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Q9EPR4

- S23A2_MOUSE

UniProt

Q9EPR4 - S23A2_MOUSE

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Protein
Solute carrier family 23 member 2
Gene
Slc23a2, Kiaa0238, Svct2, Yspl2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate By similarity.

GO - Molecular functioni

  1. L-ascorbate:sodium symporter activity Source: MGI
  2. L-ascorbic acid transporter activity Source: UniProtKB
  3. sodium-dependent L-ascorbate transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. L-ascorbic acid metabolic process Source: Ensembl
  2. L-ascorbic acid transport Source: UniProtKB
  3. response to oxidative stress Source: Ensembl
  4. transepithelial L-ascorbic acid transport Source: Ensembl
  5. vitamin transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_215258. Vitamin C (ascorbate) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 23 member 2
Alternative name(s):
Na(+)/L-ascorbic acid transporter 2
Sodium-dependent vitamin C transporter 2
Short name:
SVCT-2
Short name:
mSVCT2
Yolk sac permease-like molecule 2
Gene namesi
Name:Slc23a2
Synonyms:Kiaa0238, Svct2, Yspl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1859682. Slc23a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini9 – 110102Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei111 – 13121Helical; Reviewed prediction
Add
BLAST
Topological domaini132 – 1398Extracellular Reviewed prediction
Transmembranei140 – 16021Helical; Reviewed prediction
Add
BLAST
Topological domaini161 – 1611Cytoplasmic Reviewed prediction
Transmembranei162 – 18221Helical; Reviewed prediction
Add
BLAST
Topological domaini183 – 21634Extracellular Reviewed prediction
Add
BLAST
Transmembranei217 – 23721Helical; Reviewed prediction
Add
BLAST
Topological domaini238 – 26427Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei265 – 28218Helical; Reviewed prediction
Add
BLAST
Topological domaini283 – 2864Extracellular Reviewed prediction
Intramembranei287 – 30014Helical; Reviewed prediction
Add
BLAST
Topological domaini301 – 3077Extracellular Reviewed prediction
Transmembranei308 – 32821Helical; Reviewed prediction
Add
BLAST
Topological domaini329 – 36941Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei370 – 39021Helical; Reviewed prediction
Add
BLAST
Topological domaini391 – 41525Extracellular Reviewed prediction
Add
BLAST
Transmembranei416 – 43621Helical; Reviewed prediction
Add
BLAST
Topological domaini437 – 45923Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei460 – 48021Helical; Reviewed prediction
Add
BLAST
Topological domaini481 – 4833Extracellular Reviewed prediction
Transmembranei484 – 50421Helical; Reviewed prediction
Add
BLAST
Topological domaini505 – 51410Cytoplasmic Reviewed prediction
Transmembranei515 – 53521Helical; Reviewed prediction
Add
BLAST
Topological domaini536 – 54510Extracellular Reviewed prediction
Transmembranei546 – 56621Helical; Reviewed prediction
Add
BLAST
Topological domaini567 – 64882Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basal plasma membrane Source: UniProtKB
  3. cytoplasm Source: UniProtKB
  4. integral component of plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Elevated expression levels in the adrenals of diabetic mice.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 648648Solute carrier family 23 member 2
PRO_0000165979Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701Phosphoserine1 Publication
Modified residuei78 – 781Phosphoserine1 Publication
Modified residuei79 – 791Phosphothreonine1 Publication
Modified residuei81 – 811Phosphoserine1 Publication
Glycosylationi188 – 1881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi196 – 1961N-linked (GlcNAc...) Reviewed prediction
Modified residuei647 – 6471Phosphothreonine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9EPR4.
PRIDEiQ9EPR4.

PTM databases

PhosphoSiteiQ9EPR4.

Expressioni

Tissue specificityi

Expressed in metabolically active and specialized tissues, including high expression in brain and adrenals. Detected in a wide range of tissues. Expression in kidney is almost undetectable.1 Publication

Gene expression databases

ArrayExpressiQ9EPR4.
BgeeiQ9EPR4.
GenevestigatoriQ9EPR4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028815.

