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Protein

Solute carrier organic anion transporter family member 2A1

Gene

Slco2a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

GO - Molecular functioni

GO - Biological processi

  • prostaglandin transport Source: MGI
  • sodium-independent organic anion transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-879518. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2A1
Alternative name(s):
Prostaglandin transporter
Short name:
PGT
Solute carrier family 21 member 2
Gene namesi
Name:Slco2a1
Synonyms:Oatp2a1, Slc21a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1346021. Slco2a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 52Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini53 – 71ExtracellularSequence analysisAdd BLAST19
Transmembranei72 – 92Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini93 – 98CytoplasmicSequence analysis6
Transmembranei99 – 123Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini124 – 167ExtracellularSequence analysisAdd BLAST44
Transmembranei168 – 196Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini197 – 215CytoplasmicSequence analysisAdd BLAST19
Transmembranei216 – 236Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini237 – 254ExtracellularSequence analysisAdd BLAST18
Transmembranei255 – 279Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini280 – 320CytoplasmicSequence analysisAdd BLAST41
Transmembranei321 – 342Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini343 – 362ExtracellularSequence analysisAdd BLAST20
Transmembranei363 – 386Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini387 – 390CytoplasmicSequence analysis4
Transmembranei391 – 414Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini415 – 517ExtracellularSequence analysisAdd BLAST103
Transmembranei518 – 540Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini541 – 549CytoplasmicSequence analysis9
Transmembranei550 – 575Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini576 – 609ExtracellularSequence analysisAdd BLAST34
Transmembranei610 – 628Helical; Name=12Sequence analysisAdd BLAST19
Topological domaini629 – 643CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi610V → M: No effect. 1 Publication1
Mutagenesisi611I → G: No effect. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2073699.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910591 – 643Solute carrier organic anion transporter family member 2A1Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi443 ↔ 469PROSITE-ProRule annotation
Disulfide bondi447 ↔ 458PROSITE-ProRule annotation
Disulfide bondi449 ↔ 473PROSITE-ProRule annotation
Glycosylationi477N-linked (GlcNAc...)Sequence analysis1
Glycosylationi490N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9EPT5.
PeptideAtlasiQ9EPT5.
PRIDEiQ9EPT5.

PTM databases

iPTMnetiQ9EPT5.
PhosphoSitePlusiQ9EPT5.

Expressioni

Tissue specificityi

Highly expressed in lung and liver. Detected at lower levels in kidney and skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000032548.
ExpressionAtlasiQ9EPT5. baseline and differential.
GenevisibleiQ9EPT5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035148.

Chemistry databases

BindingDBiQ9EPT5.

Structurei

3D structure databases

ProteinModelPortaliQ9EPT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini437 – 495Kazal-likePROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiQ9EPT5.
KOiK14345.
OMAiIYLNCSC.
OrthoDBiEOG091G08QD.
PhylomeDBiQ9EPT5.
TreeFamiTF317540.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9EPT5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLLPKPGAR QGSGTSSVPA RRCSRSVFNN IKVFVLCHGL LQLCQLLYSA
60 70 80 90 100
YFKSSLTTIE KRFGLSSSSS GLISSLNEIS NAILIIFVSY FGSRVNRPRM
110 120 130 140 150
IGIGGLLLAA GAFVLTLPHF LSEPYQYAST TAGNSSHFQT DLCQKHLPGL
160 170 180 190 200
LPSKCHSTVP DTQKETSSMW SLMVVAQLLA GVGTVPIQPF GISYVDDFAE
210 220 230 240 250
PTNSPLYISI LFAIAVFGPA FGYLLGSVML RIFVDYGRVD TATVNLSPGD
260 270 280 290 300
PRWIGAWWLG LLISSGFLIV TSLPFFFFPR AMSRGAERSV IAEETMKMEE
310 320 330 340 350
DKSRGSLMDF IKRFPRIFLR LLMNPLFMLV VLSQCTFSSV IAGLSTFLNK
360 370 380 390 400
FLEKQYDASA AYANLLIGAV NLPAAALGML FGGILMKRFV FPLQTIPRVA
410 420 430 440 450
ATIMTISIIL CAPLFFMGCS TPAVAEVYPP STPSSIHPQP PACRRDCLCP
460 470 480 490 500
DSVFHPVCGD NGVEYLSPCH AGCSSLNVSS AASKQPIYLN CSCVTGGSAS
510 520 530 540 550
AKTGSCPTSC AQLLLPSIFL ISFVALIACV SHNPLYMMVL RVVNQDEKSF
560 570 580 590 600
AIGVQFLLMR LLAWLPSPSL YGLLIDSSCI RWNYLCSGRR GACAYYDNDA
610 620 630 640
LRNRYLGLQV IYKVLGTLLL FFISWRVKKN REYSLQENAS GLI
Length:643
Mass (Da):70,147
Last modified:January 10, 2003 - v2
Checksum:iAC487386F847D9D8
GO
Isoform 2 (identifier: Q9EPT5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-414: GAVNLPAAAL...TISIILCAPL → AHQVLYIRSL...PAMLAAAAST
     415-643: Missing.

Note: No experimental confirmation available.
Show »
Length:414
Mass (Da):44,901
Checksum:iE9E97C62A1F43799
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3L → F in AAG40332 (PubMed:10484490).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006128368 – 414GAVNL…LCAPL → AHQVLYIRSLPPAAGTACAQ IPSSTLSAETMESSTSPPAM LAAAAST in isoform 2. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_006129415 – 643Missing in isoform 2. 1 PublicationAdd BLAST229

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323958 mRNA. Translation: AAG40332.1.
BC035200 mRNA. Translation: AAH35200.1.
CCDSiCCDS23448.1. [Q9EPT5-1]
RefSeqiNP_201571.2. NM_033314.3. [Q9EPT5-1]
UniGeneiMm.207106.
Mm.412758.

Genome annotation databases

EnsembliENSMUST00000035148; ENSMUSP00000035148; ENSMUSG00000032548. [Q9EPT5-1]
ENSMUST00000188664; ENSMUSP00000140533; ENSMUSG00000032548. [Q9EPT5-2]
GeneIDi24059.
KEGGimmu:24059.
UCSCiuc009rgd.1. mouse. [Q9EPT5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323958 mRNA. Translation: AAG40332.1.
BC035200 mRNA. Translation: AAH35200.1.
CCDSiCCDS23448.1. [Q9EPT5-1]
RefSeqiNP_201571.2. NM_033314.3. [Q9EPT5-1]
UniGeneiMm.207106.
Mm.412758.

3D structure databases

ProteinModelPortaliQ9EPT5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035148.

Chemistry databases

BindingDBiQ9EPT5.
ChEMBLiCHEMBL2073699.

PTM databases

iPTMnetiQ9EPT5.
PhosphoSitePlusiQ9EPT5.

Proteomic databases

PaxDbiQ9EPT5.
PeptideAtlasiQ9EPT5.
PRIDEiQ9EPT5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035148; ENSMUSP00000035148; ENSMUSG00000032548. [Q9EPT5-1]
ENSMUST00000188664; ENSMUSP00000140533; ENSMUSG00000032548. [Q9EPT5-2]
GeneIDi24059.
KEGGimmu:24059.
UCSCiuc009rgd.1. mouse. [Q9EPT5-1]

Organism-specific databases

CTDi6578.
MGIiMGI:1346021. Slco2a1.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG108345.
InParanoidiQ9EPT5.
KOiK14345.
OMAiIYLNCSC.
OrthoDBiEOG091G08QD.
PhylomeDBiQ9EPT5.
TreeFamiTF317540.

Enzyme and pathway databases

ReactomeiR-MMU-879518. Transport of organic anions.

Miscellaneous databases

ChiTaRSiSlco2a1. mouse.
PROiQ9EPT5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032548.
ExpressionAtlasiQ9EPT5. baseline and differential.
GenevisibleiQ9EPT5. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO2A1_MOUSE
AccessioniPrimary (citable) accession number: Q9EPT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.