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Q9EPZ7

- SO1C1_RAT

UniProt

Q9EPZ7 - SO1C1_RAT

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Protein
Solute carrier organic anion transporter family member 1C1
Gene
Slco1c1, Bsat1, Oatp1c1, Oatpf, Slc21a14
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency By similarity. May play a signifiant role in regulating T4 flux into and out of the brain.1 Publication

GO - Molecular functioni

  1. bile acid transmembrane transporter activity Source: RGD

GO - Biological processi

  1. bile acid and bile salt transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi2.A.60.1.10. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1C1
Alternative name(s):
BBB-specific anion transporter type 1
Blood-brain barrier-specific anion transporter 1
Solute carrier family 21 member 14
Thyroxine transporter
Gene namesi
Name:Slco1c1
Synonyms:Bsat1, Oatp1c1, Oatpf, Slc21a14
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi628660. Slco1c1.

Subcellular locationi

Cell membrane; Multi-pass membrane protein
Note: Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei44 – 6320Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini64 – 8219Extracellular Reviewed prediction
Add
BLAST
Transmembranei83 – 10321Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini104 – 1096Cytoplasmic Reviewed prediction
Transmembranei110 – 13425Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini135 – 18753Extracellular Reviewed prediction
Add
BLAST
Transmembranei188 – 21629Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini217 – 23519Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei236 – 25621Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini257 – 27418Extracellular Reviewed prediction
Add
BLAST
Transmembranei275 – 29925Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini300 – 35253Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei353 – 37422Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini375 – 39420Extracellular Reviewed prediction
Add
BLAST
Transmembranei395 – 41824Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini419 – 4224Cytoplasmic Reviewed prediction
Transmembranei423 – 44624Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini447 – 558112Extracellular Reviewed prediction
Add
BLAST
Transmembranei559 – 58123Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini582 – 5909Cytoplasmic Reviewed prediction
Transmembranei591 – 61626Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini617 – 65034Extracellular Reviewed prediction
Add
BLAST
Transmembranei651 – 66818Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini669 – 71648Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 716716Solute carrier organic anion transporter family member 1C1
PRO_0000191057Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi453 – 4531N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi480 ↔ 506 By similarity
Disulfide bondi484 ↔ 495 By similarity
Disulfide bondi486 ↔ 510 By similarity
Glycosylationi524 – 5241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi537 – 5371N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9EPZ7.
PRIDEiQ9EPZ7.

PTM databases

PhosphoSiteiQ9EPZ7.

Expressioni

Tissue specificityi

Highly expressed in cerebral microvessels (at protein level). Brain-specific. Not detected in glioma cells, kidney, heart, lung or liver. Highly expressed in cerebral microvessels throughout the brain and in tanycytes of the third ventricle.1 Publication

Gene expression databases

GenevestigatoriQ9EPZ7.

Interactioni

Protein-protein interaction databases

BioGridi250000. 1 interaction.
STRINGi10116.ENSRNOP00000013230.

Structurei

3D structure databases

ProteinModelPortaliQ9EPZ7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini474 – 52956Kazal-like
Add
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG305397.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ9EPZ7.
KOiK08747.
PhylomeDBiQ9EPZ7.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EPZ7-1 [UniParc]FASTAAdd to Basket

« Hide

MDTSSKENAH LFHKNSAQPA GGPSFKAGYP STEEARPCCG KLKVFLGALS    50
FVYFAKALTE GYLKSTITQI ERRFDIPSSL VGIIDGSFEI GNLLVITFVS 100
YFGAKLHRPK IIGAGCLVMG FGTMLIAVPQ FFMEKYSYEK YERYSPSSNL 150
TPNISPCYLE SSSPSPRSIV GKSQNKINDE CEVDTSSSMW VYVFLGNLLR 200
GLGETPIQPL GIAYLDDFAS EDNAAFYIGC VQTVAIIGPI FGFLLGSLCA 250
KLYVDIGFVN LDHITITPKD PQWVGAWWLG YLIAGFLSLL AAVPFWCLPK 300
TLPRSQSRED SGSSSEKSKF ITDDPVNYQM APREESMKIM EMARDFLPSL 350
KSLFRNPVYI LYLCASTVQF NSLFGMVTYK PKYIEQQYGQ SSSKANFVIG 400
LINIPAVALG IFSGGIVMKK FRLGICEATK LYLGSSVFGY LLFLSLFALG 450
CENSSVAGLT VSYQGTKPVS YHERALFSDC NSRCKCSDSK WEPMCGDNGI 500
TYASACLAGC QSSSRSGKNI IFSNCTCVGF AAPKSGNWSG MMGRCQKDNG 550
CSQMFLYFLV ISVITSYTLS LGGIPGYILL LRCIQPQLKS FALGIYTLAV 600
RVLAGIPAPV YFGVLIDTSC LKWGFKKCGS RGSCRLYDSH AFRHIYLGLT 650
TLLGTVSVFL STAVLLVLKK KYVSKRSSFI TAREKIVMSS SVKKETCAAR 700
DHGLQPKYWP GKETRL 716
Length:716
Mass (Da):78,627
Last modified:March 1, 2001 - v1
Checksum:i487734B82A50A6EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF306546 mRNA. Translation: AAG37066.1.
RefSeqiNP_445893.1. NM_053441.1.
UniGeneiRn.45744.

Genome annotation databases

GeneIDi84511.
KEGGirno:84511.
UCSCiRGD:628660. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF306546 mRNA. Translation: AAG37066.1 .
RefSeqi NP_445893.1. NM_053441.1.
UniGenei Rn.45744.

3D structure databases

ProteinModelPortali Q9EPZ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 250000. 1 interaction.
STRINGi 10116.ENSRNOP00000013230.

Protein family/group databases

TCDBi 2.A.60.1.10. the organo anion transporter (oat) family.

PTM databases

PhosphoSitei Q9EPZ7.

Proteomic databases

PaxDbi Q9EPZ7.
PRIDEi Q9EPZ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 84511.
KEGGi rno:84511.
UCSCi RGD:628660. rat.

Organism-specific databases

CTDi 53919.
RGDi 628660. Slco1c1.

Phylogenomic databases

eggNOGi NOG305397.
HOGENOMi HOG000231269.
HOVERGENi HBG063896.
InParanoidi Q9EPZ7.
KOi K08747.
PhylomeDBi Q9EPZ7.

Miscellaneous databases

NextBioi 617093.
PROi Q9EPZ7.

Gene expression databases

Genevestigatori Q9EPZ7.

Family and domain databases

InterProi IPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view ]
PANTHERi PTHR11388. PTHR11388. 1 hit.
Pfami PF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view ]
SMARTi SM00280. KAZAL. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 5 hits.
TIGRFAMsi TIGR00805. oat. 1 hit.
PROSITEi PS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain capillary.
  2. "Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier."
    Roberts L.M., Woodford K., Zhou M., Black D.S., Haggerty J.E., Tate E.H., Grindstaff K.K., Mengesha W., Raman C., Zerangue N.
    Endocrinology 149:6251-6261(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION.

Entry informationi

Entry nameiSO1C1_RAT
AccessioniPrimary (citable) accession number: Q9EPZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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