SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9EPT5

- SO2A1_MOUSE

UniProt

Q9EPT5 - SO2A1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Solute carrier organic anion transporter family member 2A1
Gene
Slco2a1, Oatp2a1, Slc21a2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

GO - Molecular functioni

  1. prostaglandin transmembrane transporter activity Source: MGI

GO - Biological processi

  1. prostaglandin transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_210189. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2A1
Alternative name(s):
Prostaglandin transporter
Short name:
PGT
Solute carrier family 21 member 2
Gene namesi
Name:Slco2a1
Synonyms:Oatp2a1, Slc21a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1346021. Slco2a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei33 – 5220Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini53 – 7119Extracellular Reviewed prediction
Add
BLAST
Transmembranei72 – 9221Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini93 – 986Cytoplasmic Reviewed prediction
Transmembranei99 – 12325Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini124 – 16744Extracellular Reviewed prediction
Add
BLAST
Transmembranei168 – 19629Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini197 – 21519Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei216 – 23621Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini237 – 25418Extracellular Reviewed prediction
Add
BLAST
Transmembranei255 – 27925Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini280 – 32041Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei321 – 34222Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini343 – 36220Extracellular Reviewed prediction
Add
BLAST
Transmembranei363 – 38624Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini387 – 3904Cytoplasmic Reviewed prediction
Transmembranei391 – 41424Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini415 – 517103Extracellular Reviewed prediction
Add
BLAST
Transmembranei518 – 54023Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini541 – 5499Cytoplasmic Reviewed prediction
Transmembranei550 – 57526Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini576 – 60934Extracellular Reviewed prediction
Add
BLAST
Transmembranei610 – 62819Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini629 – 64315Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi610 – 6101V → M: No effect. 1 Publication
Mutagenesisi611 – 6111I → G: No effect. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 643643Solute carrier organic anion transporter family member 2A1
PRO_0000191059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi134 – 1341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi443 ↔ 469 By similarity
Disulfide bondi447 ↔ 458 By similarity
Disulfide bondi449 ↔ 473 By similarity
Glycosylationi477 – 4771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi490 – 4901N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9EPT5.
PRIDEiQ9EPT5.

PTM databases

PhosphoSiteiQ9EPT5.

Expressioni

Tissue specificityi

Highly expressed in lung and liver. Detected at lower levels in kidney and skeletal muscle.

Gene expression databases

ArrayExpressiQ9EPT5.
BgeeiQ9EPT5.
GenevestigatoriQ9EPT5.

Structurei

3D structure databases

ProteinModelPortaliQ9EPT5.
SMRiQ9EPT5. Positions 447-475.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini437 – 49559Kazal-like
Add
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG271773.
GeneTreeiENSGT00740000114981.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiQ9EPT5.
KOiK14345.
OMAiIYLNCSC.
OrthoDBiEOG7QG43R.
PhylomeDBiQ9EPT5.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9EPT5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGLLPKPGAR QGSGTSSVPA RRCSRSVFNN IKVFVLCHGL LQLCQLLYSA    50
YFKSSLTTIE KRFGLSSSSS GLISSLNEIS NAILIIFVSY FGSRVNRPRM 100
IGIGGLLLAA GAFVLTLPHF LSEPYQYAST TAGNSSHFQT DLCQKHLPGL 150
LPSKCHSTVP DTQKETSSMW SLMVVAQLLA GVGTVPIQPF GISYVDDFAE 200
PTNSPLYISI LFAIAVFGPA FGYLLGSVML RIFVDYGRVD TATVNLSPGD 250
PRWIGAWWLG LLISSGFLIV TSLPFFFFPR AMSRGAERSV IAEETMKMEE 300
DKSRGSLMDF IKRFPRIFLR LLMNPLFMLV VLSQCTFSSV IAGLSTFLNK 350
FLEKQYDASA AYANLLIGAV NLPAAALGML FGGILMKRFV FPLQTIPRVA 400
ATIMTISIIL CAPLFFMGCS TPAVAEVYPP STPSSIHPQP PACRRDCLCP 450
DSVFHPVCGD NGVEYLSPCH AGCSSLNVSS AASKQPIYLN CSCVTGGSAS 500
AKTGSCPTSC AQLLLPSIFL ISFVALIACV SHNPLYMMVL RVVNQDEKSF 550
AIGVQFLLMR LLAWLPSPSL YGLLIDSSCI RWNYLCSGRR GACAYYDNDA 600
LRNRYLGLQV IYKVLGTLLL FFISWRVKKN REYSLQENAS GLI 643
Length:643
Mass (Da):70,147
Last modified:January 10, 2003 - v2
Checksum:iAC487386F847D9D8
GO
Isoform 2 (identifier: Q9EPT5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-414: GAVNLPAAAL...TISIILCAPL → AHQVLYIRSL...PAMLAAAAST
     415-643: Missing.

