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Protein

Peptide YY

Gene

Pyy

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei30 – 312Cleavage; by FAPBy similarity

GO - Molecular functioni

  1. G-protein coupled receptor binding Source: GO_Central
  2. neuropeptide hormone activity Source: MGI

GO - Biological processi

  1. cell-cell signaling Source: GO_Central
  2. digestion Source: GO_Central
  3. eating behavior Source: MGI
  4. neuropeptide signaling pathway Source: GO_Central
  5. regulation of appetite Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_319210. Peptide ligand-binding receptors.
REACT_331048. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide YYBy similarity
Short name:
PYYBy similarity
Alternative name(s):
Peptide tyrosine tyrosine
Cleaved into the following chain:
Peptide YY(3-36)By similarity
Alternative name(s):
PYY-IIBy similarity
Gene namesi
Name:Pyy
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:99924. Pyy.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828By similarityAdd
BLAST
Peptidei29 – 6436Peptide YYPRO_0000025387Add
BLAST
Peptidei31 – 6434Peptide YY(3-36)By similarityPRO_0000430664Add
BLAST
Propeptidei68 – 9831PRO_0000025388Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411PhosphoserineBy similarity
Modified residuei64 – 641Tyrosine amideBy similarity

Post-translational modificationi

The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiQ9EPS2.
PRIDEiQ9EPS2.

Expressioni

Gene expression databases

BgeeiQ9EPS2.
CleanExiMM_PYY.
ExpressionAtlasiQ9EPS2. baseline and differential.
GenevestigatoriQ9EPS2.

Structurei

3D structure databases

SMRiQ9EPS2. Positions 29-64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43897.
GeneTreeiENSGT00390000010775.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiQ9EPS2.
KOiK05233.
OrthoDBiEOG7WDN4S.
PhylomeDBiQ9EPS2.
TreeFamiTF332778.

Family and domain databases

InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EPS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAVRRPWPV TVAMLLILLA CLGALVDAYP AKPEAPGEDA SPEELSRYYA
60 70 80 90
SLRHYLNLVT RQRYGKRDVP AALFSKLLFT DDSDSENLPF RPEGLDQW
Length:98
Mass (Da):11,064
Last modified:May 16, 2003 - v2
Checksum:i7AF165A1052C3249
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 932PE → SR (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC010821 mRNA. Translation: AAH10821.1.
AF325866 Genomic DNA. Translation: AAG42908.1.
CCDSiCCDS36339.1.
RefSeqiNP_663410.1. NM_145435.1.
UniGeneiMm.46248.

Genome annotation databases

EnsembliENSMUST00000017455; ENSMUSP00000017455; ENSMUSG00000017311.
GeneIDi217212.
KEGGimmu:217212.
UCSCiuc007lqo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC010821 mRNA. Translation: AAH10821.1.
AF325866 Genomic DNA. Translation: AAG42908.1.
CCDSiCCDS36339.1.
RefSeqiNP_663410.1. NM_145435.1.
UniGeneiMm.46248.

3D structure databases

SMRiQ9EPS2. Positions 29-64.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ9EPS2.
PRIDEiQ9EPS2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017455; ENSMUSP00000017455; ENSMUSG00000017311.
GeneIDi217212.
KEGGimmu:217212.
UCSCiuc007lqo.2. mouse.

Organism-specific databases

CTDi5697.
MGIiMGI:99924. Pyy.

Phylogenomic databases

eggNOGiNOG43897.
GeneTreeiENSGT00390000010775.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiQ9EPS2.
KOiK05233.
OrthoDBiEOG7WDN4S.
PhylomeDBiQ9EPS2.
TreeFamiTF332778.

Enzyme and pathway databases

ReactomeiREACT_319210. Peptide ligand-binding receptors.
REACT_331048. G alpha (i) signalling events.

Miscellaneous databases

NextBioi375645.
PROiQ9EPS2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EPS2.
CleanExiMM_PYY.
ExpressionAtlasiQ9EPS2. baseline and differential.
GenevestigatoriQ9EPS2.

Family and domain databases

InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  2. "Mouse PYY promoter."
    Brown G.J., James R., Eddie L.W.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-93.
    Strain: BALB/c.
    Tissue: Liver.

Entry informationi

Entry nameiPYY_MOUSE
AccessioniPrimary (citable) accession number: Q9EPS2
Secondary accession number(s): Q91XD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 16, 2003
Last modified: April 1, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.