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Protein

Zinc finger protein 354C

Gene

Znf354c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as a transcription repressor. Binds to 5'-CCACA-3' core sequence. Suppresses osteogenic effects of RUNX2. May be involved in osteoblastic differentiation. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri218 – 240C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 354C
Alternative name(s):
Protein AJ18
Gene namesi
Name:Znf354c
Synonyms:Zfp354c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69405. Zfp354c.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804101 – 560Zinc finger protein 354CAdd BLAST560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki112Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki169Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9EPU7.
PRIDEiQ9EPU7.

Expressioni

Tissue specificityi

Expressed in brain. Very low expression in adult bone tissues. Overexpression suppresses alkaline phosphatase induction by BMP7.1 Publication

Developmental stagei

Expressed during osteoblast differentiation and bone development. Detected in embryonic bone formation in calvariae and tibiae. Very low expression in neonate bone tissues. Expressed in kidney and brain.1 Publication

Interactioni

Subunit structurei

Interacts with RUNX2. Binds consensus element OSE2.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000248.

Structurei

3D structure databases

ProteinModelPortaliQ9EPU7.
SMRiQ9EPU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 84KRABPROSITE-ProRule annotationAdd BLAST71

Domaini

KRAB domain is not required for nuclear targeting or for DNA binding.1 Publication
Zinc finger region is involved in nuclear targeting and DNA-binding.1 Publication

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri218 – 240C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri498 – 520C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9EPU7.
KOiK09228.
PhylomeDBiQ9EPU7.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 6 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.

Sequencei

Sequence statusi: Complete.

Q9EPU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDLLAARG TEPVTFRDVA VSFSQDEWLH LDPAQRTLYR EVMLENYSNL
60 70 80 90 100
ASLGFQASIP PVIGKLQKGQ DPCMEREAPE DTCLDFQIQS EIEASSPEQD
110 120 130 140 150
VFIEGPSRGL LKNRSTKCAY WKISFGELVK YERLETAQEQ EKKAHEPGAA
160 170 180 190 200
SPKEVTSEDG IPTDPELEKP LFMNKALVSQ ETDPIERVPG MYHTSEKDLP
210 220 230 240 250
QDFDLMRNFQ IYPGQKPYVC SECGKGFSQS LHLLEHKRIH TGEKPYKCSE
260 270 280 290 300
CGKSFSHRSS LLAHQRTHTG EKPYKCSECE KAFGSSSTLI KHLRVHTGEK
310 320 330 340 350
PYRCRECGKA FSQCSTLTVH QRIHTGEKLY KCAECDKAFN CRAKLHRHQR
360 370 380 390 400
IHTGEKPYKC AECGKGYSQF PSLAEHQRLH TGGQLCQCLQ CGRTFTRVST
410 420 430 440 450
LIEHQRIHTG QKPYQCNECG KTFNQYSSFN EHRKIHTGEK LYTCEECGKA
460 470 480 490 500
FGCKSNLYRH QRIHTGEKPY QCNQCGKAFS QYSFLTEHER IHTGEKLYKC
510 520 530 540 550
MECGKAYSYR SNLCRHKKVH LKERLYKWKE YGTPFMYGSS LAPHQRCLKG
560
EKPEDLNSSL
Length:560
Mass (Da):64,193
Last modified:March 1, 2001 - v1
Checksum:i09249239626F22F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321874 mRNA. Translation: AAG41994.1.
RefSeqiNP_076478.1. NM_023988.1.
UniGeneiRn.230042.

Genome annotation databases

GeneIDi78972.
KEGGirno:78972.
UCSCiRGD:69405. rat.

Similar proteinsi

Entry informationi

Entry nameiZ354C_RAT
AccessioniPrimary (citable) accession number: Q9EPU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2001
Last modified: August 30, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families