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Q9EPR4

- S23A2_MOUSE

UniProt

Q9EPR4 - S23A2_MOUSE

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Protein

Solute carrier family 23 member 2

Gene

Slc23a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate (By similarity).By similarity

GO - Molecular functioni

  1. L-ascorbate:sodium symporter activity Source: MGI
  2. L-ascorbic acid transporter activity Source: UniProtKB
  3. sodium-dependent L-ascorbate transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. L-ascorbic acid metabolic process Source: Ensembl
  2. L-ascorbic acid transport Source: UniProtKB
  3. response to oxidative stress Source: Ensembl
  4. transepithelial L-ascorbic acid transport Source: Ensembl
  5. vitamin transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_215258. Vitamin C (ascorbate) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 23 member 2
Alternative name(s):
Na(+)/L-ascorbic acid transporter 2
Sodium-dependent vitamin C transporter 2
Short name:
SVCT-2
Short name:
mSVCT2
Yolk sac permease-like molecule 2
Gene namesi
Name:Slc23a2
Synonyms:Kiaa0238, Svct2, Yspl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1859682. Slc23a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini9 – 110102CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence AnalysisAdd
BLAST
Topological domaini132 – 1398ExtracellularSequence Analysis
Transmembranei140 – 16021HelicalSequence AnalysisAdd
BLAST
Topological domaini161 – 1611CytoplasmicSequence Analysis
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST
Topological domaini183 – 21634ExtracellularSequence AnalysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence AnalysisAdd
BLAST
Topological domaini238 – 26427CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei265 – 28218HelicalSequence AnalysisAdd
BLAST
Topological domaini283 – 2864ExtracellularSequence Analysis
Intramembranei287 – 30014HelicalSequence AnalysisAdd
BLAST
Topological domaini301 – 3077ExtracellularSequence Analysis
Transmembranei308 – 32821HelicalSequence AnalysisAdd
BLAST
Topological domaini329 – 36941CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei370 – 39021HelicalSequence AnalysisAdd
BLAST
Topological domaini391 – 41525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei416 – 43621HelicalSequence AnalysisAdd
BLAST
Topological domaini437 – 45923CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei460 – 48021HelicalSequence AnalysisAdd
BLAST
Topological domaini481 – 4833ExtracellularSequence Analysis
Transmembranei484 – 50421HelicalSequence AnalysisAdd
BLAST
Topological domaini505 – 51410CytoplasmicSequence Analysis
Transmembranei515 – 53521HelicalSequence AnalysisAdd
BLAST
Topological domaini536 – 54510ExtracellularSequence Analysis
Transmembranei546 – 56621HelicalSequence AnalysisAdd
BLAST
Topological domaini567 – 64882CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basal plasma membrane Source: UniProtKB
  3. cytoplasm Source: UniProtKB
  4. integral component of plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Elevated expression levels in the adrenals of diabetic mice.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 648648Solute carrier family 23 member 2PRO_0000165979Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701Phosphoserine1 Publication
Modified residuei78 – 781Phosphoserine1 Publication
Modified residuei79 – 791Phosphothreonine1 Publication
Modified residuei81 – 811Phosphoserine1 Publication
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis
Modified residuei647 – 6471Phosphothreonine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9EPR4.
PaxDbiQ9EPR4.
PRIDEiQ9EPR4.

PTM databases

PhosphoSiteiQ9EPR4.

Expressioni

Tissue specificityi

Expressed in metabolically active and specialized tissues, including high expression in brain and adrenals. Detected in a wide range of tissues. Expression in kidney is almost undetectable.1 Publication

Gene expression databases

BgeeiQ9EPR4.
ExpressionAtlasiQ9EPR4. baseline and differential.
GenevestigatoriQ9EPR4.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028815.

Structurei

3D structure databases

ProteinModelPortaliQ9EPR4.
SMRiQ9EPR4. Positions 93-526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2233.
GeneTreeiENSGT00390000015686.
HOGENOMiHOG000038201.
HOVERGENiHBG056256.
InParanoidiQ9EPR4.
KOiK14611.
OMAiKHPTFFT.
OrthoDBiEOG7R56RZ.
PhylomeDBiQ9EPR4.
TreeFamiTF313272.

