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Protein

Sodium/potassium/calcium exchanger 3

Gene

Slc24a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transports 1 Ca2+ and 1 K+ in exchange for 4 Na+.By similarity

GO - Molecular functioni

GO - Biological processi

  • calcium ion transmembrane transport Source: RGD
  • cation transport Source: RGD
  • cellular calcium ion homeostasis Source: RGD
Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Potassium transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Calcium, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium/calcium exchanger 3
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 3
Solute carrier family 24 member 3
Gene namesi
Name:Slc24a3
Synonyms:Nckx3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69256. Slc24a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 88ExtracellularSequence analysisAdd BLAST63
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 133CytoplasmicSequence analysisAdd BLAST24
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Topological domaini155 – 163ExtracellularSequence analysis9
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Topological domaini185 – 191CytoplasmicSequence analysis7
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Topological domaini213 – 215ExtracellularSequence analysis3
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Topological domaini237 – 465CytoplasmicSequence analysisAdd BLAST229
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Topological domaini487 – 491ExtracellularSequence analysis5
Transmembranei492 – 512HelicalSequence analysisAdd BLAST21
Topological domaini513 – 530CytoplasmicSequence analysisAdd BLAST18
Transmembranei531 – 551HelicalSequence analysisAdd BLAST21
Topological domaini552 – 561ExtracellularSequence analysis10
Transmembranei562 – 582HelicalSequence analysisAdd BLAST21
Topological domaini583 – 596CytoplasmicSequence analysisAdd BLAST14
Transmembranei597 – 617HelicalSequence analysisAdd BLAST21
Topological domaini618 – 624ExtracellularSequence analysis7

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 25Sequence analysisAdd BLAST›25
ChainiPRO_000001937226 – 624Sodium/potassium/calcium exchanger 3Add BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Modified residuei289PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9EPQ0.

PTM databases

iPTMnetiQ9EPQ0.
PhosphoSitePlusiQ9EPQ0.

Expressioni

Tissue specificityi

Abundant in the brain. Expressed at low levels in the aorta, uterus and intestine.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012683.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati130 – 170Alpha-1Add BLAST41
Repeati499 – 530Alpha-2Add BLAST32

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1307. Eukaryota.
ENOG410Y9YY. LUCA.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
InParanoidiQ9EPQ0.
KOiK13751.
PhylomeDBiQ9EPQ0.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
IPR030248. SLC24A3.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PTHR10846:SF22. PTHR10846:SF22. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EPQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RDLLLSQLCF LASVALLLWS LSSLREQKEL DLMDLIGEDR KWMVGRKLMQ
60 70 80 90 100
VNDTLTSEDA GLRSSKNCTE PALHEFPRDI FSNEDRRQGA VVLHVLCAMY
110 120 130 140 150
MFYALAIVCD DFFVPSLEKI CERLHLSEDV AGATFMAAGS SAPELFTSVI
160 170 180 190 200
GVFITKGDVG VGTIVGSAVF NILCIIGVCG LFAGQVVALS SWCLLRDSIY
210 220 230 240 250
YTLSVVALIV FIYDEKVSWW ESLVLVLMYL IYIIIMKYNA CIHQCFERRT
260 270 280 290 300
KGAGNMVNGL ANNAEIDDSS NCDATVVLLK KANFHRKASV IMVDELLSAY
310 320 330 340 350
PHQLSFSEAG LRIMITSHFP PKTRLSMASR MLINERQRLI NSRAYTNGES
360 370 380 390 400
EVAIKIPIKH TVENGTGPSS APDRGVNGTR RDDIVAEADN ETENENEDEN
410 420 430 440 450
NENDEEEDED DDEGPYTPFD PPSGKLETVK WAFTWPLSFV LYFTVPNCNK
460 470 480 490 500
PHWEKWFMVT FASSTLWIAA FSYMMVWMVT IIGYTLGIPD VIMGITFLAA
510 520 530 540 550
GTSVPDCMAS LIVARQGMGD MAVSNSIGSN VFDILIGLGL PWALQTLAVD
560 570 580 590 600
YGSYIRLNSR GLIYSVGLLL ASVFVTVFGV HLNKWQLDKK LGCGCLFLYG
610 620
VFLCFSIMTE FNVFTFVNLP MCGD
Length:624
Mass (Da):69,389
Last modified:March 1, 2001 - v1
Checksum:iADCA175AF1BF1141
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009158 mRNA. Translation: AAG32680.1.
RefSeqiNP_445957.2. NM_053505.2.
UniGeneiRn.206123.

Genome annotation databases

GeneIDi85267.
KEGGirno:85267.
UCSCiRGD:69256. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009158 mRNA. Translation: AAG32680.1.
RefSeqiNP_445957.2. NM_053505.2.
UniGeneiRn.206123.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012683.

PTM databases

iPTMnetiQ9EPQ0.
PhosphoSitePlusiQ9EPQ0.

Proteomic databases

PaxDbiQ9EPQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi85267.
KEGGirno:85267.
UCSCiRGD:69256. rat.

Organism-specific databases

CTDi57419.
RGDi69256. Slc24a3.

Phylogenomic databases

eggNOGiKOG1307. Eukaryota.
ENOG410Y9YY. LUCA.
HOGENOMiHOG000231933.
HOVERGENiHBG054881.
InParanoidiQ9EPQ0.
KOiK13751.
PhylomeDBiQ9EPQ0.

Family and domain databases

InterProiIPR004481. K/Na/Ca-exchanger.
IPR004837. NaCa_Exmemb.
IPR030248. SLC24A3.
[Graphical view]
PANTHERiPTHR10846. PTHR10846. 1 hit.
PTHR10846:SF22. PTHR10846:SF22. 1 hit.
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00367. TIGR00367. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNCKX3_RAT
AccessioniPrimary (citable) accession number: Q9EPQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2001
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.