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Q9EQ09

- OLR1_MOUSE

UniProt

Q9EQ09 - OLR1_MOUSE

Protein

Oxidized low-density lipoprotein receptor 1

Gene

Olr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria By similarity.By similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. low-density lipoprotein receptor activity Source: MGI

    GO - Biological processi

    1. cell death Source: Ensembl
    2. immune system process Source: UniProtKB-KW
    3. inflammatory response Source: UniProtKB-KW
    4. leukocyte cell-cell adhesion Source: Ensembl
    5. lipoprotein metabolic process Source: Ensembl
    6. receptor-mediated endocytosis Source: GOC
    7. response to hydrogen peroxide Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Cell adhesion, Immunity, Inflammatory response

    Keywords - Ligandi

    Lectin

    Enzyme and pathway databases

    ReactomeiREACT_225233. Cell surface interactions at the vascular wall.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxidized low-density lipoprotein receptor 1
    Short name:
    Ox-LDL receptor 1
    Alternative name(s):
    Lectin-like oxidized LDL receptor 1
    Short name:
    LOX-1
    Short name:
    Lectin-like oxLDL receptor 1
    Lectin-type oxidized LDL receptor 1
    Cleaved into the following chain:
    Gene namesi
    Name:Olr1
    Synonyms:Lox1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1261434. Olr1.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity. Cell membrane By similarity; Single-pass type II membrane protein By similarity. Membrane raft By similarity. Secreted By similarity
    Note: A secreted form also exists. Localization to membrane rafts requires palmitoylation By similarity.By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. extrinsic component of plasma membrane Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane raft Source: UniProtKB-SubCell
    5. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 363Oxidized low-density lipoprotein receptor 1, soluble formPRO_0000017446
    Chaini1 – 363363Oxidized low-density lipoprotein receptor 1PRO_0000017445Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi45 – 451S-palmitoyl cysteineBy similarity
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi235 ↔ 246PROSITE-ProRule annotation
    Disulfide bondi262 ↔ 354PROSITE-ProRule annotation
    Disulfide bondi333 ↔ 346PROSITE-ProRule annotation

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ9EQ09.
    PRIDEiQ9EQ09.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9EQ09.
    BgeeiQ9EQ09.
    GenevestigatoriQ9EQ09.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000032265.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EQ09.
    SMRiQ9EQ09. Positions 216-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini55 – 363309ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5423Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati96 – 141461Add
    BLAST
    Repeati142 – 187462Add
    BLAST
    Repeati188 – 233463Add
    BLAST
    Domaini242 – 355114C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni55 – 241187NeckAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili57 – 232176Sequence AnalysisAdd
    BLAST

    Domaini

    The cytoplasmic region is required for subcellular sorting on the cell surface.By similarity
    The C-type lectin domain mediates the recognition and binding of oxLDL.By similarity
    The Neck region contains 3 internal repeats that are only found in rodents.

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG242244.
    GeneTreeiENSGT00700000104266.
    HOGENOMiHOG000220927.
    HOVERGENiHBG056863.
    InParanoidiQ3U3M1.
    KOiK08763.
    OMAiSICQKKA.
    OrthoDBiEOG747PJT.
    TreeFamiTF336674.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9EQ09-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTFDDKMKPA NDEPDQKSCG KKPKGLHLLS SPWWFPAAMT LVILCLVLSV    50
    TLIVQWTQLR QVSDLLKQYQ ANLTQQDRIL EGQMLAQQKA ENTSQESKKE 100
    LKGKIDTLTQ KLNEKSKEQE ELLQKNQNLQ EALQRAANSS EESQRELKGK 150
    IDTITRKLDE KSKEQEELLQ MIQNLQEALQ RAANSSEESQ RELKGKIDTL 200
    TLKLNEKSKE QEELLQKNQN LQEALQRAAN FSGPCPQDWL WHKENCYLFH 250
    GPFSWEKNRQ TCQSLGGQLL QINGADDLTF ILQAISHTTS PFWIGLHRKK 300
    PGQPWLWENG TPLNFQFFKT RGVSLQLYSS GNCAYLQDGA VFAENCILIA 350
    FSICQKKTNH LQI 363
    Length:363
    Mass (Da):41,643
    Last modified:July 27, 2011 - v2
    Checksum:i8F370C86B58F11A8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti93 – 931T → A in AAG44998. (PubMed:9588202)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF303744 mRNA. Translation: AAG44998.1.
    AK154687 mRNA. Translation: BAE32764.1.
    CCDSiCCDS20588.1.
    PIRiJE0111.
    RefSeqiNP_619589.2. NM_138648.2.
    UniGeneiMm.293626.

    Genome annotation databases

    EnsembliENSMUST00000032265; ENSMUSP00000032265; ENSMUSG00000030162.
    GeneIDi108078.
    KEGGimmu:108078.
    UCSCiuc009efw.2. mouse.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Oxidised LDL receptor

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF303744 mRNA. Translation: AAG44998.1 .
    AK154687 mRNA. Translation: BAE32764.1 .
    CCDSi CCDS20588.1.
    PIRi JE0111.
    RefSeqi NP_619589.2. NM_138648.2.
    UniGenei Mm.293626.

    3D structure databases

    ProteinModelPortali Q9EQ09.
    SMRi Q9EQ09. Positions 216-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000032265.

    Proteomic databases

    PaxDbi Q9EQ09.
    PRIDEi Q9EQ09.

    Protocols and materials databases

    DNASUi 108078.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032265 ; ENSMUSP00000032265 ; ENSMUSG00000030162 .
    GeneIDi 108078.
    KEGGi mmu:108078.
    UCSCi uc009efw.2. mouse.

    Organism-specific databases

    CTDi 4973.
    MGIi MGI:1261434. Olr1.

    Phylogenomic databases

    eggNOGi NOG242244.
    GeneTreei ENSGT00700000104266.
    HOGENOMi HOG000220927.
    HOVERGENi HBG056863.
    InParanoidi Q3U3M1.
    KOi K08763.
    OMAi SICQKKA.
    OrthoDBi EOG747PJT.
    TreeFami TF336674.

    Enzyme and pathway databases

    Reactomei REACT_225233. Cell surface interactions at the vascular wall.

    Miscellaneous databases

    NextBioi 360012.
    PROi Q9EQ09.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9EQ09.
    Bgeei Q9EQ09.
    Genevestigatori Q9EQ09.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High affinity binding of oxidized LDL to mouse lectin-like oxidized LDL receptor (LOX-1)."
      Hoshikawa H., Sawamura T., Kakutani M., Aoyama T., Nakamura T., Masaki T.
      Biochem. Biophys. Res. Commun. 245:841-846(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Mouse LOX-1 is expressed in mast cells after IgE cross-linking."
      Park S.-H., Ahn H.-J., Cho J.-J.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.

    Entry informationi

    Entry nameiOLR1_MOUSE
    AccessioniPrimary (citable) accession number: Q9EQ09
    Secondary accession number(s): Q3U3M1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3