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Protein

Solute carrier family 23 member 2

Gene

Slc23a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate (By similarity).By similarity

GO - Molecular functioni

  • L-ascorbate:sodium symporter activity Source: MGI
  • L-ascorbic acid transmembrane transporter activity Source: UniProtKB
  • sodium-dependent L-ascorbate transmembrane transporter activity Source: MGI

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-MMU-196836 Vitamin C (ascorbate) metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 23 member 2
Alternative name(s):
Na(+)/L-ascorbic acid transporter 2
Sodium-dependent vitamin C transporter 2
Short name:
SVCT-2
Short name:
mSVCT2
Yolk sac permease-like molecule 2
Gene namesi
Name:Slc23a2
Synonyms:Kiaa0238, Svct2, Yspl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1859682 Slc23a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini9 – 110CytoplasmicSequence analysisAdd BLAST102
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 139ExtracellularSequence analysis8
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161CytoplasmicSequence analysis1
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 216ExtracellularSequence analysisAdd BLAST34
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 264CytoplasmicSequence analysisAdd BLAST27
Transmembranei265 – 282HelicalSequence analysisAdd BLAST18
Topological domaini283 – 286ExtracellularSequence analysis4
Intramembranei287 – 300HelicalSequence analysisAdd BLAST14
Topological domaini301 – 307ExtracellularSequence analysis7
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 369CytoplasmicSequence analysisAdd BLAST41
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391 – 415ExtracellularSequence analysisAdd BLAST25
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Topological domaini437 – 459CytoplasmicSequence analysisAdd BLAST23
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Topological domaini481 – 483ExtracellularSequence analysis3
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 514CytoplasmicSequence analysis10
Transmembranei515 – 535HelicalSequence analysisAdd BLAST21
Topological domaini536 – 545ExtracellularSequence analysis10
Transmembranei546 – 566HelicalSequence analysisAdd BLAST21
Topological domaini567 – 648CytoplasmicSequence analysisAdd BLAST82

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Elevated expression levels in the adrenals of diabetic mice.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659791 – 648Solute carrier family 23 member 2Add BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70PhosphoserineCombined sources1
Modified residuei75PhosphothreonineBy similarity1
Modified residuei78PhosphoserineCombined sources1
Modified residuei79PhosphothreonineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei647PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9EPR4
PaxDbiQ9EPR4
PeptideAtlasiQ9EPR4
PRIDEiQ9EPR4

PTM databases

iPTMnetiQ9EPR4
PhosphoSitePlusiQ9EPR4
SwissPalmiQ9EPR4

Expressioni

Tissue specificityi

Expressed in metabolically active and specialized tissues, including high expression in brain and adrenals. Detected in a wide range of tissues. Expression in kidney is almost undetectable.1 Publication

Gene expression databases

BgeeiENSMUSG00000027340
ExpressionAtlasiQ9EPR4 baseline and differential
GenevisibleiQ9EPR4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028815

Structurei

3D structure databases

ProteinModelPortaliQ9EPR4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1292 Eukaryota
COG2233 LUCA
GeneTreeiENSGT00390000015686
HOGENOMiHOG000038201
HOVERGENiHBG056256
InParanoidiQ9EPR4
KOiK14611
OMAiMGVGKNT
OrthoDBiEOG091G063Y
PhylomeDBiQ9EPR4
TreeFamiTF313272

