Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 23 member 2

Gene

Slc23a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate (By similarity).By similarity

GO - Molecular functioni

  • L-ascorbate:sodium symporter activity Source: MGI
  • L-ascorbic acid transporter activity Source: UniProtKB
  • sodium-dependent L-ascorbate transmembrane transporter activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-196836. Vitamin C (ascorbate) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 23 member 2
Alternative name(s):
Na(+)/L-ascorbic acid transporter 2
Sodium-dependent vitamin C transporter 2
Short name:
SVCT-2
Short name:
mSVCT2
Yolk sac permease-like molecule 2
Gene namesi
Name:Slc23a2
Synonyms:Kiaa0238, Svct2, Yspl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1859682. Slc23a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini9 – 110CytoplasmicSequence analysisAdd BLAST102
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 139ExtracellularSequence analysis8
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161CytoplasmicSequence analysis1
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 216ExtracellularSequence analysisAdd BLAST34
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 264CytoplasmicSequence analysisAdd BLAST27
Transmembranei265 – 282HelicalSequence analysisAdd BLAST18
Topological domaini283 – 286ExtracellularSequence analysis4
Intramembranei287 – 300HelicalSequence analysisAdd BLAST14
Topological domaini301 – 307ExtracellularSequence analysis7
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 369CytoplasmicSequence analysisAdd BLAST41
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391 – 415ExtracellularSequence analysisAdd BLAST25
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Topological domaini437 – 459CytoplasmicSequence analysisAdd BLAST23
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Topological domaini481 – 483ExtracellularSequence analysis3
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 514CytoplasmicSequence analysis10
Transmembranei515 – 535HelicalSequence analysisAdd BLAST21
Topological domaini536 – 545ExtracellularSequence analysis10
Transmembranei546 – 566HelicalSequence analysisAdd BLAST21
Topological domaini567 – 648CytoplasmicSequence analysisAdd BLAST82

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • basal plasma membrane Source: UniProtKB
  • basolateral plasma membrane Source: MGI
  • cytoplasm Source: UniProtKB
  • integral component of plasma membrane Source: Ensembl
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Elevated expression levels in the adrenals of diabetic mice.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659791 – 648Solute carrier family 23 member 2Add BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70PhosphoserineCombined sources1
Modified residuei75PhosphothreonineBy similarity1
Modified residuei78PhosphoserineCombined sources1
Modified residuei79PhosphothreonineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1
Glycosylationi196N-linked (GlcNAc...)Sequence analysis1
Modified residuei647PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9EPR4.
PaxDbiQ9EPR4.
PeptideAtlasiQ9EPR4.
PRIDEiQ9EPR4.

PTM databases

iPTMnetiQ9EPR4.
PhosphoSitePlusiQ9EPR4.

Expressioni

Tissue specificityi

Expressed in metabolically active and specialized tissues, including high expression in brain and adrenals. Detected in a wide range of tissues. Expression in kidney is almost undetectable.1 Publication

Gene expression databases

BgeeiENSMUSG00000027340.
ExpressionAtlasiQ9EPR4. baseline and differential.
GenevisibleiQ9EPR4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028815.

Structurei

3D structure databases

ProteinModelPortaliQ9EPR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1292. Eukaryota.
COG2233. LUCA.
GeneTreeiENSGT00390000015686.
HOGENOMiHOG000038201.
HOVERGENiHBG056256.
InParanoidiQ9EPR4.
KOiK14611.
OMAiIGMEGLM.
OrthoDBiEOG091G063Y.
PhylomeDBiQ9EPR4.
TreeFamiTF313272.

Family and domain databases

InterProiIPR029956. SlC23A2.
IPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF33. PTHR11119:SF33. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9EPR4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMGIGKNTAS KSVEAGGSTE GKYEEEAKHS NFFTLPVVIN GGATSSGEQD
60 70 80 90 100
NEDTELMAIY TTENGIAEKS SLAETLDSTG SLDPQRSDMI YTIEDVPPWY
110 120 130 140 150
LCIFLGLQHY LTCFSGTIAV PFLLADAMCV GDDQWATSQL IGTIFFCVGI
160 170 180 190 200
TTLLQTTFGC RLPLFQASAF AFLAPARAIL SLDKWKCNTT EITVANGTAE
210 220 230 240 250
LLEHIWHPRI QEIQGAIIMS SLIEVVIGLL GLPGALLRYI GPLTITPTVA
260 270 280 290 300
LIGLSGFQAA GERAGKHWGI AMLTIFLVLL FSQYARNVKF PLPIYKSKKG
310 320 330 340 350
WTAYKFQLFK MFPIILAILV SWLLCFIFTV TDVFPSNSTD YGYYARTDAR
360 370 380 390 400
KGVLLVAPWF KVPYPFQWGM PTVSAAGVIG MLSAVVASII ESIGDYYACA
410 420 430 440 450
RLSCAPPPPI HAINRGIFVE GLSCVLDGIF GTGNGSTSSS PNIGVLGITK
460 470 480 490 500
VGSRRVIQYG AALMLGLGMV GKFSALFASL PDPVLGALFC TLFGMITAVG
510 520 530 540 550
LSNLQFIDLN SSRNLFVLGF SIFFGLVLPS YLRQNPLVTG ITGIDQILNV
560 570 580 590 600
LLTTAMFVGG CVAFILDNTI PGTPEERGIK KWKKGVSKGS KSLDGMESYN
610 620 630 640
LPFGMNIIKK YRCFSYLPIS PTFAGYTWKG FGKSENSRSS DKDSQATV
Length:648
Mass (Da):70,049
Last modified:September 22, 2009 - v2
Checksum:i2590BB11B2A257CB
GO
Isoform 2 (identifier: Q9EPR4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-272: LPLFQASAFA...RAGKHWGIAM → DYSCQWNGRA...SLVEYLKQSH
     273-648: Missing.

Note: No experimental confirmation available.
Show »
Length:272
Mass (Da):30,188
Checksum:i1C8D45706B56F5BC
GO

Sequence cautioni

The sequence AAG02252 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA90751 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC65509 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007367162 – 272LPLFQ…WGIAM → DYSCQWNGRAVGTHLASPNP RDPGGYHHVLTDRSGHWPPW PAWGSAEVYWTLDHHTHRGP HWPLWFPGSRRESRKALGHC HAVSVLRELQGWGTIFTTMW DSLVEYLKQSH in isoform 2. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_007368273 – 648Missing in isoform 2. 1 PublicationAdd BLAST376

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY004874 mRNA. Translation: AAG02252.1. Different initiation.
AK087175 mRNA. Translation: BAC39819.1.
AL831706 Genomic DNA. Translation: CAM26800.1.
CH466519 Genomic DNA. Translation: EDL28341.1.
BC050823 mRNA. Translation: AAH50823.1.
AB038145 mRNA. Translation: BAA90751.1. Different initiation.
AK122227 Transcribed RNA. Translation: BAC65509.1. Sequence problems.
CCDSiCCDS16769.1. [Q9EPR4-1]
RefSeqiNP_061294.2. NM_018824.2. [Q9EPR4-1]
XP_006499969.1. XM_006499906.3. [Q9EPR4-1]
XP_006499970.1. XM_006499907.3. [Q9EPR4-1]
XP_011238000.1. XM_011239698.2. [Q9EPR4-1]
XP_017174620.1. XM_017319131.1. [Q9EPR4-1]
UniGeneiMm.103581.

Genome annotation databases

EnsembliENSMUST00000028815; ENSMUSP00000028815; ENSMUSG00000027340. [Q9EPR4-1]
GeneIDi54338.
KEGGimmu:54338.
UCSCiuc008mmi.1. mouse. [Q9EPR4-1]
uc008mmj.1. mouse. [Q9EPR4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY004874 mRNA. Translation: AAG02252.1. Different initiation.
AK087175 mRNA. Translation: BAC39819.1.
AL831706 Genomic DNA. Translation: CAM26800.1.
CH466519 Genomic DNA. Translation: EDL28341.1.
BC050823 mRNA. Translation: AAH50823.1.
AB038145 mRNA. Translation: BAA90751.1. Different initiation.
AK122227 Transcribed RNA. Translation: BAC65509.1. Sequence problems.
CCDSiCCDS16769.1. [Q9EPR4-1]
RefSeqiNP_061294.2. NM_018824.2. [Q9EPR4-1]
XP_006499969.1. XM_006499906.3. [Q9EPR4-1]
XP_006499970.1. XM_006499907.3. [Q9EPR4-1]
XP_011238000.1. XM_011239698.2. [Q9EPR4-1]
XP_017174620.1. XM_017319131.1. [Q9EPR4-1]
UniGeneiMm.103581.

3D structure databases

ProteinModelPortaliQ9EPR4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028815.

PTM databases

iPTMnetiQ9EPR4.
PhosphoSitePlusiQ9EPR4.

Proteomic databases

EPDiQ9EPR4.
PaxDbiQ9EPR4.
PeptideAtlasiQ9EPR4.
PRIDEiQ9EPR4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028815; ENSMUSP00000028815; ENSMUSG00000027340. [Q9EPR4-1]
GeneIDi54338.
KEGGimmu:54338.
UCSCiuc008mmi.1. mouse. [Q9EPR4-1]
uc008mmj.1. mouse. [Q9EPR4-2]

Organism-specific databases

CTDi9962.
MGIiMGI:1859682. Slc23a2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1292. Eukaryota.
COG2233. LUCA.
GeneTreeiENSGT00390000015686.
HOGENOMiHOG000038201.
HOVERGENiHBG056256.
InParanoidiQ9EPR4.
KOiK14611.
OMAiIGMEGLM.
OrthoDBiEOG091G063Y.
PhylomeDBiQ9EPR4.
TreeFamiTF313272.

Enzyme and pathway databases

ReactomeiR-MMU-196836. Vitamin C (ascorbate) metabolism.

Miscellaneous databases

PROiQ9EPR4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027340.
ExpressionAtlasiQ9EPR4. baseline and differential.
GenevisibleiQ9EPR4. MM.

Family and domain databases

InterProiIPR029956. SlC23A2.
IPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PTHR11119:SF33. PTHR11119:SF33. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS23A2_MOUSE
AccessioniPrimary (citable) accession number: Q9EPR4
Secondary accession number(s): Q80Y23, Q8C327, Q9JM78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: September 22, 2009
Last modified: November 2, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.