Structurei

3D structure databases

ProteinModelPortaliQ9EPR4.
SMRiQ9EPR4. Positions 93-526.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2233.
GeneTreeiENSGT00390000015686.
HOGENOMiHOG000038201.
HOVERGENiHBG056256.
InParanoidiQ80Y23.
KOiK14611.
OMAiKHPTFFT.
OrthoDBiEOG7R56RZ.
PhylomeDBiQ9EPR4.
TreeFamiTF313272.

Family and domain databases

InterProiIPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9EPR4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMGIGKNTAS KSVEAGGSTE GKYEEEAKHS NFFTLPVVIN GGATSSGEQD    50
NEDTELMAIY TTENGIAEKS SLAETLDSTG SLDPQRSDMI YTIEDVPPWY 100
LCIFLGLQHY LTCFSGTIAV PFLLADAMCV GDDQWATSQL IGTIFFCVGI 150
TTLLQTTFGC RLPLFQASAF AFLAPARAIL SLDKWKCNTT EITVANGTAE 200
LLEHIWHPRI QEIQGAIIMS SLIEVVIGLL GLPGALLRYI GPLTITPTVA 250
LIGLSGFQAA GERAGKHWGI AMLTIFLVLL FSQYARNVKF PLPIYKSKKG 300
WTAYKFQLFK MFPIILAILV SWLLCFIFTV TDVFPSNSTD YGYYARTDAR 350
KGVLLVAPWF KVPYPFQWGM PTVSAAGVIG MLSAVVASII ESIGDYYACA 400
RLSCAPPPPI HAINRGIFVE GLSCVLDGIF GTGNGSTSSS PNIGVLGITK 450
VGSRRVIQYG AALMLGLGMV GKFSALFASL PDPVLGALFC TLFGMITAVG 500
LSNLQFIDLN SSRNLFVLGF SIFFGLVLPS YLRQNPLVTG ITGIDQILNV 550
LLTTAMFVGG CVAFILDNTI PGTPEERGIK KWKKGVSKGS KSLDGMESYN 600
LPFGMNIIKK YRCFSYLPIS PTFAGYTWKG FGKSENSRSS DKDSQATV 648
Length:648
Mass (Da):70,049
Last modified:September 22, 2009 - v2
Checksum:i2590BB11B2A257CB
GO
Isoform 2 (identifier: Q9EPR4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-272: LPLFQASAFA...RAGKHWGIAM → DYSCQWNGRA...SLVEYLKQSH
     273-648: Missing.

Note: No experimental confirmation available.

Show »
Length:272
Mass (Da):30,188
Checksum:i1C8D45706B56F5BC
GO

Sequence cautioni

The sequence AAG02252.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA90751.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC65509.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei162 – 272111LPLFQ…WGIAM → DYSCQWNGRAVGTHLASPNP RDPGGYHHVLTDRSGHWPPW PAWGSAEVYWTLDHHTHRGP HWPLWFPGSRRESRKALGHC HAVSVLRELQGWGTIFTTMW DSLVEYLKQSH in isoform 2.
VSP_007367Add
BLAST
Alternative sequencei273 – 648376Missing in isoform 2.
VSP_007368Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY004874 mRNA. Translation: AAG02252.1. Different initiation.
AK087175 mRNA. Translation: BAC39819.1.
AL831706 Genomic DNA. Translation: CAM26800.1.
CH466519 Genomic DNA. Translation: EDL28341.1.
BC050823 mRNA. Translation: AAH50823.1.
AB038145 mRNA. Translation: BAA90751.1. Different initiation.
AK122227 Transcribed RNA. Translation: BAC65509.1. Sequence problems.
CCDSiCCDS16769.1. [Q9EPR4-1]
RefSeqiNP_061294.2. NM_018824.2. [Q9EPR4-1]
XP_006499969.1. XM_006499906.1. [Q9EPR4-1]
XP_006499970.1. XM_006499907.1. [Q9EPR4-1]
UniGeneiMm.103581.