Note: No experimental confirmation available.

Show »
Length:414
Mass (Da):44,901
Checksum:iE9E97C62A1F43799
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei368 – 41447GAVNL…LCAPL → AHQVLYIRSLPPAAGTACAQ IPSSTLSAETMESSTSPPAM LAAAAST in isoform 2.
VSP_006128Add
BLAST
Alternative sequencei415 – 643229Missing in isoform 2.
VSP_006129Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31L → F in AAG40332. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF323958 mRNA. Translation: AAG40332.1.
BC035200 mRNA. Translation: AAH35200.1.
CCDSiCCDS23448.1. [Q9EPT5-1]
RefSeqiNP_201571.2. NM_033314.3. [Q9EPT5-1]
UniGeneiMm.207106.
Mm.412758.

Genome annotation databases

EnsembliENSMUST00000035148; ENSMUSP00000035148; ENSMUSG00000032548. [Q9EPT5-1]
GeneIDi24059.
KEGGimmu:24059.
UCSCiuc009rgd.1. mouse. [Q9EPT5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF323958 mRNA. Translation: AAG40332.1 .
BC035200 mRNA. Translation: AAH35200.1 .
CCDSi CCDS23448.1. [Q9EPT5-1 ]
RefSeqi NP_201571.2. NM_033314.3. [Q9EPT5-1 ]
UniGenei Mm.207106.
Mm.412758.

3D structure databases

ProteinModelPortali Q9EPT5.
SMRi Q9EPT5. Positions 447-475.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2073699.

PTM databases

PhosphoSitei Q9EPT5.

Proteomic databases

PaxDbi Q9EPT5.
PRIDEi Q9EPT5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000035148 ; ENSMUSP00000035148 ; ENSMUSG00000032548 . [Q9EPT5-1 ]
GeneIDi 24059.
KEGGi mmu:24059.
UCSCi uc009rgd.1. mouse. [Q9EPT5-1 ]

Organism-specific databases

CTDi 6578.
MGIi MGI:1346021. Slco2a1.

Phylogenomic databases

eggNOGi NOG271773.
GeneTreei ENSGT00740000114981.
HOGENOMi HOG000231269.
HOVERGENi HBG108345.
InParanoidi Q9EPT5.
KOi K14345.
OMAi IYLNCSC.
OrthoDBi EOG7QG43R.
PhylomeDBi Q9EPT5.
TreeFami TF317540.

Enzyme and pathway databases

Reactomei REACT_210189. Transport of organic anions.

Miscellaneous databases

ChiTaRSi SLCO2A1. mouse.
NextBioi 304017.
PROi Q9EPT5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9EPT5.
Bgeei Q9EPT5.
Genevestigatori Q9EPT5.

Family and domain databases

InterProi IPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view ]
PANTHERi PTHR11388. PTHR11388. 1 hit.
Pfami PF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view ]
SMARTi SM00280. KAZAL. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 3 hits.
TIGRFAMsi TIGR00805. oat. 1 hit.
PROSITEi PS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities."
    Pucci M.L., Bao Y., Chan B., Itoh S., Lu R., Copeland N.G., Gilbert D.J., Jenkins N.A., Schuster V.L.
    Am. J. Physiol. 277:R734-R741(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), MUTAGENESIS OF VAL-610 AND ILE-611.
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Mammary cancer.

Entry informationi

Entry nameiSO2A1_MOUSE
AccessioniPrimary (citable) accession number: Q9EPT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: September 3, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi