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Protein

Xylosyltransferase 2

Gene

Xylt2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the formation of heparan sulfate and chondroitin sulfate proteoglycans (By similarity). Probably catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes (By similarity).By similarity

Catalytic activityi

Transfers a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxy group of an acceptor protein substrate.

Cofactori

Pathwayi: chondroitin sulfate biosynthesis

This protein is involved in the pathway chondroitin sulfate biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway chondroitin sulfate biosynthesis and in Glycan metabolism.

Pathwayi: heparan sulfate biosynthesis

This protein is involved in the pathway heparan sulfate biosynthesis, which is part of Glycan metabolism.
View all proteins of this organism that are known to be involved in the pathway heparan sulfate biosynthesis and in Glycan metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00755.
UPA00756.

Protein family/group databases

CAZyiGT14. Glycosyltransferase Family 14.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylosyltransferase 2 (EC:2.4.2.26)
Alternative name(s):
Peptide O-xylosyltransferase 2
Xylosyltransferase II
Gene namesi
Name:Xylt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619765. Xylt2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515CytoplasmicSequence analysisAdd
BLAST
Transmembranei16 – 3621Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini37 – 864828LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 864864Xylosyltransferase 2PRO_0000191409Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence analysis
Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence analysis
Glycosylationi682 – 6821N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Contains disulfide bonds.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9EPI0.
PRIDEiQ9EPI0.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

MINTiMINT-4579569.
STRINGi10116.ENSRNOP00000052446.

Structurei

3D structure databases

ProteinModelPortaliQ9EPI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0799. Eukaryota.
ENOG410XQ7M. LUCA.
HOGENOMiHOG000070086.
HOVERGENiHBG059443.
InParanoidiQ9EPI0.
PhylomeDBiQ9EPI0.

Family and domain databases

InterProiIPR003406. Glyco_trans_14.
IPR024448. XylT.
[Graphical view]
PfamiPF02485. Branch. 1 hit.
PF12529. Xylo_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EPI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVASARVQKL VRRYKLAIAT ALAILLLQGL VVWSFSGLEE DEPGEKGRQR
60 70 80 90 100
KPRPLDPGEG SKDTDSSAGR RGSAGRRHGR WRGRAESPGV PVAKVVRAVT
110 120 130 140 150
SRQRASRRVP PAPPPEAPGR QNLSGAAAGE ALIGAAGFPQ HGDTGSVEGA
160 170 180 190 200
PQPTDNSFTP KCEIVGKDAL SALARASTKH CQQEIANVVC LHQAGNLMPK
210 220 230 240 250
SVPRHCQLAG KVSPGIQWEE VRAQQPVSGP LVRIAYMLVV HGRAVRQLKR
260 270 280 290 300
LLKAVYHEEH FFYIHVDKRS NYLYREVVEL AQHYDNVRVT PWRMVTIWGG
310 320 330 340 350
ASLLRMYLRS MKDLLETPGW TWDFFINLSA TDYPTRTNEE LVAFLSKNRD
360 370 380 390 400
KNFLKSHGRD NSRFIKKQGL DRLFHECDSH MWRLGERQIP AGIVVDGGSD
410 420 430 440 450
WFVLTRSFVE YVVYTEDPLV AQLRQFYTYT LLPAESFFHT VLENSPACES
460 470 480 490 500
LVDNNLRVTN WNRKLGCKCQ YKHIVDWCGC SPNDFKPQDF LRLQQVSRPT
510 520 530 540 550
FFARKFESTV NQEVLEILDF HLYGSYPPGT PALKAYWENI YDMADGPSGL
560 570 580 590 600
SDVLLTAYTA FARISLRHAA TVSPLATAVC RFEPRGLPSS VHLYFYDDHF
610 620 630 640 650
QGYLVTQAVQ PSAQGPAETL EMWLMPQRLL KPLGHSDQAS RLQSLEVGTE
660 670 680 690 700
WDPKERLFRN FGGLLGPLDE PVAMQRWARG PNLTATVVWI DPTYVVATSY
710 720 730 740 750
DITVDADTEV TQYKPPLSLP LRPGAWTVRL LQFWEPLGET RFLVLPLTFN
760 770 780 790 800
HKLPLRKDDA SWLHAGPPHN EYMEQSFQGL SGILNLPQPE AVEEAARRHT
810 820 830 840 850
ELTGPALEAW TDGELSSFWS VAGLCAIGPS SCPSLELCRL TSWSSLSPDP
860
KSELGPVKAD GRLR
Length:864
Mass (Da):96,790
Last modified:March 1, 2001 - v1
Checksum:iED6586B9D886D21D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ295749 mRNA. Translation: CAC16796.2.
UniGeneiRn.22727.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ295749 mRNA. Translation: CAC16796.2.
UniGeneiRn.22727.

3D structure databases

ProteinModelPortaliQ9EPI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4579569.
STRINGi10116.ENSRNOP00000052446.

Protein family/group databases

CAZyiGT14. Glycosyltransferase Family 14.

Proteomic databases

PaxDbiQ9EPI0.
PRIDEiQ9EPI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi619765. Xylt2.

Phylogenomic databases

eggNOGiKOG0799. Eukaryota.
ENOG410XQ7M. LUCA.
HOGENOMiHOG000070086.
HOVERGENiHBG059443.
InParanoidiQ9EPI0.
PhylomeDBiQ9EPI0.

Enzyme and pathway databases

UniPathwayiUPA00755.
UPA00756.

Miscellaneous databases

PROiQ9EPI0.

Family and domain databases

InterProiIPR003406. Glyco_trans_14.
IPR024448. XylT.
[Graphical view]
PfamiPF02485. Branch. 1 hit.
PF12529. Xylo_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and expression of human UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase and its first isoform XT-II."
    Goetting C., Kuhn J., Zahn R., Brinkmann T., Kleesiek K.
    J. Mol. Biol. 304:517-528(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiXYLT2_RAT
AccessioniPrimary (citable) accession number: Q9EPI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2001
Last modified: January 20, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.