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Protein

GDNF family receptor alpha-4

Gene

Gfra4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.

GO - Molecular functioni

  • glial cell-derived neurotrophic factor receptor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-RNO-5673001. RAF/MAP kinase cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
GDNF family receptor alpha-4
Short name:
GDNF receptor alpha-4
Short name:
GDNFR-alpha-4
Short name:
GFR-alpha-4
Alternative name(s):
Persephin receptor
Gene namesi
Name:Gfra4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620503. Gfra4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 250GDNF family receptor alpha-4PRO_0000010797
Signal peptidei1 – ?Sequence analysis
Propeptidei251 – 27323Removed in mature formSequence analysisPRO_0000010798Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis
Lipidationi250 – 2501GPI-anchor amidated asparagineSequence analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9EPI2.

Expressioni

Tissue specificityi

Weakly expressed in heart, brain and testis.

Gene expression databases

BgeeiENSRNOG00000021241.
GenevisibleiQ9EPI2. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042875.

Structurei

3D structure databases

ProteinModelPortaliQ9EPI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GDNFR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J23G. Eukaryota.
ENOG4111972. LUCA.
GeneTreeiENSGT00550000074579.
HOGENOMiHOG000231728.
HOVERGENiHBG051727.
InParanoidiQ9EPI2.
OMAiTFVPACA.
OrthoDBiEOG091G0NA3.

Family and domain databases

InterProiIPR016017. GDNF/GAS1.
IPR003438. GDNF_rcpt.
[Graphical view]
PfamiPF02351. GDNF. 2 hits.
[Graphical view]
PRINTSiPR01316. GDNFRECEPTOR.
SMARTiSM00907. GDNF. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform A (identifier: Q9EPI2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSGAYLRVL NERPGQAVLW SLGCQRGSAS STEGNRCVEA AEACTADEQC
60 70 80 90 100
QQLRSEYVAQ CLGRAGWRGP GSCVRSRCRR ALRRFFARGP PALTHALLFC
110 120 130 140 150
GCEGPACAER RRQTFAPACA FSGPQLAPPS CLKPLDRCER SRRCRPRLFA
160 170 180 190 200
FQASCAPAPG SRDGCPEEGG PRCLRAYAGL VGTVVTPNYL DNVSARVAPW
210 220 230 240 250
CGCEASGNRR EECEAFRKLF TRNPCLDGAI QAFDSSQPSV LQDQWNPYQN
260 270
AGCCFLWVSS MSILTALALQ ALL
Note: GPI-anchored form.
Length:273
Mass (Da):29,682
Last modified:April 23, 2003 - v2
Checksum:iE0BB76ABE2AC6B04
GO
Isoform B (identifier: Q9EPI2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     253-273: CCFLWVSSMSILTALALQALL → QAKVEA

Show »
Length:258
Mass (Da):28,043
Checksum:iE0CAD2451EF5669E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti257 – 2571W → R in 50% of the molecules. 1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei253 – 27321CCFLW…LQALL → QAKVEA in isoform B. 1 PublicationVSP_007230Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ294475 mRNA. Translation: CAC16420.1.
AJ294476 mRNA. Translation: CAC16421.1.
RefSeqiNP_076457.1. NM_023967.1. [Q9EPI2-2]
UniGeneiRn.230120.

Genome annotation databases

EnsembliENSRNOT00000047947; ENSRNOP00000042875; ENSRNOG00000021241. [Q9EPI2-2]
GeneIDi66023.
KEGGirno:66023.
UCSCiRGD:620503. rat. [Q9EPI2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ294475 mRNA. Translation: CAC16420.1.
AJ294476 mRNA. Translation: CAC16421.1.
RefSeqiNP_076457.1. NM_023967.1. [Q9EPI2-2]
UniGeneiRn.230120.

3D structure databases

ProteinModelPortaliQ9EPI2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042875.

Proteomic databases

PaxDbiQ9EPI2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000047947; ENSRNOP00000042875; ENSRNOG00000021241. [Q9EPI2-2]
GeneIDi66023.
KEGGirno:66023.
UCSCiRGD:620503. rat. [Q9EPI2-1]

Organism-specific databases

CTDi64096.
RGDi620503. Gfra4.

Phylogenomic databases

eggNOGiENOG410J23G. Eukaryota.
ENOG4111972. LUCA.
GeneTreeiENSGT00550000074579.
HOGENOMiHOG000231728.
HOVERGENiHBG051727.
InParanoidiQ9EPI2.
OMAiTFVPACA.
OrthoDBiEOG091G0NA3.

Enzyme and pathway databases

ReactomeiR-RNO-5673001. RAF/MAP kinase cascade.

Miscellaneous databases

PROiQ9EPI2.

Gene expression databases

BgeeiENSRNOG00000021241.
GenevisibleiQ9EPI2. RN.

Family and domain databases

InterProiIPR016017. GDNF/GAS1.
IPR003438. GDNF_rcpt.
[Graphical view]
PfamiPF02351. GDNF. 2 hits.
[Graphical view]
PRINTSiPR01316. GDNFRECEPTOR.
SMARTiSM00907. GDNF. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGFRA4_RAT
AccessioniPrimary (citable) accession number: Q9EPI2
Secondary accession number(s): Q9EPI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: September 7, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.