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Q9EPT5

- SO2A1_MOUSE

UniProt

Q9EPT5 - SO2A1_MOUSE

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Protein

Solute carrier organic anion transporter family member 2A1

Gene

Slco2a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

GO - Molecular functioni

  1. prostaglandin transmembrane transporter activity Source: MGI

GO - Biological processi

  1. prostaglandin transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_210189. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2A1
Alternative name(s):
Prostaglandin transporter
Short name:
PGT
Solute carrier family 21 member 2
Gene namesi
Name:Slco2a1
Synonyms:Oatp2a1, Slc21a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1346021. Slco2a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei33 – 5220Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini53 – 7119ExtracellularSequence AnalysisAdd
BLAST
Transmembranei72 – 9221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini93 – 986CytoplasmicSequence Analysis
Transmembranei99 – 12325Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini124 – 16744ExtracellularSequence AnalysisAdd
BLAST
Transmembranei168 – 19629Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini197 – 21519CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei216 – 23621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini237 – 25418ExtracellularSequence AnalysisAdd
BLAST
Transmembranei255 – 27925Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini280 – 32041CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei321 – 34222Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini343 – 36220ExtracellularSequence AnalysisAdd
BLAST
Transmembranei363 – 38624Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini387 – 3904CytoplasmicSequence Analysis
Transmembranei391 – 41424Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini415 – 517103ExtracellularSequence AnalysisAdd
BLAST
Transmembranei518 – 54023Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini541 – 5499CytoplasmicSequence Analysis
Transmembranei550 – 57526Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini576 – 60934ExtracellularSequence AnalysisAdd
BLAST
Transmembranei610 – 62819Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini629 – 64315CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi610 – 6101V → M: No effect. 1 Publication
Mutagenesisi611 – 6111I → G: No effect. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 643643Solute carrier organic anion transporter family member 2A1PRO_0000191059Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi443 ↔ 469PROSITE-ProRule annotation
Disulfide bondi447 ↔ 458PROSITE-ProRule annotation
Disulfide bondi449 ↔ 473PROSITE-ProRule annotation
Glycosylationi477 – 4771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi490 – 4901N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9EPT5.
PRIDEiQ9EPT5.

PTM databases

PhosphoSiteiQ9EPT5.

Expressioni

Tissue specificityi

Highly expressed in lung and liver. Detected at lower levels in kidney and skeletal muscle.

Gene expression databases

BgeeiQ9EPT5.
ExpressionAtlasiQ9EPT5. baseline and differential.
GenevestigatoriQ9EPT5.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ9EPT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini437 – 49559Kazal-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG271773.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiQ9EPT5.
KOiK14345.
OMAiIYLNCSC.
OrthoDBiEOG7QG43R.
PhylomeDBiQ9EPT5.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9EPT5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLLPKPGAR QGSGTSSVPA RRCSRSVFNN IKVFVLCHGL LQLCQLLYSA
60 70 80 90 100
YFKSSLTTIE KRFGLSSSSS GLISSLNEIS NAILIIFVSY FGSRVNRPRM
110 120 130 140 150
IGIGGLLLAA GAFVLTLPHF LSEPYQYAST TAGNSSHFQT DLCQKHLPGL
160 170 180 190 200
LPSKCHSTVP DTQKETSSMW SLMVVAQLLA GVGTVPIQPF GISYVDDFAE
210 220 230 240 250
PTNSPLYISI LFAIAVFGPA FGYLLGSVML RIFVDYGRVD TATVNLSPGD
260 270 280 290 300
PRWIGAWWLG LLISSGFLIV TSLPFFFFPR AMSRGAERSV IAEETMKMEE
310 320 330 340 350
DKSRGSLMDF IKRFPRIFLR LLMNPLFMLV VLSQCTFSSV IAGLSTFLNK
360 370 380 390 400
FLEKQYDASA AYANLLIGAV NLPAAALGML FGGILMKRFV FPLQTIPRVA
410 420 430 440 450
ATIMTISIIL CAPLFFMGCS TPAVAEVYPP STPSSIHPQP PACRRDCLCP
460 470 480 490 500
DSVFHPVCGD NGVEYLSPCH AGCSSLNVSS AASKQPIYLN CSCVTGGSAS
510 520 530 540 550
AKTGSCPTSC AQLLLPSIFL ISFVALIACV SHNPLYMMVL RVVNQDEKSF
560 570 580 590 600
AIGVQFLLMR LLAWLPSPSL YGLLIDSSCI RWNYLCSGRR GACAYYDNDA
610 620 630 640
LRNRYLGLQV IYKVLGTLLL FFISWRVKKN REYSLQENAS GLI
Length:643
Mass (Da):70,147
Last modified:January 10, 2003 - v2
Checksum:iAC487386F847D9D8
GO
Isoform 2 (identifier: Q9EPT5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-414: GAVNLPAAAL...TISIILCAPL → AHQVLYIRSL...PAMLAAAAST
     415-643: Missing.

