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Protein

Chloride intracellular channel protein 5

Gene

Clic5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal hearing. It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (By similarity).By similarity

GO - Molecular functioni

  • chloride channel activity Source: RGD
  • voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel, Voltage-gated channel
Biological processHearing, Ion transport, Transport
LigandChloride

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride intracellular channel protein 5
Gene namesi
Name:Clic5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi620659 Clic5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 54Helical; Note=After insertion into the membraneSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442161 – 251Chloride intracellular channel protein 5Add BLAST251

Proteomic databases

PaxDbiQ9EPT8
PRIDEiQ9EPT8

PTM databases

iPTMnetiQ9EPT8
PhosphoSitePlusiQ9EPT8

Expressioni

Tissue specificityi

Detected in cochlea, in cochlear and vestibular hair cell bundles in the organ of Corti (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000047218
GenevisibleiQ9EPT8 RN

Interactioni

Subunit structurei

Component of a multimeric complex consisting of several cytoskeletal proteins, including actin, ezrin, alpha-actinin, gelsolin, and IQGAP1.By similarity

Protein-protein interaction databases

BioGridi250191, 1 interactor
STRINGi10116.ENSRNOP00000067890

Structurei

3D structure databases

ProteinModelPortaliQ9EPT8
SMRiQ9EPT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 241GST C-terminalAdd BLAST141

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 98Required for insertion into the membraneBy similarityAdd BLAST98

Domaini

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion (By similarity).By similarity

Sequence similaritiesi

Belongs to the chloride channel CLIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1422 Eukaryota
ENOG410ZRK6 LUCA
GeneTreeiENSGT00550000074477
HOGENOMiHOG000231548
HOVERGENiHBG050994
InParanoidiQ9EPT8
KOiK05025
OMAiANGDDRD
PhylomeDBiQ9EPT8
TreeFamiTF315438

Family and domain databases

InterProiView protein in InterPro
IPR002946 CLIC
IPR030264 CLIC-5
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR43920:SF6 PTHR43920:SF6, 1 hit
PfamiView protein in Pfam
PF13417 GST_N_3, 1 hit
PRINTSiPR01263 INTCLCHANNEL
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR00862 O-ClC, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q9EPT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDSATANGD DRDPEIELFV KAGIDGESIG NCPFSQRLFM ILWLKGVVFN
60 70 80 90 100
VTTVDLKRKP ADLHNLAPGT HPPFLTFNGD VKTDVNKIEE FLEETLTPEK
110 120 130 140 150
YPKLAARHRE SNTAGIDIFS KFSAYIKNTK QQNNAALERG LTKALRKLDD
160 170 180 190 200
YLNTPLPEEI DTNTHGDEKG SQRKFLDGDE LTLADCNLLP KLHVVKIVAK
210 220 230 240 250
KYRNYDIPAE MTGLWRYLKN AYARDEFTNT CAADSEIELA YADVARRLSR

S
Length:251
Mass (Da):28,299
Last modified:March 1, 2001 - v1
Checksum:i11079FDE8508D53C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323174 mRNA Translation: AAG49367.1
RefSeqiNP_446055.1, NM_053603.2
UniGeneiRn.1838

Genome annotation databases

EnsembliENSRNOT00000073667; ENSRNOP00000067890; ENSRNOG00000047218
ENSRNOT00000079517; ENSRNOP00000072035; ENSRNOG00000047218
GeneIDi94272
KEGGirno:94272
UCSCiRGD:620659 rat

Similar proteinsi

Entry informationi

Entry nameiCLIC5_RAT
AccessioniPrimary (citable) accession number: Q9EPT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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