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Q9EPZ7

- SO1C1_RAT

UniProt

Q9EPZ7 - SO1C1_RAT

Protein

Solute carrier organic anion transporter family member 1C1

Gene

Slco1c1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Mediates the Na+-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency By similarity. May play a signifiant role in regulating T4 flux into and out of the brain.By similarity1 Publication

    GO - Molecular functioni

    1. bile acid transmembrane transporter activity Source: RGD

    GO - Biological processi

    1. bile acid and bile salt transport Source: RGD

    Keywords - Biological processi

    Ion transport, Transport

    Protein family/group databases

    TCDBi2.A.60.1.10. the organo anion transporter (oat) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 1C1
    Alternative name(s):
    BBB-specific anion transporter type 1
    Blood-brain barrier-specific anion transporter 1
    Solute carrier family 21 member 14
    Thyroxine transporter
    Gene namesi
    Name:Slco1c1
    Synonyms:Bsat1, Oatp1c1, Oatpf, Slc21a14
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi628660. Slco1c1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 716716Solute carrier organic anion transporter family member 1C1PRO_0000191057Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi453 – 4531N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi480 ↔ 506PROSITE-ProRule annotation
    Disulfide bondi484 ↔ 495PROSITE-ProRule annotation
    Disulfide bondi486 ↔ 510PROSITE-ProRule annotation
    Glycosylationi524 – 5241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi537 – 5371N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9EPZ7.
    PRIDEiQ9EPZ7.

    PTM databases

    PhosphoSiteiQ9EPZ7.

    Expressioni

    Tissue specificityi

    Highly expressed in cerebral microvessels (at protein level). Brain-specific. Not detected in glioma cells, kidney, heart, lung or liver. Highly expressed in cerebral microvessels throughout the brain and in tanycytes of the third ventricle.1 Publication

    Gene expression databases

    GenevestigatoriQ9EPZ7.

    Interactioni

    Protein-protein interaction databases

    BioGridi250000. 1 interaction.
    STRINGi10116.ENSRNOP00000013230.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EPZ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4343CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini64 – 8219ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini104 – 1096CytoplasmicSequence Analysis
    Topological domaini135 – 18753ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini217 – 23519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini257 – 27418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini300 – 35253CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini375 – 39420ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini419 – 4224CytoplasmicSequence Analysis
    Topological domaini447 – 558112ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini582 – 5909CytoplasmicSequence Analysis
    Topological domaini617 – 65034ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini669 – 71648CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6320Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei83 – 10321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei110 – 13425Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei188 – 21629Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei275 – 29925Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei353 – 37422Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei395 – 41824Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei423 – 44624Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei559 – 58123Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei591 – 61626Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei651 – 66818Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini474 – 52956Kazal-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Kazal-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG305397.
    HOGENOMiHOG000231269.
    HOVERGENiHBG063896.
    InParanoidiQ9EPZ7.
    KOiK08747.
    PhylomeDBiQ9EPZ7.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view]
    PANTHERiPTHR11388. PTHR11388. 1 hit.
    PfamiPF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view]
    SMARTiSM00280. KAZAL. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 5 hits.
    TIGRFAMsiTIGR00805. oat. 1 hit.
    PROSITEiPS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9EPZ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTSSKENAH LFHKNSAQPA GGPSFKAGYP STEEARPCCG KLKVFLGALS    50
    FVYFAKALTE GYLKSTITQI ERRFDIPSSL VGIIDGSFEI GNLLVITFVS 100
    YFGAKLHRPK IIGAGCLVMG FGTMLIAVPQ FFMEKYSYEK YERYSPSSNL 150
    TPNISPCYLE SSSPSPRSIV GKSQNKINDE CEVDTSSSMW VYVFLGNLLR 200
    GLGETPIQPL GIAYLDDFAS EDNAAFYIGC VQTVAIIGPI FGFLLGSLCA 250
    KLYVDIGFVN LDHITITPKD PQWVGAWWLG YLIAGFLSLL AAVPFWCLPK 300
    TLPRSQSRED SGSSSEKSKF ITDDPVNYQM APREESMKIM EMARDFLPSL 350
    KSLFRNPVYI LYLCASTVQF NSLFGMVTYK PKYIEQQYGQ SSSKANFVIG 400
    LINIPAVALG IFSGGIVMKK FRLGICEATK LYLGSSVFGY LLFLSLFALG 450
    CENSSVAGLT VSYQGTKPVS YHERALFSDC NSRCKCSDSK WEPMCGDNGI 500
    TYASACLAGC QSSSRSGKNI IFSNCTCVGF AAPKSGNWSG MMGRCQKDNG 550
    CSQMFLYFLV ISVITSYTLS LGGIPGYILL LRCIQPQLKS FALGIYTLAV 600
    RVLAGIPAPV YFGVLIDTSC LKWGFKKCGS RGSCRLYDSH AFRHIYLGLT 650
    TLLGTVSVFL STAVLLVLKK KYVSKRSSFI TAREKIVMSS SVKKETCAAR 700
    DHGLQPKYWP GKETRL 716
    Length:716
    Mass (Da):78,627
    Last modified:March 1, 2001 - v1
    Checksum:i487734B82A50A6EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF306546 mRNA. Translation: AAG37066.1.
    RefSeqiNP_445893.1. NM_053441.1.
    UniGeneiRn.45744.

    Genome annotation databases

    GeneIDi84511.
    KEGGirno:84511.
    UCSCiRGD:628660. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF306546 mRNA. Translation: AAG37066.1 .
    RefSeqi NP_445893.1. NM_053441.1.
    UniGenei Rn.45744.

    3D structure databases

    ProteinModelPortali Q9EPZ7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 250000. 1 interaction.
    STRINGi 10116.ENSRNOP00000013230.

    Protein family/group databases

    TCDBi 2.A.60.1.10. the organo anion transporter (oat) family.

    PTM databases

    PhosphoSitei Q9EPZ7.

    Proteomic databases

    PaxDbi Q9EPZ7.
    PRIDEi Q9EPZ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 84511.
    KEGGi rno:84511.
    UCSCi RGD:628660. rat.

    Organism-specific databases

    CTDi 53919.
    RGDi 628660. Slco1c1.

    Phylogenomic databases

    eggNOGi NOG305397.
    HOGENOMi HOG000231269.
    HOVERGENi HBG063896.
    InParanoidi Q9EPZ7.
    KOi K08747.
    PhylomeDBi Q9EPZ7.

    Miscellaneous databases

    NextBioi 617093.
    PROi Q9EPZ7.

    Gene expression databases

    Genevestigatori Q9EPZ7.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view ]
    PANTHERi PTHR11388. PTHR11388. 1 hit.
    Pfami PF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view ]
    SMARTi SM00280. KAZAL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 5 hits.
    TIGRFAMsi TIGR00805. oat. 1 hit.
    PROSITEi PS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain capillary.
    2. "Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier."
      Roberts L.M., Woodford K., Zhou M., Black D.S., Haggerty J.E., Tate E.H., Grindstaff K.K., Mengesha W., Raman C., Zerangue N.
      Endocrinology 149:6251-6261(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION.

    Entry informationi

    Entry nameiSO1C1_RAT
    AccessioniPrimary (citable) accession number: Q9EPZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3