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Q9EPS2 (PYY_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptide YY

Short name=PYY
Alternative name(s):
Peptide tyrosine tyrosine
Gene names
Name:Pyy
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length98 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

Subcellular location

Secreted.

Sequence similarities

Belongs to the NPY family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processeating behavior

Inferred from direct assay PubMed 15374756. Source: MGI

   Cellular_componentextracellular space

Inferred from direct assay PubMed 17693256. Source: MGI

   Molecular_functionneuropeptide hormone activity

Inferred from direct assay PubMed 15374756. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 By similarity
Peptide29 – 6436Peptide YY
PRO_0000025387
Propeptide68 – 9831
PRO_0000025388

Amino acid modifications

Modified residue411Phosphoserine By similarity
Modified residue641Tyrosine amide By similarity

Experimental info

Sequence conflict92 – 932PE → SR Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9EPS2 [UniParc].

Last modified May 16, 2003. Version 2.
Checksum: 7AF165A1052C3249

FASTA9811,064
        10         20         30         40         50         60 
MVAVRRPWPV TVAMLLILLA CLGALVDAYP AKPEAPGEDA SPEELSRYYA SLRHYLNLVT 

        70         80         90 
RQRYGKRDVP AALFSKLLFT DDSDSENLPF RPEGLDQW 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
[2]"Mouse PYY promoter."
Brown G.J., James R., Eddie L.W.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-93.
Strain: BALB/c.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC010821 mRNA. Translation: AAH10821.1.
AF325866 Genomic DNA. Translation: AAG42908.1.
CCDSCCDS36339.1.
RefSeqNP_663410.1. NM_145435.1.
UniGeneMm.46248.

3D structure databases

ProteinModelPortalQ9EPS2.
SMRQ9EPS2. Positions 29-64.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ9EPS2.
PRIDEQ9EPS2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000017455; ENSMUSP00000017455; ENSMUSG00000017311.
GeneID217212.
KEGGmmu:217212.
UCSCuc007lqo.2. mouse.

Organism-specific databases

CTD5697.
MGIMGI:99924. Pyy.

Phylogenomic databases

eggNOGNOG43897.
GeneTreeENSGT00390000010775.
HOGENOMHOG000252942.
HOVERGENHBG006485.
InParanoidQ9EPS2.
KOK05233.
OrthoDBEOG7WDN4S.
PhylomeDBQ9EPS2.
TreeFamTF332778.

Gene expression databases

BgeeQ9EPS2.
CleanExMM_PYY.
GenevestigatorQ9EPS2.

Family and domain databases

InterProIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERPTHR10533. PTHR10533. 1 hit.
PfamPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSPR00278. PANCHORMONE.
ProDomPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00309. PAH. 1 hit.
[Graphical view]
PROSITEPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio375645.
PROQ9EPS2.
SOURCESearch...

Entry information

Entry namePYY_MOUSE
AccessionPrimary (citable) accession number: Q9EPS2
Secondary accession number(s): Q91XD0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 16, 2003
Last modified: July 9, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot