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Q9EPW9

- TLR6_MOUSE

UniProt

Q9EPW9 - TLR6_MOUSE

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Protein

Toll-like receptor 6

Gene
Tlr6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Cooperates with TLR2 for the cellular activation.1 Publication

GO - Molecular functioni

  1. diacyl lipopeptide binding Source: MGI
  2. lipopeptide binding Source: UniProtKB
  3. protein heterodimerization activity Source: MGI
  4. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. cellular response to diacyl bacterial lipopeptide Source: Ensembl
  2. defense response to bacterium Source: Ensembl
  3. detection of diacyl bacterial lipopeptide Source: InterPro
  4. inflammatory response Source: UniProtKB-KW
  5. innate immune response Source: UniProtKB-KW
  6. microglial cell activation involved in immune response Source: Ensembl
  7. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
  8. nitric oxide metabolic process Source: Ensembl
  9. pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response Source: Ensembl
  10. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  11. positive regulation of interleukin-12 biosynthetic process Source: UniProtKB
  12. positive regulation of interleukin-6 biosynthetic process Source: UniProtKB
  13. positive regulation of JUN kinase activity Source: Ensembl
  14. regulation of cytokine secretion Source: InterPro
  15. T-helper 1 type immune response Source: UniProtKB
  16. toll-like receptor 6 signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 6
Alternative name(s):
CD_antigen: CD286
Gene namesi
Name:Tlr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1341296. Tlr6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 584557Extracellular Reviewed predictionAdd
BLAST
Transmembranei585 – 60521Helical; Reviewed predictionAdd
BLAST
Topological domaini606 – 795190Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. phagocytic vesicle membrane Source: UniProtKB-SubCell
  3. Toll-like receptor 2-Toll-like receptor 6 protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi680 – 6801P → H: Dominant negative mutant, blocks response to Gram-positive pathogens. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed predictionAdd
BLAST
Chaini28 – 795768Toll-like receptor 6PRO_0000034732Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi114 – 1141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi117 ↔ 1391 Publication
Glycosylationi144 – 1441N-linked (GlcNAc...)1 Publication
Glycosylationi195 – 1951N-linked (GlcNAc...)1 Publication
Glycosylationi214 – 2141N-linked (GlcNAc...)1 Publication
Disulfide bondi235 ↔ 2651 Publication
Glycosylationi253 – 2531N-linked (GlcNAc...)1 Publication
Glycosylationi285 – 2851N-linked (GlcNAc...)
Disulfide bondi348 ↔ 3731 Publication
Glycosylationi359 – 3591N-linked (GlcNAc...)1 Publication
Glycosylationi401 – 4011N-linked (GlcNAc...)1 Publication
Disulfide bondi424 ↔ 4471 Publication
Glycosylationi434 – 4341N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9EPW9.

PTM databases

PhosphoSiteiQ9EPW9.

Expressioni

Tissue specificityi

Detected in thymus, spleen, ovary and lung.

Gene expression databases

ArrayExpressiQ9EPW9.
BgeeiQ9EPW9.
CleanExiMM_TLR6.
GenevestigatoriQ9EPW9.

Interactioni

Subunit structurei

Binds MYD88 via their respective TIR domains By similarity. Heterodimer with TLR2 via their respective extracellular domains.1 Publication

Protein-protein interaction databases

IntActiQ9EPW9. 1 interaction.

Structurei

Secondary structure

1
795
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi35 – 373
Beta strandi56 – 583
Helixi69 – 713
Turni72 – 743
Beta strandi80 – 823
Turni93 – 986
Beta strandi104 – 1063
Beta strandi124 – 1274
Helixi140 – 1445
Beta strandi150 – 1545
Turni160 – 1634
Helixi164 – 1663
Beta strandi171 – 18010
Beta strandi185 – 1873
Beta strandi190 – 1934
Beta strandi196 – 2038
Beta strandi205 – 2073
Beta strandi214 – 22916
Helixi235 – 24612
Beta strandi252 – 26110
Helixi263 – 27311
Beta strandi276 – 28813
Beta strandi306 – 3149
Helixi321 – 3299
Beta strandi334 – 3418
Beta strandi357 – 3593
Turni367 – 3726
Beta strandi381 – 3833
Helixi394 – 3974
Turni398 – 4014
Beta strandi407 – 4093
Beta strandi432 – 4343
Helixi442 – 4454
Beta strandi453 – 4564
Turni467 – 4704
Beta strandi476 – 4794

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3A79X-ray2.90B1-482[»]
ProteinModelPortaliQ9EPW9.
SMRiQ9EPW9. Positions 33-785.

Miscellaneous databases

EvolutionaryTraceiQ9EPW9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati54 – 7724LRR 1Add
BLAST
Repeati78 – 10124LRR 2Add
BLAST
Repeati102 – 12524LRR 3Add
BLAST
Repeati126 – 15025LRR 4Add
BLAST
Repeati151 – 17525LRR 5Add
BLAST
Repeati176 – 19924LRR 6Add
BLAST
Repeati200 – 22324LRR 7Add
BLAST
Repeati224 – 25027LRR 8Add
BLAST
Repeati251 – 27828LRR 9Add
BLAST
Repeati279 – 30830LRR 10Add
BLAST
Repeati309 – 33729LRR 11Add
BLAST
Repeati338 – 36124LRR 12Add
BLAST
Repeati362 – 38827LRR 13Add
BLAST
Repeati389 – 41426LRR 14Add
BLAST
Repeati415 – 43723LRR 15Add
BLAST
Repeati438 – 45720LRR 16Add
BLAST
Repeati458 – 47821LRR 17Add
BLAST
Repeati479 – 50022LRR 18Add
BLAST
Repeati501 – 52424LRR 19Add
BLAST
Domaini525 – 57652LRRCTAdd
BLAST
Domaini640 – 784145TIRAdd
BLAST

Sequence similaritiesi

Contains 1 LRRCT domain.
Contains 1 TIR domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG272762.
HOVERGENiHBG023180.
InParanoidiQ9EPW9.
KOiK10169.
PhylomeDBiQ9EPW9.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027187. TLR6.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF23. PTHR24365:SF23. 1 hit.
PfamiPF00560. LRR_1. 2 hits.
PF12799. LRR_4. 1 hit.
PF13504. LRR_7. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 1 hit.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EPW9-1 [UniParc]FASTAAdd to Basket

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MSQDRKPIVG SFHFVCALAL IVGSMTPFSN ELESMVDYSN RNLTHVPKDL    50
PPRTKALSLS QNSISELRMP DISFLSELRV LRLSHNRIRS LDFHVFLFNQ 100
DLEYLDVSHN RLQNISCCPM ASLRHLDLSF NDFDVLPVCK EFGNLTKLTF 150
LGLSAAKFRQ LDLLPVAHLH LSCILLDLVS YHIKGGETES LQIPNTTVLH 200
LVFHPNSLFS VQVNMSVNAL GHLQLSNIKL NDENCQRLMT FLSELTRGPT 250
LLNVTLQHIE TTWKCSVKLF QFFWPRPVEY LNIYNLTITE RIDREEFTYS 300
ETALKSLMIE HVKNQVFLFS KEALYSVFAE MNIKMLSISD TPFIHMVCPP 350
SPSSFTFLNF TQNVFTDSVF QGCSTLKRLQ TLILQRNGLK NFFKVALMTK 400
NMSSLETLDV SLNSLNSHAY DRTCAWAESI LVLNLSSNML TGSVFRCLPP 450
KVKVLDLHNN RIMSIPKDVT HLQALQELNV ASNSLTDLPG CGAFSSLSVL 500
VIDHNSVSHP SEDFFQSCQN IRSLTAGNNP FQCTCELRDF VKNIGWVARE 550
VVEGWPDSYR CDYPESSKGT ALRDFHMSPL SCDTVLLTVT IGATMLVLAV 600
TGAFLCLYFD LPWYVRMLCQ WTQTRHRARH IPLEELQRNL QFHAFVSYSE 650
HDSAWVKNEL LPNLEKDDIR VCLHERNFVP GKSIVENIIN FIEKSYKAIF 700
VLSPHFIQSE WCHYELYFAH HNLFHEGSDN LILILLEPIL QNNIPSRYHK 750
LRALMAQRTY LEWPTEKGKR GLFWANLRAS FIMKLALVNE DDVKT 795
Length:795
Mass (Da):91,116
Last modified:January 31, 2002 - v2
Checksum:i34D8BD175A26C233
GO

