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Q9EPT5

- SO2A1_MOUSE

UniProt

Q9EPT5 - SO2A1_MOUSE

Protein

Solute carrier organic anion transporter family member 2A1

Gene

Slco2a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (10 Jan 2003)
      Previous versions | rss
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    Functioni

    May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

    GO - Molecular functioni

    1. prostaglandin transmembrane transporter activity Source: MGI

    GO - Biological processi

    1. prostaglandin transport Source: MGI

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_210189. Transport of organic anions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 2A1
    Alternative name(s):
    Prostaglandin transporter
    Short name:
    PGT
    Solute carrier family 21 member 2
    Gene namesi
    Name:Slco2a1
    Synonyms:Oatp2a1, Slc21a2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1346021. Slco2a1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi610 – 6101V → M: No effect. 1 Publication
    Mutagenesisi611 – 6111I → G: No effect. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 643643Solute carrier organic anion transporter family member 2A1PRO_0000191059Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi443 ↔ 469PROSITE-ProRule annotation
    Disulfide bondi447 ↔ 458PROSITE-ProRule annotation
    Disulfide bondi449 ↔ 473PROSITE-ProRule annotation
    Glycosylationi477 – 4771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi490 – 4901N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9EPT5.
    PRIDEiQ9EPT5.

    PTM databases

    PhosphoSiteiQ9EPT5.

    Expressioni

    Tissue specificityi

    Highly expressed in lung and liver. Detected at lower levels in kidney and skeletal muscle.

    Gene expression databases

    ArrayExpressiQ9EPT5.
    BgeeiQ9EPT5.
    GenevestigatoriQ9EPT5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EPT5.
    SMRiQ9EPT5. Positions 447-475.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini53 – 7119ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini93 – 986CytoplasmicSequence Analysis
    Topological domaini124 – 16744ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini197 – 21519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini237 – 25418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini280 – 32041CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini343 – 36220ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini387 – 3904CytoplasmicSequence Analysis
    Topological domaini415 – 517103ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini541 – 5499CytoplasmicSequence Analysis
    Topological domaini576 – 60934ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini629 – 64315CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5220Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 12325Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei168 – 19629Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei216 – 23621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei255 – 27925Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei321 – 34222Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei363 – 38624Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei391 – 41424Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei518 – 54023Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei550 – 57526Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei610 – 62819Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini437 – 49559Kazal-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Kazal-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG271773.
    GeneTreeiENSGT00740000114981.
    HOGENOMiHOG000231269.
    HOVERGENiHBG108345.
    InParanoidiQ9EPT5.
    KOiK14345.
    OMAiIYLNCSC.
    OrthoDBiEOG7QG43R.
    PhylomeDBiQ9EPT5.
    TreeFamiTF317540.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view]
    PANTHERiPTHR11388. PTHR11388. 1 hit.
    PfamiPF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view]
    SMARTiSM00280. KAZAL. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 3 hits.
    TIGRFAMsiTIGR00805. oat. 1 hit.
    PROSITEiPS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9EPT5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLLPKPGAR QGSGTSSVPA RRCSRSVFNN IKVFVLCHGL LQLCQLLYSA    50
    YFKSSLTTIE KRFGLSSSSS GLISSLNEIS NAILIIFVSY FGSRVNRPRM 100
    IGIGGLLLAA GAFVLTLPHF LSEPYQYAST TAGNSSHFQT DLCQKHLPGL 150
    LPSKCHSTVP DTQKETSSMW SLMVVAQLLA GVGTVPIQPF GISYVDDFAE 200
    PTNSPLYISI LFAIAVFGPA FGYLLGSVML RIFVDYGRVD TATVNLSPGD 250
    PRWIGAWWLG LLISSGFLIV TSLPFFFFPR AMSRGAERSV IAEETMKMEE 300
    DKSRGSLMDF IKRFPRIFLR LLMNPLFMLV VLSQCTFSSV IAGLSTFLNK 350
    FLEKQYDASA AYANLLIGAV NLPAAALGML FGGILMKRFV FPLQTIPRVA 400
    ATIMTISIIL CAPLFFMGCS TPAVAEVYPP STPSSIHPQP PACRRDCLCP 450
    DSVFHPVCGD NGVEYLSPCH AGCSSLNVSS AASKQPIYLN CSCVTGGSAS 500
    AKTGSCPTSC AQLLLPSIFL ISFVALIACV SHNPLYMMVL RVVNQDEKSF 550
    AIGVQFLLMR LLAWLPSPSL YGLLIDSSCI RWNYLCSGRR GACAYYDNDA 600
    LRNRYLGLQV IYKVLGTLLL FFISWRVKKN REYSLQENAS GLI 643
    Length:643
    Mass (Da):70,147
    Last modified:January 10, 2003 - v2
    Checksum:iAC487386F847D9D8
    GO
    Isoform 2 (identifier: Q9EPT5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         368-414: GAVNLPAAAL...TISIILCAPL → AHQVLYIRSL...PAMLAAAAST
         415-643: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:414
    Mass (Da):44,901
    Checksum:iE9E97C62A1F43799
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31L → F in AAG40332. (PubMed:10484490)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei368 – 41447GAVNL…LCAPL → AHQVLYIRSLPPAAGTACAQ IPSSTLSAETMESSTSPPAM LAAAAST in isoform 2. 1 PublicationVSP_006128Add
    BLAST
    Alternative sequencei415 – 643229Missing in isoform 2. 1 PublicationVSP_006129Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF323958 mRNA. Translation: AAG40332.1.
    BC035200 mRNA. Translation: AAH35200.1.
    CCDSiCCDS23448.1. [Q9EPT5-1]
    RefSeqiNP_201571.2. NM_033314.3. [Q9EPT5-1]
    UniGeneiMm.207106.
    Mm.412758.

