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Q9EPQ1

- TLR1_MOUSE

UniProt

Q9EPQ1 - TLR1_MOUSE

Protein

Toll-like receptor 1

Gene

Tlr1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response By similarity.By similarity

    GO - Molecular functioni

    1. transmembrane signaling receptor activity Source: UniProtKB
    2. triacyl lipopeptide binding Source: UniProtKB

    GO - Biological processi

    1. activation of NF-kappaB-inducing kinase activity Source: UniProtKB
    2. cellular response to triacyl bacterial lipopeptide Source: Ensembl
    3. defense response Source: MGI
    4. detection of triacyl bacterial lipopeptide Source: UniProtKB
    5. inflammatory response Source: UniProtKB-KW
    6. innate immune response Source: UniProtKB-KW
    7. macrophage activation Source: UniProtKB
    8. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
    9. positive regulation of interleukin-6 biosynthetic process Source: UniProtKB
    10. positive regulation of tumor necrosis factor biosynthetic process Source: UniProtKB
    11. regulation of cytokine secretion Source: InterPro
    12. toll-like receptor 1 signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Immunity, Inflammatory response, Innate immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Toll-like receptor 1
    Alternative name(s):
    Toll/interleukin-1 receptor-like protein
    Short name:
    TIL
    CD_antigen: CD281
    Gene namesi
    Name:Tlr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1341295. Tlr1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: UniProtKB
    3. phagocytic vesicle Source: UniProtKB
    4. phagocytic vesicle membrane Source: UniProtKB-SubCell
    5. Toll-like receptor 1-Toll-like receptor 2 protein complex Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 795770Toll-like receptor 1PRO_0000034706Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi113 ↔ 135By similarity
    Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi226 ↔ 233By similarity
    Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi346 ↔ 371By similarity
    Disulfide bondi422 ↔ 445By similarity
    Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9EPQ1.

    PTM databases

    PhosphoSiteiQ9EPQ1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9EPQ1.
    BgeeiQ9EPQ1.
    CleanExiMM_TLR1.
    GenevestigatoriQ9EPQ1.

    Interactioni

    Subunit structurei

    Binds MYD88 (via TIR domains) By similarity. Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2 By similarity. Interacts with CNPY3.By similarity1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EPQ1.
    SMRiQ9EPQ1. Positions 29-580, 628-788.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 582557ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini604 – 795192CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei583 – 60321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati54 – 7724LRR 1Add
    BLAST
    Repeati78 – 10124LRR 2Add
    BLAST
    Repeati102 – 12524LRR 3Add
    BLAST
    Repeati126 – 15025LRR 4Add
    BLAST
    Repeati151 – 17525LRR 5Add
    BLAST
    Repeati176 – 19924LRR 6Add
    BLAST
    Repeati200 – 22324LRR 7Add
    BLAST
    Repeati224 – 25027LRR 8Add
    BLAST
    Repeati251 – 27828LRR 9Add
    BLAST
    Repeati279 – 30830LRR 10Add
    BLAST
    Repeati309 – 33729LRR 11Add
    BLAST
    Repeati338 – 36124LRR 12Add
    BLAST
    Repeati362 – 38827LRR 13Add
    BLAST
    Repeati389 – 41426LRR 14Add
    BLAST
    Repeati415 – 43723LRR 15Add
    BLAST
    Repeati438 – 45720LRR 16Add
    BLAST
    Repeati458 – 47821LRR 17Add
    BLAST
    Repeati479 – 50022LRR 18Add
    BLAST
    Repeati501 – 52424LRR 19Add
    BLAST
    Domaini524 – 57956LRRCTAdd
    BLAST
    Domaini638 – 782145TIRPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni316 – 3194Interaction with bacterial lipopeptideBy similarity

    Sequence similaritiesi

    Belongs to the Toll-like receptor family.Curated
    Contains 19 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 TIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG272762.
    GeneTreeiENSGT00700000104367.
    HOGENOMiHOG000008676.
    HOVERGENiHBG023180.
    InParanoidiQ9EPQ1.
    KOiK05398.
    OMAiKEFGNMS.
    OrthoDBiEOG7GN2M5.
    PhylomeDBiQ9EPQ1.
    TreeFamiTF351113.

    Family and domain databases

    Gene3Di3.40.50.10140. 1 hit.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR000157. TIR_dom.
    IPR027190. TLR1.
    IPR017241. Toll-like_receptor.
    [Graphical view]
    PANTHERiPTHR24365:SF261. PTHR24365:SF261. 1 hit.
    PfamiPF12799. LRR_4. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
    SMARTiSM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS51450. LRR. 10 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9EPQ1-1 [UniParc]FASTAAdd to Basket

