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Protein

X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

Gene

Rpgrip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells.1 Publication

GO - Biological processi

  • eye photoreceptor cell development Source: MGI
  • neural precursor cell proliferation Source: MGI
  • response to stimulus Source: UniProtKB-KW
  • retina development in camera-type eye Source: MGI
  • visual perception Source: MGI
Complete GO annotation...

Keywords - Biological processi

Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1
Short name:
RPGR-interacting protein 1
Gene namesi
Name:Rpgrip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1932134. Rpgrip1.

Subcellular locationi

GO - Cellular componenti

  • axoneme Source: MGI
  • cilium Source: MGI
  • nonmotile primary cilium Source: MGI
  • photoreceptor connecting cilium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Disruption phenotypei

Mutant mice are born at the expected Mendelian rate, appear healthy and are fertile. They have initially a complete set of photoreceptor cells in the retina, but the photreceptor cells present defects in the outer segments indicative of cell death, and loss of photoreceptor cells is almost complete after three months.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13311331X-linked retinitis pigmentosa GTPase regulator-interacting protein 1PRO_0000097433Add
BLAST

Proteomic databases

EPDiQ9EPQ2.
PaxDbiQ9EPQ2.
PRIDEiQ9EPQ2.

PTM databases

PhosphoSiteiQ9EPQ2.

Expressioni

Tissue specificityi

Colocalizes with RGPR in the photoreceptor connecting cilium, a thin bridge linking the cell body and the light-sensing outer segment (at protein level).3 Publications

Gene expression databases

BgeeiQ9EPQ2.
ExpressionAtlasiQ9EPQ2. baseline and differential.
GenevisibleiQ9EPQ2. MM.

Interactioni

Subunit structurei

Interacts with NPHP4. Interacts with NEK4 (By similarity). Forms homodimers and elongated homopolymers. Interacts with RPGR. Interacts with SPATA7 (PubMed:25398945).By similarity3 Publications

Protein-protein interaction databases

BioGridi219040. 2 interactions.
STRINGi10090.ENSMUSP00000107230.

Structurei

3D structure databases

ProteinModelPortaliQ9EPQ2.
SMRiQ9EPQ2. Positions 1142-1328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini750 – 854105C2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1136 – 1326191Interaction with RPGRBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili236 – 352117Sequence analysisAdd
BLAST
Coiled coili498 – 54649Sequence analysisAdd
BLAST
Coiled coili908 – 99992Sequence analysisAdd
BLAST

Domaini

The C2 domain does not bind calcium ions, and does not bind phosphoinositides.By similarity

Sequence similaritiesi

Belongs to the RPGRIP1 family.Curated
Contains 1 C2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGZN. Eukaryota.
ENOG410YNUX. LUCA.
GeneTreeiENSGT00520000055620.
HOGENOMiHOG000154182.
HOVERGENiHBG060744.
InParanoidiQ9EPQ2.
KOiK16512.
OMAiLEAMMTK.
OrthoDBiEOG77Q4VX.
PhylomeDBiQ9EPQ2.
TreeFamiTF328883.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR021656. C2-C2_1.
IPR000008. C2_dom.
IPR031134. RPGRIP1.
IPR031139. RPGRIP1_fam.
[Graphical view]
PANTHERiPTHR14240. PTHR14240. 1 hit.
PTHR14240:SF3. PTHR14240:SF3. 1 hit.
PfamiPF00168. C2. 1 hit.
PF11618. C2-C2_1. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9EPQ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQHLLEYMPE DLPVRDTDSS PLLKGTSGKN VRAQPHLGRM NQKELNCRRL
60 70 80 90 100
HLHEEPTLVK EPSPKQRDKN RRRRTNVQRS TTTQPDLRTL AVLQEPERRR
110 120 130 140 150
RPWVSASPSP SAPPRAPVPG RKAHVQRLCP STAVGSAQPR VHAGRRLPHI
160 170 180 190 200
AGPNDRRSHT APPAFKDYVA DKNTRIEITR EPSQLTHTMT TDSTHVEEIP
210 220 230 240 250
RSPEKTSKVE KPEQRSSEEC TQKAAELRAS IKENVELIRL KKLLQERNTS
260 270 280 290 300
LAATEAQLTR VQEAYEDLLQ KNQGILDTAH NAFLSQVNEL KAELSEESKK
310 320 330 340 350
AVSLRTQLGD VSILQITLKE FQVRVEDLEK ERKLLSDSYD RLLENMLDSS
360 370 380 390 400
HQPLDSSHQP HWSTELTGKQ LPPQVCPLLD QMGTALEETK VFRQATNKAA
410 420 430 440 450
QDGKLKFQDT DILYQHEQEE ESLQSTATVA SSPEELCELA AQPTLLPQTD
460 470 480 490 500
QRESSEPKAQ DENDLSQVLS ELQVSHAETT LELEKTRDML LLQRKINMCY
510 520 530 540 550
QEELEATLTK ADRENRDHEE KLERLNHLLD FKNSRIKQLE GILRSHGLPT
560 570 580 590 600
SEQLKDVAYG TLPPSLCLEP LAAHRGDDEV DMSLLHPSEN LFELHVHQAF
610 620 630 640 650
LTPAALTQAG DTQPTTFCTY SFYDFETHCT PLSTGPQPLY DFTSQYVVQA
660 670 680 690 700
DYLLLHYLQG TSVRLDLHQA MASEYHVLAT GWISLDKVLG TVERVHGLAT
710 720 730 740 750
LAGAGGEDLG VLEYWMRLCL PLKPSLQACN KRKKAQAYLS VSVLGARKVQ
760 770 780 790 800
SNESRSETWA PQNELRVEIT RCCGLRSRRL GRQPSPYVMY RFFTFPDHDT
810 820 830 840 850
IIIPASSNPY FKDQALFPVL VTSDLDQYLR REALSVYVFD DEDPEPGSYL
860 870 880 890 900
GRAQVPLLPL AQNKSIKGDF NLTDSGEKSN GSIKVQLDWK SHYLAPEGFQ
910 920 930 940 950
MSEAEKPEGE EKEEEGGEEE VKEEEVEEEE EEEEEEEEVK EEKEEEEEEE
960 970 980 990 1000
REEEEEKEEE KEEEEEEDEK EEEEEEEEEE EEEEEDENKD VLEASFTEEW
1010 1020 1030 1040 1050
VPFFSQDQIA STEIPIEAGQ YPEKRKPPVI AEKKEREHQV ASYSRRKHSK
1060 1070 1080 1090 1100
KPGVQDKNRM EYLSCNILNG NTQQMHYTEW KFSGLKKAED GGLKAQDKRE
1110 1120 1130 1140 1150
EPPSPRSALR QEHPSHPRNA FSLADQESCE QASEVSETQT TDSDDIIVTP
1160 1170 1180 1190 1200
QAQTVPKADS EKMCIEIVSL AFCPEADVMS DETIQQVYVE YKFCDLPLSE
1210 1220 1230 1240 1250
TETPMSLRKP RAGEEIHFHF SKVIDLDPVE HQSRRQFLFA MLHAQDSDEG
1260 1270 1280 1290 1300
RFKFTVVSDP LDEEKKECQD IGYAYLELWQ IFQSGKDILE QELEIVSPRN
1310 1320 1330
QAIQIGRLKV SLQAAAALHG IYKEMTEDLF S
Length:1,331
Mass (Da):151,996
Last modified:March 1, 2001 - v1
Checksum:iAEDA7F33750D593E
GO
Isoform 2 (identifier: Q9EPQ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     399-399: Missing.
     552-554: EQL → GKS
     555-1331: Missing.