    Genome annotation databases

    EnsembliENSMUST00000035148; ENSMUSP00000035148; ENSMUSG00000032548. [Q9EPT5-1]
    GeneIDi24059.
    KEGGimmu:24059.
    UCSCiuc009rgd.1. mouse. [Q9EPT5-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF323958 mRNA. Translation: AAG40332.1 .
    BC035200 mRNA. Translation: AAH35200.1 .
    CCDSi CCDS23448.1. [Q9EPT5-1 ]
    RefSeqi NP_201571.2. NM_033314.3. [Q9EPT5-1 ]
    UniGenei Mm.207106.
    Mm.412758.

    3D structure databases

    ProteinModelPortali Q9EPT5.
    SMRi Q9EPT5. Positions 447-475.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2073699.

    PTM databases

    PhosphoSitei Q9EPT5.

    Proteomic databases

    PaxDbi Q9EPT5.
    PRIDEi Q9EPT5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035148 ; ENSMUSP00000035148 ; ENSMUSG00000032548 . [Q9EPT5-1 ]
    GeneIDi 24059.
    KEGGi mmu:24059.
    UCSCi uc009rgd.1. mouse. [Q9EPT5-1 ]

    Organism-specific databases

    CTDi 6578.
    MGIi MGI:1346021. Slco2a1.

    Phylogenomic databases

    eggNOGi NOG271773.
    GeneTreei ENSGT00740000114981.
    HOGENOMi HOG000231269.
    HOVERGENi HBG108345.
    InParanoidi Q9EPT5.
    KOi K14345.
    OMAi IYLNCSC.
    OrthoDBi EOG7QG43R.
    PhylomeDBi Q9EPT5.
    TreeFami TF317540.

    Enzyme and pathway databases

    Reactomei REACT_210189. Transport of organic anions.

    Miscellaneous databases

    ChiTaRSi SLCO2A1. mouse.
    NextBioi 304017.
    PROi Q9EPT5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9EPT5.
    Bgeei Q9EPT5.
    Genevestigatori Q9EPT5.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view ]
    PANTHERi PTHR11388. PTHR11388. 1 hit.
    Pfami PF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view ]
    SMARTi SM00280. KAZAL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 3 hits.
    TIGRFAMsi TIGR00805. oat. 1 hit.
    PROSITEi PS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities."
      Pucci M.L., Bao Y., Chan B., Itoh S., Lu R., Copeland N.G., Gilbert D.J., Jenkins N.A., Schuster V.L.
      Am. J. Physiol. 277:R734-R741(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), MUTAGENESIS OF VAL-610 AND ILE-611.
      Tissue: Lung.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: FVB/N.
      Tissue: Mammary cancer.

    Entry informationi

    Entry nameiSO2A1_MOUSE
    AccessioniPrimary (citable) accession number: Q9EPT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: January 10, 2003
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3