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Protein

Syncoilin

Gene

Sync

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins.2 Publications

GO - Molecular functioni

GO - Biological processi

  • intermediate filament-based process Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Syncoilin
Alternative name(s):
Syncoilin intermediate filament 1
Syncoilin-1
Gene namesi
Name:Sync
Synonyms:Sync1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1916078. Sync.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Intermediate filament

Pathology & Biotechi

Disruption phenotypei

Displays no obvious abnormalities, have a reduced capacity to generate force during isometric contractions in skeletal muscle.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003061811 – 470SyncoilinAdd BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineCombined sources1
Modified residuei314PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9EPM5.
PRIDEiQ9EPM5.

PTM databases

iPTMnetiQ9EPM5.
PhosphoSitePlusiQ9EPM5.

Expressioni

Tissue specificityi

Detected strongly in skeletal muscle and heart and weakly in lung (at protein level). Highly expressed in skeletal muscle and lung and weakly in lung and testis.1 Publication

Inductioni

Up-regulated in dystrophic muscle (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000001333.
CleanExiMM_SYNC.
ExpressionAtlasiQ9EPM5. baseline and differential.
GenevisibleiQ9EPM5. MM.

Interactioni

Subunit structurei

May link the dystrophin-associated glycoprotein complex (DAPC) to intracellular desmin (DES) filaments. Interacts with DES and DTNA.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DTNAQ9Y4J83EBI-7424051,EBI-949471From Homo sapiens.

Protein-protein interaction databases

BioGridi213071. 2 interactors.
IntActiQ9EPM5. 2 interactors.
MINTiMINT-148967.
STRINGi10090.ENSMUSP00000099659.

Structurei

3D structure databases

ProteinModelPortaliQ9EPM5.
SMRiQ9EPM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 148HeadAdd BLAST148
Regioni149 – 157Rod9
Regioni158 – 192Coil 1AAdd BLAST35
Regioni193 – 219Linker 1Add BLAST27
Regioni220 – 297Coil 1bAdd BLAST78
Regioni298 – 337Linker 2Add BLAST40
Regioni338 – 445Coil 2Add BLAST108
Regioni446 – 470TailAdd BLAST25

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKIK. Eukaryota.
ENOG410Y2YI. LUCA.
GeneTreeiENSGT00390000018108.
HOGENOMiHOG000010275.
HOVERGENiHBG108528.
InParanoidiQ9EPM5.
KOiK10377.
OMAiECVAYQY.
OrthoDBiEOG091G0V3M.
PhylomeDBiQ9EPM5.

Family and domain databases

InterProiView protein in InterPro
IPR001664. IF.
IPR027702. Syncoilin.
PANTHERiPTHR23239. PTHR23239. 1 hit.
PTHR23239:SF255. PTHR23239:SF255. 1 hit.
PfamiView protein in Pfam
PF00038. Filament. 1 hit.
SMARTiView protein in SMART
SM01391. Filament. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9EPM5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPEPLRGG DGARASREPH TEASFPLQES ESPKEAKTFN PEATLSLEGT
60 70 80 90 100
VNLEDILYLG ASGDFEESFY EEEYEKPALT LFIDESRQPD EALGLEEPVR
110 120 130 140 150
PEEMLSVEES VTPDEVQISE QPVEPAKSPT ACEGEMVATE GSLPAQPIPN
160 170 180 190 200
TEEDPLSVED LERLEARFQQ CVQAVSQLEE ERDQLIHELV LLREPALQEV
210 220 230 240 250
QQVHQDILAA YKLHAQAELE RDGLREEIRT VKQKLFKVTK ECVAYQYQLE
260 270 280 290 300
CRQQDVAQFA DCREALTTRA AQLSEELTQL RDACQKQKEQ LQQQLEAPPT
310 320 330 340 350
QSDGHFLQES RRLSTQFENL MAESRQGLEE EYEPQLLRLL ERKEAGTKAL
360 370 380 390 400
QDTQAEIQEM REALRPLEAE ARQLQLQNRN LEDQITLVRQ KRDEEVQQYR
410 420 430 440 450
EQLEEMEERQ RQLRSGVQVQ QQKNKEMERL RMSLAEELST YKAMLPKSLE
460 470
QADAPTSQAG GVEAQSPGTV
Length:470
Mass (Da):53,630
Last modified:March 1, 2001 - v1
Checksum:i3D3B6026B099B229
GO
Isoform 21 Publication (identifier: Q9EPM5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     443-453: AMLPKSLEQAD → SVFSASQVSQI
     454-470: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:453
Mass (Da):52,041
Checksum:i9F7360528BE73B54
GO
Isoform 31 Publication (identifier: Q9EPM5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:367
Mass (Da):42,230
Checksum:i4C0EE9F8994C9F1C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23A → E in AAI06856 (PubMed:15489334).Curated1
Sequence conflicti79L → Q in AAI06856 (PubMed:15489334).Curated1
Sequence conflicti377Q → K in BAC38387 (PubMed:16141072).Curated1
Sequence conflicti432M → T in AAI06856 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0525501 – 103Missing in isoform 3. 1 PublicationAdd BLAST103
Alternative sequenceiVSP_052551443 – 453AMLPKSLEQAD → SVFSASQVSQI in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_052552454 – 470Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251641 mRNA. Translation: CAC17787.1.
AK004279 mRNA. Translation: BAB23246.1.
AK081983 mRNA. Translation: BAC38387.1.
AK160756 mRNA. Translation: BAE35992.1.
AK166916 mRNA. Translation: BAE39114.1.
AL607123 Genomic DNA. Translation: CAM22957.1.
BC106855 mRNA. Translation: AAI06856.1.
CCDSiCCDS18687.1. [Q9EPM5-1]
RefSeqiNP_075974.3. NM_023485.3. [Q9EPM5-1]
UniGeneiMm.132243.

Genome annotation databases

EnsembliENSMUST00000102599; ENSMUSP00000099659; ENSMUSG00000001333. [Q9EPM5-1]
GeneIDi68828.
KEGGimmu:68828.
UCSCiuc008uwq.1. mouse. [Q9EPM5-2]
uc008uwr.1. mouse. [Q9EPM5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSYNCI_MOUSE
AccessioniPrimary (citable) accession number: Q9EPM5
Secondary accession number(s): Q3KP79
, Q3TKN1, Q3TUH9, Q8C4J4, Q9CT88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2001
Last modified: September 27, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families