ID   ACOX3_MOUSE             Reviewed;         700 AA.
AC   Q9EPL9; Q7TPP6; Q80UQ0;
DT   02-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 2.
DT   16-JUN-2009, entry version 58.
DE   RecName: Full=Peroxisomal acyl-coenzyme A oxidase 3;
DE            EC=1.3.3.6;
DE   AltName: Full=Pristanoyl-CoA oxidase;
DE   AltName: Full=Branched-chain acyl-CoA oxidase;
DE            Short=BRCACox;
GN   Name=Acox3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Van Veldhoven P.P., Ghys K.;
RT   "Cloning of the mouse pristanoyl-CoA oxidase.";
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N, and FVB/N-3; TISSUE=Liver, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Oxidizes the CoA-esters of 2-methyl-branched fatty acids
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA +
CC       H(2)O(2).
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation.
CC   -!- SUBCELLULAR LOCATION: Peroxisome (Potential).
CC   -!- SIMILARITY: Belongs to the acyl-CoA oxidase family.
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DR   EMBL; AJ278430; CAC20692.1; -; mRNA.
DR   EMBL; BC044725; AAH44725.1; -; mRNA.
DR   EMBL; BC055019; AAH55019.1; -; mRNA.
DR   IPI; IPI00318108; -.
DR   RefSeq; NP_109646.2; -.
DR   UniGene; Mm.291503; -.
DR   HSSP; P07872; 1IS2.
DR   PRIDE; Q9EPL9; -.
DR   Ensembl; ENSMUSG00000029098; Mus musculus.
DR   GeneID; 80911; -.
DR   KEGG; mmu:80911; -.
DR   MGI; MGI:1933156; Acox3.
DR   HOGENOM; Q9EPL9; -.
DR   HOVERGEN; Q9EPL9; -.
DR   BRENDA; 1.3.3.6; 244.
DR   NextBio; 350282; -.
DR   ArrayExpress; Q9EPL9; -.
DR   Bgee; Q9EPL9; -.
DR   CleanEx; MM_ACOX3; -.
DR   GermOnline; ENSMUSG00000029098; Mus musculus.
DR   GO; GO:0005782; C:peroxisomal matrix; TAS:MGI.
DR   GO; GO:0003995; F:acyl-CoA dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0016402; F:pristanoyl-CoA oxidase activity; TAS:MGI.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; TAS:MGI.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR006090; Acyl-CoA_Oxase/DH_1.
DR   InterPro; IPR006091; Acyl-CoA_Oxase/DH_M.
DR   InterPro; IPR012258; Acyl-CoA_oxidase.
DR   InterPro; IPR002655; Acyl-CoA_oxidase_C.
DR   InterPro; IPR013786; AcylCoA_DH/ox_N.
DR   InterPro; IPR013764; AcylCoA_oxidase/DH_1/2_C.
DR   Gene3D; G3DSA:2.40.110.10; Acyl_CoA_DH/ox_M; 1.
DR   Gene3D; G3DSA:1.10.540.10; AcylCoA_DH/ox_N; 1.
DR   Gene3D; G3DSA:1.20.140.10; AcylCoA_DH_1/2_C; 2.
DR   PANTHER; PTHR10909:SF11; Acyl-CoA_oxidase; 1.
DR   Pfam; PF01756; ACOX; 1.
DR   Pfam; PF00441; Acyl-CoA_dh_1; 1.
DR   Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR   PIRSF; PIRSF000168; Acyl-CoA_oxidase; 1.
PE   2: Evidence at transcript level;
KW   FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism;
KW   Oxidoreductase; Peroxisome.
FT   CHAIN         1    700       Peroxisomal acyl-coenzyme A oxidase 3.
FT                                /FTId=PRO_0000204686.
FT   MOTIF       698    700       Microbody targeting signal (By
FT                                similarity).
FT   CONFLICT    177    178       DP -> ES (in Ref. 1; CAC20692).
FT   CONFLICT    364    364       Y -> H (in Ref. 1; CAC20692).
FT   CONFLICT    408    409       KP -> NR (in Ref. 1; CAC20692).
FT   CONFLICT    555    555       C -> V (in Ref. 1; CAC20692).
FT   CONFLICT    576    576       H -> Y (in Ref. 2; AAH44725).
FT   CONFLICT    593    594       TL -> SV (in Ref. 1; CAC20692).
FT   CONFLICT    607    607       L -> S (in Ref. 1; CAC20692).
FT   CONFLICT    669    669       A -> R (in Ref. 1; CAC20692).
FT   CONFLICT    681    681       A -> R (in Ref. 1; CAC20692).
SQ   SEQUENCE   700 AA;  78404 MW;  85C448E38A4A0C67 CRC64;
     MGSLPEEKDS ALWSDTPKGP LSAYRARASF NSGELLLFWD GQDVIHFKKT IFSTLENDPL
     FARSYGADLP LEKLRELNFL RCKRVFEYGF FKVEELLKNP LKILVLINCL GMYDWSLANK
     CVLHMLVFGT TVFVSGSEKH FKYLEKIYSL EIFGCFALTE LSHGSNTKAM RTTAHYDPDT
     QEFILHSPDF EAAKFWVGNL GKTATHAVVF AQLYMPDGQC HGLHSFLVQI RDTKTLLPMT
     GVMVGDIGKK LGQNGLDNGF AMFNKVRIPR QNLLDRTGNI TSEGTYNSPF KDVRQRLGAS
     LGSLSSGRIS IISMSVVNLK LAVSIAIRFS ATRCQFGPTD KEEIPVLEYP LQQWRILPYL
     AAAYALDHFS KTIFMDLIEV QSARLRGDHS DQQAELGREI HALASAGKPL ASWTAQRGIQ
     ECREACGGHG YLAMNRFGDL RNDNDPNCTY EGDNNVLLQQ TSNYLLSLLE PPLQDGAHFT
     SPLKTVDFLE AYPGILGQKF LGSSKADWMD SAAPLAAYRW LVCYLLQESH RRYCQEKKSR
     GSDFEARNNS QVYGCRPLAL AFMELTVMQR FHEHIHSSGL SPSLRTVLGR LSTLYGLWCL
     SQHMALLYRG GYISGEQTGR AMEDAILTLC EQLKDDAVAL VDVIAPSDFV LNSPIAKADG
     ELYKNLWAAV LQQNGVLERA AWWPEFSANK SVADRLKSQL
//