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Q9EPZ7 (SO1C1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Solute carrier organic anion transporter family member 1C1
Alternative name(s):
BBB-specific anion transporter type 1
Blood-brain barrier-specific anion transporter 1
Solute carrier family 21 member 14
Thyroxine transporter
Gene names
Name:Slco1c1
Synonyms:Bsat1, Oatp1c1, Oatpf, Slc21a14
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length716 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates the Na+-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency By similarity. May play a signifiant role in regulating T4 flux into and out of the brain. Ref.2

Subcellular location

Cell membrane; Multi-pass membrane protein. Note: Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus. Ref.2

Tissue specificity

Highly expressed in cerebral microvessels (at protein level). Brain-specific. Not detected in glioma cells, kidney, heart, lung or liver. Highly expressed in cerebral microvessels throughout the brain and in tanycytes of the third ventricle. Ref.2

Sequence similarities

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]

Contains 1 Kazal-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 716716Solute carrier organic anion transporter family member 1C1
PRO_0000191057

Regions

Topological domain1 – 4343Cytoplasmic Potential
Transmembrane44 – 6320Helical; Name=1; Potential
Topological domain64 – 8219Extracellular Potential
Transmembrane83 – 10321Helical; Name=2; Potential
Topological domain104 – 1096Cytoplasmic Potential
Transmembrane110 – 13425Helical; Name=3; Potential
Topological domain135 – 18753Extracellular Potential
Transmembrane188 – 21629Helical; Name=4; Potential
Topological domain217 – 23519Cytoplasmic Potential
Transmembrane236 – 25621Helical; Name=5; Potential
Topological domain257 – 27418Extracellular Potential
Transmembrane275 – 29925Helical; Name=6; Potential
Topological domain300 – 35253Cytoplasmic Potential
Transmembrane353 – 37422Helical; Name=7; Potential
Topological domain375 – 39420Extracellular Potential
Transmembrane395 – 41824Helical; Name=8; Potential
Topological domain419 – 4224Cytoplasmic Potential
Transmembrane423 – 44624Helical; Name=9; Potential
Topological domain447 – 558112Extracellular Potential
Transmembrane559 – 58123Helical; Name=10; Potential
Topological domain582 – 5909Cytoplasmic Potential
Transmembrane591 – 61626Helical; Name=11; Potential
Topological domain617 – 65034Extracellular Potential
Transmembrane651 – 66818Helical; Name=12; Potential
Topological domain669 – 71648Cytoplasmic Potential
Domain474 – 52956Kazal-like

Amino acid modifications

Glycosylation4531N-linked (GlcNAc...) Potential
Glycosylation5241N-linked (GlcNAc...) Potential
Glycosylation5371N-linked (GlcNAc...) Potential
Disulfide bond480 ↔ 506 By similarity
Disulfide bond484 ↔ 495 By similarity
Disulfide bond486 ↔ 510 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9EPZ7 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 487734B82A50A6EA

FASTA71678,627
        10         20         30         40         50         60 
MDTSSKENAH LFHKNSAQPA GGPSFKAGYP STEEARPCCG KLKVFLGALS FVYFAKALTE 

        70         80         90        100        110        120 
GYLKSTITQI ERRFDIPSSL VGIIDGSFEI GNLLVITFVS YFGAKLHRPK IIGAGCLVMG 

       130        140        150        160        170        180 
FGTMLIAVPQ FFMEKYSYEK YERYSPSSNL TPNISPCYLE SSSPSPRSIV GKSQNKINDE 

       190        200        210        220        230        240 
CEVDTSSSMW VYVFLGNLLR GLGETPIQPL GIAYLDDFAS EDNAAFYIGC VQTVAIIGPI 

       250        260        270        280        290        300 
FGFLLGSLCA KLYVDIGFVN LDHITITPKD PQWVGAWWLG YLIAGFLSLL AAVPFWCLPK 

       310        320        330        340        350        360 
TLPRSQSRED SGSSSEKSKF ITDDPVNYQM APREESMKIM EMARDFLPSL KSLFRNPVYI 

       370        380        390        400        410        420 
LYLCASTVQF NSLFGMVTYK PKYIEQQYGQ SSSKANFVIG LINIPAVALG IFSGGIVMKK 

       430        440        450        460        470        480 
FRLGICEATK LYLGSSVFGY LLFLSLFALG CENSSVAGLT VSYQGTKPVS YHERALFSDC 

       490        500        510        520        530        540 
NSRCKCSDSK WEPMCGDNGI TYASACLAGC QSSSRSGKNI IFSNCTCVGF AAPKSGNWSG 

       550        560        570        580        590        600 
MMGRCQKDNG CSQMFLYFLV ISVITSYTLS LGGIPGYILL LRCIQPQLKS FALGIYTLAV 

       610        620        630        640        650        660 
RVLAGIPAPV YFGVLIDTSC LKWGFKKCGS RGSCRLYDSH AFRHIYLGLT TLLGTVSVFL 

       670        680        690        700        710 
STAVLLVLKK KYVSKRSSFI TAREKIVMSS SVKKETCAAR DHGLQPKYWP GKETRL 

« Hide

References

[1]"Blood-brain barrier genomics."
Li J.Y., Boado R.J., Pardridge W.M.
J. Cereb. Blood Flow Metab. 21:61-68(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain capillary.
[2]"Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier."
Roberts L.M., Woodford K., Zhou M., Black D.S., Haggerty J.E., Tate E.H., Grindstaff K.K., Mengesha W., Raman C., Zerangue N.
Endocrinology 149:6251-6261(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF306546 mRNA. Translation: AAG37066.1.
RefSeqNP_445893.1. NM_053441.1.
UniGeneRn.45744.

3D structure databases

ProteinModelPortalQ9EPZ7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid250000. 1 interaction.
STRING10116.ENSRNOP00000013230.

Protein family/group databases

TCDB2.A.60.1.10. the organo anion transporter (oat) family.

PTM databases

PhosphoSiteQ9EPZ7.

Proteomic databases

PaxDbQ9EPZ7.
PRIDEQ9EPZ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID84511.
KEGGrno:84511.
UCSCRGD:628660. rat.

Organism-specific databases

CTD53919.
RGD628660. Slco1c1.

Phylogenomic databases

eggNOGNOG305397.
HOGENOMHOG000231269.
HOVERGENHBG063896.
InParanoidQ9EPZ7.
KOK08747.
PhylomeDBQ9EPZ7.

Gene expression databases

GenevestigatorQ9EPZ7.

Family and domain databases

InterProIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERPTHR11388. PTHR11388. 1 hit.
PfamPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 5 hits.
TIGRFAMsTIGR00805. oat. 1 hit.
PROSITEPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio617093.
PROQ9EPZ7.

Entry information

Entry nameSO1C1_RAT
AccessionPrimary (citable) accession number: Q9EPZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families