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Q9EPQ1 (TLR1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Toll-like receptor 1
Alternative name(s):
Toll/interleukin-1 receptor-like protein
Short name=TIL
CD_antigen=CD281
Gene names
Name:Tlr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length795 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response By similarity.

Subunit structure

Binds MYD88 (via TIR domains) By similarity. Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2 By similarity. Interacts with CNPY3. Ref.5

Subcellular location

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle › phagosome membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the Toll-like receptor family.

Contains 19 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 TIR domain.

Ontologies

Keywords
   Biological processImmunity
Inflammatory response
Innate immunity
   Cellular componentCell membrane
Cytoplasmic vesicle
Membrane
   DomainLeucine-rich repeat
Repeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processMyD88-dependent toll-like receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

activation of NF-kappaB-inducing kinase activity

Non-traceable author statement PubMed 12077222. Source: UniProtKB

cellular response to triacyl bacterial lipopeptide

Inferred from electronic annotation. Source: Compara

defense response

Inferred from mutant phenotype PubMed 12091878. Source: MGI

detection of triacyl bacterial lipopeptide

Non-traceable author statement PubMed 12077222. Source: UniProtKB

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

innate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

macrophage activation

Non-traceable author statement Ref.1. Source: UniProtKB

positive regulation of interleukin-6 biosynthetic process

Inferred from mutant phenotype PubMed 12077222. Source: UniProtKB

positive regulation of tumor necrosis factor biosynthetic process

Inferred from mutant phenotype PubMed 12077222. Source: UniProtKB

regulation of cytokine secretion

Inferred from electronic annotation. Source: InterPro

toll-like receptor 1 signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular_componentToll-like receptor 1-Toll-like receptor 2 protein complex

Inferred from electronic annotation. Source: Compara

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Non-traceable author statement PubMed 11081518. Source: UniProtKB

phagocytic vesicle

Non-traceable author statement Ref.1. Source: UniProtKB

phagocytic vesicle membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontransmembrane signaling receptor activity

Non-traceable author statement PubMed 11081518. Source: UniProtKB

triacyl lipopeptide binding

Non-traceable author statement PubMed 12077222. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 795770Toll-like receptor 1
PRO_0000034706

Regions

Topological domain26 – 582557Extracellular Potential
Transmembrane583 – 60321Helical; Potential
Topological domain604 – 795192Cytoplasmic Potential
Repeat54 – 7724LRR 1
Repeat78 – 10124LRR 2
Repeat102 – 12524LRR 3
Repeat126 – 15025LRR 4
Repeat151 – 17525LRR 5
Repeat176 – 19924LRR 6
Repeat200 – 22324LRR 7
Repeat224 – 25027LRR 8
Repeat251 – 27828LRR 9
Repeat279 – 30830LRR 10
Repeat309 – 33729LRR 11
Repeat338 – 36124LRR 12
Repeat362 – 38827LRR 13
Repeat389 – 41426LRR 14
Repeat415 – 43723LRR 15
Repeat438 – 45720LRR 16
Repeat458 – 47821LRR 17
Repeat479 – 50022LRR 18
Repeat501 – 52424LRR 19
Domain524 – 57956LRRCT
Domain638 – 782145TIR
Region316 – 3194Interaction with bacterial lipopeptide By similarity

Amino acid modifications

Glycosylation381N-linked (GlcNAc...) Potential
Glycosylation591N-linked (GlcNAc...) Potential
Glycosylation881N-linked (GlcNAc...) Potential
Glycosylation1401N-linked (GlcNAc...) Potential
Glycosylation1661N-linked (GlcNAc...) Potential
Glycosylation2511N-linked (GlcNAc...) Potential
Glycosylation2961N-linked (GlcNAc...) Potential
Glycosylation3331N-linked (GlcNAc...) Potential
Glycosylation4321N-linked (GlcNAc...) Potential
Disulfide bond113 ↔ 135 By similarity
Disulfide bond226 ↔ 233 By similarity
Disulfide bond346 ↔ 371 By similarity
Disulfide bond422 ↔ 445 By similarity

Experimental info

Sequence conflict881N → D in AAG35062. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9EPQ1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 855356429872D232

FASTA79590,673
        10         20         30         40         50         60 
MTKPNSLIFY CIIVLGLTLM KIQLSEECEL IIKRPNANLT RVPKDLPLQT TTLDLSQNNI 

        70         80         90        100        110        120 
SELQTSDILS LSKLRVLIMS YNRLQYLNIS VFKFNTELEY LDLSHNELKV ILCHPTVSLK 

       130        140        150        160        170        180 
HLDLSFNAFD ALPICKEFGN MSQLQFLGLS GSRVQSSSVQ LIAHLNISKV LLVLGDAYGE 

