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Protein

Krueppel-like factor 15

Gene

Klf15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator that binds to the GA element of the CLCNKA promoter (By similarity). Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart. Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. Is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A, GATA4 and MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation (By similarity). Involved in podocyte differentiation.By similarity7 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri320 – 344C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri350 – 374C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri380 – 402C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: MGI
  • DNA binding transcription factor activity Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  • cardiac muscle hypertrophy in response to stress Source: UniProtKB
  • cellular response to peptide Source: Ensembl
  • glial cell differentiation Source: MGI
  • glomerular visceral epithelial cell differentiation Source: UniProtKB
  • negative regulation of peptidyl-lysine acetylation Source: UniProtKB
  • positive regulation of glucose import Source: MGI
  • positive regulation of glucose import in response to insulin stimulus Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of gene expression Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 15
Alternative name(s):
Cardiovascular Krueppel-like factor
Gene namesi
Name:Klf15
Synonyms:Cklf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1929988 Klf15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

KLF15 null mice are viable, but in response to pressure overload, they develop cardiac hypertrophy and fibrosis.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471881 – 415Krueppel-like factor 15Add BLAST415

Proteomic databases

PaxDbiQ9EPW2
PRIDEiQ9EPW2

PTM databases

iPTMnetiQ9EPW2
PhosphoSitePlusiQ9EPW2

Expressioni

Tissue specificityi

Expressed in aortic smooth muscle cells.1 Publication

Inductioni

In the heart, up-regulated by the CLOCK/ARNTL heterodimer. In podocytes, up-regulated by retinoic acid.2 Publications

Gene expression databases

BgeeiENSMUSG00000030087
CleanExiMM_CKLF
MM_KLF15
ExpressionAtlasiQ9EPW2 baseline and differential
GenevisibleiQ9EPW2 MM

Interactioni

Subunit structurei

Interacts with MYOCD. Interacts with EP300 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032174

Structurei

3D structure databases

ProteinModelPortaliQ9EPW2
SMRiQ9EPW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri320 – 344C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri350 – 374C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri380 – 402C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118998
HOGENOMiHOG000294058
HOVERGENiHBG052266
InParanoidiQ9EPW2
KOiK09210
OMAiVKGEHFC
OrthoDBiEOG091G09JN
PhylomeDBiQ9EPW2
TreeFamiTF350556

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q9EPW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDHLLPVDE TFSSPKCSVG YLGDRLASRQ PYHMLPSPIS EDDSDVSSPC
60 70 80 90 100
SCASPDSQAF CSCYSAGPGP EAQGSILDFL LSRATLGSGG GSGGIGDSSG
110 120 130 140 150
PVTWGSWRRA SVPVKEEHFC FPEFLSGDTD DVSRPFQPTL EEIEEFLEEN
160 170 180 190 200
MEAEVKEAPE NGSRDLETCS QLSAGSHRSH LHPESAGRER CTPPPGGTSG
210 220 230 240 250
GGAQSAGEGP AHDGPVPVLL QIQPVAVKQE AGTGPASPGQ APESVKVAQL
260 270 280 290 300
LVNIQGQTFA LLPQVVPSSN LNLPSKFVRI APVPIAAKPI GSGSLGPGPA
310 320 330 340 350
GLLVGQKFPK NPAAELLKMH KCTFPGCSKM YTKSSHLKAH LRRHTGEKPF
360 370 380 390 400
ACTWPGCGWR FSRSDELSRH RRSHSGVKPY QCPVCEKKFA RSDHLSKHIK
410
VHRFPRSSRA VRAIN
Length:415
Mass (Da):44,253
Last modified:March 1, 2001 - v1
Checksum:i127A7B80DB3E33CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317225 mRNA Translation: AAG38597.1
AK009739 mRNA Translation: BAB26470.1
AK142618 mRNA Translation: BAE25132.1
BC013486 mRNA Translation: AAH13486.1
CCDSiCCDS20360.1
RefSeqiNP_075673.1, NM_023184.3
UniGeneiMm.38343
Mm.41389

Genome annotation databases

EnsembliENSMUST00000032174; ENSMUSP00000032174; ENSMUSG00000030087
ENSMUST00000113530; ENSMUSP00000109158; ENSMUSG00000030087
ENSMUST00000203039; ENSMUSP00000144962; ENSMUSG00000030087
ENSMUST00000203607; ENSMUSP00000144808; ENSMUSG00000030087
GeneIDi66277
KEGGimmu:66277
UCSCiuc009cxj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKLF15_MOUSE
AccessioniPrimary (citable) accession number: Q9EPW2
Secondary accession number(s): Q3UQB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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