Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9EPT4 (CP11A_MESAU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cholesterol side-chain cleavage enzyme, mitochondrial

EC=1.14.15.6
Alternative name(s):
CYPXIA1
Cholesterol desmolase
Cytochrome P450 11A1
Cytochrome P450(scc)
Gene names
Name:CYP11A1
Synonyms:CYP11A
OrganismMesocricetus auratus (Golden hamster)
Taxonomic identifier10036 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Protein attributes

Sequence length520 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone By similarity.

Catalytic activity

Cholesterol + 6 reduced adrenodoxin + 3 O2 = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O.

Cofactor

Heme group By similarity.

Pathway

Lipid metabolism; C21-steroid hormone metabolism.

Subunit structure

Interacts with FDX1/adrenodoxin By similarity.

Subcellular location

Mitochondrion membrane.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3636Mitochondrion By similarity
Chain37 – 520484Cholesterol side-chain cleavage enzyme, mitochondrial
PRO_0000003586

Sites

Metal binding4581Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9EPT4 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 648C5A82D0D41D1E

FASTA52060,271
        10         20         30         40         50         60 
MLAKGLSLRS VLAKGCQPFL SPTWQSSVLA TGGGANISTN SPRPFNEIPS PGDNGWLNLY 

        70         80         90        100        110        120 
HFWRENGTHR IHYHHMQNFQ KYGPIYREKL GNKDSVYILD PEDAAQLFLS EGPYPERYLV 

       130        140        150        160        170        180 
PPWVAYHQYY KRPIGVLFKS SEAWKKDRLV LNQEVMAPEA IKNFVPLLEG VVQDFINVLH 

       190        200        210        220        230        240 
RRIKQQKSGN FSGDISDDLF RFAFESITSV VFGERLGMLE EIVDPESQRF IDAIYQMFHT 

       250        260        270        280        290        300 
SVPMLNLPPE LFRFFRTKTW KEHAAAWDMI FKKADDYTQT FYWDLRQKQE FSKYPGVLYS 

       310        320        330        340        350        360 
LLGGNKLPFK NIQANITEML AGGVDTTSMT LQWSLYEMAH NLKVQEMLRA EVLAARRQAQ 

       370        380        390        400        410        420 
GDMVKMVQLV PLLKASIKET LRLHPISVTV QRYLVDDLVL RNYRIPAKML VQVANYAMGR 

       430        440        450        460        470        480 
EPSFFPNPNK FDPTRWLEKS KNTTHFRYLS FGWGVRQCLG RRIAELEMTI FLINVLENFR 

       490        500        510        520 
IELQSLHDVG TKFNLILMPE KPILFNLQPL KKDLGTTTNR 

« Hide

References

[1]"The cDNA cloning and tissue expression of the cytochrome P450scc from Syrian hamster (Mesocricetus auratus)."
Vilchis F., Chavez B., Larrea F., Timossi C., Montiel F.
Gen. Comp. Endocrinol. 126:279-286(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF323965 mRNA. Translation: AAG42320.1.
RefSeqNP_001268569.1. NM_001281640.1.

3D structure databases

ProteinModelPortalQ9EPT4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID101827747.

Phylogenomic databases

HOVERGENHBG051098.

Enzyme and pathway databases

BRENDA1.14.15.6. 3239.
UniPathwayUPA00229.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP11A_MESAU
AccessionPrimary (citable) accession number: Q9EPT4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 1, 2001
Last modified: December 11, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways