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Protein

C-type lectin domain family 3 member A

Gene

Clec3a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Promotes cell adhesion to laminin and fibronectin.By similarity

GO - Molecular functioni

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 3 member A
Alternative name(s):
C-type lectin superfamily member 1
Cartilage-derived C-type lectin
Gene namesi
Name:Clec3a
Synonyms:Clecsf1, Gm796
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2685642. Clec3a.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001737523 – 196C-type lectin domain family 3 member AAdd BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 78PROSITE-ProRule annotation
Disulfide bondi95 ↔ 191PROSITE-ProRule annotation
Disulfide bondi167 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9EPW4.
PaxDbiQ9EPW4.
PRIDEiQ9EPW4.

PTM databases

PhosphoSitePlusiQ9EPW4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000008874.
CleanExiMM_CLEC3A.
ExpressionAtlasiQ9EPW4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009018.

Structurei

3D structure databases

ProteinModelPortaliQ9EPW4.
SMRiQ9EPW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 192C-type lectinPROSITE-ProRule annotationAdd BLAST119

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00610000086061.
HOGENOMiHOG000060248.
HOVERGENiHBG108270.
InParanoidiQ9EPW4.
KOiK17519.
OMAiKRYICEF.
OrthoDBiEOG091G0NMQ.
TreeFamiTF330481.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
PfamiView protein in Pfam
PF00059. Lectin_C. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EPW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKNGLVLCI LVVSLLLDQT DGYPSRMKAR KHSKRRVKAK DDDLKSQVEK
60 70 80 90 100
LWREVNALKE MQALQTVCLR GTKVHKKCYL ASEGLKHYHE ANEDCISKGG
110 120 130 140 150
TLVVPRNSDE INALRDYGKR SLPGVNDFWL GINDMVTEGK FLDVHGFAVS
160 170 180 190
FLNWDRAQPS GGKRENCVLF SQSAQGKWSD EACRSSKRYI CEFIIP
Length:196
Mass (Da):22,192
Last modified:March 1, 2001 - v1
Checksum:i9AE4C809D119E852
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317204 Genomic DNA. Translation: AAG48620.1.
CCDSiCCDS22690.1.
RefSeqiNP_001007224.1. NM_001007223.3.
UniGeneiMm.491796.
Mm.81117.

Genome annotation databases

EnsembliENSMUST00000009018; ENSMUSP00000009018; ENSMUSG00000008874.
GeneIDi403395.
KEGGimmu:403395.
UCSCiuc009nob.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCLC3A_MOUSE
AccessioniPrimary (citable) accession number: Q9EPW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2001
Last modified: June 7, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot