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Q9EPX2 (PPN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Papilin
Gene names
Name:Papln
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length1280 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the papilin family.

Contains 1 BPTI/Kunitz inhibitor domain.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 PLAC domain.

Contains 5 TSP type-1 domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 12801260Papilin
PRO_0000324551

Regions

Domain27 – 8155TSP type-1 1
Domain305 – 36258TSP type-1 2
Domain363 – 42260TSP type-1 3
Domain424 – 48259TSP type-1 4
Domain485 – 54056TSP type-1 5
Domain750 – 80051BPTI/Kunitz inhibitor
Domain900 – 99091Ig-like C2-type 1
Domain1039 – 112890Ig-like C2-type 2
Domain1133 – 121886Ig-like C2-type 3
Domain1231 – 127040PLAC

Amino acid modifications

Disulfide bond39 ↔ 75 By similarity
Disulfide bond43 ↔ 80 By similarity
Disulfide bond54 ↔ 65 By similarity
Disulfide bond425 ↔ 464 By similarity
Disulfide bond436 ↔ 476 By similarity
Disulfide bond440 ↔ 481 By similarity
Disulfide bond750 ↔ 800 By similarity
Disulfide bond759 ↔ 783 By similarity
Disulfide bond775 ↔ 796 By similarity
Disulfide bond926 ↔ 973 By similarity
Disulfide bond1065 ↔ 1112 By similarity
Disulfide bond1154 ↔ 1202 By similarity

Experimental info

Sequence conflict4111V → A in AAG41980. Ref.1
Sequence conflict5601M → I in AAG41980. Ref.1
Sequence conflict8371R → K in AAH05747. Ref.2
Sequence conflict8581E → D in AAH05747. Ref.2
Sequence conflict8701Y → H in AAH05747. Ref.2
Sequence conflict8831V → I in AAH05747. Ref.2
Sequence conflict9321S → P in AAH05747. Ref.2
Sequence conflict9971F → L in AAG41980. Ref.1
Sequence conflict9971F → L in AAH05747. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9EPX2 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 4288A2EE204CB3E2

FASTA1,280138,904
        10         20         30         40         50         60 
MQLFPLLFSL LLTSTPGSWA RNVRRQSDTW GTWGEWSPCS RTCGGGISFR ERPCYSQRRD 

        70         80         90        100        110        120 
GGTSCVGPAR SHRTCHTESC PDGVRDFRAE QCAEFDGTDF QGRRYRWLPY YAAPNKCELN 

       130        140        150        160        170        180 
CIPKGQNFYY KHKDAVVDGT PCEPGQRDIC VDGVCRVVGC DHKLDSIKQE DKCLQCGGDG 

       190        200        210        220        230        240 
SSCYPVTGTF DGNDLSRGYN QIFIIPAGAT SIRIEEAAAS RNFLAVKSIR GEYYLNGHWT 

       250        260        270        280        290        300 
IEAAQALPVA STVLQYERGV EGDLAPERLQ ARGPTSEPLV IELLSQESNP GVHYEYYLPA 

       310        320        330        340        350        360 
NDPGRGFSWS HGSWGDCSAE CGGGHQSRLV FCTIDNEAYP DHMCQHQPRP THRRSCNTQP 

       370        380        390        400        410        420 
CPKTKRWKVG PWTPCSVSCG GGVQSRSVYC ISSDGTGGQE AAEETQCAGL VGKPPTTQAC 

       430        440        450        460        470        480 
NLQHCAVWSV EPWGECSVTC GTGIRKRSVT CRGDEGSPVH AAACLLKDQP TLTEPCVQEA 

       490        500        510        520        530        540 
CPVFRGQAWH VGSWSLCSKS CGSGIRRRQV VCTIGPPGRC VDLQSSKPAE MEACNRQPCH 

       550        560        570        580        590        600 
LPQEVPSIQD PRTRSSDPRM LSGPRVSPVS DGREQQWAPL ERPRAQSNPR EGQDPNLSSA 

       610        620        630        640        650        660 
GRAPTLQRPP HQPPLRPSSG PRDCRHSPHG CCPDGHTPSL GPQWQGCPLA GASCLQSRYG 

       670        680        690        700        710        720 
CCPDGVSAAE GPQQAGCTRS HGSDNTGNRP GSRAVASKNP KIHQPQAHEG EPSECRSSRF 

       730        740        750        760        770        780 
GCCYDNVASA AGPLGEGCVG QPSYAYPVRC LLPSAQGSCG DWAARWYFVA SVGRCNRFWY 

