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Protein

Peroxisomal acyl-coenzyme A oxidase 3

Gene

Acox3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Oxidizes the CoA-esters of 2-methyl-branched fatty acids.By similarity

Catalytic activityi

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactori

FADBy similarity

Pathwayi

GO - Molecular functioni

  1. acyl-CoA dehydrogenase activity Source: InterPro
  2. flavin adenine dinucleotide binding Source: InterPro
  3. pristanoyl-CoA oxidase activity Source: MGI
  4. receptor binding Source: MGI

GO - Biological processi

  1. fatty acid beta-oxidation Source: MGI
  2. fatty acid beta-oxidation using acyl-CoA oxidase Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiREACT_297709. Beta-oxidation of pristanoyl-CoA.
UniPathwayiUPA00661.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal acyl-coenzyme A oxidase 3 (EC:1.3.3.6)
Alternative name(s):
Branched-chain acyl-CoA oxidase
Short name:
BRCACox
Pristanoyl-CoA oxidase
Gene namesi
Name:Acox3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1933156. Acox3.

Subcellular locationi

  1. Peroxisome Curated

GO - Cellular componenti

  1. membrane Source: MGI
  2. mitochondrion Source: MGI
  3. peroxisomal matrix Source: MGI
  4. peroxisome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 700699Peroxisomal acyl-coenzyme A oxidase 3PRO_0000204686Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei281 – 2811PhosphothreonineBy similarity
Modified residuei505 – 5051N6-succinyllysine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9EPL9.
PaxDbiQ9EPL9.
PRIDEiQ9EPL9.

PTM databases

PhosphoSiteiQ9EPL9.

Expressioni

Gene expression databases

BgeeiQ9EPL9.
CleanExiMM_ACOX3.
ExpressionAtlasiQ9EPL9. baseline and differential.
GenevestigatoriQ9EPL9.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109876.

Structurei

3D structure databases

ProteinModelPortaliQ9EPL9.
SMRiQ9EPL9. Positions 21-668.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi698 – 7003Microbody targeting signalBy similarity

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

eggNOGiCOG1960.
GeneTreeiENSGT00530000062919.
HOGENOMiHOG000245077.
HOVERGENiHBG101107.
InParanoidiQ9EPL9.
KOiK00232.
OrthoDBiEOG744T8F.
PhylomeDBiQ9EPL9.
TreeFamiTF314226.

Family and domain databases

Gene3Di2.40.110.10. 1 hit.
InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF01756. ACOX. 1 hit.
PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
[Graphical view]
PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EPL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLPEEKDS ALWSDTPKGP LSAYRARASF NSGELLLFWD GQDVIHFKKT
60 70 80 90 100
IFSTLENDPL FARSYGADLP LEKLRELNFL RCKRVFEYGF FKVEELLKNP
110 120 130 140 150
LKILVLINCL GMYDWSLANK CVLHMLVFGT TVFVSGSEKH FKYLEKIYSL
160 170 180 190 200
EIFGCFALTE LSHGSNTKAM RTTAHYDPDT QEFILHSPDF EAAKFWVGNL
210 220 230 240 250
GKTATHAVVF AQLYMPDGQC HGLHSFLVQI RDTKTLLPMT GVMVGDIGKK
260 270 280 290 300
LGQNGLDNGF AMFNKVRIPR QNLLDRTGNI TSEGTYNSPF KDVRQRLGAS
310 320 330 340 350
LGSLSSGRIS IISMSVVNLK LAVSIAIRFS ATRCQFGPTD KEEIPVLEYP
360 370 380 390 400
LQQWRILPYL AAAYALDHFS KTIFMDLIEV QSARLRGDHS DQQAELGREI
410 420 430 440 450
HALASAGKPL ASWTAQRGIQ ECREACGGHG YLAMNRFGDL RNDNDPNCTY
460 470 480 490 500
EGDNNVLLQQ TSNYLLSLLE PPLQDGAHFT SPLKTVDFLE AYPGILGQKF
510 520 530 540 550
LGSSKADWMD SAAPLAAYRW LVCYLLQESH RRYCQEKKSR GSDFEARNNS
560 570 580 590 600
QVYGCRPLAL AFMELTVMQR FHEHIHSSGL SPSLRTVLGR LSTLYGLWCL
610 620 630 640 650
SQHMALLYRG GYISGEQTGR AMEDAILTLC EQLKDDAVAL VDVIAPSDFV
660 670 680 690 700
LNSPIAKADG ELYKNLWAAV LQQNGVLERA AWWPEFSANK SVADRLKSQL
Length:700
Mass (Da):78,404
Last modified:February 20, 2007 - v2
Checksum:i85C448E38A4A0C67
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1782DP → ES in CAC20692 (Ref. 1) Curated
Sequence conflicti364 – 3641Y → H in CAC20692 (Ref. 1) Curated
Sequence conflicti408 – 4092KP → NR in CAC20692 (Ref. 1) Curated
Sequence conflicti555 – 5551C → V in CAC20692 (Ref. 1) Curated
Sequence conflicti576 – 5761H → Y in AAH44725 (PubMed:15489334).Curated
Sequence conflicti593 – 5942TL → SV in CAC20692 (Ref. 1) Curated
Sequence conflicti607 – 6071L → S in CAC20692 (Ref. 1) Curated
Sequence conflicti669 – 6691A → R in CAC20692 (Ref. 1) Curated
Sequence conflicti681 – 6811A → R in CAC20692 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278430 mRNA. Translation: CAC20692.1.
BC044725 mRNA. Translation: AAH44725.1.
BC055019 mRNA. Translation: AAH55019.1.
CCDSiCCDS19232.1.
RefSeqiNP_109646.2. NM_030721.2.
XP_006504261.1. XM_006504198.2.
UniGeneiMm.291503.

Genome annotation databases

EnsembliENSMUST00000068947; ENSMUSP00000063412; ENSMUSG00000029098.
ENSMUST00000114237; ENSMUSP00000109875; ENSMUSG00000029098.
GeneIDi80911.
KEGGimmu:80911.
UCSCiuc008xdx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278430 mRNA. Translation: CAC20692.1.
BC044725 mRNA. Translation: AAH44725.1.
BC055019 mRNA. Translation: AAH55019.1.
CCDSiCCDS19232.1.
RefSeqiNP_109646.2. NM_030721.2.
XP_006504261.1. XM_006504198.2.
UniGeneiMm.291503.

3D structure databases

ProteinModelPortaliQ9EPL9.
SMRiQ9EPL9. Positions 21-668.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109876.

PTM databases

PhosphoSiteiQ9EPL9.

Proteomic databases

MaxQBiQ9EPL9.
PaxDbiQ9EPL9.
PRIDEiQ9EPL9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068947; ENSMUSP00000063412; ENSMUSG00000029098.
ENSMUST00000114237; ENSMUSP00000109875; ENSMUSG00000029098.
GeneIDi80911.
KEGGimmu:80911.
UCSCiuc008xdx.1. mouse.

Organism-specific databases

CTDi8310.
MGIiMGI:1933156. Acox3.

Phylogenomic databases

eggNOGiCOG1960.
GeneTreeiENSGT00530000062919.
HOGENOMiHOG000245077.
HOVERGENiHBG101107.
InParanoidiQ9EPL9.
KOiK00232.
OrthoDBiEOG744T8F.
PhylomeDBiQ9EPL9.
TreeFamiTF314226.

Enzyme and pathway databases

UniPathwayiUPA00661.
ReactomeiREACT_297709. Beta-oxidation of pristanoyl-CoA.

Miscellaneous databases

NextBioi350282.
PROiQ9EPL9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EPL9.
CleanExiMM_ACOX3.
ExpressionAtlasiQ9EPL9. baseline and differential.
GenevestigatoriQ9EPL9.

Family and domain databases

Gene3Di2.40.110.10. 1 hit.
InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF01756. ACOX. 1 hit.
PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
[Graphical view]
PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the mouse pristanoyl-CoA oxidase."
    Van Veldhoven P.P., Ghys K.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N and FVB/N-3.
    Tissue: Liver and Mammary tumor.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-505, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiACOX3_MOUSE
AccessioniPrimary (citable) accession number: Q9EPL9
Secondary accession number(s): Q7TPP6, Q80UQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: February 20, 2007
Last modified: April 1, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.