Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9EPW9

- TLR6_MOUSE

UniProt

Q9EPW9 - TLR6_MOUSE

Protein

Toll-like receptor 6

Gene

Tlr6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (31 Jan 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Cooperates with TLR2 for the cellular activation.1 Publication

    GO - Molecular functioni

    1. diacyl lipopeptide binding Source: MGI
    2. lipopeptide binding Source: UniProtKB
    3. protein heterodimerization activity Source: MGI
    4. transmembrane signaling receptor activity Source: InterPro

    GO - Biological processi

    1. cellular response to diacyl bacterial lipopeptide Source: Ensembl
    2. defense response to bacterium Source: Ensembl
    3. detection of diacyl bacterial lipopeptide Source: InterPro
    4. inflammatory response Source: UniProtKB-KW
    5. innate immune response Source: UniProtKB-KW
    6. microglial cell activation involved in immune response Source: Ensembl
    7. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
    8. nitric oxide metabolic process Source: Ensembl
    9. pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response Source: Ensembl
    10. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    11. positive regulation of interleukin-12 biosynthetic process Source: UniProtKB
    12. positive regulation of interleukin-6 biosynthetic process Source: UniProtKB
    13. positive regulation of JUN kinase activity Source: Ensembl
    14. regulation of cytokine secretion Source: InterPro
    15. T-helper 1 type immune response Source: UniProtKB
    16. toll-like receptor 6 signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Immunity, Inflammatory response, Innate immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Toll-like receptor 6
    Alternative name(s):
    CD_antigen: CD286
    Gene namesi
    Name:Tlr6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1341296. Tlr6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. phagocytic vesicle membrane Source: UniProtKB-SubCell
    3. Toll-like receptor 2-Toll-like receptor 6 protein complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi680 – 6801P → H: Dominant negative mutant, blocks response to Gram-positive pathogens. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 795768Toll-like receptor 6PRO_0000034732Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi117 ↔ 1391 Publication
    Glycosylationi144 – 1441N-linked (GlcNAc...)1 Publication
    Glycosylationi195 – 1951N-linked (GlcNAc...)1 Publication
    Glycosylationi214 – 2141N-linked (GlcNAc...)1 Publication
    Disulfide bondi235 ↔ 2651 Publication
    Glycosylationi253 – 2531N-linked (GlcNAc...)1 Publication
    Glycosylationi285 – 2851N-linked (GlcNAc...)
    Disulfide bondi348 ↔ 3731 Publication
    Glycosylationi359 – 3591N-linked (GlcNAc...)1 Publication
    Glycosylationi401 – 4011N-linked (GlcNAc...)1 Publication
    Disulfide bondi424 ↔ 4471 Publication
    Glycosylationi434 – 4341N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9EPW9.

    PTM databases

    PhosphoSiteiQ9EPW9.

    Expressioni

    Tissue specificityi

    Detected in thymus, spleen, ovary and lung.

    Gene expression databases

    ArrayExpressiQ9EPW9.
    BgeeiQ9EPW9.
    CleanExiMM_TLR6.
    GenevestigatoriQ9EPW9.

    Interactioni

    Subunit structurei

    Binds MYD88 via their respective TIR domains By similarity. Heterodimer with TLR2 via their respective extracellular domains.By similarity1 Publication

    Protein-protein interaction databases

    IntActiQ9EPW9. 1 interaction.

    Structurei

    Secondary structure

    1
    795
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi35 – 373
    Beta strandi56 – 583
    Helixi69 – 713
    Turni72 – 743
    Beta strandi80 – 823
    Turni93 – 986
    Beta strandi104 – 1063
    Beta strandi124 – 1274
    Helixi140 – 1445
    Beta strandi150 – 1545
    Turni160 – 1634
    Helixi164 – 1663
    Beta strandi171 – 18010
    Beta strandi185 – 1873
    Beta strandi190 – 1934
    Beta strandi196 – 2038
    Beta strandi205 – 2073
    Beta strandi214 – 22916
    Helixi235 – 24612
    Beta strandi252 – 26110
    Helixi263 – 27311
    Beta strandi276 – 28813
    Beta strandi306 – 3149
    Helixi321 – 3299
    Beta strandi334 – 3418
    Beta strandi357 – 3593
    Turni367 – 3726
    Beta strandi381 – 3833
    Helixi394 – 3974
    Turni398 – 4014
    Beta strandi407 – 4093
    Beta strandi432 – 4343
    Helixi442 – 4454
    Beta strandi453 – 4564
    Turni467 – 4704
    Beta strandi476 – 4794

