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Protein

StAR-related lipid transfer protein 5

Gene

Stard5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-196108. Pregnenolone biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
StAR-related lipid transfer protein 5
Alternative name(s):
START domain-containing protein 5
Short name:
StARD5
Gene namesi
Name:Stard5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2156765. Stard5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213StAR-related lipid transfer protein 5PRO_0000220670Add
BLAST

Proteomic databases

EPDiQ9EPQ7.
MaxQBiQ9EPQ7.
PaxDbiQ9EPQ7.
PRIDEiQ9EPQ7.

PTM databases

iPTMnetiQ9EPQ7.

Expressioni

Tissue specificityi

Expressed in most tissues, with highest levels in liver and in kidney.

Gene expression databases

BgeeiQ9EPQ7.
ExpressionAtlasiQ9EPQ7. baseline and differential.
GenevisibleiQ9EPQ7. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9EPQ7. 3 interactions.
MINTiMINT-4135783.
STRINGi10090.ENSMUSP00000074872.

Structurei

3D structure databases

ProteinModelPortaliQ9EPQ7.
SMRiQ9EPQ7. Positions 4-212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 213213STARTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 START domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3845. Eukaryota.
ENOG41100B5. LUCA.
GeneTreeiENSGT00530000063294.
HOGENOMiHOG000137345.
HOVERGENiHBG055194.
InParanoidiQ9EPQ7.
OMAiWRPSTEF.
OrthoDBiEOG7353XV.
PhylomeDBiQ9EPQ7.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000799. StAR-like.
IPR029868. StARD5.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PANTHERiPTHR12136:SF44. PTHR12136:SF44. 1 hit.
PfamiPF01852. START. 1 hit.
[Graphical view]
PRINTSiPR00978. STARPROTEIN.
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EPQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPSWATQES EAVAEKVLRY RRDASGWKKC REGNGVSISW RPSEEFPGNL
60 70 80 90 100
YRGEGILCGT PEEVWDCIKP VASGLREKWD DNVSSFEIVQ SITDMLCVSR
110 120 130 140 150
TSTPSAAMKL ISPRDFVDLV LVKKYEDGTI SSNATHVEHP LCPPKPGFVR
160 170 180 190 200
GFNHPCGCFC EPLPGDPNKT NLVTFFQTDL SGYLPQSVVD SFFPRSMAEF
210
YPNLQKAVRK FHH
Length:213
Mass (Da):23,922
Last modified:November 15, 2002 - v2
Checksum:iB689F28F9D377209
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007808 mRNA. Translation: AAG41056.1.
AY007809 mRNA. Translation: AAG41057.1.
AF480302 mRNA. Translation: AAL89652.1.
AK009980 mRNA. Translation: BAB26624.2.
AK080060 mRNA. Translation: BAC37819.1.
AK085852 mRNA. Translation: BAC39551.1.
AK142503 mRNA. Translation: BAE25090.1.
AK158178 mRNA. Translation: BAE34395.1.
BC058226 mRNA. Translation: AAH58226.1.
CCDSiCCDS21411.1.
RefSeqiNP_075866.2. NM_023377.4.
UniGeneiMm.357953.

Genome annotation databases

EnsembliENSMUST00000075418; ENSMUSP00000074872; ENSMUSG00000046027.
GeneIDi170460.
KEGGimmu:170460.
UCSCiuc009idq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007808 mRNA. Translation: AAG41056.1.
AY007809 mRNA. Translation: AAG41057.1.
AF480302 mRNA. Translation: AAL89652.1.
AK009980 mRNA. Translation: BAB26624.2.
AK080060 mRNA. Translation: BAC37819.1.
AK085852 mRNA. Translation: BAC39551.1.
AK142503 mRNA. Translation: BAE25090.1.
AK158178 mRNA. Translation: BAE34395.1.
BC058226 mRNA. Translation: AAH58226.1.
CCDSiCCDS21411.1.
RefSeqiNP_075866.2. NM_023377.4.
UniGeneiMm.357953.

3D structure databases

ProteinModelPortaliQ9EPQ7.
SMRiQ9EPQ7. Positions 4-212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9EPQ7. 3 interactions.
MINTiMINT-4135783.
STRINGi10090.ENSMUSP00000074872.

PTM databases

iPTMnetiQ9EPQ7.

Proteomic databases

EPDiQ9EPQ7.
MaxQBiQ9EPQ7.
PaxDbiQ9EPQ7.
PRIDEiQ9EPQ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075418; ENSMUSP00000074872; ENSMUSG00000046027.
GeneIDi170460.
KEGGimmu:170460.
UCSCiuc009idq.1. mouse.

Organism-specific databases

CTDi80765.
MGIiMGI:2156765. Stard5.

Phylogenomic databases

eggNOGiKOG3845. Eukaryota.
ENOG41100B5. LUCA.
GeneTreeiENSGT00530000063294.
HOGENOMiHOG000137345.
HOVERGENiHBG055194.
InParanoidiQ9EPQ7.
OMAiWRPSTEF.
OrthoDBiEOG7353XV.
PhylomeDBiQ9EPQ7.

Enzyme and pathway databases

ReactomeiR-MMU-196108. Pregnenolone biosynthesis.

Miscellaneous databases

ChiTaRSiStard5. mouse.
NextBioi370099.
PROiQ9EPQ7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EPQ7.
ExpressionAtlasiQ9EPQ7. baseline and differential.
GenevisibleiQ9EPQ7. MM.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000799. StAR-like.
IPR029868. StARD5.
IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PANTHERiPTHR12136:SF44. PTHR12136:SF44. 1 hit.
PfamiPF01852. START. 1 hit.
[Graphical view]
PRINTSiPR00978. STARPROTEIN.
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis."
    Wines M.E., Lee L., Katari M.S., Zhang L., DeRossi C., Shi Y., Perkins S., Feldman M., McCombie W.R., Holdener B.C.
    Genomics 72:88-98(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster / NIH.
  2. "The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6."
    Soccio R.E., Adams R.M., Romanowski M.J., Sehayek E., Burley S.K., Breslow J.L.
    Proc. Natl. Acad. Sci. U.S.A. 99:6943-6948(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Liver.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Aorta, Heart, Inner ear, Kidney, Tongue and Vein.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney and Liver.

Entry informationi

Entry nameiSTAR5_MOUSE
AccessioniPrimary (citable) accession number: Q9EPQ7
Secondary accession number(s): Q9CQY0, Q9EPQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: March 16, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.