Q9EPW2Q3UQB0KLF15_MOUSEKrueppel-like factor 15Cardiovascular Krueppel-like factorKlf15CklfMus musculusMouseEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMusThe Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4.NUCLEOTIDE SEQUENCE [MRNA]The transcriptional landscape of the mammalian genome.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy.FUNCTION AS INHIBITOR OF CARDIAC HYPERTROPHYFUNCTION AS REPRESSOR OF GATA4 AND MEF2ADISRUPTION PHENOTYPEERRATUM OF PUBMED:17438289The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts.FUNCTION AS INHIBITOR OF CARDIAC FIBROSIS AND CCN2 EXPRESSIONDISRUPTION PHENOTYPERegulation of cardiac gene expression by KLF15, a repressor of myocardin activity.FUNCTION AS NEGATIVE REGULATOR OF MYOCDINTERACTION WITH MYOCDKlf15 deficiency is a molecular link between heart failure and aortic aneurysm formation.FUNCTION AS NEGATIVE REGULATOR OF TP53 ACETYLATIONKruppel-like factor 15 (KLF15) is a key regulator of podocyte differentiation.FUNCTION IN PODOCYTE DIFFERENTIATIONINDUCTIONCircadian rhythms govern cardiac repolarization and arrhythmogenesis.FUNCTION IN KCNIP2 CIRCADIAN EXPRESSIONINDUCTIONBINDING TO THE KCNIP2 PROMOTERKruppel-like factor 15 is critical for vascular inflammation.FUNCTION AS INHIBITOR OF VASCULAR INFLAMMATIONTISSUE SPECIFICITYTranscriptional regulator that binds to the GA element of the CLCNKA promoter (By similarity). Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart. Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. Is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A, GATA4 and MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation (By similarity). Involved in podocyte differentiation.Interacts with MYOCD. Interacts with EP300 (By similarity).NucleusExpressed in aortic smooth muscle cells.In the heart, up-regulated by the CLOCK/BMAL1 heterodimer. In podocytes, up-regulated by retinoic acid.The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.KLF15 null mice are viable, but in response to pressure overload, they develop cardiac hypertrophy and fibrosis.Belongs to the Sp1 C2H2-type zinc-finger protein family.ActivatorDNA-bindingMetal-bindingNucleusReference proteomeRepeatTranscriptionTranscription regulationZincZinc-fingerMVDHLLPVDETFSSPKCSVGYLGDRLASRQPYHMLPSPISEDDSDVSSPCSCASPDSQAFCSCYSAGPGPEAQGSILDFLLSRATLGSGGGSGGIGDSSGPVTWGSWRRASVPVKEEHFCFPEFLSGDTDDVSRPFQPTLEEIEEFLEENMEAEVKEAPENGSRDLETCSQLSAGSHRSHLHPESAGRERCTPPPGGTSGGGAQSAGEGPAHDGPVPVLLQIQPVAVKQEAGTGPASPGQAPESVKVAQLLVNIQGQTFALLPQVVPSSNLNLPSKFVRIAPVPIAAKPIGSGSLGPGPAGLLVGQKFPKNPAAELLKMHKCTFPGCSKMYTKSSHLKAHLRRHTGEKPFACTWPGCGWRFSRSDELSRHRRSHSGVKPYQCPVCEKKFARSDHLSKHIKVHRFPRSSRAVRAIN
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