Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9EPL9

- ACOX3_MOUSE

UniProt

Q9EPL9 - ACOX3_MOUSE

Protein

Peroxisomal acyl-coenzyme A oxidase 3

Gene

Acox3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (20 Feb 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Oxidizes the CoA-esters of 2-methyl-branched fatty acids.By similarity

    Catalytic activityi

    Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

    Cofactori

    FAD.By similarity

    Pathwayi

    GO - Molecular functioni

    1. acyl-CoA dehydrogenase activity Source: InterPro
    2. flavin adenine dinucleotide binding Source: InterPro
    3. pristanoyl-CoA oxidase activity Source: MGI

    GO - Biological processi

    1. fatty acid beta-oxidation Source: MGI
    2. fatty acid beta-oxidation using acyl-CoA oxidase Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00661.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal acyl-coenzyme A oxidase 3 (EC:1.3.3.6)
    Alternative name(s):
    Branched-chain acyl-CoA oxidase
    Short name:
    BRCACox
    Pristanoyl-CoA oxidase
    Gene namesi
    Name:Acox3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1933156. Acox3.

    Subcellular locationi

    Peroxisome Curated

    GO - Cellular componenti

    1. mitochondrion Source: MGI
    2. peroxisomal matrix Source: MGI

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 700699Peroxisomal acyl-coenzyme A oxidase 3PRO_0000204686Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei281 – 2811PhosphothreonineBy similarity
    Modified residuei505 – 5051N6-succinyllysine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9EPL9.
    PaxDbiQ9EPL9.
    PRIDEiQ9EPL9.

    PTM databases

    PhosphoSiteiQ9EPL9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9EPL9.
    BgeeiQ9EPL9.
    CleanExiMM_ACOX3.
    GenevestigatoriQ9EPL9.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000109876.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EPL9.
    SMRiQ9EPL9. Positions 21-668.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi698 – 7003Microbody targeting signalBy similarity

    Sequence similaritiesi

    Belongs to the acyl-CoA oxidase family.Curated

    Phylogenomic databases

    eggNOGiCOG1960.
    GeneTreeiENSGT00530000062919.
    HOGENOMiHOG000245077.
    HOVERGENiHBG101107.
    KOiK00232.
    OrthoDBiEOG744T8F.
    PhylomeDBiQ9EPL9.
    TreeFamiTF314226.

    Family and domain databases

    Gene3Di2.40.110.10. 1 hit.
    InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR012258. Acyl-CoA_oxidase.
    IPR002655. Acyl-CoA_oxidase_C.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view]
    PfamiPF01756. ACOX. 1 hit.
    PF00441. Acyl-CoA_dh_1. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
    SUPFAMiSSF47203. SSF47203. 2 hits.
    SSF56645. SSF56645. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9EPL9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSLPEEKDS ALWSDTPKGP LSAYRARASF NSGELLLFWD GQDVIHFKKT    50
    IFSTLENDPL FARSYGADLP LEKLRELNFL RCKRVFEYGF FKVEELLKNP 100
    LKILVLINCL GMYDWSLANK CVLHMLVFGT TVFVSGSEKH FKYLEKIYSL 150
    EIFGCFALTE LSHGSNTKAM RTTAHYDPDT QEFILHSPDF EAAKFWVGNL 200
    GKTATHAVVF AQLYMPDGQC HGLHSFLVQI RDTKTLLPMT GVMVGDIGKK 250
    LGQNGLDNGF AMFNKVRIPR QNLLDRTGNI TSEGTYNSPF KDVRQRLGAS 300
    LGSLSSGRIS IISMSVVNLK LAVSIAIRFS ATRCQFGPTD KEEIPVLEYP 350
    LQQWRILPYL AAAYALDHFS KTIFMDLIEV QSARLRGDHS DQQAELGREI 400
    HALASAGKPL ASWTAQRGIQ ECREACGGHG YLAMNRFGDL RNDNDPNCTY 450
    EGDNNVLLQQ TSNYLLSLLE PPLQDGAHFT SPLKTVDFLE AYPGILGQKF 500
    LGSSKADWMD SAAPLAAYRW LVCYLLQESH RRYCQEKKSR GSDFEARNNS 550
    QVYGCRPLAL AFMELTVMQR FHEHIHSSGL SPSLRTVLGR LSTLYGLWCL 600
    SQHMALLYRG GYISGEQTGR AMEDAILTLC EQLKDDAVAL VDVIAPSDFV 650
    LNSPIAKADG ELYKNLWAAV LQQNGVLERA AWWPEFSANK SVADRLKSQL 700
    Length:700
    Mass (Da):78,404
    Last modified:February 20, 2007 - v2
    Checksum:i85C448E38A4A0C67
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti177 – 1782DP → ES in CAC20692. 1 PublicationCurated
    Sequence conflicti364 – 3641Y → H in CAC20692. 1 PublicationCurated
    Sequence conflicti408 – 4092KP → NR in CAC20692. 1 PublicationCurated
    Sequence conflicti555 – 5551C → V in CAC20692. 1 PublicationCurated
    Sequence conflicti576 – 5761H → Y in AAH44725. (PubMed:15489334)Curated
    Sequence conflicti593 – 5942TL → SV in CAC20692. 1 PublicationCurated
    Sequence conflicti607 – 6071L → S in CAC20692. 1 PublicationCurated
    Sequence conflicti669 – 6691A → R in CAC20692. 1 PublicationCurated
    Sequence conflicti681 – 6811A → R in CAC20692. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278430 mRNA. Translation: CAC20692.1.
    BC044725 mRNA. Translation: AAH44725.1.
    BC055019 mRNA. Translation: AAH55019.1.
    CCDSiCCDS19232.1.
    RefSeqiNP_109646.2. NM_030721.2.
    XP_006504261.1. XM_006504198.1.
    UniGeneiMm.291503.

    Genome annotation databases

    EnsembliENSMUST00000068947; ENSMUSP00000063412; ENSMUSG00000029098.
    ENSMUST00000114237; ENSMUSP00000109875; ENSMUSG00000029098.
    GeneIDi80911.
    KEGGimmu:80911.
    UCSCiuc008xdx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278430 mRNA. Translation: CAC20692.1 .
    BC044725 mRNA. Translation: AAH44725.1 .
    BC055019 mRNA. Translation: AAH55019.1 .
    CCDSi CCDS19232.1.
    RefSeqi NP_109646.2. NM_030721.2.
    XP_006504261.1. XM_006504198.1.
    UniGenei Mm.291503.

    3D structure databases

    ProteinModelPortali Q9EPL9.
    SMRi Q9EPL9. Positions 21-668.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000109876.

    PTM databases

    PhosphoSitei Q9EPL9.

    Proteomic databases

    MaxQBi Q9EPL9.
    PaxDbi Q9EPL9.
    PRIDEi Q9EPL9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000068947 ; ENSMUSP00000063412 ; ENSMUSG00000029098 .
    ENSMUST00000114237 ; ENSMUSP00000109875 ; ENSMUSG00000029098 .
    GeneIDi 80911.
    KEGGi mmu:80911.
    UCSCi uc008xdx.1. mouse.

    Organism-specific databases

    CTDi 8310.
    MGIi MGI:1933156. Acox3.

    Phylogenomic databases

    eggNOGi COG1960.
    GeneTreei ENSGT00530000062919.
    HOGENOMi HOG000245077.
    HOVERGENi HBG101107.
    KOi K00232.
    OrthoDBi EOG744T8F.
    PhylomeDBi Q9EPL9.
    TreeFami TF314226.

    Enzyme and pathway databases

    UniPathwayi UPA00661 .

    Miscellaneous databases

    NextBioi 350282.
    PROi Q9EPL9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9EPL9.
    Bgeei Q9EPL9.
    CleanExi MM_ACOX3.
    Genevestigatori Q9EPL9.

    Family and domain databases

    Gene3Di 2.40.110.10. 1 hit.
    InterProi IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR012258. Acyl-CoA_oxidase.
    IPR002655. Acyl-CoA_oxidase_C.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view ]
    Pfami PF01756. ACOX. 1 hit.
    PF00441. Acyl-CoA_dh_1. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000168. Acyl-CoA_oxidase. 1 hit.
    SUPFAMi SSF47203. SSF47203. 2 hits.
    SSF56645. SSF56645. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the mouse pristanoyl-CoA oxidase."
      Van Veldhoven P.P., Ghys K.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N and FVB/N-3.
      Tissue: Liver and Mammary tumor.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-505, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiACOX3_MOUSE
    AccessioniPrimary (citable) accession number: Q9EPL9
    Secondary accession number(s): Q7TPP6, Q80UQ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2001
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3