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Q9EPR4

- S23A2_MOUSE

UniProt

Q9EPR4 - S23A2_MOUSE

Protein

Solute carrier family 23 member 2

Gene

Slc23a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (22 Sep 2009)
      Previous versions | rss
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    Functioni

    Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate By similarity.By similarity

    GO - Molecular functioni

    1. L-ascorbate:sodium symporter activity Source: MGI
    2. L-ascorbic acid transporter activity Source: UniProtKB
    3. sodium-dependent L-ascorbate transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. L-ascorbic acid metabolic process Source: Ensembl
    2. L-ascorbic acid transport Source: UniProtKB
    3. response to oxidative stress Source: Ensembl
    4. transepithelial L-ascorbic acid transport Source: Ensembl
    5. vitamin transmembrane transport Source: GOC

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    ReactomeiREACT_215258. Vitamin C (ascorbate) metabolism.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 23 member 2
    Alternative name(s):
    Na(+)/L-ascorbic acid transporter 2
    Sodium-dependent vitamin C transporter 2
    Short name:
    SVCT-2
    Short name:
    mSVCT2
    Yolk sac permease-like molecule 2
    Gene namesi
    Name:Slc23a2
    Synonyms:Kiaa0238, Svct2, Yspl2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1859682. Slc23a2.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basal plasma membrane Source: UniProtKB
    3. cytoplasm Source: UniProtKB
    4. integral component of plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Elevated expression levels in the adrenals of diabetic mice.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 648648Solute carrier family 23 member 2PRO_0000165979Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei70 – 701Phosphoserine1 Publication
    Modified residuei78 – 781Phosphoserine1 Publication
    Modified residuei79 – 791Phosphothreonine1 Publication
    Modified residuei81 – 811Phosphoserine1 Publication
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis
    Modified residuei647 – 6471Phosphothreonine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ9EPR4.
    PRIDEiQ9EPR4.

    PTM databases

    PhosphoSiteiQ9EPR4.

    Expressioni

    Tissue specificityi

    Expressed in metabolically active and specialized tissues, including high expression in brain and adrenals. Detected in a wide range of tissues. Expression in kidney is almost undetectable.1 Publication

    Gene expression databases

    ArrayExpressiQ9EPR4.
    BgeeiQ9EPR4.
    GenevestigatoriQ9EPR4.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000028815.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EPR4.
    SMRiQ9EPR4. Positions 93-526.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini9 – 110102CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini132 – 1398ExtracellularSequence Analysis
    Topological domaini161 – 1611CytoplasmicSequence Analysis
    Topological domaini183 – 21634ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini238 – 26427CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini283 – 2864ExtracellularSequence Analysis
    Topological domaini301 – 3077ExtracellularSequence Analysis
    Topological domaini329 – 36941CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini391 – 41525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini437 – 45923CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini481 – 4833ExtracellularSequence Analysis
    Topological domaini505 – 51410CytoplasmicSequence Analysis
    Topological domaini536 – 54510ExtracellularSequence Analysis
    Topological domaini567 – 64882CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei287 – 30014HelicalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei111 – 13121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei162 – 18221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei265 – 28218HelicalSequence AnalysisAdd
    BLAST
    Transmembranei308 – 32821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei370 – 39021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei416 – 43621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei460 – 48021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei484 – 50421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei515 – 53521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei546 – 56621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2233.
    GeneTreeiENSGT00390000015686.
    HOGENOMiHOG000038201.
    HOVERGENiHBG056256.
    InParanoidiQ80Y23.
    KOiK14611.
    OMAiKHPTFFT.
    OrthoDBiEOG7R56RZ.
    PhylomeDBiQ9EPR4.
    TreeFamiTF313272.

    Family and domain databases

    InterProiIPR006042. Xan_ur_permease.
    IPR006043. Xant/urac/vitC.
    [Graphical view]
    PANTHERiPTHR11119. PTHR11119. 1 hit.
    PfamiPF00860. Xan_ur_permease. 1 hit.
    [Graphical view]
    PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9EPR4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMGIGKNTAS KSVEAGGSTE GKYEEEAKHS NFFTLPVVIN GGATSSGEQD    50
    NEDTELMAIY TTENGIAEKS SLAETLDSTG SLDPQRSDMI YTIEDVPPWY 100
    LCIFLGLQHY LTCFSGTIAV PFLLADAMCV GDDQWATSQL IGTIFFCVGI 150
    TTLLQTTFGC RLPLFQASAF AFLAPARAIL SLDKWKCNTT EITVANGTAE 200
    LLEHIWHPRI QEIQGAIIMS SLIEVVIGLL GLPGALLRYI GPLTITPTVA 250
    LIGLSGFQAA GERAGKHWGI AMLTIFLVLL FSQYARNVKF PLPIYKSKKG 300
    WTAYKFQLFK MFPIILAILV SWLLCFIFTV TDVFPSNSTD YGYYARTDAR 350
    KGVLLVAPWF KVPYPFQWGM PTVSAAGVIG MLSAVVASII ESIGDYYACA 400
    RLSCAPPPPI HAINRGIFVE GLSCVLDGIF GTGNGSTSSS PNIGVLGITK 450
    VGSRRVIQYG AALMLGLGMV GKFSALFASL PDPVLGALFC TLFGMITAVG 500
    LSNLQFIDLN SSRNLFVLGF SIFFGLVLPS YLRQNPLVTG ITGIDQILNV 550
    LLTTAMFVGG CVAFILDNTI PGTPEERGIK KWKKGVSKGS KSLDGMESYN 600
    LPFGMNIIKK YRCFSYLPIS PTFAGYTWKG FGKSENSRSS DKDSQATV 648
    Length:648
    Mass (Da):70,049
    Last modified:September 22, 2009 - v2
    Checksum:i2590BB11B2A257CB
    GO
    Isoform 2 (identifier: Q9EPR4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         162-272: LPLFQASAFA...RAGKHWGIAM → DYSCQWNGRA...SLVEYLKQSH
         273-648: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:272
    Mass (Da):30,188
    Checksum:i1C8D45706B56F5BC
    GO

    Sequence cautioni

    The sequence AAG02252.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA90751.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC65509.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei162 – 272111LPLFQ…WGIAM → DYSCQWNGRAVGTHLASPNP RDPGGYHHVLTDRSGHWPPW PAWGSAEVYWTLDHHTHRGP HWPLWFPGSRRESRKALGHC HAVSVLRELQGWGTIFTTMW DSLVEYLKQSH in isoform 2. 1 PublicationVSP_007367Add
    BLAST
    Alternative sequencei273 – 648376Missing in isoform 2. 1 PublicationVSP_007368Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY004874 mRNA. Translation: AAG02252.1. Different initiation.
    AK087175 mRNA. Translation: BAC39819.1.
    AL831706 Genomic DNA. Translation: CAM26800.1.
    CH466519 Genomic DNA. Translation: EDL28341.1.
    BC050823 mRNA. Translation: AAH50823.1.
    AB038145 mRNA. Translation: BAA90751.1. Different initiation.
    AK122227 Transcribed RNA. Translation: BAC65509.1. Sequence problems.
    CCDSiCCDS16769.1. [Q9EPR4-1]
    RefSeqiNP_061294.2. NM_018824.2. [Q9EPR4-1]
    XP_006499969.1. XM_006499906.1. [Q9EPR4-1]
    XP_006499970.1. XM_006499907.1. [Q9EPR4-1]
    UniGeneiMm.103581.

    Genome annotation databases

    EnsembliENSMUST00000028815; ENSMUSP00000028815; ENSMUSG00000027340. [Q9EPR4-1]
    GeneIDi54338.
    KEGGimmu:54338.
    UCSCiuc008mmi.1. mouse. [Q9EPR4-1]
    uc008mmj.1. mouse. [Q9EPR4-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY004874 mRNA. Translation: AAG02252.1 . Different initiation.
    AK087175 mRNA. Translation: BAC39819.1 .
    AL831706 Genomic DNA. Translation: CAM26800.1 .
    CH466519 Genomic DNA. Translation: EDL28341.1 .
    BC050823 mRNA. Translation: AAH50823.1 .
    AB038145 mRNA. Translation: BAA90751.1 . Different initiation.
    AK122227 Transcribed RNA. Translation: BAC65509.1 . Sequence problems.
    CCDSi CCDS16769.1. [Q9EPR4-1 ]
    RefSeqi NP_061294.2. NM_018824.2. [Q9EPR4-1 ]
    XP_006499969.1. XM_006499906.1. [Q9EPR4-1 ]
    XP_006499970.1. XM_006499907.1. [Q9EPR4-1 ]
    UniGenei Mm.103581.

    3D structure databases

    ProteinModelPortali Q9EPR4.
    SMRi Q9EPR4. Positions 93-526.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000028815.

    PTM databases

    PhosphoSitei Q9EPR4.

    Proteomic databases

    PaxDbi Q9EPR4.
    PRIDEi Q9EPR4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028815 ; ENSMUSP00000028815 ; ENSMUSG00000027340 . [Q9EPR4-1 ]
    GeneIDi 54338.
    KEGGi mmu:54338.
    UCSCi uc008mmi.1. mouse. [Q9EPR4-1 ]
    uc008mmj.1. mouse. [Q9EPR4-2 ]

    Organism-specific databases

    CTDi 9962.
    MGIi MGI:1859682. Slc23a2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG2233.
    GeneTreei ENSGT00390000015686.
    HOGENOMi HOG000038201.
    HOVERGENi HBG056256.
    InParanoidi Q80Y23.
    KOi K14611.
    OMAi KHPTFFT.
    OrthoDBi EOG7R56RZ.
    PhylomeDBi Q9EPR4.
    TreeFami TF313272.

    Enzyme and pathway databases

    Reactomei REACT_215258. Vitamin C (ascorbate) metabolism.

    Miscellaneous databases

    NextBioi 311116.
    PROi Q9EPR4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9EPR4.
    Bgeei Q9EPR4.
    Genevestigatori Q9EPR4.

    Family and domain databases

    InterProi IPR006042. Xan_ur_permease.
    IPR006043. Xant/urac/vitC.
    [Graphical view ]
    PANTHERi PTHR11119. PTHR11119. 1 hit.
    Pfami PF00860. Xan_ur_permease. 1 hit.
    [Graphical view ]
    PROSITEi PS01116. XANTH_URACIL_PERMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and genomic organization of the mouse gene slc23a1 encoding a vitamin C transporter."
      Gispert S., Dutra A., Lieberman A., Friedlich D., Nussbaum R.L.
      DNA Res. 7:339-345(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: 129/SvEv.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Lung.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Embryo.
    6. "Mouse sodium dependent vitamin C transporter 2 (mSVCT2)."
      Fujita I., Hirano J., Tanaka K.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-647 (ISOFORM 1).
      Tissue: Brain.
    7. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 108-648 (ISOFORM 1).
      Tissue: Brain.
    8. "Upregulation of sodium-dependent vitamin C transporter 2 expression in adrenals increases norepinephrine production and aggravates hyperlipidemia in mice with streptozotocin-induced diabetes."
      Wu X., Iguchi T., Hirano J., Fujita I., Ueda H., Itoh N., Tanaka K., Nakanishi T.
      Biochem. Pharmacol. 74:1020-1028(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DISEASE.
    9. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; SER-78; THR-79; SER-81 AND THR-647, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiS23A2_MOUSE
    AccessioniPrimary (citable) accession number: Q9EPR4
    Secondary accession number(s): Q80Y23, Q8C327, Q9JM78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3