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Protein

Toll-like receptor 1

Gene

Tlr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Acts as a coreceptor for M.tuberculosis lipoproteins LprG, LpqH and PhoS1 (pstS1), in conjunction with TLR2 and for some but not all lipoproteins CD14 and/or CD36. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712).By similarity1 Publication

GO - Molecular functioni

  • lipopeptide binding Source: GO_Central
  • protein heterodimerization activity Source: MGI
  • Toll-like receptor 2 binding Source: MGI
  • transmembrane signaling receptor activity Source: UniProtKB
  • triacyl lipopeptide binding Source: UniProtKB

GO - Biological processi

  • activation of NF-kappaB-inducing kinase activity Source: UniProtKB
  • cellular response to diacyl bacterial lipopeptide Source: GO_Central
  • cellular response to triacyl bacterial lipopeptide Source: UniProtKB
  • defense response Source: MGI
  • defense response to bacterium Source: GO_Central
  • detection of triacyl bacterial lipopeptide Source: UniProtKB
  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • macrophage activation Source: UniProtKB
  • MyD88-dependent toll-like receptor signaling pathway Source: InterPro
  • positive regulation of interleukin-6 biosynthetic process Source: UniProtKB
  • positive regulation of tumor necrosis factor biosynthetic process Source: UniProtKB
  • regulation of cytokine secretion Source: InterPro
  • toll-like receptor 1 signaling pathway Source: InterPro
  • toll-like receptor signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-1461957. Beta defensins.
R-MMU-5686938. Regulation of TLR by endogenous ligand.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 1
Alternative name(s):
Toll/interleukin-1 receptor-like protein
Short name:
TIL
CD_antigen: CD281
Gene namesi
Name:Tlr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1341295. Tlr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 582ExtracellularSequence analysisAdd BLAST557
Transmembranei583 – 603HelicalSequence analysisAdd BLAST21
Topological domaini604 – 795CytoplasmicSequence analysisAdd BLAST192

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003470626 – 795Toll-like receptor 1Add BLAST770

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...)Sequence analysis1
Glycosylationi59N-linked (GlcNAc...)Sequence analysis1
Glycosylationi88N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi113 ↔ 135By similarity
Glycosylationi140N-linked (GlcNAc...)Sequence analysis1
Glycosylationi166N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi226 ↔ 233By similarity
Glycosylationi251N-linked (GlcNAc...)Sequence analysis1
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1
Glycosylationi333N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi346 ↔ 371By similarity
Disulfide bondi422 ↔ 445By similarity
Glycosylationi432N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9EPQ1.
PaxDbiQ9EPQ1.
PRIDEiQ9EPQ1.

PTM databases

iPTMnetiQ9EPQ1.
PhosphoSitePlusiQ9EPQ1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044827.
CleanExiMM_TLR1.
ExpressionAtlasiQ9EPQ1. baseline and differential.
GenevisibleiQ9EPQ1. MM.

Interactioni

Subunit structurei

Interacts (via extracellular domain) with TLR2. TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36 (By similarity). Binds MYD88 (via TIR domain). Interacts with CNPY3 (PubMed:17998391).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060793.

Structurei

3D structure databases

ProteinModelPortaliQ9EPQ1.
SMRiQ9EPQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati54 – 77LRR 1Add BLAST24
Repeati78 – 101LRR 2Add BLAST24
Repeati102 – 125LRR 3Add BLAST24
Repeati126 – 150LRR 4Add BLAST25
Repeati151 – 175LRR 5Add BLAST25
Repeati176 – 199LRR 6Add BLAST24
Repeati200 – 223LRR 7Add BLAST24
Repeati224 – 250LRR 8Add BLAST27
Repeati251 – 278LRR 9Add BLAST28
Repeati279 – 308LRR 10Add BLAST30
Repeati309 – 337LRR 11Add BLAST29
Repeati338 – 361LRR 12Add BLAST24
Repeati362 – 388LRR 13Add BLAST27
Repeati389 – 414LRR 14Add BLAST26
Repeati415 – 437LRR 15Add BLAST23
Repeati438 – 457LRR 16Add BLAST20
Repeati458 – 478LRR 17Add BLAST21
Repeati479 – 500LRR 18Add BLAST22
Repeati501 – 524LRR 19Add BLAST24
Domaini524 – 579LRRCTAdd BLAST56
Domaini638 – 782TIRPROSITE-ProRule annotationAdd BLAST145

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni316 – 319Interaction with bacterial lipopeptideBy similarity4