Show »
Length:553
Mass (Da):62,963
Checksum:i3BC001461F109746
GO
Isoform 3 (identifier: Q9EPQ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-319: Missing.
     320-345: EFQVRVEDLEKERKLLSDSYDRLLEN → MLKLCNKDAGSYSFEDPSDTEPGVFS
     399-399: Missing.
     552-867: Missing.

Show »
Length:695
Mass (Da):80,026
Checksum:iA29EA1E45C263F6B
GO
Isoform 4 (identifier: Q9EPQ2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-319: Missing.
     320-345: EFQVRVEDLEKERKLLSDSYDRLLEN → MLKLCNKDAGSYSFEDPSDTEPGVFS
     541-867: Missing.

Show »
Length:685
Mass (Da):78,977
Checksum:iB54B3C39E11BB587
GO
Isoform 5 (identifier: Q9EPQ2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1074: Missing.

Show »
Length:257
Mass (Da):29,286
Checksum:i1B9D4EE6787784AA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti921 – 9211V → A in BAB29938 (PubMed:16141072).Curated
Sequence conflicti1096 – 10961Q → H in BAB29685 (PubMed:16141072).Curated
Sequence conflicti1156 – 11561P → L in BAB29685 (PubMed:16141072).Curated
Sequence conflicti1197 – 11971P → S in BAB29685 (PubMed:16141072).Curated
Sequence conflicti1204 – 12041P → S in BAB29685 (PubMed:16141072).Curated
Sequence conflicti1210 – 12112PR → LM in BAB29685 (PubMed:16141072).Curated
Sequence conflicti1219 – 12191H → Y in BAB29685 (PubMed:16141072).Curated
Sequence conflicti1222 – 12221K → N in BAB29685 (PubMed:16141072).Curated
Sequence conflicti1252 – 12521F → V in BAB29685 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 10741074Missing in isoform 5. 1 PublicationVSP_009529Add
BLAST
Alternative sequencei1 – 319319Missing in isoform 3 and isoform 4. 1 PublicationVSP_009528Add
BLAST
Alternative sequencei320 – 34526EFQVR…RLLEN → MLKLCNKDAGSYSFEDPSDT EPGVFS in isoform 3 and isoform 4. 1 PublicationVSP_009530Add
BLAST
Alternative sequencei399 – 3991Missing in isoform 2 and isoform 3. 2 PublicationsVSP_009531
Alternative sequencei541 – 867327Missing in isoform 4. 1 PublicationVSP_009533Add
BLAST
Alternative sequencei552 – 867316Missing in isoform 3. 1 PublicationVSP_009534Add
BLAST
Alternative sequencei552 – 5543EQL → GKS in isoform 2. 1 PublicationVSP_009532
Alternative sequencei555 – 1331777Missing in isoform 2. 1 PublicationVSP_009535Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008297 mRNA. Translation: AAG22857.1.
AK015037 mRNA. Translation: BAB29685.1.
AK015701 mRNA. Translation: BAB29938.1.
AK029955 mRNA. Translation: BAC26697.1.
AK039097 mRNA. Translation: BAC30237.1.
BC016092 mRNA. Translation: AAH16092.1.
CCDSiCCDS36918.1. [Q9EPQ2-1]
RefSeqiNP_001161987.1. NM_001168515.1.
NP_076368.1. NM_023879.3. [Q9EPQ2-1]
XP_006519759.1. XM_006519696.2. [Q9EPQ2-3]
UniGeneiMm.21662.

Genome annotation databases

EnsembliENSMUST00000111603; ENSMUSP00000107230; ENSMUSG00000057132. [Q9EPQ2-1]
GeneIDi77945.
KEGGimmu:77945.
UCSCiuc007tok.2. mouse. [Q9EPQ2-1]
uc007ton.1. mouse. [Q9EPQ2-4]
uc007too.1. mouse. [Q9EPQ2-3]
uc011zkl.1. mouse. [Q9EPQ2-5]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008297 mRNA. Translation: AAG22857.1.
AK015037 mRNA. Translation: BAB29685.1.
AK015701 mRNA. Translation: BAB29938.1.
AK029955 mRNA. Translation: BAC26697.1.
AK039097 mRNA. Translation: BAC30237.1.
BC016092 mRNA. Translation: AAH16092.1.
CCDSiCCDS36918.1. [Q9EPQ2-1]
RefSeqiNP_001161987.1. NM_001168515.1.
NP_076368.1. NM_023879.3. [Q9EPQ2-1]
XP_006519759.1. XM_006519696.2. [Q9EPQ2-3]
UniGeneiMm.21662.

3D structure databases

ProteinModelPortaliQ9EPQ2.
SMRiQ9EPQ2. Positions 1142-1328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219040. 2 interactions.
STRINGi10090.ENSMUSP00000107230.

PTM databases

PhosphoSiteiQ9EPQ2.

Proteomic databases

EPDiQ9EPQ2.
PaxDbiQ9EPQ2.
PRIDEiQ9EPQ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111603; ENSMUSP00000107230; ENSMUSG00000057132. [Q9EPQ2-1]
GeneIDi77945.
KEGGimmu:77945.
UCSCiuc007tok.2. mouse. [Q9EPQ2-1]
uc007ton.1. mouse. [Q9EPQ2-4]
uc007too.1. mouse. [Q9EPQ2-3]
uc011zkl.1. mouse. [Q9EPQ2-5]

Organism-specific databases

CTDi57096.
MGIiMGI:1932134. Rpgrip1.

Phylogenomic databases

eggNOGiENOG410IGZN. Eukaryota.
ENOG410YNUX. LUCA.
GeneTreeiENSGT00520000055620.
HOGENOMiHOG000154182.
HOVERGENiHBG060744.
InParanoidiQ9EPQ2.
KOiK16512.
OMAiLEAMMTK.
OrthoDBiEOG77Q4VX.
PhylomeDBiQ9EPQ2.
TreeFamiTF328883.

Miscellaneous databases

ChiTaRSiRpgrip1. mouse.
NextBioi347867.
PROiQ9EPQ2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EPQ2.
ExpressionAtlasiQ9EPQ2. baseline and differential.
GenevisibleiQ9EPQ2. MM.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR021656. C2-C2_1.
IPR000008. C2_dom.
IPR031134. RPGRIP1.
IPR031139. RPGRIP1_fam.
[Graphical view]
PANTHERiPTHR14240. PTHR14240. 1 hit.
PTHR14240:SF3. PTHR14240:SF3. 1 hit.
PfamiPF00168. C2. 1 hit.
PF11618. C2-C2_1. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Retinitis pigmentosa GTPase regulator (RPGR)-interacting protein is stably associated with the photoreceptor ciliary axoneme and anchors RPGR to the connecting cilium."
    Hong D.H., Yue G., Adamian M., Li T.
    J. Biol. Chem. 276:12091-12099(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH RPGR, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5).
    Strain: C57BL/6J.
    Tissue: Hypothalamus and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Eye and Retina.
  4. "Species-specific subcellular localization of RPGR and RPGRIP isoforms: implications for the phenotypic variability of congenital retinopathies among species."
    Mavlyutov T.A., Zhao H., Ferreira P.A.
    Hum. Mol. Genet. 11:1899-1907(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "The retinitis pigmentosa GTPase regulator (RPGR)-interacting protein: subserving RPGR function and participating in disk morphogenesis."
    Zhao Y., Hong D.-H., Pawlyk B., Yue G., Adamian M., Grynberg M., Godzik A., Li T.
    Proc. Natl. Acad. Sci. U.S.A. 100:3965-3970(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, SUBUNIT, TISSUE SPECIFICITY, INTERACTION WITH RPGR.
  6. Cited for: INTERACTION WITH SPATA7.

Entry informationi

Entry nameiRPGR1_MOUSE
AccessioniPrimary (citable) accession number: Q9EPQ2
Secondary accession number(s): Q8CAC2
, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.