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Protein

Solute carrier organic anion transporter family member 1C1

Gene

Slco1c1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency (By similarity). May play a signifiant role in regulating T4 flux into and out of the brain.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi2.A.60.1.10. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1C1
Alternative name(s):
BBB-specific anion transporter type 1
Blood-brain barrier-specific anion transporter 1
Solute carrier family 21 member 14
Thyroxine transporter
Gene namesi
Name:Slco1c1
Synonyms:Bsat1, Oatp1c1, Oatpf, Slc21a14
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628660. Slco1c1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43CytoplasmicSequence analysisAdd BLAST43
Transmembranei44 – 63Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini64 – 82ExtracellularSequence analysisAdd BLAST19
Transmembranei83 – 103Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini104 – 109CytoplasmicSequence analysis6
Transmembranei110 – 134Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini135 – 187ExtracellularSequence analysisAdd BLAST53
Transmembranei188 – 216Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini217 – 235CytoplasmicSequence analysisAdd BLAST19
Transmembranei236 – 256Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini257 – 274ExtracellularSequence analysisAdd BLAST18
Transmembranei275 – 299Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini300 – 352CytoplasmicSequence analysisAdd BLAST53
Transmembranei353 – 374Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini375 – 394ExtracellularSequence analysisAdd BLAST20
Transmembranei395 – 418Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini419 – 422CytoplasmicSequence analysis4
Transmembranei423 – 446Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini447 – 558ExtracellularSequence analysisAdd BLAST112
Transmembranei559 – 581Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini582 – 590CytoplasmicSequence analysis9
Transmembranei591 – 616Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini617 – 650ExtracellularSequence analysisAdd BLAST34
Transmembranei651 – 668Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini669 – 716CytoplasmicSequence analysisAdd BLAST48

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910571 – 716Solute carrier organic anion transporter family member 1C1Add BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi453N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi480 ↔ 506PROSITE-ProRule annotation
Disulfide bondi484 ↔ 495PROSITE-ProRule annotation
Disulfide bondi486 ↔ 510PROSITE-ProRule annotation
Glycosylationi524N-linked (GlcNAc...)Sequence analysis1
Glycosylationi537N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9EPZ7.
PRIDEiQ9EPZ7.

PTM databases

PhosphoSitePlusiQ9EPZ7.
UniCarbKBiQ9EPZ7.

Expressioni

Tissue specificityi

Highly expressed in cerebral microvessels (at protein level). Brain-specific. Not detected in glioma cells, kidney, heart, lung or liver. Highly expressed in cerebral microvessels throughout the brain and in tanycytes of the third ventricle.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi250000. 1 interactor.
STRINGi10116.ENSRNOP00000013230.

Structurei

3D structure databases

ProteinModelPortaliQ9EPZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini474 – 529Kazal-likePROSITE-ProRule annotationAdd BLAST56

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ9EPZ7.
KOiK08747.
PhylomeDBiQ9EPZ7.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
IPR030764. OATP1C1.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PTHR11388:SF99. PTHR11388:SF99. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EPZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSSKENAH LFHKNSAQPA GGPSFKAGYP STEEARPCCG KLKVFLGALS
60 70 80 90 100
FVYFAKALTE GYLKSTITQI ERRFDIPSSL VGIIDGSFEI GNLLVITFVS
110 120 130 140 150
YFGAKLHRPK IIGAGCLVMG FGTMLIAVPQ FFMEKYSYEK YERYSPSSNL
160 170 180 190 200
TPNISPCYLE SSSPSPRSIV GKSQNKINDE CEVDTSSSMW VYVFLGNLLR
210 220 230 240 250
GLGETPIQPL GIAYLDDFAS EDNAAFYIGC VQTVAIIGPI FGFLLGSLCA
260 270 280 290 300
KLYVDIGFVN LDHITITPKD PQWVGAWWLG YLIAGFLSLL AAVPFWCLPK
310 320 330 340 350
TLPRSQSRED SGSSSEKSKF ITDDPVNYQM APREESMKIM EMARDFLPSL
360 370 380 390 400
KSLFRNPVYI LYLCASTVQF NSLFGMVTYK PKYIEQQYGQ SSSKANFVIG
410 420 430 440 450
LINIPAVALG IFSGGIVMKK FRLGICEATK LYLGSSVFGY LLFLSLFALG
460 470 480 490 500
CENSSVAGLT VSYQGTKPVS YHERALFSDC NSRCKCSDSK WEPMCGDNGI
510 520 530 540 550
TYASACLAGC QSSSRSGKNI IFSNCTCVGF AAPKSGNWSG MMGRCQKDNG
560 570 580 590 600
CSQMFLYFLV ISVITSYTLS LGGIPGYILL LRCIQPQLKS FALGIYTLAV
610 620 630 640 650
RVLAGIPAPV YFGVLIDTSC LKWGFKKCGS RGSCRLYDSH AFRHIYLGLT
660 670 680 690 700
TLLGTVSVFL STAVLLVLKK KYVSKRSSFI TAREKIVMSS SVKKETCAAR
710
DHGLQPKYWP GKETRL
Length:716
Mass (Da):78,627
Last modified:March 1, 2001 - v1
Checksum:i487734B82A50A6EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306546 mRNA. Translation: AAG37066.1.
RefSeqiNP_445893.1. NM_053441.1.
UniGeneiRn.45744.

Genome annotation databases

GeneIDi84511.
KEGGirno:84511.
UCSCiRGD:628660. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306546 mRNA. Translation: AAG37066.1.
RefSeqiNP_445893.1. NM_053441.1.
UniGeneiRn.45744.

3D structure databases

ProteinModelPortaliQ9EPZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250000. 1 interactor.
STRINGi10116.ENSRNOP00000013230.

Protein family/group databases

TCDBi2.A.60.1.10. the organo anion transporter (oat) family.

PTM databases

PhosphoSitePlusiQ9EPZ7.
UniCarbKBiQ9EPZ7.

Proteomic databases

PaxDbiQ9EPZ7.
PRIDEiQ9EPZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi84511.
KEGGirno:84511.
UCSCiRGD:628660. rat.

Organism-specific databases

CTDi53919.
RGDi628660. Slco1c1.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ9EPZ7.
KOiK08747.
PhylomeDBiQ9EPZ7.

Miscellaneous databases

PROiQ9EPZ7.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
IPR030764. OATP1C1.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PTHR11388:SF99. PTHR11388:SF99. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO1C1_RAT
AccessioniPrimary (citable) accession number: Q9EPZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.