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Protein

Estradiol 17-beta-dehydrogenase 11

Gene

Hsd17b11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione.

Catalytic activityi

17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei172 – 1721SubstrateBy similarity
Active sitei185 – 1851Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi40 – 6425NADPBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiR-MMU-193144. Estrogen biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Estradiol 17-beta-dehydrogenase 11 (EC:1.1.1.62)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase 11
Short name:
17-beta-HSD 11
Short name:
17bHSD11
Short name:
17betaHSD11
17-beta-hydroxysteroid dehydrogenase XI
Short name:
17-beta-HSD XI
Short name:
17betaHSDXI
Dehydrogenase/reductase SDR family member 8
Gene namesi
Name:Hsd17b11
Synonyms:Dhrs8, Pan1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2149821. Hsd17b11.

Subcellular locationi

  • Secreted Curated
  • Cytoplasm

  • Note: According to PubMed:12697717 it is cytoplasmic. However, the relevance of such result remains unclear.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 298277Estradiol 17-beta-dehydrogenase 11PRO_0000031971Add
BLAST

Proteomic databases

EPDiQ9EQ06.
MaxQBiQ9EQ06.
PaxDbiQ9EQ06.
PRIDEiQ9EQ06.

PTM databases

iPTMnetiQ9EQ06.
PhosphoSiteiQ9EQ06.

Expressioni

Gene expression databases

BgeeiQ9EQ06.
CleanExiMM_HSD17B11.
GenevisibleiQ9EQ06. MM.

Interactioni

Protein-protein interaction databases

BioGridi227794. 1 interaction.
IntActiQ9EQ06. 4 interactions.
MINTiMINT-1862554.
STRINGi10090.ENSMUSP00000031251.

Structurei

3D structure databases

ProteinModelPortaliQ9EQ06.
SMRiQ9EQ06. Positions 30-273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1201. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00540000069900.
HOVERGENiHBG051352.
InParanoidiQ9EQ06.
OMAiFLLAYXL.
OrthoDBiEOG7Z3F50.
PhylomeDBiQ9EQ06.
TreeFamiTF312837.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9EQ06-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKYLLDLILL LPLLIVFSIE SLVKLFIPKK KKSVAGEIVL ITGAGHGIGR
60 70 80 90 100
LTAYEFAKLN TKLVLWDINK NGIEETAAKC RKLGAQAHPF VVDCSQREEI
110 120 130 140 150
YSAAKKVKEE VGDVSILVNN AGVVYTADLF ATQDPQIEKT FEVNVLAHFW
160 170 180 190 200
TTKAFLPVMM KNNHGHIVTV ASAAGHTVVP FLLAYCSSKF AAVGFHRALT
210 220 230 240 250
DELAALGRTG VRTSCLCPNF INTGFIKNPS TNLGPTLEPE EVVEHLMHGI
260 270 280 290
LTEKQMIFVP SSIALLTVLE RIVPERFLQV LKHRINVKFD AVVGYKDK
Length:298
Mass (Da):32,881
Last modified:March 1, 2001 - v1
Checksum:i8ED9279FFBF20EA1
GO
Isoform 2 (identifier: Q9EQ06-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-232: N → K
     233-298: Missing.

Note: No experimental confirmation available.
Show »
Length:232
Mass (Da):25,347
Checksum:i459D085EEB194051
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei232 – 2321N → K in isoform 2. 1 PublicationVSP_015013
Alternative sequencei233 – 29866Missing in isoform 2. 1 PublicationVSP_015014Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF304306 mRNA. Translation: AAG41413.1.
AY053570 mRNA. Translation: AAL14859.1.
AK049355 mRNA. Translation: BAC33704.1.
AK154803 mRNA. Translation: BAE32840.1.
AK155174 mRNA. Translation: BAE33094.1.
AK155202 mRNA. Translation: BAE33115.1.
AK155327 mRNA. Translation: BAE33194.1.
AK158327 mRNA. Translation: BAE34459.1.
AK170939 mRNA. Translation: BAE42129.1.
BC038340 mRNA. Translation: AAH38340.1.
CCDSiCCDS19481.1. [Q9EQ06-1]
RefSeqiNP_444492.1. NM_053262.3. [Q9EQ06-1]
UniGeneiMm.46019.