Family and domain databases

InterProiIPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9EPR4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMGIGKNTAS KSVEAGGSTE GKYEEEAKHS NFFTLPVVIN GGATSSGEQD
60 70 80 90 100
NEDTELMAIY TTENGIAEKS SLAETLDSTG SLDPQRSDMI YTIEDVPPWY
110 120 130 140 150
LCIFLGLQHY LTCFSGTIAV PFLLADAMCV GDDQWATSQL IGTIFFCVGI
160 170 180 190 200
TTLLQTTFGC RLPLFQASAF AFLAPARAIL SLDKWKCNTT EITVANGTAE
210 220 230 240 250
LLEHIWHPRI QEIQGAIIMS SLIEVVIGLL GLPGALLRYI GPLTITPTVA
260 270 280 290 300
LIGLSGFQAA GERAGKHWGI AMLTIFLVLL FSQYARNVKF PLPIYKSKKG
310 320 330 340 350
WTAYKFQLFK MFPIILAILV SWLLCFIFTV TDVFPSNSTD YGYYARTDAR
360 370 380 390 400
KGVLLVAPWF KVPYPFQWGM PTVSAAGVIG MLSAVVASII ESIGDYYACA
410 420 430 440 450
RLSCAPPPPI HAINRGIFVE GLSCVLDGIF GTGNGSTSSS PNIGVLGITK
460 470 480 490 500
VGSRRVIQYG AALMLGLGMV GKFSALFASL PDPVLGALFC TLFGMITAVG
510 520 530 540 550
LSNLQFIDLN SSRNLFVLGF SIFFGLVLPS YLRQNPLVTG ITGIDQILNV
560 570 580 590 600
LLTTAMFVGG CVAFILDNTI PGTPEERGIK KWKKGVSKGS KSLDGMESYN
610 620 630 640
LPFGMNIIKK YRCFSYLPIS PTFAGYTWKG FGKSENSRSS DKDSQATV
Length:648
Mass (Da):70,049
Last modified:September 22, 2009 - v2
Checksum:i2590BB11B2A257CB
GO
Isoform 2 (identifier: Q9EPR4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-272: LPLFQASAFA...RAGKHWGIAM → DYSCQWNGRA...SLVEYLKQSH
     273-648: Missing.

Note: No experimental confirmation available.

Show »
Length:272
Mass (Da):30,188
Checksum:i1C8D45706B56F5BC
GO

Sequence cautioni

The sequence AAG02252.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA90751.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC65509.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei162 – 272111LPLFQ…WGIAM → DYSCQWNGRAVGTHLASPNP RDPGGYHHVLTDRSGHWPPW PAWGSAEVYWTLDHHTHRGP HWPLWFPGSRRESRKALGHC HAVSVLRELQGWGTIFTTMW DSLVEYLKQSH in isoform 2. 1 PublicationVSP_007367Add
BLAST
Alternative sequencei273 – 648376Missing in isoform 2. 1 PublicationVSP_007368Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY004874 mRNA. Translation: AAG02252.1. Different initiation.
AK087175 mRNA. Translation: BAC39819.1.
AL831706 Genomic DNA. Translation: CAM26800.1.
CH466519 Genomic DNA. Translation: EDL28341.1.
BC050823 mRNA. Translation: AAH50823.1.
AB038145 mRNA. Translation: BAA90751.1. Different initiation.
AK122227 Transcribed RNA. Translation: BAC65509.1. Sequence problems.
CCDSiCCDS16769.1. [Q9EPR4-1]
RefSeqiNP_061294.2. NM_018824.2. [Q9EPR4-1]
XP_006499969.1. XM_006499906.1. [Q9EPR4-1]
XP_006499970.1. XM_006499907.1. [Q9EPR4-1]
UniGeneiMm.103581.

