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Protein

Heat shock protein beta-8

Gene

Hspb8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Displays temperature-dependent chaperone activity.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionChaperone
Biological processStress response

Enzyme and pathway databases

ReactomeiR-RNO-3371571 HSF1-dependent transactivation

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-8
Short name:
HspB8
Alternative name(s):
Alpha-crystallin C chain
Small stress protein-like protein HSP22
Gene namesi
Name:Hspb8
Synonyms:Cryac, Hsp22
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi71003 Hspb8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259491 – 196Heat shock protein beta-8Add BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineCombined sources1
Modified residuei57PhosphoserineCombined sources1
Modified residuei63PhosphothreonineBy similarity1
Modified residuei71Asymmetric dimethylarginineBy similarity1
Modified residuei78Asymmetric dimethylarginineBy similarity1

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ9EPX0
PRIDEiQ9EPX0

PTM databases

iPTMnetiQ9EPX0
PhosphoSitePlusiQ9EPX0

Expressioni

Inductioni

By heat shock.1 Publication

Gene expression databases

BgeeiENSRNOG00000022392
GenevisibleiQ9EPX0 RN

Interactioni

Subunit structurei

Monomer. Interacts with HSPB1 (By similarity). Interacts with DNAJB6 (By similarity). Interacts with BAG3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250211, 1 interactor
IntActiQ9EPX0, 1 interactor
STRINGi10116.ENSRNOP00000033432

Structurei

3D structure databases

ProteinModelPortaliQ9EPX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 185sHSPPROSITE-ProRule annotationAdd BLAST112

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00760000119238
HOGENOMiHOG000233955
HOVERGENiHBG054766
InParanoidiQ9EPX0
KOiK08879
OMAiDWPDWAR
OrthoDBiEOG091G0USC
PhylomeDBiQ9EPX0
TreeFamiTF105049

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR001436 Alpha-crystallin/HSP
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9EPX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGQLPFPC SYPSRLRRDP FRDSPLSSRL LDDGFGMDPF PDDLTAPWPE
60 70 80 90 100
WALPRLSSAW PGTLRSGMVP RGPTATARFG VPAEGRNPPP FPGEPWKVCV
110 120 130 140 150
NVHSFKPEEL MVKTKDGYVE VSGKHEEKQQ EGGIVSKNFT KKIQLPAEVD
160 170 180 190
PVTVFASLSP EGLLIIEAPQ VPPYSPFGES SFNNELPQDN QEVTCS
Length:196
Mass (Da):21,592
Last modified:March 1, 2001 - v1
Checksum:i7DF3288BB9846635
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF314540 mRNA Translation: AAG34700.1
BC061748 mRNA Translation: AAH61748.1
RefSeqiNP_446064.1, NM_053612.2
UniGeneiRn.102906

Genome annotation databases

EnsembliENSRNOT00000039275; ENSRNOP00000033432; ENSRNOG00000022392
GeneIDi113906
KEGGirno:113906
UCSCiRGD:71003 rat

Similar proteinsi

Entry informationi

Entry nameiHSPB8_RAT
AccessioniPrimary (citable) accession number: Q9EPX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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