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Protein
Submitted name:

Solute carrier family 25, member 27, isoform CRA_d

Gene

Slc25a27

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • cellular triglyceride homeostasis Source: RGD
  • inner ear development Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of mitochondrial calcium ion concentration Source: RGD
  • negative regulation of mitochondrial membrane potential Source: RGD
  • neuron death Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • regulation of glucose import Source: RGD
  • transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

TransportUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Solute carrier family 25, member 27, isoform CRA_dImported
Submitted name:
Uncoupling protein UCP-4, isoform cImported
Gene namesi
Name:Slc25a27Imported
Synonyms:Ucp-4Imported
ORF Names:rCG_43627Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620787. Slc25a27.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei305 – 32723HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical part of cell Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrion Source: GOC
  • neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039207.

Family & Domainsi

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EPH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFPEEESLQ PLTQRWPRTS KFLLSGCAAT VAELATFPLD LTKTRLQMQG
60 70 80 90 100
EAALAKLGDG AMESAPYRGM MRTALGIVQE EGFLKLWQGV TPAIYRHVVY
110 120 130 140 150
SGGRMVTYEH LREVVFGKSE DEHYPLWKSV IGGMMAGVIG QFLANPTDLV
160 170 180 190 200
KVQMQMEGKR RLEGKPLRFR GVHHAFAKIL AEGGIRGLWA GWIPNIQRAA
210 220 230 240 250
LVNMGDLTTY DTVKHYLVLN TALEDNIATH GLSSLCSGLV ASILGTPADV
260 270 280 290 300
IKSRIMNQPR DKQGRGLLYK SSTDCVIQAV QGEGFLSLYK GFLPSWLRMV
310 320 330 340 350
KTGRFCFFLC FLYISLTCTL QVFFILLSDV WPHERPIHLP FKNLYCRGFF
360
FFQPFLRIMF PFLTD
Length:365
Mass (Da):41,144
Last modified:March 1, 2001 - v1
Checksum:i477B389BBE1F7525
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ300164 mRNA. Translation: CAC20900.1.
CH473987 Genomic DNA. Translation: EDM18704.1.
RefSeqiXP_006244672.1. XM_006244610.2.
UniGeneiRn.163043.

Genome annotation databases

GeneIDi85262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ300164 mRNA. Translation: CAC20900.1.
CH473987 Genomic DNA. Translation: EDM18704.1.
RefSeqiXP_006244672.1. XM_006244610.2.
UniGeneiRn.163043.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039207.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi85262.

Organism-specific databases

CTDi9481.
RGDi620787. Slc25a27.

Phylogenomic databases

eggNOGiKOG0753. Eukaryota.
ENOG410XRV1. LUCA.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Three different isoforms of UCP-4 are expressed in rat preoptic hypothalamus."
    Alberati-Giani D., Gatti S., Rial E., Danel F., Hauser N., Bubendorff C., Bartfai T.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague DawleyImported.
    Tissue: BrainImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.

Entry informationi

Entry nameiQ9EPH5_RAT
AccessioniPrimary (citable) accession number: Q9EPH5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.