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 19 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000008676.
HOVERGENiHBG023180.
InParanoidiQ9EPQ1.
KOiK05398.
OMAiETSIIHM.
OrthoDBiEOG091G0356.
PhylomeDBiQ9EPQ1.
TreeFamiTF351113.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027190. TLR1.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF261. PTHR24365:SF261. 2 hits.
PfamiPF12799. LRR_4. 1 hit.
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 6 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EPQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKPNSLIFY CIIVLGLTLM KIQLSEECEL IIKRPNANLT RVPKDLPLQT
60 70 80 90 100
TTLDLSQNNI SELQTSDILS LSKLRVLIMS YNRLQYLNIS VFKFNTELEY
110 120 130 140 150
LDLSHNELKV ILCHPTVSLK HLDLSFNAFD ALPICKEFGN MSQLQFLGLS
160 170 180 190 200
GSRVQSSSVQ LIAHLNISKV LLVLGDAYGE KEDPESLRHV STETLHIVFP
210 220 230 240 250
SKREFRFLLD VSVSTTIGLE LSNIKCVLED QGCSYFLRAL SKLGKNLKLS
260 270 280 290 300
NLTLNNVETT WNSFINILQI VWHTPVKYFS ISNVKLQGQL AFRMFNYSDT
310 320 330 340 350
SLKALSIHQV VTDVFSFPQS YIYSIFANMN IQNFTMSGTH MVHMLCPSQV
360 370 380 390 400
SPFLHVDFTD NLLTDMVFKD CRNLVRLKTL SLQKNQLKNL ENIILTSAKM
410 420 430 440 450
TSLQKLDISQ NSLRYSDGGI PCAWTQSLLV LNLSSNMLTG SVFRCLPPKV
460 470 480 490 500
KVLDLHNNRI MSIPKDVTHL QALQELNVAS NSLTDLPGCG AFSSLSVLVI
510 520 530 540 550
DHNSVSHPSE DFFQSCQNIR SLTAGNNPFQ CTCELRDFVK NIGWVAREVV
560 570 580 590 600
EGWPDSYRCD YPESSRGTAL RDFHMSPLSC DTVLLTVTIG ATMLVLAVTG
610 620 630 640 650
AFLCLYFDLP WYVRMLCQWT QTRHRARHIP LEELQRNLQF HAFVSYSGHD
660 670 680 690 700
SAWVKNELLP NLEKDDIQIC LHERNFVPGK SIVENIINFI EKSYKSIFVL
710 720 730 740 750
SPHFIQSEWC HYELYFAHHN LFHEGSDNLI LILLAPIPQY SIPTNYHKLK
760 770 780 790
TLMSRRTYLE WPTEKNKHGL FWANLRASIN VKLVNQAEGT CYTQQ
Length:795
Mass (Da):90,673
Last modified:March 1, 2001 - v1
Checksum:i855356429872D232
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88N → D in AAG35062 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009154 mRNA. Translation: AAG37302.1.
AF316985 mRNA. Translation: AAG35062.1.
CCDSiCCDS19302.1.
RefSeqiNP_001263374.1. NM_001276445.1.
NP_109607.1. NM_030682.2.
XP_006503914.1. XM_006503851.2.
XP_006503915.1. XM_006503852.3.
XP_006503916.1. XM_006503853.1.
XP_006503917.1. XM_006503854.1.
XP_006503919.1. XM_006503856.1.
XP_011239022.1. XM_011240720.2.
UniGeneiMm.273024.

Genome annotation databases

EnsembliENSMUST00000059349; ENSMUSP00000060793; ENSMUSG00000044827.
ENSMUST00000197315; ENSMUSP00000142500; ENSMUSG00000044827.
GeneIDi21897.
KEGGimmu:21897.
UCSCiuc008xmw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009154 mRNA. Translation: AAG37302.1.
AF316985 mRNA. Translation: AAG35062.1.
CCDSiCCDS19302.1.
RefSeqiNP_001263374.1. NM_001276445.1.
NP_109607.1. NM_030682.2.
XP_006503914.1. XM_006503851.2.
XP_006503915.1. XM_006503852.3.
XP_006503916.1. XM_006503853.1.
XP_006503917.1. XM_006503854.1.
XP_006503919.1. XM_006503856.1.
XP_011239022.1. XM_011240720.2.
UniGeneiMm.273024.

3D structure databases

ProteinModelPortaliQ9EPQ1.
SMRiQ9EPQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060793.

PTM databases

iPTMnetiQ9EPQ1.
PhosphoSitePlusiQ9EPQ1.

Proteomic databases

MaxQBiQ9EPQ1.
PaxDbiQ9EPQ1.
PRIDEiQ9EPQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059349; ENSMUSP00000060793; ENSMUSG00000044827.
ENSMUST00000197315; ENSMUSP00000142500; ENSMUSG00000044827.
GeneIDi21897.
KEGGimmu:21897.
UCSCiuc008xmw.2. mouse.

Organism-specific databases

CTDi7096.
MGIiMGI:1341295. Tlr1.

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000008676.
HOVERGENiHBG023180.
InParanoidiQ9EPQ1.
KOiK05398.
OMAiETSIIHM.
OrthoDBiEOG091G0356.
PhylomeDBiQ9EPQ1.
TreeFamiTF351113.

Enzyme and pathway databases

ReactomeiR-MMU-1461957. Beta defensins.
R-MMU-5686938. Regulation of TLR by endogenous ligand.

Miscellaneous databases

PROiQ9EPQ1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044827.
CleanExiMM_TLR1.
ExpressionAtlasiQ9EPQ1. baseline and differential.
GenevisibleiQ9EPQ1. MM.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027190. TLR1.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF261. PTHR24365:SF261. 2 hits.
PfamiPF12799. LRR_4. 1 hit.
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 6 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLR1_MOUSE
AccessioniPrimary (citable) accession number: Q9EPQ1
Secondary accession number(s): Q9EPW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.