Q9EPS2 (PYY_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide YY
Short name=PYY

Alternative name(s):
Peptide tyrosine tyrosine

Gene names

Name:

Pyy

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	98 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
Subcellular location	Secreted.
Sequence similarities	Belongs to the NPY family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	eating behavior Inferred from direct assay PubMed 15374756. Source: MGI
Cellular_component	extracellular space Inferred from direct assay PubMed 17693256. Source: MGI
Molecular_function	neuropeptide hormone activity Inferred from direct assay PubMed 15374756. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	By similarity
	Peptide	29 – 64	36	Peptide YY		PRO_0000025387
	Propeptide	68 – 98	31			PRO_0000025388
Amino acid modifications
	Modified residue	41	1	Phosphoserine By similarity
	Modified residue	64	1	Tyrosine amide By similarity
Experimental info
	Sequence conflict	92 – 93	2	PE → SR Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9EPS2 [UniParc]. Last modified May 16, 2003. Version 2. Checksum: 7AF165A1052C3249	FASTA	98	11,064
	10 20 30 40 50 60 MVAVRRPWPV TVAMLLILLA CLGALVDAYP AKPEAPGEDA SPEELSRYYA SLRHYLNLVT 70 80 90 RQRYGKRDVP AALFSKLLFT DDSDSENLPF RPEGLDQW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[2]	"Mouse PYY promoter." Brown G.J., James R., Eddie L.W. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-93. Strain: BALB/c. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC010821 mRNA. Translation: AAH10821.1. AF325866 Genomic DNA. Translation: AAG42908.1.
IPI	IPI00227771.
RefSeq	NP_663410.1. NM_145435.1.
UniGene	Mm.46248.
3D structure databases
ProteinModelPortal	Q9EPS2.
SMR	Q9EPS2. Positions 29-64.
ModBase	Search...
Proteomic databases
PaxDb	Q9EPS2.
PRIDE	Q9EPS2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000017455; ENSMUSP00000017455; ENSMUSG00000017311.
GeneID	217212.
KEGG	mmu:217212.
Organism-specific databases
CTD	5697.
MGI	MGI:99924. Pyy.
Phylogenomic databases
eggNOG	NOG43897.
GeneTree	ENSGT00390000010775.
HOGENOM	HOG000252942.
HOVERGEN	HBG006485.
InParanoid	Q9EPS2.
KO	K05233.
OrthoDB	EOG4P5KBR.
Gene expression databases
ArrayExpress	Q9EPS2.
Bgee	Q9EPS2.
CleanEx	MM_PYY.
Genevestigator	Q9EPS2.
GermOnline	ENSMUSG00000017311. Mus musculus.
Family and domain databases
InterPro	IPR001955. Pancreatic_hormone-like. IPR020392. Pancreatic_hormone-like_CS. [Graphical view]
PANTHER	PTHR10533. PTHR10533. 1 hit.
Pfam	PF00159. Hormone_3. 1 hit. [Graphical view]
PRINTS	PR00278. PANCHORMONE.
ProDom	PD001267. Pancreatic_hormone-like. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00309. PAH. 1 hit. [Graphical view]
PROSITE	PS00265. PANCREATIC_HORMONE_1. 1 hit. PS50276. PANCREATIC_HORMONE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	375645.
SOURCE	Search...

Entry information

Entry name

PYY_MOUSE

Accession

Primary (citable) accession number: Q9EPS2
Secondary accession number(s): Q91XD0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	May 16, 2003
Last modified:	April 3, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program