Publication
    Note: Secreted upon association with IL12B.

    GO - Cellular componenti

    1. extracellular space Source: MGI
    2. interleukin-23 complex Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Disruption phenotypei

    Mice have no overt phenotype but display compromised humoral and delayed-type hypersensitivity responses. They also have impaired secretion of IL17 and IL17F, higher succeptibility to Klebsiella pneumoniae and Citrobacter rodentium infection, do not develop experimentally-induced autoimmune encephalitis a mouse model of multiple sclerosis, collagen-induced arthritis a rodent model of rheumatoid arthritis and also spontaneous colitis induced by IL10 deficiency a rodent model of inflammatory bowel disease. Transgenic mice expressing Il23a ubiquitously display multiorgan inflammation and infertility, express acute phase genes, have impaired growth and dye prematurely.5 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 196175Interleukin-23 subunit alphaPRO_0000259489Add
    BLAST

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ9EQ14.

    Expressioni

    Tissue specificityi

    Secreted by activated dendritic cells (at protein level). Detected in various tissues with higher expression in polarized Th1 cells and activated macrophages.1 Publication

    Inductioni

    Up-regulated in trigeminal glanglia after herpes simplex virus type 1 infection, in the lung of mice infected with mycobacteria or Klebsiella pneumoniae. Up-regulated in microglia by combined LPS and IFNG stimulation. Up-regulated by FASLG.4 Publications

    Gene expression databases

    BgeeiQ9EQ14.
    CleanExiMM_IL23A.
    GenevestigatoriQ9EQ14.

    Interactioni

    Subunit structurei

    Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    IL12BP294602EBI-2481329,EBI-1029614From a different organism.
    Il12bP434323EBI-2481329,EBI-2481353

    Protein-protein interaction databases

    IntActiQ9EQ14. 2 interactions.
    STRINGi10090.ENSMUSP00000026449.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EQ14.
    SMRiQ9EQ14. Positions 21-188.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-6 superfamily.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42887.
    GeneTreeiENSGT00390000006482.
    HOGENOMiHOG000048728.
    HOVERGENiHBG081786.
    InParanoidiQ9EQ14.
    KOiK05426.
    OMAiIHQGLVF.
    OrthoDBiEOG76HQ32.
    PhylomeDBiQ9EQ14.
    TreeFamiTF337234.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR010831. IL-23_alpha.
    IPR003573. IL-6/IL-23/GCSF/MGF.
    [Graphical view]
    PANTHERiPTHR15947. PTHR15947. 1 hit.
    PfamiPF00489. IL6. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9EQ14-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDCRAVIML WLLPWVTQGL AVPRSSSPDW AQCQQLSRNL CMLAWNAHAP    50
    AGHMNLLREE EDEETKNNVP RIQCEDGCDP QGLKDNSQFC LQRIRQGLAF 100
    YKHLLDSDIF KGEPALLPDS PMEQLHTSLL GLSQLLQPED HPRETQQMPS 150
    LSSSQQWQRP LLRSKILRSL QAFLAIAARV FAHGAATLTE PLVPTA 196
    Length:196
    Mass (Da):22,071
    Last modified:March 1, 2001 - v1
    Checksum:iDAF4A318A2DD3B7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF301619 mRNA. Translation: AAG37231.1.
    BC019953 mRNA. Translation: AAH19953.1.
    CCDSiCCDS24270.1.
    RefSeqiNP_112542.1. NM_031252.2.
    UniGeneiMm.125482.

    Genome annotation databases

    EnsembliENSMUST00000026449; ENSMUSP00000026449; ENSMUSG00000025383.
    GeneIDi83430.
    KEGGimmu:83430.
    UCSCiuc007hmc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF301619 mRNA. Translation: AAG37231.1 .
    BC019953 mRNA. Translation: AAH19953.1 .
    CCDSi CCDS24270.1.
    RefSeqi NP_112542.1. NM_031252.2.
    UniGenei Mm.125482.

    3D structure databases

    ProteinModelPortali Q9EQ14.
    SMRi Q9EQ14. Positions 21-188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9EQ14. 2 interactions.
    STRINGi 10090.ENSMUSP00000026449.

    Proteomic databases

    PRIDEi Q9EQ14.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026449 ; ENSMUSP00000026449 ; ENSMUSG00000025383 .
    GeneIDi 83430.
    KEGGi mmu:83430.
    UCSCi uc007hmc.1. mouse.

    Organism-specific databases

    CTDi 51561.
    MGIi MGI:1932410. Il23a.

    Phylogenomic databases

    eggNOGi NOG42887.
    GeneTreei ENSGT00390000006482.
    HOGENOMi HOG000048728.
    HOVERGENi HBG081786.
    InParanoidi Q9EQ14.
    KOi K05426.
    OMAi IHQGLVF.
    OrthoDBi EOG76HQ32.
    PhylomeDBi Q9EQ14.
    TreeFami TF337234.

    Miscellaneous databases

    NextBioi 350550.
    PROi Q9EQ14.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9EQ14.
    CleanExi MM_IL23A.
    Genevestigatori Q9EQ14.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR010831. IL-23_alpha.
    IPR003573. IL-6/IL-23/GCSF/MGF.
    [Graphical view ]
    PANTHERi PTHR15947. PTHR15947. 1 hit.
    Pfami PF00489. IL6. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH IL12B, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Monocyte.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    3. "Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death."
      Wiekowski M.T., Leach M.W., Evans E.W., Sullivan L., Chen S.-C., Vassileva G., Bazan J.F., Gorman D.M., Kastelein R.A., Narula S., Lira S.A.
      J. Immunol. 166:7563-7570(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present."
      Cooper A.M., Kipnis A., Turner J., Magram J., Ferrante J., Orme I.M.
      J. Immunol. 168:1322-1327(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY MYCOBACTERIAL INFECTION.
    5. "Herpes simplex virus type 1 infection induces upregulation of interleukin-23 (p19) mRNA expression in trigeminal ganglia of BALB/c mice."
      Broberg E.K., Setaelae N., Eraelinna J.-P., Salmi A.A., Roeyttae M., Hukkanen V.
      J. Interferon Cytokine Res. 22:641-651(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY HERPES SIMPLEX VIRUS TYPE 1 INFECTION.
    6. "Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation."
      Murphy C.A., Langrish C.L., Chen Y., Blumenschein W., McClanahan T.K., Kastelein R.A., Sedgwick J.D., Cua D.J.
      J. Exp. Med. 198:1951-1957(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    7. Cited for: FUNCTION.
    8. "Differential expression and regulation of IL-23 and IL-12 subunits and receptors in adult mouse microglia."
      Li J., Gran B., Zhang G.-X., Ventura E.S., Siglienti I., Rostami A., Kamoun M.
      J. Neurol. Sci. 215:95-103(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY LPS AND IFNG.
    9. "Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain."
      Cua D.J., Sherlock J., Chen Y., Murphy C.A., Joyce B., Seymour B., Lucian L., To W., Kwan S., Churakova T., Zurawski S., Wiekowski M.T., Lira S.A., Gorman D., Kastelein R.A., Sedgwick J.D.
      Nature 421:744-748(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    10. "Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice."
      Ghilardi N., Kljavin N., Chen Q., Lucas S., Gurney A.L., de Sauvage F.J.
      J. Immunol. 172:2827-2833(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    11. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    12. "Fas ligand induces cell-autonomous IL-23 production in dendritic cells, a mechanism for Fas ligand-induced IL-17 production."
      Kidoya H., Umemura M., Kawabe T., Matsuzaki G., Yahagi A., Imamura R., Suda T.
      J. Immunol. 175:8024-8031(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY FASLG.
    13. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    14. Cited for: FUNCTION.
    15. Cited for: FUNCTION.

    Entry informationi

    Entry nameiIL23A_MOUSE
    AccessioniPrimary (citable) accession number: Q9EQ14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3