Note: No experimental confirmation available.

Show »
Length:414
Mass (Da):44,901
Checksum:iE9E97C62A1F43799
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31L → F in AAG40332. (PubMed:10484490)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei368 – 41447GAVNL…LCAPL → AHQVLYIRSLPPAAGTACAQ IPSSTLSAETMESSTSPPAM LAAAAST in isoform 2. 1 PublicationVSP_006128Add
BLAST
Alternative sequencei415 – 643229Missing in isoform 2. 1 PublicationVSP_006129Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323958 mRNA. Translation: AAG40332.1.
BC035200 mRNA. Translation: AAH35200.1.
CCDSiCCDS23448.1. [Q9EPT5-1]
RefSeqiNP_201571.2. NM_033314.3. [Q9EPT5-1]
UniGeneiMm.207106.
Mm.412758.

Genome annotation databases

EnsembliENSMUST00000035148; ENSMUSP00000035148; ENSMUSG00000032548. [Q9EPT5-1]
ENSMUST00000188664; ENSMUSP00000140533; ENSMUSG00000032548. [Q9EPT5-2]
GeneIDi24059.
KEGGimmu:24059.
UCSCiuc009rgd.1. mouse. [Q9EPT5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323958 mRNA. Translation: AAG40332.1 .
BC035200 mRNA. Translation: AAH35200.1 .
CCDSi CCDS23448.1. [Q9EPT5-1 ]
RefSeqi NP_201571.2. NM_033314.3. [Q9EPT5-1 ]
UniGenei Mm.207106.
Mm.412758.

3D structure databases

ProteinModelPortali Q9EPT5.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q9EPT5.
ChEMBLi CHEMBL2073699.

PTM databases

PhosphoSitei Q9EPT5.

Proteomic databases

PaxDbi Q9EPT5.
PRIDEi Q9EPT5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000035148 ; ENSMUSP00000035148 ; ENSMUSG00000032548 . [Q9EPT5-1 ]
ENSMUST00000188664 ; ENSMUSP00000140533 ; ENSMUSG00000032548 . [Q9EPT5-2 ]
GeneIDi 24059.
KEGGi mmu:24059.
UCSCi uc009rgd.1. mouse. [Q9EPT5-1 ]

Organism-specific databases

CTDi 6578.
MGIi MGI:1346021. Slco2a1.

Phylogenomic databases

eggNOGi NOG271773.
GeneTreei ENSGT00760000119014.
HOGENOMi HOG000231269.
HOVERGENi HBG108345.
InParanoidi Q9EPT5.
KOi K14345.
OMAi IYLNCSC.
OrthoDBi EOG7QG43R.
PhylomeDBi Q9EPT5.
TreeFami TF317540.

Enzyme and pathway databases

Reactomei REACT_210189. Transport of organic anions.

Miscellaneous databases

ChiTaRSi Slco2a1. mouse.
NextBioi 304017.
PROi Q9EPT5.
SOURCEi Search...

Gene expression databases

Bgeei Q9EPT5.
ExpressionAtlasi Q9EPT5. baseline and differential.
Genevestigatori Q9EPT5.

Family and domain databases

InterProi IPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view ]
PANTHERi PTHR11388. PTHR11388. 1 hit.
Pfami PF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view ]
SMARTi SM00280. KAZAL. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 3 hits.
TIGRFAMsi TIGR00805. oat. 1 hit.
PROSITEi PS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities."
    Pucci M.L., Bao Y., Chan B., Itoh S., Lu R., Copeland N.G., Gilbert D.J., Jenkins N.A., Schuster V.L.
    Am. J. Physiol. 277:R734-R741(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), MUTAGENESIS OF VAL-610 AND ILE-611.
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Mammary cancer.

Entry informationi

Entry nameiSO2A1_MOUSE
AccessioniPrimary (citable) accession number: Q9EPT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: November 26, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3