Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heat shock protein beta-8

Gene

Hspb8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Displays temperature-dependent chaperone activity.1 Publication

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Enzyme and pathway databases

ReactomeiR-RNO-3371571. HSF1-dependent transactivation.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-8
Short name:
HspB8
Alternative name(s):
Alpha-crystallin C chain
Small stress protein-like protein HSP22
Gene namesi
Name:Hspb8
Synonyms:Cryac, Hsp22
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi71003. Hspb8.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Translocates to nuclear foci during heat shock.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196Heat shock protein beta-8PRO_0000125949Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241PhosphoserineCombined sources
Modified residuei57 – 571PhosphoserineCombined sources
Modified residuei63 – 631PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9EPX0.
PRIDEiQ9EPX0.

PTM databases

iPTMnetiQ9EPX0.
PhosphoSiteiQ9EPX0.

Expressioni

Inductioni

By heat shock.1 Publication

Gene expression databases

BgeeiENSRNOG00000022392.
GenevisibleiQ9EPX0. RN.

Interactioni

Subunit structurei

Monomer. Interacts with HSPB1. Interacts with DNAJB6 (By similarity).By similarity

Protein-protein interaction databases

BioGridi250211. 1 interaction.
STRINGi10116.ENSRNOP00000033432.

Structurei

3D structure databases

ProteinModelPortaliQ9EPX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233955.
HOVERGENiHBG054766.
InParanoidiQ9EPX0.
KOiK08879.
OMAiQTPPYYL.
OrthoDBiEOG091G0USC.
PhylomeDBiQ9EPX0.
TreeFamiTF105049.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EPX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGQLPFPC SYPSRLRRDP FRDSPLSSRL LDDGFGMDPF PDDLTAPWPE
60 70 80 90 100
WALPRLSSAW PGTLRSGMVP RGPTATARFG VPAEGRNPPP FPGEPWKVCV
110 120 130 140 150
NVHSFKPEEL MVKTKDGYVE VSGKHEEKQQ EGGIVSKNFT KKIQLPAEVD
160 170 180 190
PVTVFASLSP EGLLIIEAPQ VPPYSPFGES SFNNELPQDN QEVTCS
Length:196
Mass (Da):21,592
Last modified:March 1, 2001 - v1
Checksum:i7DF3288BB9846635
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314540 mRNA. Translation: AAG34700.1.
BC061748 mRNA. Translation: AAH61748.1.
RefSeqiNP_446064.1. NM_053612.2.
UniGeneiRn.102906.

Genome annotation databases

EnsembliENSRNOT00000039275; ENSRNOP00000033432; ENSRNOG00000022392.
GeneIDi113906.
KEGGirno:113906.
UCSCiRGD:71003. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314540 mRNA. Translation: AAG34700.1.
BC061748 mRNA. Translation: AAH61748.1.
RefSeqiNP_446064.1. NM_053612.2.
UniGeneiRn.102906.

3D structure databases

ProteinModelPortaliQ9EPX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250211. 1 interaction.
STRINGi10116.ENSRNOP00000033432.

PTM databases

iPTMnetiQ9EPX0.
PhosphoSiteiQ9EPX0.

Proteomic databases

PaxDbiQ9EPX0.
PRIDEiQ9EPX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000039275; ENSRNOP00000033432; ENSRNOG00000022392.
GeneIDi113906.
KEGGirno:113906.
UCSCiRGD:71003. rat.

Organism-specific databases

CTDi26353.
RGDi71003. Hspb8.

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233955.
HOVERGENiHBG054766.
InParanoidiQ9EPX0.
KOiK08879.
OMAiQTPPYYL.
OrthoDBiEOG091G0USC.
PhylomeDBiQ9EPX0.
TreeFamiTF105049.

Enzyme and pathway databases

ReactomeiR-RNO-3371571. HSF1-dependent transactivation.

Miscellaneous databases

PROiQ9EPX0.

Gene expression databases

BgeeiENSRNOG00000022392.
GenevisibleiQ9EPX0. RN.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSPB8_RAT
AccessioniPrimary (citable) accession number: Q9EPX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.