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    MTKPNSLIFY CIIVLGLTLM KIQLSEECEL IIKRPNANLT RVPKDLPLQT    50
    TTLDLSQNNI SELQTSDILS LSKLRVLIMS YNRLQYLNIS VFKFNTELEY 100
    LDLSHNELKV ILCHPTVSLK HLDLSFNAFD ALPICKEFGN MSQLQFLGLS 150
    GSRVQSSSVQ LIAHLNISKV LLVLGDAYGE KEDPESLRHV STETLHIVFP 200
    SKREFRFLLD VSVSTTIGLE LSNIKCVLED QGCSYFLRAL SKLGKNLKLS 250
    NLTLNNVETT WNSFINILQI VWHTPVKYFS ISNVKLQGQL AFRMFNYSDT 300
    SLKALSIHQV VTDVFSFPQS YIYSIFANMN IQNFTMSGTH MVHMLCPSQV 350
    SPFLHVDFTD NLLTDMVFKD CRNLVRLKTL SLQKNQLKNL ENIILTSAKM 400
    TSLQKLDISQ NSLRYSDGGI PCAWTQSLLV LNLSSNMLTG SVFRCLPPKV 450
    KVLDLHNNRI MSIPKDVTHL QALQELNVAS NSLTDLPGCG AFSSLSVLVI 500
    DHNSVSHPSE DFFQSCQNIR SLTAGNNPFQ CTCELRDFVK NIGWVAREVV 550
    EGWPDSYRCD YPESSRGTAL RDFHMSPLSC DTVLLTVTIG ATMLVLAVTG 600
    AFLCLYFDLP WYVRMLCQWT QTRHRARHIP LEELQRNLQF HAFVSYSGHD 650
    SAWVKNELLP NLEKDDIQIC LHERNFVPGK SIVENIINFI EKSYKSIFVL 700
    SPHFIQSEWC HYELYFAHHN LFHEGSDNLI LILLAPIPQY SIPTNYHKLK 750
    TLMSRRTYLE WPTEKNKHGL FWANLRASIN VKLVNQAEGT CYTQQ 795
    Length:795
    Mass (Da):90,673
    Last modified:March 1, 2001 - v1
    Checksum:i855356429872D232
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti88 – 881N → D in AAG35062. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY009154 mRNA. Translation: AAG37302.1.
    AF316985 mRNA. Translation: AAG35062.1.
    CCDSiCCDS19302.1.
    RefSeqiNP_001263374.1. NM_001276445.1.
    NP_109607.1. NM_030682.2.
    XP_006503913.1. XM_006503850.1.
    XP_006503914.1. XM_006503851.1.
    XP_006503915.1. XM_006503852.1.
    XP_006503916.1. XM_006503853.1.
    XP_006503917.1. XM_006503854.1.
    XP_006503918.1. XM_006503855.1.
    XP_006503919.1. XM_006503856.1.
    UniGeneiMm.273024.

    Genome annotation databases

    EnsembliENSMUST00000059349; ENSMUSP00000060793; ENSMUSG00000044827.
    GeneIDi21897.
    KEGGimmu:21897.
    UCSCiuc008xmv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY009154 mRNA. Translation: AAG37302.1 .
    AF316985 mRNA. Translation: AAG35062.1 .
    CCDSi CCDS19302.1.
    RefSeqi NP_001263374.1. NM_001276445.1.
    NP_109607.1. NM_030682.2.
    XP_006503913.1. XM_006503850.1.
    XP_006503914.1. XM_006503851.1.
    XP_006503915.1. XM_006503852.1.
    XP_006503916.1. XM_006503853.1.
    XP_006503917.1. XM_006503854.1.
    XP_006503918.1. XM_006503855.1.
    XP_006503919.1. XM_006503856.1.
    UniGenei Mm.273024.

    3D structure databases

    ProteinModelPortali Q9EPQ1.
    SMRi Q9EPQ1. Positions 29-580, 628-788.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9EPQ1.

    Proteomic databases

    PRIDEi Q9EPQ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000059349 ; ENSMUSP00000060793 ; ENSMUSG00000044827 .
    GeneIDi 21897.
    KEGGi mmu:21897.
    UCSCi uc008xmv.1. mouse.

    Organism-specific databases

    CTDi 7096.
    MGIi MGI:1341295. Tlr1.

    Phylogenomic databases

    eggNOGi NOG272762.
    GeneTreei ENSGT00700000104367.
    HOGENOMi HOG000008676.
    HOVERGENi HBG023180.
    InParanoidi Q9EPQ1.
    KOi K05398.
    OMAi KEFGNMS.
    OrthoDBi EOG7GN2M5.
    PhylomeDBi Q9EPQ1.
    TreeFami TF351113.

    Miscellaneous databases

    NextBioi 301432.
    PROi Q9EPQ1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9EPQ1.
    Bgeei Q9EPQ1.
    CleanExi MM_TLR1.
    Genevestigatori Q9EPQ1.

    Family and domain databases

    Gene3Di 3.40.50.10140. 1 hit.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR000157. TIR_dom.
    IPR027190. TLR1.
    IPR017241. Toll-like_receptor.
    [Graphical view ]
    PANTHERi PTHR24365:SF261. PTHR24365:SF261. 1 hit.
    Pfami PF12799. LRR_4. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037595. Toll-like_receptor. 1 hit.
    SMARTi SM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS51450. LRR. 10 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors."
      Ozinsky A., Underhill D.M., Fontenot J.D., Hajjar A.M., Smith K.D., Wilson C.B., Schroeder L., Aderem A.
      Proc. Natl. Acad. Sci. U.S.A. 97:13766-13771(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Macrophage.
    2. "Functional interactions between Toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin."
      Hajjar A.M., O'Mahony D.S., Ozinsky A., Underhill D.M., Aderem A., Klebanoff S.J., Wilson C.B.
      J. Immunol. 166:15-19(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Macrophage.
    3. "Cloning of Mus musculus Toll-like receptor 1."
      Thomson D.P., Campbell C.C., Liew F.Y., Xu D.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Spleen.
    4. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 681-692, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    5. "A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses."
      Takahashi K., Shibata T., Akashi-Takamura S., Kiyokawa T., Wakabayashi Y., Tanimura N., Kobayashi T., Matsumoto F., Fukui R., Kouro T., Nagai Y., Takatsu K., Saitoh S., Miyake K.
      J. Exp. Med. 204:2963-2976(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CNPY3.

    Entry informationi

    Entry nameiTLR1_MOUSE
    AccessioniPrimary (citable) accession number: Q9EPQ1
    Secondary accession number(s): Q9EPW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3