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Protein

T-box transcription factor TBX18

Gene

Tbx18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart, the coronary vessels, the ureter, and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area.5 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi149 – 336188T-boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • protein heterodimerization activity Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II transcription corepressor activity Source: BHF-UCL
  • RNA polymerase II transcription factor binding Source: BHF-UCL
  • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB
  • transcription regulatory region sequence-specific DNA binding Source: BHF-UCL

GO - Biological processi

  • anatomical structure formation involved in morphogenesis Source: MGI
  • anterior/posterior axis specification Source: MGI
  • cell differentiation Source: MGI
  • cochlea morphogenesis Source: MGI
  • morphogenesis of embryonic epithelium Source: MGI
  • negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation Source: BHF-UCL
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • positive regulation of cell-cell adhesion Source: MGI
  • positive regulation of epithelial cell proliferation Source: MGI
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • positive regulation of mesenchymal cell proliferation involved in ureter development Source: MGI
  • renal system development Source: MGI
  • sensory perception of sound Source: MGI
  • sinoatrial node development Source: MGI
  • smooth muscle cell differentiation Source: MGI
  • somitogenesis Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • ureter development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX18
Short name:
T-box protein 18
Gene namesi
Name:Tbx18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1923615. Tbx18.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Deficient mice fail to maintain anterior-posterior polarity, resulting in abnormal dorsal-ventral polarity of the somites. Mutant mice display neonatal lethality and abnormal morphology of vertebrae, ribs, spinal nerves and coronary vessels. Besides, mutant mice develop anomalies of the urinary tract, including hydroureter and hydronephrosis.4 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 613613T-box transcription factor TBX18PRO_0000184447Add
BLAST

Proteomic databases

PaxDbiQ9EPZ6.
PRIDEiQ9EPZ6.

PTM databases

iPTMnetiQ9EPZ6.
PhosphoSiteiQ9EPZ6.

Expressioni

Developmental stagei

Expressed in the renal pelvis and ureter smooth muscle layer at embryonal day E17.5 (at protein level) (PubMed:26235987). During development expression is most prominent in the proepicardial organ and in the epicardium. Expressed also in the cranial paraxial mesoderm, the presomitic mesoderm, the anterior somite half, the genital ridge and the developing limb buds (PubMed:11118889).2 Publications

Gene expression databases

CleanExiMM_TBX18.

Interactioni

Subunit structurei

Homodimer. Can form a heterodimer with TBX15. Interacts with GATA4 AND NKX2-5. Interacts (via engrailed homology 1 repressor motif) with TLE3; this interaction represses TBX18 transcriptional activity. Interacts with PAX3. Interacts with SIX1 (By similarity).By similarity2 Publications

GO - Molecular functioni

  • protein heterodimerization activity Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL
  • RNA polymerase II transcription factor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi218079. 1 interaction.
STRINGi10090.ENSMUSP00000034991.

Structurei

3D structure databases

ProteinModelPortaliQ9EPZ6.
SMRiQ9EPZ6. Positions 147-336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi18 – 2811Engrailed homology 1 repressor1 PublicationAdd
BLAST
Motifi36 – 405Nuclear localization signal1 Publication

Sequence similaritiesi

Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3586. Eukaryota.
ENOG410Y98J. LUCA.
HOGENOMiHOG000039966.
HOVERGENiHBG055831.
InParanoidiQ9EPZ6.
KOiK10183.
PhylomeDBiQ9EPZ6.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EPZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKRRGSPC SMLSLKAHAF SVEALIGAEK QQQLQKKRRK LATEEAAGAV
60 70 80 90 100
EDAGCSRSGG AGEHGCSEAD EEAAAPPPAA GAASGPARSC ADAERSCGSR
110 120 130 140 150
GAAGSCEDGF LQGASPLASP GGSPKGSPVP GLARPGTPLP APQAPRVDLQ
160 170 180 190 200
GAELWKRFHE IGTEMIITKA GRRMFPAMRV KISGLDPHQQ YYIAMDIVPV
210 220 230 240 250
DNKRYRYVYH SSKWMVAGNA DSPVPPRVYI HPDSPASGET WMRQVISFDK
260 270 280 290 300
LKLTNNELDD QGHIILHSMH KYQPRVHVIR KDCGDDLSPI KPVPSGEGVK
310 320 330 340 350
AFSFPETVFT TVTAYQNQQI TRLKIDRNPF AKGFRDSGRN RMGLEALVES
360 370 380 390 400
YAFWRPSLRT LTFEDIPGIP KQGNTSSSAL LQGTGNAVPA THPHLLSGSS
410 420 430 440 450
CSSPAFHLGP NTSQLCSLTP ADYSACARSG LALNRYSTSL AETYSRLTNQ
460 470 480 490 500
SSETFAPPRT PSYVSVSSNP SVNMSMGGTD GDTFSCPQTS LSMQISGMSP
510 520 530 540 550
QLQYIMPSPS GNAFAANQTH QSSYNTFRLH SPCALYGYNF STSPKLAASP
560 570 580 590 600
EKIVSSQGSF LGSSPSGTMT DRQMLPPVEG VHLLSSGGQQ SFFDSRTLGS
610
LTLPSSQVSA HMV
Length:613
Mass (Da):65,464
Last modified:March 1, 2001 - v1
Checksum:iA9E64D395725AB38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306666 mRNA. Translation: AAG48598.1.
CCDSiCCDS40718.1.
RefSeqiNP_076303.3. NM_023814.4.
UniGeneiMm.158789.

Genome annotation databases

GeneIDi76365.
KEGGimmu:76365.

Cross-referencesi

Web resourcesi

Protein Spotlight

At the heart of things - Issue 165 of November 2014

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306666 mRNA. Translation: AAG48598.1.
CCDSiCCDS40718.1.
RefSeqiNP_076303.3. NM_023814.4.
UniGeneiMm.158789.

3D structure databases

ProteinModelPortaliQ9EPZ6.
SMRiQ9EPZ6. Positions 147-336.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218079. 1 interaction.
STRINGi10090.ENSMUSP00000034991.

PTM databases

iPTMnetiQ9EPZ6.
PhosphoSiteiQ9EPZ6.

Proteomic databases

PaxDbiQ9EPZ6.
PRIDEiQ9EPZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi76365.
KEGGimmu:76365.

Organism-specific databases

CTDi9096.
MGIiMGI:1923615. Tbx18.

Phylogenomic databases

eggNOGiKOG3586. Eukaryota.
ENOG410Y98J. LUCA.
HOGENOMiHOG000039966.
HOVERGENiHBG055831.
InParanoidiQ9EPZ6.
KOiK10183.
PhylomeDBiQ9EPZ6.

Miscellaneous databases

PROiQ9EPZ6.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TBX18.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBX18_MOUSE
AccessioniPrimary (citable) accession number: Q9EPZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.