Sequence cautioni

The sequence AAG38563.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA78632.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811Y → H in BAA78632. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020808 mRNA. Translation: BAA78632.1. Different initiation.
AF314636 mRNA. Translation: AAG38563.1. Different initiation.
RefSeqiNP_035734.3. NM_011604.3.
XP_006503920.1. XM_006503857.1.
XP_006503921.1. XM_006503858.1.
XP_006503922.1. XM_006503859.1.
XP_006503923.1. XM_006503860.1.
UniGeneiMm.42146.

Genome annotation databases

GeneIDi21899.
KEGGimmu:21899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020808 mRNA. Translation: BAA78632.1 . Different initiation.
AF314636 mRNA. Translation: AAG38563.1 . Different initiation.
RefSeqi NP_035734.3. NM_011604.3.
XP_006503920.1. XM_006503857.1.
XP_006503921.1. XM_006503858.1.
XP_006503922.1. XM_006503859.1.
XP_006503923.1. XM_006503860.1.
UniGenei Mm.42146.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3A79 X-ray 2.90 B 1-482 [» ]
ProteinModelPortali Q9EPW9.
SMRi Q9EPW9. Positions 33-785.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9EPW9. 1 interaction.

PTM databases

PhosphoSitei Q9EPW9.

Proteomic databases

PRIDEi Q9EPW9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 21899.
KEGGi mmu:21899.

Organism-specific databases

CTDi 10333.
MGIi MGI:1341296. Tlr6.

Phylogenomic databases

eggNOGi NOG272762.
HOVERGENi HBG023180.
InParanoidi Q9EPW9.
KOi K10169.
PhylomeDBi Q9EPW9.

Miscellaneous databases

EvolutionaryTracei Q9EPW9.
NextBioi 301440.
PROi Q9EPW9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9EPW9.
Bgeei Q9EPW9.
CleanExi MM_TLR6.
Genevestigatori Q9EPW9.

Family and domain databases

Gene3Di 3.40.50.10140. 1 hit.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027187. TLR6.
IPR017241. Toll-like_receptor.
[Graphical view ]
PANTHERi PTHR24365:SF23. PTHR24365:SF23. 1 hit.
Pfami PF00560. LRR_1. 2 hits.
PF12799. LRR_4. 1 hit.
PF13504. LRR_7. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view ]
PIRSFi PIRSF037595. Toll-like_receptor. 1 hit.
SMARTi SM00369. LRR_TYP. 1 hit.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS51450. LRR. 10 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "TLR6: a novel member of an expanding Toll-like receptor family."
    Takeuchi O., Kawai T., Sanjo H., Copeland N.G., Gilbert D.J., Jenkins N.A., Takeda K., Akira S.
    Gene 231:59-65(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors."
    Ozinsky A., Underhill D.M., Fontenot J.D., Hajjar A.M., Smith K.D., Wilson C.B., Schroeder L., Aderem A.
    Proc. Natl. Acad. Sci. U.S.A. 97:13766-13771(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF PRO-680.
    Strain: BALB/c.
    Tissue: Macrophage.
  3. "Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer."
    Kang J.Y., Nan X., Jin M.S., Youn S.J., Ryu Y.H., Mah S., Han S.H., Lee H., Paik S.G., Lee J.O.
    Immunity 31:873-884(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 1-483 IN COMPLEX WITH TLR2 AND LIPOPEPTIDE, DISULFIDE BONDS, GLYCOSYLATION AT ASN-144; ASN-195; ASN-214; ASN-253; ASN-359; ASN-401 AND ASN-434, FUNCTION, LRR REPEATS, SUBUNIT.

Entry informationi

Entry nameiTLR6_MOUSE
AccessioniPrimary (citable) accession number: Q9EPW9
Secondary accession number(s): Q9WTQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: January 31, 2002
Last modified: September 3, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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