Family and domain databases

InterProiView protein in InterPro
IPR029956 SlC23A2
IPR006042 Xan_ur_permease
IPR006043 Xant/urac/vitC
PANTHERiPTHR11119:SF33 PTHR11119:SF33, 1 hit
PfamiView protein in Pfam
PF00860 Xan_ur_permease, 1 hit
PROSITEiView protein in PROSITE
PS01116 XANTH_URACIL_PERMASE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9EPR4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMGIGKNTAS KSVEAGGSTE GKYEEEAKHS NFFTLPVVIN GGATSSGEQD
60 70 80 90 100
NEDTELMAIY TTENGIAEKS SLAETLDSTG SLDPQRSDMI YTIEDVPPWY
110 120 130 140 150
LCIFLGLQHY LTCFSGTIAV PFLLADAMCV GDDQWATSQL IGTIFFCVGI
160 170 180 190 200
TTLLQTTFGC RLPLFQASAF AFLAPARAIL SLDKWKCNTT EITVANGTAE
210 220 230 240 250
LLEHIWHPRI QEIQGAIIMS SLIEVVIGLL GLPGALLRYI GPLTITPTVA
260 270 280 290 300
LIGLSGFQAA GERAGKHWGI AMLTIFLVLL FSQYARNVKF PLPIYKSKKG
310 320 330 340 350
WTAYKFQLFK MFPIILAILV SWLLCFIFTV TDVFPSNSTD YGYYARTDAR
360 370 380 390 400
KGVLLVAPWF KVPYPFQWGM PTVSAAGVIG MLSAVVASII ESIGDYYACA
410 420 430 440 450
RLSCAPPPPI HAINRGIFVE GLSCVLDGIF GTGNGSTSSS PNIGVLGITK
460 470 480 490 500
VGSRRVIQYG AALMLGLGMV GKFSALFASL PDPVLGALFC TLFGMITAVG
510 520 530 540 550
LSNLQFIDLN SSRNLFVLGF SIFFGLVLPS YLRQNPLVTG ITGIDQILNV
560 570 580 590 600
LLTTAMFVGG CVAFILDNTI PGTPEERGIK KWKKGVSKGS KSLDGMESYN
610 620 630 640
LPFGMNIIKK YRCFSYLPIS PTFAGYTWKG FGKSENSRSS DKDSQATV
Length:648
Mass (Da):70,049
Last modified:September 22, 2009 - v2
Checksum:i2590BB11B2A257CB
GO
Isoform 2 (identifier: Q9EPR4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-272: LPLFQASAFA...RAGKHWGIAM → DYSCQWNGRA...SLVEYLKQSH
     273-648: Missing.

Note: No experimental confirmation available.
Show »
Length:272
Mass (Da):30,188
Checksum:i1C8D45706B56F5BC
GO

Sequence cautioni

The sequence AAG02252 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA90751 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC65509 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007367162 – 272LPLFQ…WGIAM → DYSCQWNGRAVGTHLASPNP RDPGGYHHVLTDRSGHWPPW PAWGSAEVYWTLDHHTHRGP HWPLWFPGSRRESRKALGHC HAVSVLRELQGWGTIFTTMW DSLVEYLKQSH in isoform 2. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_007368273 – 648Missing in isoform 2. 1 PublicationAdd BLAST376

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY004874 mRNA Translation: AAG02252.1 Different initiation.
AK087175 mRNA Translation: BAC39819.1
AL831706 Genomic DNA Translation: CAM26800.1
CH466519 Genomic DNA Translation: EDL28341.1
BC050823 mRNA Translation: AAH50823.1
AB038145 mRNA Translation: BAA90751.1 Different initiation.
AK122227 Transcribed RNA Translation: BAC65509.1 Sequence problems.
CCDSiCCDS16769.1 [Q9EPR4-1]
RefSeqiNP_061294.2, NM_018824.2 [Q9EPR4-1]
XP_006499969.1, XM_006499906.3 [Q9EPR4-1]
XP_006499970.1, XM_006499907.3 [Q9EPR4-1]
XP_011238000.1, XM_011239698.2 [Q9EPR4-1]
XP_017174620.1, XM_017319131.1
UniGeneiMm.103581

Genome annotation databases

EnsembliENSMUST00000028815; ENSMUSP00000028815; ENSMUSG00000027340 [Q9EPR4-1]
GeneIDi54338
KEGGimmu:54338
UCSCiuc008mmi.1 mouse [Q9EPR4-1]
uc008mmj.1 mouse [Q9EPR4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS23A2_MOUSE
AccessioniPrimary (citable) accession number: Q9EPR4
Secondary accession number(s): Q80Y23, Q8C327, Q9JM78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: September 22, 2009
Last modified: May 23, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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