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Protein

Peptide YY

Gene

Pyy

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

GO - Molecular functioni

  • G-protein coupled receptor binding Source: MGI
  • neuropeptide hormone activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide YYBy similarity
Short name:
PYYBy similarity
Alternative name(s):
Peptide tyrosine tyrosine
Cleaved into the following chain:
Peptide YY(3-36)By similarity
Alternative name(s):
PYY-IIBy similarity
Gene namesi
Name:Pyy
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:99924 Pyy

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28By similarityAdd BLAST28
PeptideiPRO_000002538729 – 64Peptide YYAdd BLAST36
PeptideiPRO_000043066431 – 64Peptide YY(3-36)By similarityAdd BLAST34
PropeptideiPRO_000002538868 – 98Add BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineBy similarity1
Modified residuei64Tyrosine amideBy similarity1

Post-translational modificationi

The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei30 – 31Cleavage; by FAPBy similarity2

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

MaxQBiQ9EPS2
PaxDbiQ9EPS2
PRIDEiQ9EPS2

Expressioni

Gene expression databases

BgeeiENSMUSG00000017311
CleanExiMM_PYY
ExpressionAtlasiQ9EPS2 baseline and differential
GenevisibleiQ9EPS2 MM

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: MGI
  • neuropeptide hormone activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017455

Structurei

3D structure databases

ProteinModelPortaliQ9EPS2
SMRiQ9EPS2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0E4 Eukaryota
ENOG4111U8V LUCA
GeneTreeiENSGT00390000010775
HOGENOMiHOG000252942
HOVERGENiHBG006485
InParanoidiQ9EPS2
KOiK05233
PhylomeDBiQ9EPS2
TreeFamiTF332778

Family and domain databases

CDDicd00126 PAH, 1 hit
InterProiView protein in InterPro
IPR001955 Pancreatic_hormone-like
IPR020392 Pancreatic_hormone-like_CS
PANTHERiPTHR10533 PTHR10533, 1 hit
PfamiView protein in Pfam
PF00159 Hormone_3, 1 hit
PRINTSiPR00278 PANCHORMONE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001267 Pancreatic_hormone-like, 1 hit
SMARTiView protein in SMART
SM00309 PAH, 1 hit
PROSITEiView protein in PROSITE
PS00265 PANCREATIC_HORMONE_1, 1 hit
PS50276 PANCREATIC_HORMONE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EPS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAVRRPWPV TVAMLLILLA CLGALVDAYP AKPEAPGEDA SPEELSRYYA
60 70 80 90
SLRHYLNLVT RQRYGKRDVP AALFSKLLFT DDSDSENLPF RPEGLDQW
Length:98
Mass (Da):11,064
Last modified:May 16, 2003 - v2
Checksum:i7AF165A1052C3249
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti92 – 93PE → SR (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC010821 mRNA Translation: AAH10821.1
AF325866 Genomic DNA Translation: AAG42908.1
CCDSiCCDS36339.1
RefSeqiNP_663410.1, NM_145435.1
UniGeneiMm.46248

Genome annotation databases

EnsembliENSMUST00000017455; ENSMUSP00000017455; ENSMUSG00000017311
GeneIDi217212
KEGGimmu:217212
UCSCiuc007lqo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPYY_MOUSE
AccessioniPrimary (citable) accession number: Q9EPS2
Secondary accession number(s): Q91XD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 16, 2003
Last modified: May 23, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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