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Q9EQ14

- IL23A_MOUSE

UniProt

Q9EQ14 - IL23A_MOUSE

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Protein

Interleukin-23 subunit alpha

Gene
Il23a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.10 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. defense response to Gram-negative bacterium Source: Ensembl
  2. defense response to virus Source: UniProtKB-KW
  3. inflammatory response Source: UniProtKB-KW
  4. innate immune response Source: UniProtKB-KW
  5. negative regulation of interleukin-10 production Source: Ensembl
  6. positive regulation of activated T cell proliferation Source: Ensembl
  7. positive regulation of activation of JAK2 kinase activity Source: Ensembl
  8. positive regulation of defense response to virus by host Source: BHF-UCL
  9. positive regulation of granulocyte macrophage colony-stimulating factor production Source: Ensembl
  10. positive regulation of interferon-gamma production Source: Ensembl
  11. positive regulation of interleukin-10 production Source: Ensembl
  12. positive regulation of interleukin-12 production Source: Ensembl
  13. positive regulation of interleukin-17 production Source: Ensembl
  14. positive regulation of memory T cell differentiation Source: BHF-UCL
  15. positive regulation of natural killer cell proliferation Source: Ensembl
  16. positive regulation of neutrophil chemotaxis Source: BHF-UCL
  17. positive regulation of NK T cell activation Source: Ensembl
  18. positive regulation of NK T cell proliferation Source: Ensembl
  19. positive regulation of osteoclast differentiation Source: Ensembl
  20. positive regulation of T cell mediated cytotoxicity Source: BHF-UCL
  21. positive regulation of T-helper 17 cell lineage commitment Source: BHF-UCL
  22. positive regulation of T-helper 17 type immune response Source: BHF-UCL
  23. positive regulation of T-helper 1 type immune response Source: BHF-UCL
  24. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  25. positive regulation of tumor necrosis factor production Source: Ensembl
  26. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
  27. positive regulation of tyrosine phosphorylation of Stat4 protein Source: Ensembl
  28. positive regulation of tyrosine phosphorylation of Stat5 protein Source: Ensembl
  29. regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
  30. T cell proliferation Source: MGI
  31. tissue remodeling Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense, Immunity, Inflammatory response, Innate immunity, Tissue remodeling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-23 subunit alpha
Short name:
IL-23 subunit alpha
Short name:
IL-23-A
Alternative name(s):
Interleukin-23 subunit p19
Short name:
IL-23p19
Gene namesi
Name:Il23a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1932410. Il23a.

Subcellular locationi

Secreted
Note: Secreted upon association with IL12B.1 Publication

GO - Cellular componenti

  1. extracellular space Source: MGI
  2. interleukin-23 complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice have no overt phenotype but display compromised humoral and delayed-type hypersensitivity responses. They also have impaired secretion of IL17 and IL17F, higher succeptibility to Klebsiella pneumoniae and Citrobacter rodentium infection, do not develop experimentally-induced autoimmune encephalitis a mouse model of multiple sclerosis, collagen-induced arthritis a rodent model of rheumatoid arthritis and also spontaneous colitis induced by IL10 deficiency a rodent model of inflammatory bowel disease. Transgenic mice expressing Il23a ubiquitously display multiorgan inflammation and infertility, express acute phase genes, have impaired growth and dye prematurely.5 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed predictionAdd
BLAST
Chaini22 – 196175Interleukin-23 subunit alphaPRO_0000259489Add
BLAST

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9EQ14.

Expressioni

Tissue specificityi

Secreted by activated dendritic cells (at protein level). Detected in various tissues with higher expression in polarized Th1 cells and activated macrophages.1 Publication

Inductioni

Up-regulated in trigeminal glanglia after herpes simplex virus type 1 infection, in the lung of mice infected with mycobacteria or Klebsiella pneumoniae. Up-regulated in microglia by combined LPS and IFNG stimulation. Up-regulated by FASLG.4 Publications

Gene expression databases

BgeeiQ9EQ14.
CleanExiMM_IL23A.
GenevestigatoriQ9EQ14.

Interactioni

Subunit structurei

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23.

Binary interactionsi

WithEntry#Exp.IntActNotes
IL12BP294602EBI-2481329,EBI-1029614From a different organism.
Il12bP434323EBI-2481329,EBI-2481353

Protein-protein interaction databases

IntActiQ9EQ14. 2 interactions.
STRINGi10090.ENSMUSP00000026449.