Genome annotation databases

EnsembliENSMUST00000028815; ENSMUSP00000028815; ENSMUSG00000027340. [Q9EPR4-1]
GeneIDi54338.
KEGGimmu:54338.
UCSCiuc008mmi.1. mouse. [Q9EPR4-1]
uc008mmj.1. mouse. [Q9EPR4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY004874 mRNA. Translation: AAG02252.1 . Different initiation.
AK087175 mRNA. Translation: BAC39819.1 .
AL831706 Genomic DNA. Translation: CAM26800.1 .
CH466519 Genomic DNA. Translation: EDL28341.1 .
BC050823 mRNA. Translation: AAH50823.1 .
AB038145 mRNA. Translation: BAA90751.1 . Different initiation.
AK122227 Transcribed RNA. Translation: BAC65509.1 . Sequence problems.
CCDSi CCDS16769.1. [Q9EPR4-1 ]
RefSeqi NP_061294.2. NM_018824.2. [Q9EPR4-1 ]
XP_006499969.1. XM_006499906.1. [Q9EPR4-1 ]
XP_006499970.1. XM_006499907.1. [Q9EPR4-1 ]
UniGenei Mm.103581.

3D structure databases

ProteinModelPortali Q9EPR4.
SMRi Q9EPR4. Positions 93-526.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000028815.

PTM databases

PhosphoSitei Q9EPR4.

Proteomic databases

MaxQBi Q9EPR4.
PaxDbi Q9EPR4.
PRIDEi Q9EPR4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028815 ; ENSMUSP00000028815 ; ENSMUSG00000027340 . [Q9EPR4-1 ]
GeneIDi 54338.
KEGGi mmu:54338.
UCSCi uc008mmi.1. mouse. [Q9EPR4-1 ]
uc008mmj.1. mouse. [Q9EPR4-2 ]

Organism-specific databases

CTDi 9962.
MGIi MGI:1859682. Slc23a2.
Rougei Search...

Phylogenomic databases

eggNOGi COG2233.
GeneTreei ENSGT00390000015686.
HOGENOMi HOG000038201.
HOVERGENi HBG056256.
InParanoidi Q9EPR4.
KOi K14611.
OMAi KHPTFFT.
OrthoDBi EOG7R56RZ.
PhylomeDBi Q9EPR4.
TreeFami TF313272.

Enzyme and pathway databases

Reactomei REACT_215258. Vitamin C (ascorbate) metabolism.

Miscellaneous databases

NextBioi 311116.
PROi Q9EPR4.
SOURCEi Search...

Gene expression databases

Bgeei Q9EPR4.
ExpressionAtlasi Q9EPR4. baseline and differential.
Genevestigatori Q9EPR4.

Family and domain databases

InterProi IPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view ]
PANTHERi PTHR11119. PTHR11119. 1 hit.
Pfami PF00860. Xan_ur_permease. 1 hit.
[Graphical view ]
PROSITEi PS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and genomic organization of the mouse gene slc23a1 encoding a vitamin C transporter."
    Gispert S., Dutra A., Lieberman A., Friedlich D., Nussbaum R.L.
    DNA Res. 7:339-345(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: 129/SvEv.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryo.
  6. "Mouse sodium dependent vitamin C transporter 2 (mSVCT2)."
    Fujita I., Hirano J., Tanaka K.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-647 (ISOFORM 1).
    Tissue: Brain.
  7. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 108-648 (ISOFORM 1).
    Tissue: Brain.
  8. "Upregulation of sodium-dependent vitamin C transporter 2 expression in adrenals increases norepinephrine production and aggravates hyperlipidemia in mice with streptozotocin-induced diabetes."
    Wu X., Iguchi T., Hirano J., Fujita I., Ueda H., Itoh N., Tanaka K., Nakanishi T.
    Biochem. Pharmacol. 74:1020-1028(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DISEASE.
  9. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; SER-78; THR-79; SER-81 AND THR-647, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS23A2_MOUSE
AccessioniPrimary (citable) accession number: Q9EPR4
Secondary accession number(s): Q80Y23, Q8C327, Q9JM78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: September 22, 2009
Last modified: October 29, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3