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Q9EPL9

- ACOX3_MOUSE

UniProt

Q9EPL9 - ACOX3_MOUSE

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Protein

Peroxisomal acyl-coenzyme A oxidase 3

Gene

Acox3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Oxidizes the CoA-esters of 2-methyl-branched fatty acids.By similarity

Catalytic activityi

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactori

FAD.By similarity

Pathwayi

GO - Molecular functioni

  1. acyl-CoA dehydrogenase activity Source: InterPro
  2. flavin adenine dinucleotide binding Source: InterPro
  3. pristanoyl-CoA oxidase activity Source: MGI

GO - Biological processi

  1. fatty acid beta-oxidation Source: MGI
  2. fatty acid beta-oxidation using acyl-CoA oxidase Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00661.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal acyl-coenzyme A oxidase 3 (EC:1.3.3.6)
Alternative name(s):
Branched-chain acyl-CoA oxidase
Short name:
BRCACox
Pristanoyl-CoA oxidase
Gene namesi
Name:Acox3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1933156. Acox3.

Subcellular locationi

Peroxisome Curated

GO - Cellular componenti

  1. mitochondrion Source: MGI
  2. peroxisomal matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 700699Peroxisomal acyl-coenzyme A oxidase 3PRO_0000204686Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei281 – 2811PhosphothreonineBy similarity
Modified residuei505 – 5051N6-succinyllysine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9EPL9.
PaxDbiQ9EPL9.
PRIDEiQ9EPL9.

PTM databases

PhosphoSiteiQ9EPL9.

Expressioni

Gene expression databases

BgeeiQ9EPL9.
CleanExiMM_ACOX3.
ExpressionAtlasiQ9EPL9. baseline and differential.
GenevestigatoriQ9EPL9.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109876.

Structurei

3D structure databases

ProteinModelPortaliQ9EPL9.
SMRiQ9EPL9. Positions 21-668.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi698 – 7003Microbody targeting signalBy similarity

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

eggNOGiCOG1960.
GeneTreeiENSGT00530000062919.
HOGENOMiHOG000245077.
HOVERGENiHBG101107.
InParanoidiQ9EPL9.
KOiK00232.
OrthoDBiEOG744T8F.
PhylomeDBiQ9EPL9.
TreeFamiTF314226.

Family and domain databases

Gene3Di2.40.110.10. 1 hit.
InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF01756. ACOX. 1 hit.
PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
[Graphical view]
PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EPL9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSLPEEKDS ALWSDTPKGP LSAYRARASF NSGELLLFWD GQDVIHFKKT
60 70 80 90 100
IFSTLENDPL FARSYGADLP LEKLRELNFL RCKRVFEYGF FKVEELLKNP
110 120 130 140 150
LKILVLINCL GMYDWSLANK CVLHMLVFGT TVFVSGSEKH FKYLEKIYSL
160 170 180 190 200
EIFGCFALTE LSHGSNTKAM RTTAHYDPDT QEFILHSPDF EAAKFWVGNL
210 220 230 240 250
GKTATHAVVF AQLYMPDGQC HGLHSFLVQI RDTKTLLPMT GVMVGDIGKK
260 270 280 290 300
LGQNGLDNGF AMFNKVRIPR QNLLDRTGNI TSEGTYNSPF KDVRQRLGAS
310 320 330 340 350
LGSLSSGRIS IISMSVVNLK LAVSIAIRFS ATRCQFGPTD KEEIPVLEYP
360 370 380 390 400
LQQWRILPYL AAAYALDHFS KTIFMDLIEV QSARLRGDHS DQQAELGREI
410 420 430 440 450
HALASAGKPL ASWTAQRGIQ ECREACGGHG YLAMNRFGDL RNDNDPNCTY
460 470 480 490 500
EGDNNVLLQQ TSNYLLSLLE PPLQDGAHFT SPLKTVDFLE AYPGILGQKF
510 520 530 540 550
LGSSKADWMD SAAPLAAYRW LVCYLLQESH RRYCQEKKSR GSDFEARNNS
560 570 580 590 600
QVYGCRPLAL AFMELTVMQR FHEHIHSSGL SPSLRTVLGR LSTLYGLWCL
610 620 630 640 650
SQHMALLYRG GYISGEQTGR AMEDAILTLC EQLKDDAVAL VDVIAPSDFV
660 670 680 690 700
LNSPIAKADG ELYKNLWAAV LQQNGVLERA AWWPEFSANK SVADRLKSQL
Length:700
Mass (Da):78,404
Last modified:February 20, 2007 - v2
Checksum:i85C448E38A4A0C67
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1782DP → ES in CAC20692. 1 PublicationCurated
Sequence conflicti364 – 3641Y → H in CAC20692. 1 PublicationCurated
Sequence conflicti408 – 4092KP → NR in CAC20692. 1 PublicationCurated
Sequence conflicti555 – 5551C → V in CAC20692. 1 PublicationCurated
Sequence conflicti576 – 5761H → Y in AAH44725. (PubMed:15489334)Curated
Sequence conflicti593 – 5942TL → SV in CAC20692. 1 PublicationCurated
Sequence conflicti607 – 6071L → S in CAC20692. 1 PublicationCurated
Sequence conflicti669 – 6691A → R in CAC20692. 1 PublicationCurated
Sequence conflicti681 – 6811A → R in CAC20692. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ278430 mRNA. Translation: CAC20692.1.
BC044725 mRNA. Translation: AAH44725.1.
BC055019 mRNA. Translation: AAH55019.1.
CCDSiCCDS19232.1.
RefSeqiNP_109646.2. NM_030721.2.
XP_006504261.1. XM_006504198.1.
UniGeneiMm.291503.

Genome annotation databases

EnsembliENSMUST00000068947; ENSMUSP00000063412; ENSMUSG00000029098.
ENSMUST00000114237; ENSMUSP00000109875; ENSMUSG00000029098.
GeneIDi80911.
KEGGimmu:80911.
UCSCiuc008xdx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ278430 mRNA. Translation: CAC20692.1 .
BC044725 mRNA. Translation: AAH44725.1 .
BC055019 mRNA. Translation: AAH55019.1 .
CCDSi CCDS19232.1.
RefSeqi NP_109646.2. NM_030721.2.
XP_006504261.1. XM_006504198.1.
UniGenei Mm.291503.

3D structure databases

ProteinModelPortali Q9EPL9.
SMRi Q9EPL9. Positions 21-668.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000109876.

PTM databases

PhosphoSitei Q9EPL9.

Proteomic databases

MaxQBi Q9EPL9.
PaxDbi Q9EPL9.
PRIDEi Q9EPL9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000068947 ; ENSMUSP00000063412 ; ENSMUSG00000029098 .
ENSMUST00000114237 ; ENSMUSP00000109875 ; ENSMUSG00000029098 .
GeneIDi 80911.
KEGGi mmu:80911.
UCSCi uc008xdx.1. mouse.

Organism-specific databases

CTDi 8310.
MGIi MGI:1933156. Acox3.

Phylogenomic databases

eggNOGi COG1960.
GeneTreei ENSGT00530000062919.
HOGENOMi HOG000245077.
HOVERGENi HBG101107.
InParanoidi Q9EPL9.
KOi K00232.
OrthoDBi EOG744T8F.
PhylomeDBi Q9EPL9.
TreeFami TF314226.

Enzyme and pathway databases

UniPathwayi UPA00661 .

Miscellaneous databases

NextBioi 350282.
PROi Q9EPL9.
SOURCEi Search...

Gene expression databases

Bgeei Q9EPL9.
CleanExi MM_ACOX3.
ExpressionAtlasi Q9EPL9. baseline and differential.
Genevestigatori Q9EPL9.

Family and domain databases

Gene3Di 2.40.110.10. 1 hit.
InterProi IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view ]
Pfami PF01756. ACOX. 1 hit.
PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
[Graphical view ]
PIRSFi PIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMi SSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the mouse pristanoyl-CoA oxidase."
    Van Veldhoven P.P., Ghys K.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N and FVB/N-3.
    Tissue: Liver and Mammary tumor.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-505, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiACOX3_MOUSE
AccessioniPrimary (citable) accession number: Q9EPL9
Secondary accession number(s): Q7TPP6, Q80UQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3