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Q9EPS2

- PYY_MOUSE

UniProt

Q9EPS2 - PYY_MOUSE

Protein

Peptide YY

Gene

Pyy

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

    GO - Molecular functioni

    1. neuropeptide hormone activity Source: MGI

    GO - Biological processi

    1. eating behavior Source: MGI

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide YY
    Short name:
    PYY
    Alternative name(s):
    Peptide tyrosine tyrosine
    Gene namesi
    Name:Pyy
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:99924. Pyy.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828By similarityAdd
    BLAST
    Peptidei29 – 6436Peptide YYPRO_0000025387Add
    BLAST
    Propeptidei68 – 9831PRO_0000025388Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei41 – 411PhosphoserineBy similarity
    Modified residuei64 – 641Tyrosine amideBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Phosphoprotein

    Proteomic databases

    PaxDbiQ9EPS2.
    PRIDEiQ9EPS2.

    Expressioni

    Gene expression databases

    BgeeiQ9EPS2.
    CleanExiMM_PYY.
    GenevestigatoriQ9EPS2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EPS2.
    SMRiQ9EPS2. Positions 29-64.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NPY family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43897.
    GeneTreeiENSGT00390000010775.
    HOGENOMiHOG000252942.
    HOVERGENiHBG006485.
    InParanoidiQ9EPS2.
    KOiK05233.
    OrthoDBiEOG7WDN4S.
    PhylomeDBiQ9EPS2.
    TreeFamiTF332778.

    Family and domain databases

    InterProiIPR001955. Pancreatic_hormone-like.
    IPR020392. Pancreatic_hormone-like_CS.
    [Graphical view]
    PANTHERiPTHR10533. PTHR10533. 1 hit.
    PfamiPF00159. Hormone_3. 1 hit.
    [Graphical view]
    PRINTSiPR00278. PANCHORMONE.
    ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00309. PAH. 1 hit.
    [Graphical view]
    PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
    PS50276. PANCREATIC_HORMONE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9EPS2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVAVRRPWPV TVAMLLILLA CLGALVDAYP AKPEAPGEDA SPEELSRYYA   50
    SLRHYLNLVT RQRYGKRDVP AALFSKLLFT DDSDSENLPF RPEGLDQW 98
    Length:98
    Mass (Da):11,064
    Last modified:May 16, 2003 - v2
    Checksum:i7AF165A1052C3249
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti92 – 932PE → SR1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC010821 mRNA. Translation: AAH10821.1.
    AF325866 Genomic DNA. Translation: AAG42908.1.
    CCDSiCCDS36339.1.
    RefSeqiNP_663410.1. NM_145435.1.
    UniGeneiMm.46248.

    Genome annotation databases

    EnsembliENSMUST00000017455; ENSMUSP00000017455; ENSMUSG00000017311.
    GeneIDi217212.
    KEGGimmu:217212.
    UCSCiuc007lqo.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC010821 mRNA. Translation: AAH10821.1 .
    AF325866 Genomic DNA. Translation: AAG42908.1 .
    CCDSi CCDS36339.1.
    RefSeqi NP_663410.1. NM_145435.1.
    UniGenei Mm.46248.

    3D structure databases

    ProteinModelPortali Q9EPS2.
    SMRi Q9EPS2. Positions 29-64.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9EPS2.
    PRIDEi Q9EPS2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000017455 ; ENSMUSP00000017455 ; ENSMUSG00000017311 .
    GeneIDi 217212.
    KEGGi mmu:217212.
    UCSCi uc007lqo.2. mouse.

    Organism-specific databases

    CTDi 5697.
    MGIi MGI:99924. Pyy.

    Phylogenomic databases

    eggNOGi NOG43897.
    GeneTreei ENSGT00390000010775.
    HOGENOMi HOG000252942.
    HOVERGENi HBG006485.
    InParanoidi Q9EPS2.
    KOi K05233.
    OrthoDBi EOG7WDN4S.
    PhylomeDBi Q9EPS2.
    TreeFami TF332778.

    Miscellaneous databases

    NextBioi 375645.
    PROi Q9EPS2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9EPS2.
    CleanExi MM_PYY.
    Genevestigatori Q9EPS2.

    Family and domain databases

    InterProi IPR001955. Pancreatic_hormone-like.
    IPR020392. Pancreatic_hormone-like_CS.
    [Graphical view ]
    PANTHERi PTHR10533. PTHR10533. 1 hit.
    Pfami PF00159. Hormone_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00278. PANCHORMONE.
    ProDomi PD001267. Pancreatic_hormone-like. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00309. PAH. 1 hit.
    [Graphical view ]
    PROSITEi PS00265. PANCREATIC_HORMONE_1. 1 hit.
    PS50276. PANCREATIC_HORMONE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    2. "Mouse PYY promoter."
      Brown G.J., James R., Eddie L.W.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-93.
      Strain: BALB/c.
      Tissue: Liver.

    Entry informationi

    Entry nameiPYY_MOUSE
    AccessioniPrimary (citable) accession number: Q9EPS2
    Secondary accession number(s): Q91XD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: May 16, 2003
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3