Genome annotation databases

EnsembliENSMUST00000028815; ENSMUSP00000028815; ENSMUSG00000027340. [Q9EPR4-1]
GeneIDi54338.
KEGGimmu:54338.
UCSCiuc008mmi.1. mouse. [Q9EPR4-1]
uc008mmj.1. mouse. [Q9EPR4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY004874 mRNA. Translation: AAG02252.1 . Different initiation.
AK087175 mRNA. Translation: BAC39819.1 .
AL831706 Genomic DNA. Translation: CAM26800.1 .
CH466519 Genomic DNA. Translation: EDL28341.1 .
BC050823 mRNA. Translation: AAH50823.1 .
AB038145 mRNA. Translation: BAA90751.1 . Different initiation.
AK122227 Transcribed RNA. Translation: BAC65509.1 . Sequence problems.
CCDSi CCDS16769.1. [Q9EPR4-1 ]
RefSeqi NP_061294.2. NM_018824.2. [Q9EPR4-1 ]
XP_006499969.1. XM_006499906.1. [Q9EPR4-1 ]
XP_006499970.1. XM_006499907.1. [Q9EPR4-1 ]
UniGenei Mm.103581.

3D structure databases

ProteinModelPortali Q9EPR4.
SMRi Q9EPR4. Positions 93-526.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000028815.

PTM databases

PhosphoSitei Q9EPR4.

Proteomic databases

PaxDbi Q9EPR4.
PRIDEi Q9EPR4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028815 ; ENSMUSP00000028815 ; ENSMUSG00000027340 . [Q9EPR4-1 ]
GeneIDi 54338.
KEGGi mmu:54338.
UCSCi uc008mmi.1. mouse. [Q9EPR4-1 ]
uc008mmj.1. mouse. [Q9EPR4-2 ]

Organism-specific databases

CTDi 9962.
MGIi MGI:1859682. Slc23a2.
Rougei Search...

Phylogenomic databases

eggNOGi COG2233.
GeneTreei ENSGT00390000015686.
HOGENOMi HOG000038201.
HOVERGENi HBG056256.
InParanoidi Q80Y23.
KOi K14611.
OMAi KHPTFFT.
OrthoDBi EOG7R56RZ.
PhylomeDBi Q9EPR4.
TreeFami TF313272.

Enzyme and pathway databases

Reactomei REACT_215258. Vitamin C (ascorbate) metabolism.

Miscellaneous databases

NextBioi 311116.
PROi Q9EPR4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9EPR4.
Bgeei Q9EPR4.
Genevestigatori Q9EPR4.

Family and domain databases

InterProi IPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view ]
PANTHERi PTHR11119. PTHR11119. 1 hit.
Pfami PF00860. Xan_ur_permease. 1 hit.
[Graphical view ]
PROSITEi PS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and genomic organization of the mouse gene slc23a1 encoding a vitamin C transporter."
    Gispert S., Dutra A., Lieberman A., Friedlich D., Nussbaum R.L.
    DNA Res. 7:339-345(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: 129/SvEv.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryo.
  6. "Mouse sodium dependent vitamin C transporter 2 (mSVCT2)."
    Fujita I., Hirano J., Tanaka K.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-647 (ISOFORM 1).
    Tissue: Brain.
  7. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 108-648 (ISOFORM 1).
    Tissue: Brain.
  8. "Upregulation of sodium-dependent vitamin C transporter 2 expression in adrenals increases norepinephrine production and aggravates hyperlipidemia in mice with streptozotocin-induced diabetes."
    Wu X., Iguchi T., Hirano J., Fujita I., Ueda H., Itoh N., Tanaka K., Nakanishi T.
    Biochem. Pharmacol. 74:1020-1028(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DISEASE.
  9. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; SER-78; THR-79; SER-81 AND THR-647, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS23A2_MOUSE
AccessioniPrimary (citable) accession number: Q9EPR4
Secondary accession number(s): Q80Y23, Q8C327, Q9JM78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: September 22, 2009
Last modified: September 3, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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