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Protein

Papilin

Gene

Papln

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI02.972.

Names & Taxonomyi

Protein namesi
Recommended name:
Papilin
Gene namesi
Name:Papln
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2386139. Papln.

Subcellular locationi

GO - Cellular componenti

  • basement membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000032455121 – 1280PapilinAdd BLAST1260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 75By similarity
Disulfide bondi43 ↔ 80By similarity
Disulfide bondi54 ↔ 65By similarity
Disulfide bondi425 ↔ 464By similarity
Disulfide bondi436 ↔ 476By similarity
Disulfide bondi440 ↔ 481By similarity
Disulfide bondi750 ↔ 800By similarity
Disulfide bondi759 ↔ 783By similarity
Disulfide bondi775 ↔ 796By similarity
Disulfide bondi926 ↔ 973By similarity
Disulfide bondi1065 ↔ 1112By similarity
Disulfide bondi1154 ↔ 1202By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9EPX2.
PaxDbiQ9EPX2.
PRIDEiQ9EPX2.

PTM databases

iPTMnetiQ9EPX2.
PhosphoSitePlusiQ9EPX2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021223.
CleanExiMM_PAPLN.
ExpressionAtlasiQ9EPX2. baseline and differential.
GenevisibleiQ9EPX2. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9EPX2. 1 interactor.
STRINGi10090.ENSMUSP00000113806.

Structurei

3D structure databases

ProteinModelPortaliQ9EPX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 81TSP type-1 1PROSITE-ProRule annotationAdd BLAST55
Domaini305 – 362TSP type-1 2PROSITE-ProRule annotationAdd BLAST58
Domaini363 – 422TSP type-1 3PROSITE-ProRule annotationAdd BLAST60
Domaini424 – 482TSP type-1 4PROSITE-ProRule annotationAdd BLAST59
Domaini485 – 540TSP type-1 5PROSITE-ProRule annotationAdd BLAST56
Domaini750 – 800BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd BLAST51
Domaini900 – 990Ig-like C2-type 1Add BLAST91
Domaini1039 – 1128Ig-like C2-type 2Add BLAST90
Domaini1133 – 1218Ig-like C2-type 3Add BLAST86
Domaini1231 – 1270PLACPROSITE-ProRule annotationAdd BLAST40

Sequence similaritiesi

Belongs to the papilin family.Curated
Contains 1 BPTI/Kunitz inhibitor domain.PROSITE-ProRule annotation
Contains 1 PLAC domain.PROSITE-ProRule annotation
Contains 5 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3510. Eukaryota.
KOG4597. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00760000118885.
HOGENOMiHOG000060119.
HOVERGENiHBG108281.
InParanoidiQ9EPX2.
TreeFamiTF316874.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
4.10.410.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
IPR002223. Kunitz_BPTI.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR020901. Prtase_inh_Kunz-CS.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF07679. I-set. 1 hit.
PF00047. ig. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 5 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
PR00759. BASICPTASE.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00406. IGv. 3 hits.
SM00131. KU. 1 hit.
SM00209. TSP1. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF57362. SSF57362. 1 hit.
SSF82895. SSF82895. 5 hits.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
PS50835. IG_LIKE. 3 hits.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EPX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLFPLLFSL LLTSTPGSWA RNVRRQSDTW GTWGEWSPCS RTCGGGISFR
60 70 80 90 100
ERPCYSQRRD GGTSCVGPAR SHRTCHTESC PDGVRDFRAE QCAEFDGTDF
110 120 130 140 150
QGRRYRWLPY YAAPNKCELN CIPKGQNFYY KHKDAVVDGT PCEPGQRDIC
160 170 180 190 200
VDGVCRVVGC DHKLDSIKQE DKCLQCGGDG SSCYPVTGTF DGNDLSRGYN
210 220 230 240 250
QIFIIPAGAT SIRIEEAAAS RNFLAVKSIR GEYYLNGHWT IEAAQALPVA
260 270 280 290 300
STVLQYERGV EGDLAPERLQ ARGPTSEPLV IELLSQESNP GVHYEYYLPA
310 320 330 340 350
NDPGRGFSWS HGSWGDCSAE CGGGHQSRLV FCTIDNEAYP DHMCQHQPRP
360 370 380 390 400
THRRSCNTQP CPKTKRWKVG PWTPCSVSCG GGVQSRSVYC ISSDGTGGQE
410 420 430 440 450
AAEETQCAGL VGKPPTTQAC NLQHCAVWSV EPWGECSVTC GTGIRKRSVT
460 470 480 490 500
CRGDEGSPVH AAACLLKDQP TLTEPCVQEA CPVFRGQAWH VGSWSLCSKS
510 520 530 540 550
CGSGIRRRQV VCTIGPPGRC VDLQSSKPAE MEACNRQPCH LPQEVPSIQD
560 570 580 590 600
PRTRSSDPRM LSGPRVSPVS DGREQQWAPL ERPRAQSNPR EGQDPNLSSA
610 620 630 640 650
GRAPTLQRPP HQPPLRPSSG PRDCRHSPHG CCPDGHTPSL GPQWQGCPLA
660 670 680 690 700
GASCLQSRYG CCPDGVSAAE GPQQAGCTRS HGSDNTGNRP GSRAVASKNP
710 720 730 740 750
KIHQPQAHEG EPSECRSSRF GCCYDNVASA AGPLGEGCVG QPSYAYPVRC
760 770 780 790 800
LLPSAQGSCG DWAARWYFVA SVGRCNRFWY GGCHGNANNF ASEQECMNTC
810 820 830 840 850
RGQHGPRRPE AGAAGHRAHV DGGQRGPGGQ QEPDWHRAGA TIPRLPSPSG
860 870 880 890 900
SPWRREQEPA PGEPPHIPAY GNRPGGQEIR PRVPGLDREA RPAVPPTHSP
910 920 930 940 950
SYRIRLAGSE PSLVQAAPGQ AVQLFCPGNI PSEFQAGWQK EGRPISSNRY
960 970 980 990 1000
QLQADGSLII SRLRPEDAGI YSCGSHRPGH EPQEIQLRVT GGDMAVFPEG
1010 1020 1030 1040 1050
QPRHFPEPRN PDLGHGPPHR GTGAEAGGHR VLSPSHPRPA TRLRLDRTQP
1060 1070 1080 1090 1100
GVVDASPGQR IRLTCRAEGF PVPTIEWQRD GQLVSSPRHQ VQPDGSLVIS
1110 1120 1130 1140 1150
RVDVEDGGYY SCVAFNGQDR DQRWVQLRVL RELTITGLPP AVTVAEGDTA
1160 1170 1180 1190 1200
RLLCVVAGES VNIRWSRNGL PIQADGHRVH QSPDGTLLIH NLRPRDEGSY
1210 1220 1230 1240 1250
TCSAFRGSQA VSRSTEVKVA LPAPAAQSRD LGKDCIDQPE LANCALILQA
1260 1270 1280
QLCGNEYYSS FCCASCSRFQ PNAQPVWQQG
Length:1,280
Mass (Da):138,904
Last modified:July 27, 2011 - v2
Checksum:i4288A2EE204CB3E2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti411V → A in AAG41980 (PubMed:11076767).Curated1
Sequence conflicti560M → I in AAG41980 (PubMed:11076767).Curated1
Sequence conflicti837R → K in AAH05747 (PubMed:15489334).Curated1
Sequence conflicti858E → D in AAH05747 (PubMed:15489334).Curated1
Sequence conflicti870Y → H in AAH05747 (PubMed:15489334).Curated1
Sequence conflicti883V → I in AAH05747 (PubMed:15489334).Curated1
Sequence conflicti932S → P in AAH05747 (PubMed:15489334).Curated1
Sequence conflicti997F → L in AAG41980 (PubMed:11076767).Curated1
Sequence conflicti997F → L in AAH05747 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314171 mRNA. Translation: AAG41980.1.
BC005747 mRNA. Translation: AAH05747.1.
BC132475 mRNA. Translation: AAI32476.1.
BC137854 mRNA. Translation: AAI37855.1.
CCDSiCCDS26031.1.
RefSeqiNP_570957.2. NM_130887.3.
UniGeneiMm.133443.
Mm.440090.

Genome annotation databases

EnsembliENSMUST00000021646; ENSMUSP00000021646; ENSMUSG00000021223.
GeneIDi170721.
KEGGimmu:170721.
UCSCiuc007odr.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314171 mRNA. Translation: AAG41980.1.
BC005747 mRNA. Translation: AAH05747.1.
BC132475 mRNA. Translation: AAI32476.1.
BC137854 mRNA. Translation: AAI37855.1.
CCDSiCCDS26031.1.
RefSeqiNP_570957.2. NM_130887.3.
UniGeneiMm.133443.
Mm.440090.

3D structure databases

ProteinModelPortaliQ9EPX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9EPX2. 1 interactor.
STRINGi10090.ENSMUSP00000113806.

Protein family/group databases

MEROPSiI02.972.

PTM databases

iPTMnetiQ9EPX2.
PhosphoSitePlusiQ9EPX2.

Proteomic databases

MaxQBiQ9EPX2.
PaxDbiQ9EPX2.
PRIDEiQ9EPX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021646; ENSMUSP00000021646; ENSMUSG00000021223.
GeneIDi170721.
KEGGimmu:170721.
UCSCiuc007odr.3. mouse.

Organism-specific databases

CTDi89932.
MGIiMGI:2386139. Papln.

Phylogenomic databases

eggNOGiKOG3510. Eukaryota.
KOG4597. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00760000118885.
HOGENOMiHOG000060119.
HOVERGENiHBG108281.
InParanoidiQ9EPX2.
TreeFamiTF316874.

Miscellaneous databases

PROiQ9EPX2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021223.
CleanExiMM_PAPLN.
ExpressionAtlasiQ9EPX2. baseline and differential.
GenevisibleiQ9EPX2. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
4.10.410.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR013151. Immunoglobulin.
IPR002223. Kunitz_BPTI.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR020901. Prtase_inh_Kunz-CS.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF07679. I-set. 1 hit.
PF00047. ig. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 5 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
PR00759. BASICPTASE.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00406. IGv. 3 hits.
SM00131. KU. 1 hit.
SM00209. TSP1. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF57362. SSF57362. 1 hit.
SSF82895. SSF82895. 5 hits.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
PS50835. IG_LIKE. 3 hits.
PS50900. PLAC. 1 hit.
PS50092. TSP1. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPN_MOUSE
AccessioniPrimary (citable) accession number: Q9EPX2
Secondary accession number(s): A2RTE8, B2RQC4, Q99JQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.