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Q9EPL9 (ACOX3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisomal acyl-coenzyme A oxidase 3

EC=1.3.3.6
Alternative name(s):
Branched-chain acyl-CoA oxidase
Short name=BRCACox
Pristanoyl-CoA oxidase
Gene names
Name:Acox3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length700 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Oxidizes the CoA-esters of 2-methyl-branched fatty acids By similarity.

Catalytic activity

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactor

FAD By similarity.

Pathway

Lipid metabolism; peroxisomal fatty acid beta-oxidation.

Subcellular location

Peroxisome Potential.

Sequence similarities

Belongs to the acyl-CoA oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 700699Peroxisomal acyl-coenzyme A oxidase 3
PRO_0000204686

Regions

Motif698 – 7003Microbody targeting signal By similarity

Amino acid modifications

Modified residue2811Phosphothreonine By similarity
Modified residue5051N6-succinyllysine Ref.3

Experimental info

Sequence conflict177 – 1782DP → ES in CAC20692. Ref.1
Sequence conflict3641Y → H in CAC20692. Ref.1
Sequence conflict408 – 4092KP → NR in CAC20692. Ref.1
Sequence conflict5551C → V in CAC20692. Ref.1
Sequence conflict5761H → Y in AAH44725. Ref.2
Sequence conflict593 – 5942TL → SV in CAC20692. Ref.1
Sequence conflict6071L → S in CAC20692. Ref.1
Sequence conflict6691A → R in CAC20692. Ref.1
Sequence conflict6811A → R in CAC20692. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9EPL9 [UniParc].

Last modified February 20, 2007. Version 2.
Checksum: 85C448E38A4A0C67

FASTA70078,404
        10         20         30         40         50         60 
MGSLPEEKDS ALWSDTPKGP LSAYRARASF NSGELLLFWD GQDVIHFKKT IFSTLENDPL 

        70         80         90        100        110        120 
FARSYGADLP LEKLRELNFL RCKRVFEYGF FKVEELLKNP LKILVLINCL GMYDWSLANK 

       130        140        150        160        170        180 
CVLHMLVFGT TVFVSGSEKH FKYLEKIYSL EIFGCFALTE LSHGSNTKAM RTTAHYDPDT 

       190        200        210        220        230        240 
QEFILHSPDF EAAKFWVGNL GKTATHAVVF AQLYMPDGQC HGLHSFLVQI RDTKTLLPMT 

       250        260        270        280        290        300 
GVMVGDIGKK LGQNGLDNGF AMFNKVRIPR QNLLDRTGNI TSEGTYNSPF KDVRQRLGAS 

       310        320        330        340        350        360 
LGSLSSGRIS IISMSVVNLK LAVSIAIRFS ATRCQFGPTD KEEIPVLEYP LQQWRILPYL 

       370        380        390        400        410        420 
AAAYALDHFS KTIFMDLIEV QSARLRGDHS DQQAELGREI HALASAGKPL ASWTAQRGIQ 

       430        440        450        460        470        480 
ECREACGGHG YLAMNRFGDL RNDNDPNCTY EGDNNVLLQQ TSNYLLSLLE PPLQDGAHFT 

       490        500        510        520        530        540 
SPLKTVDFLE AYPGILGQKF LGSSKADWMD SAAPLAAYRW LVCYLLQESH RRYCQEKKSR 

       550        560        570        580        590        600 
GSDFEARNNS QVYGCRPLAL AFMELTVMQR FHEHIHSSGL SPSLRTVLGR LSTLYGLWCL 

       610        620        630        640        650        660 
SQHMALLYRG GYISGEQTGR AMEDAILTLC EQLKDDAVAL VDVIAPSDFV LNSPIAKADG 

       670        680        690        700 
ELYKNLWAAV LQQNGVLERA AWWPEFSANK SVADRLKSQL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the mouse pristanoyl-CoA oxidase."
Van Veldhoven P.P., Ghys K.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N and FVB/N-3.
Tissue: Liver and Mammary tumor.
[3]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-505, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ278430 mRNA. Translation: CAC20692.1.
BC044725 mRNA. Translation: AAH44725.1.
BC055019 mRNA. Translation: AAH55019.1.
CCDSCCDS19232.1.
RefSeqNP_109646.2. NM_030721.2.
XP_006504261.1. XM_006504198.1.
UniGeneMm.291503.

3D structure databases

ProteinModelPortalQ9EPL9.
SMRQ9EPL9. Positions 21-668.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000109876.

PTM databases

PhosphoSiteQ9EPL9.

Proteomic databases

MaxQBQ9EPL9.
PaxDbQ9EPL9.
PRIDEQ9EPL9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000068947; ENSMUSP00000063412; ENSMUSG00000029098.
ENSMUST00000114237; ENSMUSP00000109875; ENSMUSG00000029098.
GeneID80911.
KEGGmmu:80911.
UCSCuc008xdx.1. mouse.

Organism-specific databases

CTD8310.
MGIMGI:1933156. Acox3.

Phylogenomic databases

eggNOGCOG1960.
GeneTreeENSGT00530000062919.
HOGENOMHOG000245077.
HOVERGENHBG101107.
KOK00232.
OrthoDBEOG744T8F.
PhylomeDBQ9EPL9.
TreeFamTF314226.

Enzyme and pathway databases

UniPathwayUPA00661.

Gene expression databases

ArrayExpressQ9EPL9.
BgeeQ9EPL9.
CleanExMM_ACOX3.
GenevestigatorQ9EPL9.

Family and domain databases

Gene3D2.40.110.10. 1 hit.
InterProIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamPF01756. ACOX. 1 hit.
PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
[Graphical view]
PIRSFPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.
ProtoNetSearch...

Other

NextBio350282.
PROQ9EPL9.
SOURCESearch...

Entry information

Entry nameACOX3_MOUSE
AccessionPrimary (citable) accession number: Q9EPL9
Secondary accession number(s): Q7TPP6, Q80UQ0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot