Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Oxidized low-density lipoprotein receptor 1

Gene

Olr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity).By similarity

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • low-density lipoprotein receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion, Immunity, Inflammatory response

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiR-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxidized low-density lipoprotein receptor 1
Short name:
Ox-LDL receptor 1
Alternative name(s):
Lectin-like oxidized LDL receptor 1
Short name:
LOX-1
Short name:
Lectin-like oxLDL receptor 1
Lectin-type oxidized LDL receptor 1
Cleaved into the following chain:
Gene namesi
Name:Olr1
Synonyms:Lox1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1261434. Olr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31CytoplasmicSequence analysisAdd BLAST31
Transmembranei32 – 54Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini55 – 363ExtracellularSequence analysisAdd BLAST309

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000017446? – 363Oxidized low-density lipoprotein receptor 1, soluble form
ChainiPRO_00000174451 – 363Oxidized low-density lipoprotein receptor 1Add BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi45S-palmitoyl cysteineBy similarity1
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi92N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi235 ↔ 246PROSITE-ProRule annotation
Disulfide bondi262 ↔ 354PROSITE-ProRule annotation
Disulfide bondi333 ↔ 346PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9EQ09.
PRIDEiQ9EQ09.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030162.
ExpressionAtlasiQ9EQ09. baseline and differential.
GenevisibleiQ9EQ09. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032265.

Structurei

3D structure databases

ProteinModelPortaliQ9EQ09.
SMRiQ9EQ09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati96 – 1411Add BLAST46
Repeati142 – 1872Add BLAST46
Repeati188 – 2333Add BLAST46
Domaini242 – 355C-type lectinPROSITE-ProRule annotationAdd BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni55 – 241NeckAdd BLAST187

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili57 – 232Sequence analysisAdd BLAST176

Domaini

The cytoplasmic region is required for subcellular sorting on the cell surface.By similarity
The C-type lectin domain mediates the recognition and binding of oxLDL.By similarity
The Neck region contains 3 internal repeats that are only found in rodents.

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104266.
HOGENOMiHOG000220927.
HOVERGENiHBG056863.
InParanoidiQ9EQ09.
KOiK08763.
OMAiQQANLTH.
OrthoDBiEOG091G0MM1.
TreeFamiTF336674.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQ09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFDDKMKPA NDEPDQKSCG KKPKGLHLLS SPWWFPAAMT LVILCLVLSV
60 70 80 90 100
TLIVQWTQLR QVSDLLKQYQ ANLTQQDRIL EGQMLAQQKA ENTSQESKKE
110 120 130 140 150
LKGKIDTLTQ KLNEKSKEQE ELLQKNQNLQ EALQRAANSS EESQRELKGK
160 170 180 190 200
IDTITRKLDE KSKEQEELLQ MIQNLQEALQ RAANSSEESQ RELKGKIDTL
210 220 230 240 250
TLKLNEKSKE QEELLQKNQN LQEALQRAAN FSGPCPQDWL WHKENCYLFH
260 270 280 290 300
GPFSWEKNRQ TCQSLGGQLL QINGADDLTF ILQAISHTTS PFWIGLHRKK
310 320 330 340 350
PGQPWLWENG TPLNFQFFKT RGVSLQLYSS GNCAYLQDGA VFAENCILIA
360
FSICQKKTNH LQI
Length:363
Mass (Da):41,643
Last modified:July 27, 2011 - v2
Checksum:i8F370C86B58F11A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93T → A in AAG44998 (PubMed:9588202).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303744 mRNA. Translation: AAG44998.1.
AK154687 mRNA. Translation: BAE32764.1.
CCDSiCCDS20588.1.
PIRiJE0111.
RefSeqiNP_619589.2. NM_138648.2.
UniGeneiMm.293626.

Genome annotation databases

EnsembliENSMUST00000032265; ENSMUSP00000032265; ENSMUSG00000030162.
GeneIDi108078.
KEGGimmu:108078.
UCSCiuc009efw.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Oxidised LDL receptor

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303744 mRNA. Translation: AAG44998.1.
AK154687 mRNA. Translation: BAE32764.1.
CCDSiCCDS20588.1.
PIRiJE0111.
RefSeqiNP_619589.2. NM_138648.2.
UniGeneiMm.293626.

3D structure databases

ProteinModelPortaliQ9EQ09.
SMRiQ9EQ09.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032265.

Proteomic databases

PaxDbiQ9EQ09.
PRIDEiQ9EQ09.

Protocols and materials databases

DNASUi108078.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032265; ENSMUSP00000032265; ENSMUSG00000030162.
GeneIDi108078.
KEGGimmu:108078.
UCSCiuc009efw.2. mouse.

Organism-specific databases

CTDi4973.
MGIiMGI:1261434. Olr1.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104266.
HOGENOMiHOG000220927.
HOVERGENiHBG056863.
InParanoidiQ9EQ09.
KOiK08763.
OMAiQQANLTH.
OrthoDBiEOG091G0MM1.
TreeFamiTF336674.

Enzyme and pathway databases

ReactomeiR-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ9EQ09.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030162.
ExpressionAtlasiQ9EQ09. baseline and differential.
GenevisibleiQ9EQ09. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOLR1_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ09
Secondary accession number(s): Q3U3M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.