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Q9EPW2

- KLF15_MOUSE

UniProt

Q9EPW2 - KLF15_MOUSE

Protein

Krueppel-like factor 15

Gene

Klf15

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Transcriptional regulator that binds to the GA element of the CLCNKA promoter By similarity. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart. Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. Is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A, GATA4 and MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation By similarity. Involved in podocyte differentiation.By similarity7 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri320 – 34425C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri350 – 37425C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri380 – 40223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: MGI
    4. sequence-specific DNA binding transcription factor activity Source: MGI
    5. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. cardiac muscle hypertrophy in response to stress Source: UniProtKB
    2. cellular response to peptide Source: Ensembl
    3. glial cell differentiation Source: MGI
    4. glomerular visceral epithelial cell differentiation Source: UniProtKB
    5. glucose transport Source: MGI
    6. negative regulation of peptidyl-lysine acetylation Source: UniProtKB
    7. positive regulation of transcription, DNA-templated Source: MGI
    8. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    9. regulation of gene expression Source: UniProtKB
    10. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Krueppel-like factor 15
    Alternative name(s):
    Cardiovascular Krueppel-like factor
    Gene namesi
    Name:Klf15
    Synonyms:Cklf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1929988. Klf15.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleolus Source: Ensembl
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    KLF15 null mice are viable, but in response to pressure overload, they develop cardiac hypertrophy and fibrosis.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 415415Krueppel-like factor 15PRO_0000047188Add
    BLAST

    Proteomic databases

    PRIDEiQ9EPW2.

    PTM databases

    PhosphoSiteiQ9EPW2.

    Expressioni

    Tissue specificityi

    Expressed in aortic smooth muscle cells.1 Publication

    Inductioni

    In the heart, up-regulated by the CLOCK/ARNTL heterodimer. In podocytes, up-regulated by retinoic acid.2 Publications

    Gene expression databases

    BgeeiQ9EPW2.
    CleanExiMM_CKLF.
    MM_KLF15.
    GenevestigatoriQ9EPW2.

    Interactioni

    Subunit structurei

    Interacts with MYOCD. Interacts with EP300 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EPW2.
    SMRiQ9EPW2. Positions 317-402.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri320 – 34425C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri350 – 37425C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri380 – 40223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117314.
    HOGENOMiHOG000294058.
    HOVERGENiHBG052266.
    InParanoidiQ9EPW2.
    KOiK09210.
    OMAiTAGVRSY.
    OrthoDBiEOG7JMGF2.
    PhylomeDBiQ9EPW2.
    TreeFamiTF350556.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9EPW2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDHLLPVDE TFSSPKCSVG YLGDRLASRQ PYHMLPSPIS EDDSDVSSPC    50
    SCASPDSQAF CSCYSAGPGP EAQGSILDFL LSRATLGSGG GSGGIGDSSG 100
    PVTWGSWRRA SVPVKEEHFC FPEFLSGDTD DVSRPFQPTL EEIEEFLEEN 150
    MEAEVKEAPE NGSRDLETCS QLSAGSHRSH LHPESAGRER CTPPPGGTSG 200
    GGAQSAGEGP AHDGPVPVLL QIQPVAVKQE AGTGPASPGQ APESVKVAQL 250
    LVNIQGQTFA LLPQVVPSSN LNLPSKFVRI APVPIAAKPI GSGSLGPGPA 300
    GLLVGQKFPK NPAAELLKMH KCTFPGCSKM YTKSSHLKAH LRRHTGEKPF 350
    ACTWPGCGWR FSRSDELSRH RRSHSGVKPY QCPVCEKKFA RSDHLSKHIK 400
    VHRFPRSSRA VRAIN 415
    Length:415
    Mass (Da):44,253
    Last modified:March 1, 2001 - v1
    Checksum:i127A7B80DB3E33CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF317225 mRNA. Translation: AAG38597.1.
    AK009739 mRNA. Translation: BAB26470.1.
    AK142618 mRNA. Translation: BAE25132.1.
    BC013486 mRNA. Translation: AAH13486.1.
    CCDSiCCDS20360.1.
    RefSeqiNP_075673.1. NM_023184.3.
    UniGeneiMm.41389.

    Genome annotation databases

    EnsembliENSMUST00000032174; ENSMUSP00000032174; ENSMUSG00000030087.
    ENSMUST00000113530; ENSMUSP00000109158; ENSMUSG00000030087.
    GeneIDi66277.
    KEGGimmu:66277.
    UCSCiuc009cxj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF317225 mRNA. Translation: AAG38597.1 .
    AK009739 mRNA. Translation: BAB26470.1 .
    AK142618 mRNA. Translation: BAE25132.1 .
    BC013486 mRNA. Translation: AAH13486.1 .
    CCDSi CCDS20360.1.
    RefSeqi NP_075673.1. NM_023184.3.
    UniGenei Mm.41389.

    3D structure databases

    ProteinModelPortali Q9EPW2.
    SMRi Q9EPW2. Positions 317-402.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9EPW2.

    Proteomic databases

    PRIDEi Q9EPW2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032174 ; ENSMUSP00000032174 ; ENSMUSG00000030087 .
    ENSMUST00000113530 ; ENSMUSP00000109158 ; ENSMUSG00000030087 .
    GeneIDi 66277.
    KEGGi mmu:66277.
    UCSCi uc009cxj.1. mouse.

    Organism-specific databases

    CTDi 28999.
    MGIi MGI:1929988. Klf15.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117314.
    HOGENOMi HOG000294058.
    HOVERGENi HBG052266.
    InParanoidi Q9EPW2.
    KOi K09210.
    OMAi TAGVRSY.
    OrthoDBi EOG7JMGF2.
    PhylomeDBi Q9EPW2.
    TreeFami TF350556.

    Miscellaneous databases

    NextBioi 321181.
    PROi Q9EPW2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9EPW2.
    CleanExi MM_CKLF.
    MM_KLF15.
    Genevestigatori Q9EPW2.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Kruppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4."
      Gray S.J., Feinberg M.W., Hull S., Kuo C.T., Watanabe M., Sen-Banerjee S., DePina A., Haspel R., Jain M.K.
      J. Biol. Chem. 277:34322-34328(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland and Tongue.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    4. Cited for: FUNCTION AS INHIBITOR OF CARDIAC HYPERTROPHY, FUNCTION AS REPRESSOR OF GATA4 AND MEF2A, DISRUPTION PHENOTYPE.
    5. "The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts."
      Wang B., Haldar S.M., Lu Y., Ibrahim O.A., Fisch S., Gray S., Leask A., Jain M.K.
      J. Mol. Cell. Cardiol. 45:193-197(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS INHIBITOR OF CARDIAC FIBROSIS AND CTGF EXPRESSION, DISRUPTION PHENOTYPE.
    6. Cited for: FUNCTION AS NEGATIVE REGULATOR OF MYOCD, INTERACTION WITH MYOCD.
    7. Cited for: FUNCTION AS NEGATIVE REGULATOR OF TP53 ACETYLATION.
    8. Cited for: FUNCTION IN PODOCYTE DIFFERENTIATION, INDUCTION.
    9. Cited for: FUNCTION IN KCNIP2 CIRCADIAN EXPRESSION, INDUCTION, BINDING TO THE KCNIP2 PROMOTER.
    10. Cited for: FUNCTION AS INHIBITOR OF VASCULAR INFLAMMATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiKLF15_MOUSE
    AccessioniPrimary (citable) accession number: Q9EPW2
    Secondary accession number(s): Q3UQB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3