Structurei

3D structure databases

ProteinModelPortaliQ9EQ14.
SMRiQ9EQ14. Positions 21-188.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42887.
GeneTreeiENSGT00390000006482.
HOGENOMiHOG000048728.
HOVERGENiHBG081786.
InParanoidiQ9EQ14.
KOiK05426.
OMAiIHQGLVF.
OrthoDBiEOG76HQ32.
PhylomeDBiQ9EQ14.
TreeFamiTF337234.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR010831. IL-23_alpha.
IPR003573. IL-6/IL-23/GCSF/MGF.
[Graphical view]
PANTHERiPTHR15947. PTHR15947. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQ14-1 [UniParc]FASTAAdd to Basket

« Hide

MLDCRAVIML WLLPWVTQGL AVPRSSSPDW AQCQQLSRNL CMLAWNAHAP    50
AGHMNLLREE EDEETKNNVP RIQCEDGCDP QGLKDNSQFC LQRIRQGLAF 100
YKHLLDSDIF KGEPALLPDS PMEQLHTSLL GLSQLLQPED HPRETQQMPS 150
LSSSQQWQRP LLRSKILRSL QAFLAIAARV FAHGAATLTE PLVPTA 196
Length:196
Mass (Da):22,071
Last modified:March 1, 2001 - v1
Checksum:iDAF4A318A2DD3B7C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF301619 mRNA. Translation: AAG37231.1.
BC019953 mRNA. Translation: AAH19953.1.
CCDSiCCDS24270.1.
RefSeqiNP_112542.1. NM_031252.2.
UniGeneiMm.125482.

Genome annotation databases

EnsembliENSMUST00000026449; ENSMUSP00000026449; ENSMUSG00000025383.
GeneIDi83430.
KEGGimmu:83430.
UCSCiuc007hmc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF301619 mRNA. Translation: AAG37231.1 .
BC019953 mRNA. Translation: AAH19953.1 .
CCDSi CCDS24270.1.
RefSeqi NP_112542.1. NM_031252.2.
UniGenei Mm.125482.

3D structure databases

ProteinModelPortali Q9EQ14.
SMRi Q9EQ14. Positions 21-188.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9EQ14. 2 interactions.
STRINGi 10090.ENSMUSP00000026449.

Proteomic databases

PRIDEi Q9EQ14.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026449 ; ENSMUSP00000026449 ; ENSMUSG00000025383 .
GeneIDi 83430.
KEGGi mmu:83430.
UCSCi uc007hmc.1. mouse.

Organism-specific databases

CTDi 51561.
MGIi MGI:1932410. Il23a.

Phylogenomic databases

eggNOGi NOG42887.
GeneTreei ENSGT00390000006482.
HOGENOMi HOG000048728.
HOVERGENi HBG081786.
InParanoidi Q9EQ14.
KOi K05426.
OMAi IHQGLVF.
OrthoDBi EOG76HQ32.
PhylomeDBi Q9EQ14.
TreeFami TF337234.

Miscellaneous databases

NextBioi 350550.
PROi Q9EQ14.
SOURCEi Search...

Gene expression databases

Bgeei Q9EQ14.
CleanExi MM_IL23A.
Genevestigatori Q9EQ14.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR010831. IL-23_alpha.
IPR003573. IL-6/IL-23/GCSF/MGF.
[Graphical view ]
PANTHERi PTHR15947. PTHR15947. 1 hit.
Pfami PF00489. IL6. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH IL12B, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Monocyte.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death."
    Wiekowski M.T., Leach M.W., Evans E.W., Sullivan L., Chen S.-C., Vassileva G., Bazan J.F., Gorman D.M., Kastelein R.A., Narula S., Lira S.A.
    J. Immunol. 166:7563-7570(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present."
    Cooper A.M., Kipnis A., Turner J., Magram J., Ferrante J., Orme I.M.
    J. Immunol. 168:1322-1327(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY MYCOBACTERIAL INFECTION.
  5. "Herpes simplex virus type 1 infection induces upregulation of interleukin-23 (p19) mRNA expression in trigeminal ganglia of BALB/c mice."
    Broberg E.K., Setaelae N., Eraelinna J.-P., Salmi A.A., Roeyttae M., Hukkanen V.
    J. Interferon Cytokine Res. 22:641-651(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY HERPES SIMPLEX VIRUS TYPE 1 INFECTION.
  6. "Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation."
    Murphy C.A., Langrish C.L., Chen Y., Blumenschein W., McClanahan T.K., Kastelein R.A., Sedgwick J.D., Cua D.J.
    J. Exp. Med. 198:1951-1957(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  7. Cited for: FUNCTION.
  8. "Differential expression and regulation of IL-23 and IL-12 subunits and receptors in adult mouse microglia."
    Li J., Gran B., Zhang G.-X., Ventura E.S., Siglienti I., Rostami A., Kamoun M.
    J. Neurol. Sci. 215:95-103(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY LPS AND IFNG.
  9. "Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain."
    Cua D.J., Sherlock J., Chen Y., Murphy C.A., Joyce B., Seymour B., Lucian L., To W., Kwan S., Churakova T., Zurawski S., Wiekowski M.T., Lira S.A., Gorman D., Kastelein R.A., Sedgwick J.D.
    Nature 421:744-748(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  10. "Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice."
    Ghilardi N., Kljavin N., Chen Q., Lucas S., Gurney A.L., de Sauvage F.J.
    J. Immunol. 172:2827-2833(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  11. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  12. "Fas ligand induces cell-autonomous IL-23 production in dendritic cells, a mechanism for Fas ligand-induced IL-17 production."
    Kidoya H., Umemura M., Kawabe T., Matsuzaki G., Yahagi A., Imamura R., Suda T.
    J. Immunol. 175:8024-8031(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY FASLG.
  13. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  14. Cited for: FUNCTION.
  15. Cited for: FUNCTION.

Entry informationi

Entry nameiIL23A_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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