       790        800        810        820        830        840 
GGCHGNANNF ASEQECMNTC RGQHGPRRPE AGAAGHRAHV DGGQRGPGGQ QEPDWHRAGA 

       850        860        870        880        890        900 
TIPRLPSPSG SPWRREQEPA PGEPPHIPAY GNRPGGQEIR PRVPGLDREA RPAVPPTHSP 

       910        920        930        940        950        960 
SYRIRLAGSE PSLVQAAPGQ AVQLFCPGNI PSEFQAGWQK EGRPISSNRY QLQADGSLII 

       970        980        990       1000       1010       1020 
SRLRPEDAGI YSCGSHRPGH EPQEIQLRVT GGDMAVFPEG QPRHFPEPRN PDLGHGPPHR 

      1030       1040       1050       1060       1070       1080 
GTGAEAGGHR VLSPSHPRPA TRLRLDRTQP GVVDASPGQR IRLTCRAEGF PVPTIEWQRD 

      1090       1100       1110       1120       1130       1140 
GQLVSSPRHQ VQPDGSLVIS RVDVEDGGYY SCVAFNGQDR DQRWVQLRVL RELTITGLPP 

      1150       1160       1170       1180       1190       1200 
AVTVAEGDTA RLLCVVAGES VNIRWSRNGL PIQADGHRVH QSPDGTLLIH NLRPRDEGSY 

      1210       1220       1230       1240       1250       1260 
TCSAFRGSQA VSRSTEVKVA LPAPAAQSRD LGKDCIDQPE LANCALILQA QLCGNEYYSS 

      1270       1280 
FCCASCSRFQ PNAQPVWQQG

« Hide

References

« Hide 'large scale' references
[1]"Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases."
Kramerova I.A., Kawaguchi N., Fessler L.I., Nelson R.E., Chen Y., Kramerov A.A., Kusche-Gullberg M., Kramer J.M., Ackley B.D., Sieron A.L., Prockop D.J., Fessler J.H.
Development 127:5475-5485(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Brain and Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF314171 mRNA. Translation: AAG41980.1.
BC005747 mRNA. Translation: AAH05747.1.
BC132475 mRNA. Translation: AAI32476.1.
BC137854 mRNA. Translation: AAI37855.1.
IPIIPI00110468.
RefSeqNP_570957.2. NM_130887.3.
UniGeneMm.133443.

3D structure databases

HSSPHSSP built from PDB template 1KTH based on UniProtKB P12111.
ProteinModelPortalQ9EPX2.
SMRQ9EPX2. Positions 30-299, 309-425, 750-802, 912-1220.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9EPX2. 1 interaction.
STRING10090.ENSMUSP00000113806.

Protein family/group databases

MEROPSI02.972.

PTM databases

PhosphoSiteQ9EPX2.

Proteomic databases

PaxDbQ9EPX2.
PRIDEQ9EPX2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021646; ENSMUSP00000021646; ENSMUSG00000021223.
GeneID170721.
KEGGmmu:170721.

Organism-specific databases

CTD89932.
MGIMGI:2386139. Papln.

Phylogenomic databases

eggNOGNOG242665.
GeneTreeENSGT00700000104482.
HOGENOMHOG000060119.
HOVERGENHBG108281.

Gene expression databases

ArrayExpressQ9EPX2.
BgeeQ9EPX2.
CleanExMM_PAPLN.
GenevestigatorQ9EPX2.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
4.10.410.10. 1 hit.
InterProIPR010294. ADAM_spacer1.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR002223. Prot_inh_Kunz-m.
IPR020901. Prtase_inh_Kunz-CS.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamPF05986. ADAM_spacer1. 1 hit.
PF07679. I-set. 2 hits.
PF00014. Kunitz_BPTI. 1 hit.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 4 hits.
PF07686. V-set. 1 hit.
[Graphical view]
PRINTSPR01857. ADAMTSFAMILY.
PR00759. BASICPTASE.
SMARTSM00408. IGc2. 3 hits.
SM00131. KU. 1 hit.
SM00209. TSP1. 5 hits.
[Graphical view]
SUPFAMSSF57362. Prot_inh_Kunz-m. 1 hit.
SSF82895. TSP1. 5 hits.
PROSITEPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
PS50835. IG_LIKE. 3 hits.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio370242.
SOURCESearch...

Entry information

Entry namePPN_MOUSE
AccessionPrimary (citable) accession number: Q9EPX2
Secondary accession number(s): A2RTE8, B2RQC4, Q99JQ8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 27, 2011
Last modified: May 1, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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