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3A79X-ray2.90B1-482[»]
    ProteinModelPortaliQ9EPW9.
    SMRiQ9EPW9. Positions 33-785.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9EPW9.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 584557ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini606 – 795190CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei585 – 60521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati54 – 7724LRR 11 PublicationAdd
    BLAST
    Repeati78 – 10124LRR 21 PublicationAdd
    BLAST
    Repeati102 – 12524LRR 31 PublicationAdd
    BLAST
    Repeati126 – 15025LRR 41 PublicationAdd
    BLAST
    Repeati151 – 17525LRR 51 PublicationAdd
    BLAST
    Repeati176 – 19924LRR 61 PublicationAdd
    BLAST
    Repeati200 – 22324LRR 71 PublicationAdd
    BLAST
    Repeati224 – 25027LRR 81 PublicationAdd
    BLAST
    Repeati251 – 27828LRR 91 PublicationAdd
    BLAST
    Repeati279 – 30830LRR 101 PublicationAdd
    BLAST
    Repeati309 – 33729LRR 111 PublicationAdd
    BLAST
    Repeati338 – 36124LRR 121 PublicationAdd
    BLAST
    Repeati362 – 38827LRR 131 PublicationAdd
    BLAST
    Repeati389 – 41426LRR 141 PublicationAdd
    BLAST
    Repeati415 – 43723LRR 151 PublicationAdd
    BLAST
    Repeati438 – 45720LRR 161 PublicationAdd
    BLAST
    Repeati458 – 47821LRR 171 PublicationAdd
    BLAST
    Repeati479 – 50022LRR 181 PublicationAdd
    BLAST
    Repeati501 – 52424LRR 191 PublicationAdd
    BLAST
    Domaini525 – 57652LRRCTAdd
    BLAST
    Domaini640 – 784145TIRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Toll-like receptor family.Curated
    Contains 19 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 TIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG272762.
    HOVERGENiHBG023180.
    InParanoidiQ9EPW9.
    KOiK10169.
    PhylomeDBiQ9EPW9.

    Family and domain databases

    Gene3Di3.40.50.10140. 1 hit.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000157. TIR_dom.
    IPR027187. TLR6.
    IPR017241. Toll-like_receptor.
    [Graphical view]
    PANTHERiPTHR24365:SF23. PTHR24365:SF23. 1 hit.
    PfamiPF00560. LRR_1. 2 hits.
    PF12799. LRR_4. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
    SMARTiSM00369. LRR_TYP. 1 hit.
    SM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS51450. LRR. 10 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9EPW9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQDRKPIVG SFHFVCALAL IVGSMTPFSN ELESMVDYSN RNLTHVPKDL    50
    PPRTKALSLS QNSISELRMP DISFLSELRV LRLSHNRIRS LDFHVFLFNQ 100
    DLEYLDVSHN RLQNISCCPM ASLRHLDLSF NDFDVLPVCK EFGNLTKLTF 150
    LGLSAAKFRQ LDLLPVAHLH LSCILLDLVS YHIKGGETES LQIPNTTVLH 200
    LVFHPNSLFS VQVNMSVNAL GHLQLSNIKL NDENCQRLMT FLSELTRGPT 250
    LLNVTLQHIE TTWKCSVKLF QFFWPRPVEY LNIYNLTITE RIDREEFTYS 300
    ETALKSLMIE HVKNQVFLFS KEALYSVFAE MNIKMLSISD TPFIHMVCPP 350
    SPSSFTFLNF TQNVFTDSVF QGCSTLKRLQ TLILQRNGLK NFFKVALMTK 400
    NMSSLETLDV SLNSLNSHAY DRTCAWAESI LVLNLSSNML TGSVFRCLPP 450
    KVKVLDLHNN RIMSIPKDVT HLQALQELNV ASNSLTDLPG CGAFSSLSVL 500
    VIDHNSVSHP SEDFFQSCQN IRSLTAGNNP FQCTCELRDF VKNIGWVARE 550
    VVEGWPDSYR CDYPESSKGT ALRDFHMSPL SCDTVLLTVT IGATMLVLAV 600
    TGAFLCLYFD LPWYVRMLCQ WTQTRHRARH IPLEELQRNL QFHAFVSYSE 650
    HDSAWVKNEL LPNLEKDDIR VCLHERNFVP GKSIVENIIN FIEKSYKAIF 700
    VLSPHFIQSE WCHYELYFAH HNLFHEGSDN LILILLEPIL QNNIPSRYHK 750
    LRALMAQRTY LEWPTEKGKR GLFWANLRAS FIMKLALVNE DDVKT 795
    Length:795
    Mass (Da):91,116
    Last modified:January 31, 2002 - v2
    Checksum:i34D8BD175A26C233
    GO

