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Protein

F-box/LRR-repeat protein 12

Gene

Fbxl12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • ubiquitin-dependent protein catabolic process Source: MGI

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 12
Alternative name(s):
F-box and leucine-rich repeat protein 12
F-box protein FBL12
Gene namesi
Name:Fbxl12
Synonyms:Fbl12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1354738 Fbxl12

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001198581 – 326F-box/LRR-repeat protein 12Add BLAST326

Proteomic databases

MaxQBiQ9EPX5
PaxDbiQ9EPX5
PeptideAtlasiQ9EPX5
PRIDEiQ9EPX5

PTM databases

PhosphoSitePlusiQ9EPX5

Expressioni

Gene expression databases

BgeeiENSMUSG00000066892
CleanExiMM_FBXL12
ExpressionAtlasiQ9EPX5 baseline and differential
GenevisibleiQ9EPX5 MM

Interactioni

Subunit structurei

Interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi205979, 2 interactors
MINTiQ9EPX5
STRINGi10090.ENSMUSP00000083650

Structurei

3D structure databases

ProteinModelPortaliQ9EPX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 47F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati51 – 78LRR 1Add BLAST28
Repeati86 – 111LRR 2Add BLAST26
Repeati113 – 133LRR 3Add BLAST21
Repeati161 – 185LRR 4Add BLAST25
Repeati186 – 211LRR 5Add BLAST26
Repeati212 – 236LRR 6Add BLAST25
Repeati237 – 261LRR 7Add BLAST25
Repeati266 – 291LRR 8Add BLAST26

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT1J Eukaryota
ENOG4111Z4R LUCA
GeneTreeiENSGT00390000003354
HOGENOMiHOG000112675
HOVERGENiHBG051672
InParanoidiQ9EPX5
KOiK10278
OMAiITSLPCT
OrthoDBiEOG091G0AP2
PhylomeDBiQ9EPX5
TreeFamiTF313434

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q9EPX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLFDLPDL VLLEIFSYLP VRDRIRISRV CHRWKRLVDD RWLWRHVDLT
60 70 80 90 100
LYTMRPKVMW HLLRRYMASR LYSLRMGGYL FSGSQAPQLS PALMRALGQK
110 120 130 140 150
CPNLKRLCLH VADLSMVPIT SLPSTLRTLE LHSCEISMIW LQKEQDPTVL
160 170 180 190 200
PLLECIVLDR VPAFRDEHLQ GLTRFRALRS LVLGGTYRVT ETGLDASLQE
210 220 230 240 250
LSYLQRLEVL GCTLSADSTL LAISRHLRDV RKIRLTVGGL SAQGLVFLEG
260 270 280 290 300
MPVLESLCFQ GPLITPDMPT PTQIVSSCLT MPKLRVLEVQ GLGWEGQEAE
310 320
KILCKGLPHC IVIVRACPKE SMDWWM
Length:326
Mass (Da):37,231
Last modified:March 1, 2001 - v1
Checksum:i5A670BCDBF87CC5B
GO

Sequence cautioni

The sequence AAF09134 differs from that shown. Reason: Frameshift at position 309.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176525 mRNA Translation: AAF09134.1 Frameshift.
AF313405 mRNA Translation: AAG37272.1
AK011081 mRNA Translation: BAB27385.1
AK029429 mRNA Translation: BAC26448.1
AK030910 mRNA Translation: BAC27180.1
AK137282 mRNA Translation: BAE23292.1
BC005699 mRNA Translation: AAH05699.1
BC054471 mRNA Translation: AAH54471.1
CCDSiCCDS22880.1
RefSeqiNP_001002846.1, NM_001002846.2
NP_001273458.1, NM_001286529.1
NP_001273459.1, NM_001286530.1
NP_038939.2, NM_013911.3
XP_006510460.1, XM_006510397.2
XP_006510461.1, XM_006510398.2
XP_006510462.1, XM_006510399.2
UniGeneiMm.24608
Mm.390165
Mm.489685

Genome annotation databases

EnsembliENSMUST00000086459; ENSMUSP00000083650; ENSMUSG00000066892
ENSMUST00000148631; ENSMUSP00000119124; ENSMUSG00000066892
GeneIDi30843
KEGGimmu:30843
UCSCiuc009oiz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFXL12_MOUSE
AccessioniPrimary (citable) accession number: Q9EPX5
Secondary accession number(s): Q3UVH7
, Q8CDX0, Q9CY04, Q9QZN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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