Genome annotation databases

EnsembliENSMUST00000031251; ENSMUSP00000031251; ENSMUSG00000029311. [Q9EQ06-1]
ENSMUST00000119025; ENSMUSP00000113455; ENSMUSG00000029311. [Q9EQ06-2]
GeneIDi114664.
KEGGimmu:114664.
UCSCiuc008yjy.1. mouse. [Q9EQ06-1]
uc008yjz.1. mouse. [Q9EQ06-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF304306 mRNA. Translation: AAG41413.1.
AY053570 mRNA. Translation: AAL14859.1.
AK049355 mRNA. Translation: BAC33704.1.
AK154803 mRNA. Translation: BAE32840.1.
AK155174 mRNA. Translation: BAE33094.1.
AK155202 mRNA. Translation: BAE33115.1.
AK155327 mRNA. Translation: BAE33194.1.
AK158327 mRNA. Translation: BAE34459.1.
AK170939 mRNA. Translation: BAE42129.1.
BC038340 mRNA. Translation: AAH38340.1.
CCDSiCCDS19481.1. [Q9EQ06-1]
RefSeqiNP_444492.1. NM_053262.3. [Q9EQ06-1]
UniGeneiMm.46019.

3D structure databases

ProteinModelPortaliQ9EQ06.
SMRiQ9EQ06. Positions 30-273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi227794. 1 interaction.
IntActiQ9EQ06. 4 interactions.
MINTiMINT-1862554.
STRINGi10090.ENSMUSP00000031251.

PTM databases

iPTMnetiQ9EQ06.
PhosphoSiteiQ9EQ06.

Proteomic databases

EPDiQ9EQ06.
MaxQBiQ9EQ06.
PaxDbiQ9EQ06.
PRIDEiQ9EQ06.

Protocols and materials databases

DNASUi114664.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031251; ENSMUSP00000031251; ENSMUSG00000029311. [Q9EQ06-1]
ENSMUST00000119025; ENSMUSP00000113455; ENSMUSG00000029311. [Q9EQ06-2]
GeneIDi114664.
KEGGimmu:114664.
UCSCiuc008yjy.1. mouse. [Q9EQ06-1]
uc008yjz.1. mouse. [Q9EQ06-2]

Organism-specific databases

CTDi51170.
MGIiMGI:2149821. Hsd17b11.

Phylogenomic databases

eggNOGiKOG1201. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00540000069900.
HOVERGENiHBG051352.
InParanoidiQ9EQ06.
OMAiFLLAYXL.
OrthoDBiEOG7Z3F50.
PhylomeDBiQ9EQ06.
TreeFamiTF312837.

Enzyme and pathway databases

ReactomeiR-MMU-193144. Estrogen biosynthesis.

Miscellaneous databases

PROiQ9EQ06.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EQ06.
CleanExiMM_HSD17B11.
GenevisibleiQ9EQ06. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ENZYME ACTIVITY IN VITRO.
    Strain: NIH Swiss.
  2. Chen W., Napoli J.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: BALB/cJ.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Corpora quadrigemina, Dendritic cell, Embryonic stem cell and Inner ear.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary gland.
  5. "17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells."
    Chai Z., Brereton P., Suzuki T., Sasano H., Obeyesekere V., Escher G., Saffery R., Fuller P., Enriquez C., Krozowski Z.
    Endocrinology 144:2084-2091(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE SUBCELLULAR LOCATION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiDHB11_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ06
Secondary accession number(s): Q3U2P6, Q8BR33, Q8C7S0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.