    Sequence cautioni

    The sequence AAG38563.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA78632.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti181 – 1811Y → H in BAA78632. (PubMed:10231569)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020808 mRNA. Translation: BAA78632.1. Different initiation.
    AF314636 mRNA. Translation: AAG38563.1. Different initiation.
    RefSeqiNP_035734.3. NM_011604.3.
    XP_006503920.1. XM_006503857.1.
    XP_006503921.1. XM_006503858.1.
    XP_006503922.1. XM_006503859.1.
    XP_006503923.1. XM_006503860.1.
    UniGeneiMm.42146.

    Genome annotation databases

    GeneIDi21899.
    KEGGimmu:21899.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020808 mRNA. Translation: BAA78632.1 . Different initiation.
    AF314636 mRNA. Translation: AAG38563.1 . Different initiation.
    RefSeqi NP_035734.3. NM_011604.3.
    XP_006503920.1. XM_006503857.1.
    XP_006503921.1. XM_006503858.1.
    XP_006503922.1. XM_006503859.1.
    XP_006503923.1. XM_006503860.1.
    UniGenei Mm.42146.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3A79 X-ray 2.90 B 1-482 [» ]
    ProteinModelPortali Q9EPW9.
    SMRi Q9EPW9. Positions 33-785.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9EPW9. 1 interaction.

    PTM databases

    PhosphoSitei Q9EPW9.

    Proteomic databases

    PRIDEi Q9EPW9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 21899.
    KEGGi mmu:21899.

    Organism-specific databases

    CTDi 10333.
    MGIi MGI:1341296. Tlr6.

    Phylogenomic databases

    eggNOGi NOG272762.
    HOVERGENi HBG023180.
    InParanoidi Q9EPW9.
    KOi K10169.
    PhylomeDBi Q9EPW9.

    Miscellaneous databases

    EvolutionaryTracei Q9EPW9.
    NextBioi 301440.
    PROi Q9EPW9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9EPW9.
    Bgeei Q9EPW9.
    CleanExi MM_TLR6.
    Genevestigatori Q9EPW9.

    Family and domain databases

    Gene3Di 3.40.50.10140. 1 hit.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000157. TIR_dom.
    IPR027187. TLR6.
    IPR017241. Toll-like_receptor.
    [Graphical view ]
    PANTHERi PTHR24365:SF23. PTHR24365:SF23. 1 hit.
    Pfami PF00560. LRR_1. 2 hits.
    PF12799. LRR_4. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037595. Toll-like_receptor. 1 hit.
    SMARTi SM00369. LRR_TYP. 1 hit.
    SM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS51450. LRR. 10 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "TLR6: a novel member of an expanding Toll-like receptor family."
      Takeuchi O., Kawai T., Sanjo H., Copeland N.G., Gilbert D.J., Jenkins N.A., Takeda K., Akira S.
      Gene 231:59-65(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    2. "The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors."
      Ozinsky A., Underhill D.M., Fontenot J.D., Hajjar A.M., Smith K.D., Wilson C.B., Schroeder L., Aderem A.
      Proc. Natl. Acad. Sci. U.S.A. 97:13766-13771(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF PRO-680.
      Strain: BALB/c.
      Tissue: Macrophage.
    3. "Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer."
      Kang J.Y., Nan X., Jin M.S., Youn S.J., Ryu Y.H., Mah S., Han S.H., Lee H., Paik S.G., Lee J.O.
      Immunity 31:873-884(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 1-483 IN COMPLEX WITH TLR2 AND LIPOPEPTIDE, DISULFIDE BONDS, GLYCOSYLATION AT ASN-144; ASN-195; ASN-214; ASN-253; ASN-359; ASN-401 AND ASN-434, FUNCTION, LRR REPEATS, SUBUNIT.

    Entry informationi

    Entry nameiTLR6_MOUSE
    AccessioniPrimary (citable) accession number: Q9EPW9
    Secondary accession number(s): Q9WTQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: January 31, 2002
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3