UniProtKB - Q9EPL0 (XYLT2_MOUSE)
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Protein
Xylosyltransferase 2
Gene
Xylt2
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in the formation of heparan sulfate and chondroitin sulfate proteoglycans (By similarity). Probably catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes (By similarity).By similarity
Catalytic activityi
UDP-alpha-D-xylose + [protein]-L-serine = UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine.
Cofactori
a divalent metal cationBy similarity
: chondroitin sulfate biosynthesis Pathwayi
This protein is involved in the pathway chondroitin sulfate biosynthesis, which is part of Glycan metabolism.View all proteins of this organism that are known to be involved in the pathway chondroitin sulfate biosynthesis and in Glycan metabolism.
: heparan sulfate biosynthesis Pathwayi
This protein is involved in the pathway heparan sulfate biosynthesis, which is part of Glycan metabolism.View all proteins of this organism that are known to be involved in the pathway heparan sulfate biosynthesis and in Glycan metabolism.
GO - Molecular functioni
- acetylglucosaminyltransferase activity Source: InterPro
- protein xylosyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- chondroitin sulfate biosynthetic process Source: UniProtKB-UniPathway
- chondroitin sulfate proteoglycan biosynthetic process Source: UniProtKB
- glycosaminoglycan biosynthetic process Source: MGI
- heparan sulfate proteoglycan biosynthetic process Source: UniProtKB
- heparin biosynthetic process Source: MGI
- proteoglycan biosynthetic process Source: MGI
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
Reactomei | R-MMU-1971475. A tetrasaccharide linker sequence is required for GAG synthesis. |
UniPathwayi | UPA00755. UPA00756. |
Protein family/group databases
CAZyi | GT14. Glycosyltransferase Family 14. |
Names & Taxonomyi
Protein namesi | Recommended name: Xylosyltransferase 2 (EC:2.4.2.26)Alternative name(s): Peptide O-xylosyltransferase 2 Xylosyltransferase II |
Gene namesi | Name:Xylt2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2444797. Xylt2. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 15 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 16 – 36 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 37 – 865 | LumenalSequence analysisAdd BLAST | 829 |
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191407 | 1 – 865 | Xylosyltransferase 2Add BLAST | 865 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 122 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 327 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 683 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Contains disulfide bonds.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MaxQBi | Q9EPL0. |
PaxDbi | Q9EPL0. |
PRIDEi | Q9EPL0. |
PTM databases
iPTMneti | Q9EPL0. |
PhosphoSitePlusi | Q9EPL0. |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000020868. |
CleanExi | MM_XYLT2. |
ExpressionAtlasi | Q9EPL0. baseline and differential. |
Genevisiblei | Q9EPL0. MM. |
Interactioni
Subunit structurei
Monomer.By similarity
Protein-protein interaction databases
IntActi | Q9EPL0. 1 interactor. |
STRINGi | 10090.ENSMUSP00000112052. |
Structurei
3D structure databases
ProteinModelPortali | Q9EPL0. |
SMRi | Q9EPL0. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0799. Eukaryota. ENOG410XQ7M. LUCA. |
GeneTreei | ENSGT00760000119183. |
HOGENOMi | HOG000070086. |
HOVERGENi | HBG059443. |
InParanoidi | Q9EPL0. |
KOi | K00771. |
OMAi | WRMVTIW. |
OrthoDBi | EOG091G020K. |
PhylomeDBi | Q9EPL0. |
TreeFami | TF315534. |
Family and domain databases
InterProi | View protein in InterPro IPR003406. Glyco_trans_14. IPR024448. XylT. |
Pfami | View protein in Pfam PF02485. Branch. 1 hit. PF12529. Xylo_C. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q9EPL0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVASARVQKL VRRYKLAIAT ALAILLLQGL VVWSFSGLEE DEPGEKGRQR
60 70 80 90 100
KPRPLDPGEG SKDTDSSAGR RGSAGRRHGR WRGRAESPGV PVAKVVRAVT
110 120 130 140 150
SRQRASRRVP PAPPPEAPGR QNLSGAAAGE ALIGAPGFPQ HGDTGSVEGA
160 170 180 190 200
PQPTDNTFTP KCEIVGKDAL SALARASTKQ CQQEIANVVC LHQAGNLMPK
210 220 230 240 250
SVPRHCQLAG KMSPGVQWEE IRAQQPVGGP PVRIAYMLVV HGRAIRQLKR
260 270 280 290 300
LLKAVYHEQH FFYIHVDKRS NYLYREVVEL AQHYENVRVT PWRMVTIWGG
310 320 330 340 350
ASLLRMYLRS MKDLLEIPGW TWDFFINLSA TDYPTRTNEE LVAFLSKNRD
360 370 380 390 400
KNFLKSHGRD NSRFIKKQGL DRLFHECDSH MWRLGERQIP AGIVVDGGSD
410 420 430 440 450
WFVLTRSFVE YVVYTDDPLV AQLRQFYTYT LLPAESFFHT VLENSPACAS
460 470 480 490 500
LVDNNLRVTN WNRKLGCKCQ YKHIVDWCGC SPNDFKPQDF LRLQQVSRPT
510 520 530 540 550
FFARKFESTV NQEVLEILDF HLYGSYPPST PALKAYWENI YDVADGPGGL
560 570 580 590 600
SDVLLTAYTA FARLSLRHAA TAVSPLATAV CRFEPRGLPS SVHLYFYDDH
610 620 630 640 650
FQGYLVTQAV QPSAQGPAET LEMWLMPQRS LKLLGHSDQA SRLQSLEVGT
660 670 680 690 700
EWDPKERLFR NFGGLLGPLD EPVAMQRWAR GPNLTATVVW IDPTYVVATS
710 720 730 740 750
YDITVDADTE VTQYKPPLSL PLRPGAWTVR LLQFWEPLGE TRFLVLPLTF
760 770 780 790 800
NRKLPLRKDD ASWLHAGPPH NEYMEQSFQG LSGILNLPQA EALEEAARRH
810 820 830 840 850
TELTGSALEA WTDGELSNFW SVAGLCAIGP SACPSLELCR LTSWSSLSPD
860
PKSELGPVKA DGRLR
Sequence cautioni
The sequence AAH34082 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 94 | K → N in CAC18567 (Ref. 1) Curated | 1 | |
Sequence conflicti | 460 | N → K in CAC18567 (Ref. 1) Curated | 1 | |
Sequence conflicti | 466 – 467 | GC → AG in CAC18567 (Ref. 1) Curated | 2 | |
Sequence conflicti | 478 | C → S in CAC18567 (Ref. 1) Curated | 1 | |
Sequence conflicti | 483 | N → K in CAC18567 (Ref. 1) Curated | 1 | |
Sequence conflicti | 487 | P → R in CAC18567 (Ref. 1) Curated | 1 | |
Sequence conflicti | 504 – 506 | RKF → GKL in CAC18567 (Ref. 1) Curated | 3 | |
Sequence conflicti | 515 | L → V in CAC18567 (Ref. 1) Curated | 1 | |
Sequence conflicti | 666 | L → V in CAC18567 (Ref. 1) Curated | 1 | |
Sequence conflicti | 672 | P → A in CAC18567 (Ref. 1) Curated | 1 | |
Sequence conflicti | 675 – 676 | MQ → LR in CAC18567 (Ref. 1) Curated | 2 | |
Sequence conflicti | 685 | T → R in CAC18567 (Ref. 1) Curated | 1 | |
Sequence conflicti | 768 – 770 | PPH → QPQ in CAC18567 (Ref. 1) Curated | 3 | |
Sequence conflicti | 780 | G → V in CAC18567 (Ref. 1) Curated | 1 | |
Sequence conflicti | 788 | P → S in CAC18567 (Ref. 1) Curated | 1 | |
Sequence conflicti | 799 | R → Q in CAC18567 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ291751 mRNA. Translation: CAC18567.2. AL645764 Genomic DNA. No translation available. BC034082 mRNA. Translation: AAH34082.1. Different initiation. |
CCDSi | CCDS48888.1. |
RefSeqi | NP_665827.2. NM_145828.3. |
UniGenei | Mm.100638. |
Genome annotation databases
Ensembli | ENSMUST00000116349; ENSMUSP00000112052; ENSMUSG00000020868. |
GeneIDi | 217119. |
KEGGi | mmu:217119. |
UCSCi | uc007kzi.2. mouse. |
Similar proteinsi
Entry informationi
Entry namei | XYLT2_MOUSE | |
Accessioni | Q9EPL0Primary (citable) accession number: Q9EPL0 Secondary accession number(s): Q5SUY1, Q8K060 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | March 28, 2018 | |
This is version 118 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |