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Protein

Exportin-7

Gene

Xpo7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).By similarity

GO - Molecular functioni

  • nuclear export signal receptor activity Source: MGI
  • Ran GTPase binding Source: MGI

GO - Biological processi

  • mRNA transport Source: UniProtKB-KW
  • nucleocytoplasmic transport Source: MGI
  • protein export from nucleus Source: MGI
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-7
Short name:
Exp7
Alternative name(s):
Ran-binding protein 16
Gene namesi
Name:Xpo7
Synonyms:Kiaa0745, Ranbp16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1929705. Xpo7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 10871086Exportin-7PRO_0000204714Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei570 – 5701PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9EPK7.
MaxQBiQ9EPK7.
PaxDbiQ9EPK7.
PeptideAtlasiQ9EPK7.
PRIDEiQ9EPK7.

PTM databases

iPTMnetiQ9EPK7.
PhosphoSiteiQ9EPK7.

Expressioni

Tissue specificityi

Highly expressed in testis and spleen, moderate in kidney and liver and low in heart, brain, lung and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9EPK7.
CleanExiMM_XPO7.
ExpressionAtlasiQ9EPK7. baseline and differential.
GenevisibleiQ9EPK7. MM.

Interactioni

Subunit structurei

Binds to nucleoporins. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with ARHGAP1 and SFN. Interacts with Ran and cargo proteins in a GTP-dependent manner (By similarity).By similarity

GO - Molecular functioni

  • Ran GTPase binding Source: MGI

Protein-protein interaction databases

BioGridi211141. 1 interaction.
IntActiQ9EPK7. 1 interaction.
MINTiMINT-4998171.
STRINGi10090.ENSMUSP00000022696.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 9667Importin N-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the exportin family.Curated
Contains 1 importin N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1410. Eukaryota.
ENOG410XRPR. LUCA.
GeneTreeiENSGT00730000110927.
HOVERGENiHBG018869.
InParanoidiQ9EPK7.
KOiK18460.
PhylomeDBiQ9EPK7.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9EPK7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADHVQSLAQ LENLCKQLYE TTDTTTRLQA EKALVEFTNS PDCLSKCQLL
60 70 80 90 100
LERGSSSYSQ LLAATCLTKL VSRTNNPLPL EQRIDIRNYV LNYLATRPKL
110 120 130 140 150
ATFVTQALIQ LYARITKLGW FDCQKDDYVF RNAITDVTRF LQDSVEYCII
160 170 180 190 200
GVTILSQLTN EINQADTTHP LTKHRKIASS FRDSSLFDIF TLSCNLLKQA
210 220 230 240 250
SGKNLNLNDE SQHGLLMQLL KLTHNCLNFD FIGTSTDESS DDLCTVQIPT
260 270 280 290 300
SWRSAFLDSS TLQLFFDLYH SIPPSFSPLV LSCLVQIASV RRSLFNNAER
310 320 330 340 350
AKFLSHLVDG VKRILENPQS LSDPNNYHEF CRLLARLKSN YQLGELVKVE
360 370 380 390 400
NYPDVIRLIA NFTVTSLQHW EFAPNSVHYL LSLWQRLAAS VPYVKATEPH
410 420 430 440 450
MLETYTPEVT KAYITSRLES VHIILRDGLE DPLEDTGLVQ QQLDQLSTIG
460 470 480 490 500
RCEYEKTCAL LVQLFDQSAQ SYQELLQSAS ASPMDIAVQE GRLTWLVYII
510 520 530 540 550
GAVIGGRVSF ASTDEQDAMD GELVCRVLQL MNLTDSRLAQ AGNEKLELAM
560 570 580 590 600
LSFFEQFRKI YIGDQVQKSS KLYRRLSEVL GLNDETMVLS VFIGKVITNL
610 620 630 640 650
KYWGRCEPIT SKTLQLLNDL SIGYSSVRKL VKLSAVQFML NNHTSEHFSF
660 670 680 690 700
LGINNQSNLT DMRCRTTFYT ALGRLLMVDL GEDEDQYEQF MLPLTAAFEA
710 720 730 740 750
VAQMFSTNSF NEQEAKRTLV GLVRDLRGIA FAFNAKTSFM MLFEWIYPSY
760 770 780 790 800
MPILQRAIEL WYHDPACTTP VLKLMAELVH NRSQRLQFDV SSPNGILLFR
810 820 830 840 850
ETSKMITMYG NRILTLGEVP KDQVYALKLK GISICFSMLK AALSGSYVNF
860 870 880 890 900
GVFRLYGDDA LENALQTFIK LLLSIPHSDL LDYPKLSQSY YSLLEVLTQD
910 920 930 940 950
HMNFIASLEP HVIMYILSSI SEGLTALDTM VCTGCCSCLD HIVTYLFKQL
960 970 980 990 1000
SRSTKKRTTP LNRESDCFLH IMQQHPAMIQ QMLSTVLNII IFEDCRNQWS
1010 1020 1030 1040 1050
MSRPLLGLIL LNEKYFSDLR NSIVNSQPPE KQQAMHLCFE NLMEGIERNL
1060 1070 1080
LTKNRDRFTQ NLSAFRREVN DSMKNSTYGV NSNDMMS
Length:1,087
Mass (Da):123,810
Last modified:January 23, 2007 - v3
Checksum:iC45A97F9B7AAC9FF
GO
Isoform 2 (identifier: Q9EPK7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1058-1087: Missing.

Show »
Length:1,057
Mass (Da):120,384
Checksum:i442D0D634DF59386
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771P → T in BAC29600 (PubMed:16141072).Curated
Sequence conflicti161 – 1611E → G in BAC29182 (PubMed:16141072).Curated
Sequence conflicti251 – 2511S → N in BAC65643 (PubMed:12693553).Curated
Sequence conflicti681 – 6833Missing in BAC65643 (PubMed:12693553).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1058 – 108730Missing in isoform 2. 1 PublicationVSP_018600Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297360 mRNA. Translation: CAC17621.1.
AK028303 mRNA. Translation: BAC25870.1.
AK032768 mRNA. Translation: BAC28013.1.
AK035775 mRNA. Translation: BAC29182.1.
AK036837 mRNA. Translation: BAC29600.1.
AK041768 mRNA. Translation: BAC31059.1.
AK164595 mRNA. Translation: BAE37843.1.
BC029702 mRNA. Translation: AAH29702.1.
AK122361 Transcribed RNA. Translation: BAC65643.1.
CCDSiCCDS36974.1. [Q9EPK7-1]
RefSeqiNP_075532.1. NM_023045.2. [Q9EPK7-1]
UniGeneiMm.152987.

Genome annotation databases

EnsembliENSMUST00000022696; ENSMUSP00000022696; ENSMUSG00000022100. [Q9EPK7-1]
GeneIDi65246.
KEGGimmu:65246.
UCSCiuc033gsa.1. mouse. [Q9EPK7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297360 mRNA. Translation: CAC17621.1.
AK028303 mRNA. Translation: BAC25870.1.
AK032768 mRNA. Translation: BAC28013.1.
AK035775 mRNA. Translation: BAC29182.1.
AK036837 mRNA. Translation: BAC29600.1.
AK041768 mRNA. Translation: BAC31059.1.
AK164595 mRNA. Translation: BAE37843.1.
BC029702 mRNA. Translation: AAH29702.1.
AK122361 Transcribed RNA. Translation: BAC65643.1.
CCDSiCCDS36974.1. [Q9EPK7-1]
RefSeqiNP_075532.1. NM_023045.2. [Q9EPK7-1]
UniGeneiMm.152987.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211141. 1 interaction.
IntActiQ9EPK7. 1 interaction.
MINTiMINT-4998171.
STRINGi10090.ENSMUSP00000022696.

PTM databases

iPTMnetiQ9EPK7.
PhosphoSiteiQ9EPK7.

Proteomic databases

EPDiQ9EPK7.
MaxQBiQ9EPK7.
PaxDbiQ9EPK7.
PeptideAtlasiQ9EPK7.
PRIDEiQ9EPK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022696; ENSMUSP00000022696; ENSMUSG00000022100. [Q9EPK7-1]
GeneIDi65246.
KEGGimmu:65246.
UCSCiuc033gsa.1. mouse. [Q9EPK7-1]

Organism-specific databases

CTDi23039.
MGIiMGI:1929705. Xpo7.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1410. Eukaryota.
ENOG410XRPR. LUCA.
GeneTreeiENSGT00730000110927.
HOVERGENiHBG018869.
InParanoidiQ9EPK7.
KOiK18460.
PhylomeDBiQ9EPK7.

Miscellaneous databases

PROiQ9EPK7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EPK7.
CleanExiMM_XPO7.
ExpressionAtlasiQ9EPK7. baseline and differential.
GenevisibleiQ9EPK7. MM.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR001494. Importin-beta_N.
[Graphical view]
PfamiPF03810. IBN_N. 1 hit.
[Graphical view]
SMARTiSM00913. IBN_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS50166. IMPORTIN_B_NT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Cerebellum, Head, Lung, Thymus, Vagina and Wolffian duct.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Liver.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-1087 (ISOFORM 1).
    Tissue: Brain.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiXPO7_MOUSE
AccessioniPrimary (citable) accession number: Q9EPK7
Secondary accession number(s): Q3TP94
, Q80TS9, Q8BSK5, Q8C9M7, Q8CB42, Q8CBL8, Q8CEF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.