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Q9EPT5 (SO2A1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier organic anion transporter family member 2A1
Alternative name(s):
Prostaglandin transporter
Short name=PGT
Solute carrier family 21 member 2
Gene names
Name:Slco2a1
Synonyms:Oatp2a1, Slc21a2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length643 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed in lung and liver. Detected at lower levels in kidney and skeletal muscle.

Sequence similarities

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]

Contains 1 Kazal-like domain.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprostaglandin transport

Inferred from direct assay Ref.1. Source: MGI

   Cellular_componentintegral component of plasma membrane

Inferred by curator Ref.1. Source: MGI

   Molecular_functionprostaglandin transmembrane transporter activity

Inferred from direct assay Ref.1. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9EPT5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9EPT5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     368-414: GAVNLPAAAL...TISIILCAPL → AHQVLYIRSL...PAMLAAAAST
     415-643: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 643643Solute carrier organic anion transporter family member 2A1
PRO_0000191059

Regions

Topological domain1 – 3232Cytoplasmic Potential
Transmembrane33 – 5220Helical; Name=1; Potential
Topological domain53 – 7119Extracellular Potential
Transmembrane72 – 9221Helical; Name=2; Potential
Topological domain93 – 986Cytoplasmic Potential
Transmembrane99 – 12325Helical; Name=3; Potential
Topological domain124 – 16744Extracellular Potential
Transmembrane168 – 19629Helical; Name=4; Potential
Topological domain197 – 21519Cytoplasmic Potential
Transmembrane216 – 23621Helical; Name=5; Potential
Topological domain237 – 25418Extracellular Potential
Transmembrane255 – 27925Helical; Name=6; Potential
Topological domain280 – 32041Cytoplasmic Potential
Transmembrane321 – 34222Helical; Name=7; Potential
Topological domain343 – 36220Extracellular Potential
Transmembrane363 – 38624Helical; Name=8; Potential
Topological domain387 – 3904Cytoplasmic Potential
Transmembrane391 – 41424Helical; Name=9; Potential
Topological domain415 – 517103Extracellular Potential
Transmembrane518 – 54023Helical; Name=10; Potential
Topological domain541 – 5499Cytoplasmic Potential
Transmembrane550 – 57526Helical; Name=11; Potential
Topological domain576 – 60934Extracellular Potential
Transmembrane610 – 62819Helical; Name=12; Potential
Topological domain629 – 64315Cytoplasmic Potential
Domain437 – 49559Kazal-like

Amino acid modifications

Glycosylation1341N-linked (GlcNAc...) Potential
Glycosylation4771N-linked (GlcNAc...) Potential
Glycosylation4901N-linked (GlcNAc...) Potential
Disulfide bond443 ↔ 469 By similarity
Disulfide bond447 ↔ 458 By similarity
Disulfide bond449 ↔ 473 By similarity

Natural variations

Alternative sequence368 – 41447GAVNL…LCAPL → AHQVLYIRSLPPAAGTACAQ IPSSTLSAETMESSTSPPAM LAAAAST in isoform 2.
VSP_006128
Alternative sequence415 – 643229Missing in isoform 2.
VSP_006129

Experimental info

Mutagenesis6101V → M: No effect. Ref.1
Mutagenesis6111I → G: No effect. Ref.1
Sequence conflict31L → F in AAG40332. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 10, 2003. Version 2.
Checksum: AC487386F847D9D8

FASTA64370,147
        10         20         30         40         50         60 
MGLLPKPGAR QGSGTSSVPA RRCSRSVFNN IKVFVLCHGL LQLCQLLYSA YFKSSLTTIE 

        70         80         90        100        110        120 
KRFGLSSSSS GLISSLNEIS NAILIIFVSY FGSRVNRPRM IGIGGLLLAA GAFVLTLPHF 

       130        140        150        160        170        180 
LSEPYQYAST TAGNSSHFQT DLCQKHLPGL LPSKCHSTVP DTQKETSSMW SLMVVAQLLA 

       190        200        210        220        230        240 
GVGTVPIQPF GISYVDDFAE PTNSPLYISI LFAIAVFGPA FGYLLGSVML RIFVDYGRVD 

       250        260        270        280        290        300 
TATVNLSPGD PRWIGAWWLG LLISSGFLIV TSLPFFFFPR AMSRGAERSV IAEETMKMEE 

       310        320        330        340        350        360 
DKSRGSLMDF IKRFPRIFLR LLMNPLFMLV VLSQCTFSSV IAGLSTFLNK FLEKQYDASA 

       370        380        390        400        410        420 
AYANLLIGAV NLPAAALGML FGGILMKRFV FPLQTIPRVA ATIMTISIIL CAPLFFMGCS 

       430        440        450        460        470        480 
TPAVAEVYPP STPSSIHPQP PACRRDCLCP DSVFHPVCGD NGVEYLSPCH AGCSSLNVSS 

       490        500        510        520        530        540 
AASKQPIYLN CSCVTGGSAS AKTGSCPTSC AQLLLPSIFL ISFVALIACV SHNPLYMMVL 

       550        560        570        580        590        600 
RVVNQDEKSF AIGVQFLLMR LLAWLPSPSL YGLLIDSSCI RWNYLCSGRR GACAYYDNDA 

       610        620        630        640 
LRNRYLGLQV IYKVLGTLLL FFISWRVKKN REYSLQENAS GLI 

« Hide

Isoform 2 [UniParc].

Checksum: E9E97C62A1F43799
Show »

FASTA41444,901

References

« Hide 'large scale' references
[1]"Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities."
Pucci M.L., Bao Y., Chan B., Itoh S., Lu R., Copeland N.G., Gilbert D.J., Jenkins N.A., Schuster V.L.
Am. J. Physiol. 277:R734-R741(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), MUTAGENESIS OF VAL-610 AND ILE-611.
Tissue: Lung.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: FVB/N.
Tissue: Mammary cancer.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF323958 mRNA. Translation: AAG40332.1.
BC035200 mRNA. Translation: AAH35200.1.
RefSeqNP_201571.2. NM_033314.3.
UniGeneMm.207106.
Mm.412758.

3D structure databases

ProteinModelPortalQ9EPT5.
SMRQ9EPT5. Positions 71-96, 176-233, 446-509.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL2073699.

PTM databases

PhosphoSiteQ9EPT5.

Proteomic databases

PaxDbQ9EPT5.
PRIDEQ9EPT5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000035148; ENSMUSP00000035148; ENSMUSG00000032548. [Q9EPT5-1]
GeneID24059.
KEGGmmu:24059.
UCSCuc009rgd.1. mouse. [Q9EPT5-1]

Organism-specific databases

CTD6578.
MGIMGI:1346021. Slco2a1.

Phylogenomic databases

eggNOGNOG271773.
GeneTreeENSGT00740000114981.
HOGENOMHOG000231269.
HOVERGENHBG108345.
InParanoidQ9EPT5.
KOK14345.
OMAIYLNCSC.
OrthoDBEOG7QG43R.
PhylomeDBQ9EPT5.
TreeFamTF317540.

Gene expression databases

ArrayExpressQ9EPT5.
BgeeQ9EPT5.
GenevestigatorQ9EPT5.

Family and domain databases

InterProIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERPTHR11388. PTHR11388. 1 hit.
PfamPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 3 hits.
TIGRFAMsTIGR00805. oat. 1 hit.
PROSITEPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLCO2A1. mouse.
NextBio304017.
PROQ9EPT5.
SOURCESearch...

Entry information

Entry nameSO2A1_MOUSE
AccessionPrimary (citable) accession number: Q9EPT5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: April 16, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot