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Q9EPT4

- CP11A_MESAU

UniProt

Q9EPT4 - CP11A_MESAU

Protein

Cholesterol side-chain cleavage enzyme, mitochondrial

Gene

CYP11A1

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.By similarity

    Catalytic activityi

    Cholesterol + 6 reduced adrenodoxin + 3 O2 = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O.

    Cofactori

    Heme group.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi458 – 4581Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. cholesterol monooxygenase (side-chain-cleaving) activity Source: UniProtKB
    2. heme binding Source: UniProtKB
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. C21-steroid hormone biosynthetic process Source: UniProtKB
    2. cholesterol metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Steroidogenesis, Sterol metabolism

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BRENDAi1.14.15.6. 3239.
    UniPathwayiUPA00229.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cholesterol side-chain cleavage enzyme, mitochondrial (EC:1.14.15.6)
    Alternative name(s):
    CYPXIA1
    Cholesterol desmolase
    Cytochrome P450 11A1
    Cytochrome P450(scc)
    Gene namesi
    Name:CYP11A1
    Synonyms:CYP11A
    OrganismiMesocricetus auratus (Golden hamster)
    Taxonomic identifieri10036 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3636MitochondrionBy similarityAdd
    BLAST
    Chaini37 – 520484Cholesterol side-chain cleavage enzyme, mitochondrialPRO_0000003586Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with FDX1/adrenodoxin.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EPT4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG051098.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9EPT4-1 [UniParc]FASTAAdd to Basket

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    MLAKGLSLRS VLAKGCQPFL SPTWQSSVLA TGGGANISTN SPRPFNEIPS    50
    PGDNGWLNLY HFWRENGTHR IHYHHMQNFQ KYGPIYREKL GNKDSVYILD 100
    PEDAAQLFLS EGPYPERYLV PPWVAYHQYY KRPIGVLFKS SEAWKKDRLV 150
    LNQEVMAPEA IKNFVPLLEG VVQDFINVLH RRIKQQKSGN FSGDISDDLF 200
    RFAFESITSV VFGERLGMLE EIVDPESQRF IDAIYQMFHT SVPMLNLPPE 250
    LFRFFRTKTW KEHAAAWDMI FKKADDYTQT FYWDLRQKQE FSKYPGVLYS 300
    LLGGNKLPFK NIQANITEML AGGVDTTSMT LQWSLYEMAH NLKVQEMLRA 350
    EVLAARRQAQ GDMVKMVQLV PLLKASIKET LRLHPISVTV QRYLVDDLVL 400
    RNYRIPAKML VQVANYAMGR EPSFFPNPNK FDPTRWLEKS KNTTHFRYLS 450
    FGWGVRQCLG RRIAELEMTI FLINVLENFR IELQSLHDVG TKFNLILMPE 500
    KPILFNLQPL KKDLGTTTNR 520
    Length:520
    Mass (Da):60,271
    Last modified:March 1, 2001 - v1
    Checksum:i648C5A82D0D41D1E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF323965 mRNA. Translation: AAG42320.1.
    RefSeqiNP_001268569.1. NM_001281640.1.

    Genome annotation databases

    GeneIDi101827747.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF323965 mRNA. Translation: AAG42320.1 .
    RefSeqi NP_001268569.1. NM_001281640.1.

    3D structure databases

    ProteinModelPortali Q9EPT4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101827747.

    Phylogenomic databases

    HOVERGENi HBG051098.

    Enzyme and pathway databases

    UniPathwayi UPA00229 .
    BRENDAi 1.14.15.6. 3239.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cDNA cloning and tissue expression of the cytochrome P450scc from Syrian hamster (Mesocricetus auratus)."
      Vilchis F., Chavez B., Larrea F., Timossi C., Montiel F.
      Gen. Comp. Endocrinol. 126:279-286(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCP11A_MESAU
    AccessioniPrimary (citable) accession number: Q9EPT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 4, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3