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Protein

GDNF family receptor alpha-4

Gene

Gfra4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.

GO - Molecular functioni

  • glial cell-derived neurotrophic factor receptor activity Source: RGD

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-RNO-5673001 RAF/MAP kinase cascade
R-RNO-8853659 RET signaling

Names & Taxonomyi

Protein namesi
Recommended name:
GDNF family receptor alpha-4
Short name:
GDNF receptor alpha-4
Short name:
GDNFR-alpha-4
Short name:
GFR-alpha-4
Alternative name(s):
Persephin receptor
Gene namesi
Name:Gfra4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620503 Gfra4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000010797? – 250GDNF family receptor alpha-4
Signal peptidei1 – ?Sequence analysis
PropeptideiPRO_0000010798251 – 273Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi250GPI-anchor amidated asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9EPI2

Expressioni

Tissue specificityi

Weakly expressed in heart, brain and testis.

Gene expression databases

BgeeiENSRNOG00000021241
GenevisibleiQ9EPI2 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042875

Structurei

3D structure databases

ProteinModelPortaliQ9EPI2
SMRiQ9EPI2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GDNFR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J23G Eukaryota
ENOG4111972 LUCA
GeneTreeiENSGT00550000074579
HOGENOMiHOG000231728
HOVERGENiHBG051727
InParanoidiQ9EPI2
OMAiTFVPACA
OrthoDBiEOG091G0NA3

Family and domain databases

InterProiView protein in InterPro
IPR016017 GDNF/GAS1
IPR037193 GDNF_alpha
IPR003438 GDNF_rcpt
PANTHERiPTHR10269 PTHR10269, 1 hit
PfamiView protein in Pfam
PF02351 GDNF, 2 hits
PRINTSiPR01316 GDNFRECEPTOR
SMARTiView protein in SMART
SM00907 GDNF, 2 hits
SUPFAMiSSF110035 SSF110035, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform A (identifier: Q9EPI2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSGAYLRVL NERPGQAVLW SLGCQRGSAS STEGNRCVEA AEACTADEQC
60 70 80 90 100
QQLRSEYVAQ CLGRAGWRGP GSCVRSRCRR ALRRFFARGP PALTHALLFC
110 120 130 140 150
GCEGPACAER RRQTFAPACA FSGPQLAPPS CLKPLDRCER SRRCRPRLFA
160 170 180 190 200
FQASCAPAPG SRDGCPEEGG PRCLRAYAGL VGTVVTPNYL DNVSARVAPW
210 220 230 240 250
CGCEASGNRR EECEAFRKLF TRNPCLDGAI QAFDSSQPSV LQDQWNPYQN
260 270
AGCCFLWVSS MSILTALALQ ALL
Note: GPI-anchored form.
Length:273
Mass (Da):29,682
Last modified:April 23, 2003 - v2
Checksum:iE0BB76ABE2AC6B04
GO
Isoform B (identifier: Q9EPI2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     253-273: CCFLWVSSMSILTALALQALL → QAKVEA

Show »
Length:258
Mass (Da):28,043
Checksum:iE0CAD2451EF5669E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti257W → R in 50% of the molecules. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007230253 – 273CCFLW…LQALL → QAKVEA in isoform B. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ294475 mRNA Translation: CAC16420.1
AJ294476 mRNA Translation: CAC16421.1
RefSeqiNP_076457.1, NM_023967.1 [Q9EPI2-2]
UniGeneiRn.230120

Genome annotation databases

EnsembliENSRNOT00000047947; ENSRNOP00000042875; ENSRNOG00000021241 [Q9EPI2-2]
GeneIDi66023
KEGGirno:66023
UCSCiRGD:620503 rat [Q9EPI2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGFRA4_RAT
AccessioniPrimary (citable) accession number: Q9EPI2
Secondary accession number(s): Q9EPI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: May 23, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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