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Protein

Tumor necrosis factor receptor superfamily member 21

Gene

Tnfrsf21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.6 Publications

GO - Molecular functioni

GO - Biological processi

  • adaptive immune response Source: UniProtKB
  • apoptotic process Source: MGI
  • apoptotic signaling pathway Source: GO_Central
  • B cell apoptotic process Source: UniProtKB
  • cellular response to tumor necrosis factor Source: MGI
  • humoral immune response Source: UniProtKB
  • inflammatory response Source: GO_Central
  • myelination Source: UniProtKB
  • negative regulation of B cell proliferation Source: UniProtKB
  • negative regulation of interleukin-10 secretion Source: UniProtKB
  • negative regulation of interleukin-13 secretion Source: UniProtKB
  • negative regulation of interleukin-5 secretion Source: UniProtKB
  • negative regulation of myelination Source: MGI
  • negative regulation of T cell proliferation Source: UniProtKB
  • neuron apoptotic process Source: UniProtKB
  • oligodendrocyte apoptotic process Source: UniProtKB
  • regulation of apoptotic process Source: GO_Central
  • regulation of oligodendrocyte differentiation Source: UniProtKB
  • response to lipopolysaccharide Source: GO_Central
  • T cell receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Apoptosis, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 21
Alternative name(s):
Death receptor 6
CD_antigen: CD358
Gene namesi
Name:Tnfrsf21
Synonyms:Dr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2151075. Tnfrsf21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini42 – 349308ExtracellularSequence analysisAdd
BLAST
Transmembranei350 – 37021HelicalSequence analysisAdd
BLAST
Topological domaini371 – 655285CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon Source: UniProtKB
  • integral component of plasma membrane Source: MGI
  • intrinsic component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Mice are born at the expected Mendelian rate, are viable and fertile. Mutant mice display an increased number of T-cells in the peripheral blood, but only a minor increase of the number of T-cells in spleen and thymus. T-cells from mutant mice show increased proliferative responses to antigens and produce higher levels of IL4, IL5, IL10, IL13 and IFNG. Mutant mice have normal serum levels of IgG and IgM in the absence of antigen, but produce higher levels of IgG, IgM and IgM in response to antigens. Likewise, B-cells from mutant mice display increased proliferation and decreased apoptosis in response to antigens. Mutant mice show increased levels of mature oligodendrocytes, decreased levels of apoptotic oligodendrocytes and increased myelination. Mutant mice are not susceptible to neuronal apoptosis triggered by exposure to amyloid peptides derived from APP.5 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141Sequence analysisAdd
BLAST
Chaini42 – 655614Tumor necrosis factor receptor superfamily member 21PRO_0000034603Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi67 ↔ 80PROSITE-ProRule annotation
Disulfide bondi70 ↔ 88PROSITE-ProRule annotation
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence analysis
Disulfide bondi91 ↔ 106PROSITE-ProRule annotation
Disulfide bondi109 ↔ 123PROSITE-ProRule annotation
Disulfide bondi113 ↔ 131PROSITE-ProRule annotation
Disulfide bondi133 ↔ 144PROSITE-ProRule annotation
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence analysis
Disulfide bondi150 ↔ 168PROSITE-ProRule annotation
Disulfide bondi171 ↔ 186PROSITE-ProRule annotation
Disulfide bondi192 ↔ 211PROSITE-ProRule annotation
Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence analysis
Glycosylationi257 – 2571N-linked (GlcNAc...)Sequence analysis
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence analysis
Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence analysis
Lipidationi368 – 3681S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ9EPU5.
PaxDbiQ9EPU5.
PRIDEiQ9EPU5.

PTM databases

iPTMnetiQ9EPU5.
PhosphoSiteiQ9EPU5.

Expressioni

Tissue specificityi

Detected in spleen B-cells (at protein level). Ubiquitous. Highly expressed in adult spleen, thymus, testis, prostate, ovary, small intestine, colon, brain, lung and kidney, and in fetal brain, liver and lung. Detected at lower levels in adult peripheral blood leukocytes, lung, and in fetal muscle, heart, kidney, small intestine and skin. Detected in T-cells, B-cells and monocytes. In T-cells expression is highest in Th0 cells, intermediate in Th2 cells and lower in Th1 cells. Expressed at low levels in proliferating progenitors in the spinal cord, but is highly expressed by differentiating neurons within the spinal cord and adjacent dorsal root ganglia. Expressed by developing neurons as they differentiate and enter a pro-apoptotic state. Expressed by both cell bodies and axons.4 Publications

Gene expression databases

BgeeiQ9EPU5.
GenevisibleiQ9EPU5. MM.

Interactioni

Subunit structurei

Associates with TRADD. Interacts with NGFR (By similarity). Interacts with N-APP.By similarity1 Publication

Protein-protein interaction databases

DIPiDIP-59733N.
STRINGi10090.ENSMUSP00000024708.

Structurei

Secondary structure

1
655
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi53 – 575Combined sources
Turni59 – 613Combined sources
Beta strandi64 – 685Combined sources
Beta strandi74 – 785Combined sources
Beta strandi82 – 843Combined sources
Beta strandi87 – 904Combined sources
Beta strandi118 – 1214Combined sources
Beta strandi130 – 1323Combined sources
Beta strandi137 – 1404Combined sources
Beta strandi143 – 1464Combined sources
Beta strandi154 – 1585Combined sources
Beta strandi162 – 1643Combined sources
Beta strandi167 – 1704Combined sources
Beta strandi181 – 1833Combined sources
Helixi193 – 1953Combined sources
Beta strandi198 – 2014Combined sources
Beta strandi205 – 2073Combined sources
Beta strandi210 – 2123Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4YN0X-ray2.20A42-220[»]
ProteinModelPortaliQ9EPU5.
SMRiQ9EPU5. Positions 49-216, 569-655.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati50 – 8839TNFR-Cys 1Add
BLAST
Repeati90 – 13142TNFR-Cys 2Add
BLAST
Repeati133 – 16735TNFR-Cys 3Add
BLAST
Repeati170 – 21142TNFR-Cys 4Add
BLAST
Domaini415 – 49884DeathPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 death domain.PROSITE-ProRule annotation
Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHQ6. Eukaryota.
ENOG410YYKW. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000136852.
HOVERGENiHBG054218.
InParanoidiQ9EPU5.
KOiK05157.
OMAiFSRPEHM.
OrthoDBiEOG786H2Q.
PhylomeDBiQ9EPU5.
TreeFamiTF331157.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022330. TNFR_21.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01971. TNFACTORR21.
SMARTiSM00005. DEATH. 1 hit.
SM01411. Ephrin_rec_like. 2 hits.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EPU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTRASSITA LASCSRTAGQ VGATMVAGSL LLLGFLSTIT AQPEQKTLSL
60 70 80 90 100
PGTYRHVDRT TGQVLTCDKC PAGTYVSEHC TNMSLRVCSS CPAGTFTRHE
110 120 130 140 150
NGIERCHDCS QPCPWPMIER LPCAALTDRE CICPPGMYQS NGTCAPHTVC
160 170 180 190 200
PVGWGVRKKG TENEDVRCKQ CARGTFSDVP SSVMKCKAHT DCLGQNLEVV
210 220 230 240 250
KPGTKETDNV CGMRLFFSST NPPSSGTVTF SHPEHMESHD VPSSTYEPQG
260 270 280 290 300
MNSTDSNSTA SVRTKVPSGI EEGTVPDNTS STSGKEGTNR TLPNPPQVTH
310 320 330 340 350
QQAPHHRHIL KLLPSSMEAT GEKSSTAIKA PKRGHPRQNA HKHFDINEHL
360 370 380 390 400
PWMIVLFLLL VLVLIVVCSI RKSSRTLKKG PRQDPSAIVE KAGLKKSLTP
410 420 430 440 450
TQNREKWIYY RNGHGIDILK LVAAQVGSQW KDIYQFLCNA SEREVAAFSN
460 470 480 490 500
GYTADHERAY AALQHWTIRG PEASLAQLIS ALRQHRRNDV VEKIRGLMED
510 520 530 540 550
TTQLETDKLA LPMSPSPLSP SPMPSPNVKL ENSTLLTVEP SPLDKNKCFF
560 570 580 590 600
VDESEPLLRC DSTSSGSSAL SRNGSFITKE KKDTVLRQVR LDPCDLQPIF
610 620 630 640 650
DDMLHILNPE ELRVIEEIPQ AEDKLDRLFE IIGVKSQEAS QTLLDSVYSH

LPDLL
Length:655
Mass (Da):71,983
Last modified:May 27, 2002 - v2
Checksum:i5EC7C51C7C99EFF7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931A → T in BAE22249 (PubMed:16141072).Curated
Sequence conflicti352 – 3521W → L in AAG38115 (Ref. 1) Curated
Sequence conflicti523 – 5231M → I in AAH16420 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322069 mRNA. Translation: AAG38115.1.
AY043489 mRNA. Translation: AAK74193.1.
AK043823 mRNA. Translation: BAC31664.1.
AK134704 mRNA. Translation: BAE22249.1.
BC016420 mRNA. Translation: AAH16420.1.
CCDSiCCDS28794.1.
RefSeqiNP_848704.1. NM_178589.3.
UniGeneiMm.200792.

Genome annotation databases

EnsembliENSMUST00000024708; ENSMUSP00000024708; ENSMUSG00000023915.
GeneIDi94185.
KEGGimmu:94185.
UCSCiuc008cov.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322069 mRNA. Translation: AAG38115.1.
AY043489 mRNA. Translation: AAK74193.1.
AK043823 mRNA. Translation: BAC31664.1.
AK134704 mRNA. Translation: BAE22249.1.
BC016420 mRNA. Translation: AAH16420.1.
CCDSiCCDS28794.1.
RefSeqiNP_848704.1. NM_178589.3.
UniGeneiMm.200792.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4YN0X-ray2.20A42-220[»]
ProteinModelPortaliQ9EPU5.
SMRiQ9EPU5. Positions 49-216, 569-655.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59733N.
STRINGi10090.ENSMUSP00000024708.

PTM databases

iPTMnetiQ9EPU5.
PhosphoSiteiQ9EPU5.

Proteomic databases

MaxQBiQ9EPU5.
PaxDbiQ9EPU5.
PRIDEiQ9EPU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024708; ENSMUSP00000024708; ENSMUSG00000023915.
GeneIDi94185.
KEGGimmu:94185.
UCSCiuc008cov.1. mouse.

Organism-specific databases

CTDi27242.
MGIiMGI:2151075. Tnfrsf21.

Phylogenomic databases

eggNOGiENOG410IHQ6. Eukaryota.
ENOG410YYKW. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000136852.
HOVERGENiHBG054218.
InParanoidiQ9EPU5.
KOiK05157.
OMAiFSRPEHM.
OrthoDBiEOG786H2Q.
PhylomeDBiQ9EPU5.
TreeFamiTF331157.

Miscellaneous databases

ChiTaRSiTnfrsf21. mouse.
PROiQ9EPU5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EPU5.
GenevisibleiQ9EPU5. MM.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022330. TNFR_21.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01971. TNFACTORR21.
SMARTiSM00005. DEATH. 1 hit.
SM01411. Ephrin_rec_like. 2 hits.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse DR6: mouse homolog of human TNFR-related death receptor-6 (DR6)."
    Isogai D., Ichino M., Yoshinari M., Yamaura A., Kurokawa F., Minami M.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  2. "Murine DR6: murine TNFR-related death receptor-6."
    Kim V., Machleidt T., Shi W.-X., Wang X., Cai Z.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Kidney.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain cortex and Medulla oblongata.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  5. "Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice."
    Liu J., Na S., Glasebrook A., Fox N., Solenberg P.J., Zhang Q., Song H.Y., Yang D.D.
    Immunity 15:23-34(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
  6. "Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice."
    Zhao H., Yan M., Wang H., Erickson S., Grewal I.S., Dixit V.M.
    J. Exp. Med. 194:1441-1448(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
  7. "Enhanced B cell expansion, survival, and humoral responses by targeting death receptor 6."
    Schmidt C.S., Liu J., Zhang T., Song H.Y., Sandusky G., Mintze K., Benschop R.J., Glasebrook A., Yang D.D., Na S.
    J. Exp. Med. 197:51-62(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  8. "APP binds DR6 to trigger axon pruning and neuron death via distinct caspases."
    Nikolaev A., McLaughlin T., O'Leary D.D.M., Tessier-Lavigne M.
    Nature 457:981-989(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH APP.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  10. "Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination."
    Mi S., Lee X., Hu Y., Ji B., Shao Z., Yang W., Huang G., Walus L., Rhodes K., Gong B.J., Miller R.H., Pepinsky R.B.
    Nat. Med. 17:816-821(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  11. "A DR6/p75(NTR) complex is responsible for beta-amyloid-induced cortical neuron death."
    Hu Y., Lee X., Shao Z., Apicco D., Huang G., Gong B.J., Pepinsky R.B., Mi S.
    Cell Death Dis. 4:E579-E579(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiTNR21_MOUSE
AccessioniPrimary (citable) accession number: Q9EPU5
Secondary accession number(s): Q3UYG3
, Q543Y9, Q91W77, Q91XH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: May 27, 2002
Last modified: July 6, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.