       190        200        210        220        230        240 
KEDPESLRHV STETLHIVFP SKREFRFLLD VSVSTTIGLE LSNIKCVLED QGCSYFLRAL 

       250        260        270        280        290        300 
SKLGKNLKLS NLTLNNVETT WNSFINILQI VWHTPVKYFS ISNVKLQGQL AFRMFNYSDT 

       310        320        330        340        350        360 
SLKALSIHQV VTDVFSFPQS YIYSIFANMN IQNFTMSGTH MVHMLCPSQV SPFLHVDFTD 

       370        380        390        400        410        420 
NLLTDMVFKD CRNLVRLKTL SLQKNQLKNL ENIILTSAKM TSLQKLDISQ NSLRYSDGGI 

       430        440        450        460        470        480 
PCAWTQSLLV LNLSSNMLTG SVFRCLPPKV KVLDLHNNRI MSIPKDVTHL QALQELNVAS 

       490        500        510        520        530        540 
NSLTDLPGCG AFSSLSVLVI DHNSVSHPSE DFFQSCQNIR SLTAGNNPFQ CTCELRDFVK 

       550        560        570        580        590        600 
NIGWVAREVV EGWPDSYRCD YPESSRGTAL RDFHMSPLSC DTVLLTVTIG ATMLVLAVTG 

       610        620        630        640        650        660 
AFLCLYFDLP WYVRMLCQWT QTRHRARHIP LEELQRNLQF HAFVSYSGHD SAWVKNELLP 

       670        680        690        700        710        720 
NLEKDDIQIC LHERNFVPGK SIVENIINFI EKSYKSIFVL SPHFIQSEWC HYELYFAHHN 

       730        740        750        760        770        780 
LFHEGSDNLI LILLAPIPQY SIPTNYHKLK TLMSRRTYLE WPTEKNKHGL FWANLRASIN 

       790 
VKLVNQAEGT CYTQQ

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References

[1]"The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors."
Ozinsky A., Underhill D.M., Fontenot J.D., Hajjar A.M., Smith K.D., Wilson C.B., Schroeder L., Aderem A.
Proc. Natl. Acad. Sci. U.S.A. 97:13766-13771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Macrophage.
[2]"Functional interactions between Toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin."
Hajjar A.M., O'Mahony D.S., Ozinsky A., Underhill D.M., Aderem A., Klebanoff S.J., Wilson C.B.
J. Immunol. 166:15-19(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Macrophage.
[3]"Cloning of Mus musculus Toll-like receptor 1."
Thomson D.P., Campbell C.C., Liew F.Y., Xu D.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Spleen.
[4]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 681-692, MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
[5]"A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses."
Takahashi K., Shibata T., Akashi-Takamura S., Kiyokawa T., Wakabayashi Y., Tanimura N., Kobayashi T., Matsumoto F., Fukui R., Kouro T., Nagai Y., Takatsu K., Saitoh S., Miyake K.
J. Exp. Med. 204:2963-2976(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CNPY3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY009154 mRNA. Translation: AAG37302.1.
AF316985 mRNA. Translation: AAG35062.1.
IPIIPI00110218.
RefSeqNP_001263374.1. NM_001276445.1.
NP_109607.1. NM_030682.2.
UniGeneMm.273024.

3D structure databases

ProteinModelPortalQ9EPQ1.
SMRQ9EPQ1. Positions 29-576, 628-788.
ModBaseSearch...

PTM databases

PhosphoSiteQ9EPQ1.

Proteomic databases

PRIDEQ9EPQ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000059349; ENSMUSP00000060793; ENSMUSG00000044827.
GeneID21897.
KEGGmmu:21897.

Organism-specific databases

CTD7096.
MGIMGI:1341295. Tlr1.

Phylogenomic databases

eggNOGNOG272762.
GeneTreeENSGT00700000104367.
HOGENOMHOG000008676.
HOVERGENHBG023180.
InParanoidQ9EPQ1.
KOK05398.
OMANNIETTW.
OrthoDBEOG4SBDXJ.

Gene expression databases

ArrayExpressQ9EPQ1.
BgeeQ9EPQ1.
CleanExMM_TLR1.
GenevestigatorQ9EPQ1.
GermOnlineENSMUSG00000044827. Mus musculus.

Family and domain databases

InterProIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR000157. TIR_dom.
IPR027190. TLR1.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERPTHR24365:SF23. PTHR24365:SF23. 1 hit.
PfamPF12799. LRR_4. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFPIRSF037595. Toll-like_receptor. 1 hit.
SMARTSM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMSSF52200. TIR. 1 hit.
PROSITEPS51450. LRR. 10 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio301432.
SOURCESearch...

Entry information

Entry nameTLR1_MOUSE
AccessionPrimary (citable) accession number: Q9EPQ1
Secondary accession number(s): Q9EPW5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: March 1, 2001
Last modified: May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents