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Protein

Sodium/potassium/calcium exchanger 3

Gene

Slc24a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.By similarity

GO - Molecular functioni

  • calcium, potassium:sodium antiporter activity Source: RGD
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

  • calcium ion transmembrane transport Source: RGD
  • cation transport Source: RGD
  • cellular calcium ion homeostasis Source: RGD
  • sodium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Potassium transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Calcium, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium/calcium exchanger 3
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 3
Solute carrier family 24 member 3
Gene namesi
Name:Slc24a3
Synonyms:Nckx3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69256. Slc24a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 8863ExtracellularSequence analysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST
Topological domaini110 – 13324CytoplasmicSequence analysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence analysisAdd
BLAST
Topological domaini155 – 1639ExtracellularSequence analysis
Transmembranei164 – 18421HelicalSequence analysisAdd
BLAST
Topological domaini185 – 1917CytoplasmicSequence analysis
Transmembranei192 – 21221HelicalSequence analysisAdd
BLAST
Topological domaini213 – 2153ExtracellularSequence analysis
Transmembranei216 – 23621HelicalSequence analysisAdd
BLAST
Topological domaini237 – 465229CytoplasmicSequence analysisAdd
BLAST
Transmembranei466 – 48621HelicalSequence analysisAdd
BLAST
Topological domaini487 – 4915ExtracellularSequence analysis
Transmembranei492 – 51221HelicalSequence analysisAdd
BLAST
Topological domaini513 – 53018CytoplasmicSequence analysisAdd
BLAST
Transmembranei531 – 55121HelicalSequence analysisAdd
BLAST
Topological domaini552 – 56110ExtracellularSequence analysis
Transmembranei562 – 58221HelicalSequence analysisAdd
BLAST
Topological domaini583 – 59614CytoplasmicSequence analysisAdd
BLAST
Transmembranei597 – 61721HelicalSequence analysisAdd
BLAST
Topological domaini618 – 6247ExtracellularSequence analysis

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 25›25Sequence analysisAdd
BLAST
Chaini26 – 624599Sodium/potassium/calcium exchanger 3PRO_0000019372Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence analysis
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence analysis
Modified residuei289 – 2891PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9EPQ0.
PRIDEiQ9EPQ0.

PTM databases

iPTMnetiQ9EPQ0.

Expressioni

Tissue specificityi

Abundant in the brain. Expressed at low levels in the aorta, uterus and intestine.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012683.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati130 – 17041Alpha-1Add
BLAST
Repeati499 – 53032Alpha-2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1307. Eukaryota.
ENOG410Y9YY. LUCA.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
InParanoidiQ9EPQ0.
KOiK13751.
PhylomeDBiQ9EPQ0.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
IPR030248. SLC24A3.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PTHR10846:SF22. PTHR10846:SF22. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EPQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RDLLLSQLCF LASVALLLWS LSSLREQKEL DLMDLIGEDR KWMVGRKLMQ
60 70 80 90 100
VNDTLTSEDA GLRSSKNCTE PALHEFPRDI FSNEDRRQGA VVLHVLCAMY
110 120 130 140 150
MFYALAIVCD DFFVPSLEKI CERLHLSEDV AGATFMAAGS SAPELFTSVI
160 170 180 190 200
GVFITKGDVG VGTIVGSAVF NILCIIGVCG LFAGQVVALS SWCLLRDSIY
210 220 230 240 250
YTLSVVALIV FIYDEKVSWW ESLVLVLMYL IYIIIMKYNA CIHQCFERRT
260 270 280 290 300
KGAGNMVNGL ANNAEIDDSS NCDATVVLLK KANFHRKASV IMVDELLSAY
310 320 330 340 350
PHQLSFSEAG LRIMITSHFP PKTRLSMASR MLINERQRLI NSRAYTNGES
360 370 380 390 400
EVAIKIPIKH TVENGTGPSS APDRGVNGTR RDDIVAEADN ETENENEDEN
410 420 430 440 450
NENDEEEDED DDEGPYTPFD PPSGKLETVK WAFTWPLSFV LYFTVPNCNK
460 470 480 490 500
PHWEKWFMVT FASSTLWIAA FSYMMVWMVT IIGYTLGIPD VIMGITFLAA
510 520 530 540 550
GTSVPDCMAS LIVARQGMGD MAVSNSIGSN VFDILIGLGL PWALQTLAVD
560 570 580 590 600
YGSYIRLNSR GLIYSVGLLL ASVFVTVFGV HLNKWQLDKK LGCGCLFLYG
610 620
VFLCFSIMTE FNVFTFVNLP MCGD
Length:624
Mass (Da):69,389
Last modified:March 1, 2001 - v1
Checksum:iADCA175AF1BF1141
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009158 mRNA. Translation: AAG32680.1.
RefSeqiNP_445957.2. NM_053505.2.
UniGeneiRn.206123.

Genome annotation databases

GeneIDi85267.
KEGGirno:85267.
UCSCiRGD:69256. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009158 mRNA. Translation: AAG32680.1.
RefSeqiNP_445957.2. NM_053505.2.
UniGeneiRn.206123.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012683.

PTM databases

iPTMnetiQ9EPQ0.

Proteomic databases

PaxDbiQ9EPQ0.
PRIDEiQ9EPQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi85267.
KEGGirno:85267.
UCSCiRGD:69256. rat.

Organism-specific databases

CTDi57419.
RGDi69256. Slc24a3.

Phylogenomic databases

eggNOGiKOG1307. Eukaryota.
ENOG410Y9YY. LUCA.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
InParanoidiQ9EPQ0.
KOiK13751.
PhylomeDBiQ9EPQ0.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
IPR030248. SLC24A3.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PTHR10846:SF22. PTHR10846:SF22. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3."
    Kraev A., Quednau B.D., Leach S., Li X.-F., Dong H., Winkfein R., Perizzolo M., Cai X., Yang R., Philipson K.D., Lytton J.
    J. Biol. Chem. 276:23161-23172(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNCKX3_RAT
AccessioniPrimary (citable) accession number: Q9EPQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.