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Protein

Peroxisomal acyl-coenzyme A oxidase 3

Gene

Acox3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Oxidizes the CoA-esters of 2-methyl-branched fatty acids.By similarity

Catalytic activityi

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactori

FADBy similarity

Pathwayi: peroxisomal fatty acid beta-oxidation

This protein is involved in the pathway peroxisomal fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway peroxisomal fatty acid beta-oxidation and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-MMU-389887 Beta-oxidation of pristanoyl-CoA
R-MMU-9033241 Peroxisomal protein import
UniPathwayiUPA00661

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal acyl-coenzyme A oxidase 3 (EC:1.3.3.6)
Alternative name(s):
Branched-chain acyl-CoA oxidase
Short name:
BRCACox
Pristanoyl-CoA oxidase
Gene namesi
Name:Acox3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1933156 Acox3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002046861 – 700Peroxisomal acyl-coenzyme A oxidase 3Add BLAST700

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1
Modified residuei281PhosphothreonineBy similarity1
Modified residuei505N6-succinyllysineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9EPL9
MaxQBiQ9EPL9
PaxDbiQ9EPL9
PeptideAtlasiQ9EPL9
PRIDEiQ9EPL9

PTM databases

iPTMnetiQ9EPL9
PhosphoSitePlusiQ9EPL9
SwissPalmiQ9EPL9

Expressioni

Gene expression databases

BgeeiENSMUSG00000029098
CleanExiMM_ACOX3
ExpressionAtlasiQ9EPL9 baseline and differential
GenevisibleiQ9EPL9 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063412

Structurei

3D structure databases

ProteinModelPortaliQ9EPL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi698 – 700Microbody targeting signalBy similarity3

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

eggNOGiKOG0136 Eukaryota
COG1960 LUCA
GeneTreeiENSGT00530000062919
HOGENOMiHOG000245077
HOVERGENiHBG101107
InParanoidiQ9EPL9
KOiK00232
OMAiGTEKHQK
PhylomeDBiQ9EPL9
TreeFamiTF314226

Family and domain databases

CDDicd01150 AXO, 1 hit
InterProiView protein in InterPro
IPR034171 ACO
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR012258 Acyl-CoA_oxidase
IPR002655 Acyl-CoA_oxidase_C
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF01756 ACOX, 1 hit
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PIRSFiPIRSF000168 Acyl-CoA_oxidase, 1 hit
SUPFAMiSSF47203 SSF47203, 2 hits
SSF56645 SSF56645, 1 hit

Sequencei

Sequence statusi: Complete.

Q9EPL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLPEEKDS ALWSDTPKGP LSAYRARASF NSGELLLFWD GQDVIHFKKT
60 70 80 90 100
IFSTLENDPL FARSYGADLP LEKLRELNFL RCKRVFEYGF FKVEELLKNP
110 120 130 140 150
LKILVLINCL GMYDWSLANK CVLHMLVFGT TVFVSGSEKH FKYLEKIYSL
160 170 180 190 200
EIFGCFALTE LSHGSNTKAM RTTAHYDPDT QEFILHSPDF EAAKFWVGNL
210 220 230 240 250
GKTATHAVVF AQLYMPDGQC HGLHSFLVQI RDTKTLLPMT GVMVGDIGKK
260 270 280 290 300
LGQNGLDNGF AMFNKVRIPR QNLLDRTGNI TSEGTYNSPF KDVRQRLGAS
310 320 330 340 350
LGSLSSGRIS IISMSVVNLK LAVSIAIRFS ATRCQFGPTD KEEIPVLEYP
360 370 380 390 400
LQQWRILPYL AAAYALDHFS KTIFMDLIEV QSARLRGDHS DQQAELGREI
410 420 430 440 450
HALASAGKPL ASWTAQRGIQ ECREACGGHG YLAMNRFGDL RNDNDPNCTY
460 470 480 490 500
EGDNNVLLQQ TSNYLLSLLE PPLQDGAHFT SPLKTVDFLE AYPGILGQKF
510 520 530 540 550
LGSSKADWMD SAAPLAAYRW LVCYLLQESH RRYCQEKKSR GSDFEARNNS
560 570 580 590 600
QVYGCRPLAL AFMELTVMQR FHEHIHSSGL SPSLRTVLGR LSTLYGLWCL
610 620 630 640 650
SQHMALLYRG GYISGEQTGR AMEDAILTLC EQLKDDAVAL VDVIAPSDFV
660 670 680 690 700
LNSPIAKADG ELYKNLWAAV LQQNGVLERA AWWPEFSANK SVADRLKSQL
Length:700
Mass (Da):78,404
Last modified:February 20, 2007 - v2
Checksum:i85C448E38A4A0C67
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177 – 178DP → ES in CAC20692 (Ref. 1) Curated2
Sequence conflicti364Y → H in CAC20692 (Ref. 1) Curated1
Sequence conflicti408 – 409KP → NR in CAC20692 (Ref. 1) Curated2
Sequence conflicti555C → V in CAC20692 (Ref. 1) Curated1
Sequence conflicti576H → Y in AAH44725 (PubMed:15489334).Curated1
Sequence conflicti593 – 594TL → SV in CAC20692 (Ref. 1) Curated2
Sequence conflicti607L → S in CAC20692 (Ref. 1) Curated1
Sequence conflicti669A → R in CAC20692 (Ref. 1) Curated1
Sequence conflicti681A → R in CAC20692 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278430 mRNA Translation: CAC20692.1
BC044725 mRNA Translation: AAH44725.1
BC055019 mRNA Translation: AAH55019.1
CCDSiCCDS19232.1
RefSeqiNP_109646.2, NM_030721.2
XP_006504261.1, XM_006504198.3
XP_017176670.1, XM_017321181.1
UniGeneiMm.291503

Genome annotation databases

EnsembliENSMUST00000068947; ENSMUSP00000063412; ENSMUSG00000029098
ENSMUST00000114237; ENSMUSP00000109875; ENSMUSG00000029098
GeneIDi80911
KEGGimmu:80911
UCSCiuc008xdx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiACOX3_MOUSE
AccessioniPrimary (citable) accession number: Q9EPL9
Secondary accession number(s): Q7TPP6, Q80UQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: February 20, 2007
Last modified: May 23, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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