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Protein

Alpha-1B-glycoprotein

Gene

A1bg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.

Protein family/group databases

MEROPSiI43.950.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1B-glycoprotein
Alternative name(s):
Alpha-1-B glycoprotein
C44
Liver regeneration-related protein 1
Gene namesi
Name:A1bgImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi69417. A1bg.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 513493Alpha-1B-glycoproteinSequence analysisPRO_0000014503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi49 ↔ 96PROSITE-ProRule annotationBy similarity
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence analysis
Disulfide bondi153 ↔ 195PROSITE-ProRule annotationBy similarity
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis
Disulfide bondi245 ↔ 292PROSITE-ProRule annotationBy similarity
Disulfide bondi343 ↔ 392PROSITE-ProRule annotationBy similarity
Glycosylationi369 – 3691N-linked (GlcNAc...)Sequence analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence analysis
Glycosylationi389 – 3891N-linked (GlcNAc...)Sequence analysis
Disulfide bondi441 ↔ 488PROSITE-ProRule annotationBy similarity
Glycosylationi485 – 4851N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9EPH1.
PRIDEiQ9EPH1.

Expressioni

Tissue specificityi

Isoform 1 is expressed in normal liver. Isoform 2 is expressed in the regenerating liver after partial hepatectomy and at very low levels in the normal lung, brain and testis.2 Publications

Developmental stagei

In females, isoform 1 is expressed at day 35 with higher levels detected at day 56. Isoform 1 is not detected in males of any age.1 Publication

Inductioni

Isoform 1 is up-regulated by continuous exposure to growth hormone.1 Publication

Gene expression databases

GenevisibleiQ9EPH1. RN.

Interactioni

Subunit structurei

Interacts with CRISP3.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006273.

Structurei

3D structure databases

ProteinModelPortaliQ9EPH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 126105Ig-like V-type 1Sequence analysisAdd
BLAST
Domaini127 – 21993Ig-like V-type 2Sequence analysisAdd
BLAST
Domaini220 – 31293Ig-like V-type 3Sequence analysisAdd
BLAST
Domaini313 – 415103Ig-like V-type 4Sequence analysisAdd
BLAST
Domaini416 – 51398Ig-like V-type 5Sequence analysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IY79. Eukaryota.
ENOG4111984. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000152502.
HOVERGENiHBG000037.
InParanoidiQ9EPH1.
OMAiTHETLAC.
OrthoDBiEOG78SQGZ.
PhylomeDBiQ9EPH1.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00409. IG. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9EPH1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLLTTVLLL WGFTLGPGNA LWLDSGSEPE LRAEPQSLLE PWANLTLVCA
60 70 80 90 100
VDLPTKVFEL IMNGWFLSQV RLETPVLSYR FSLGAITSNN SGVYRCRCGV
110 120 130 140 150
EPPVDIQLPA LSKWTMLSNA LEVTGKEPLP PPSAHADPVS WITPGGLPVY
160 170 180 190 200
IMCRVAMRGV TYLLRKEGVD GTQKPDVQHK GTAGFLIYKP GNYSCSYLTH
210 220 230 240 250
AGGKPSEPSA IVTIKMSATQ LPPSLCLMGS YLTIYPQKTH ETLACKAPRN
260 270 280 290 300
AAEFQLRQGE RVLNIQGFSP TRDATIYYVN LKELDNQSPF TCRYRMHKYM
310 320 330 340 350
HVWSEDSKPV ELMWSDEKLP APVLTAEPSS HNLEPGSTVQ LRCTAHKAGL
360 370 380 390 400
RFGLQRQGKP DLVVVQMLNS SGTEAVFELH NISTIDSGNY SCIYMEQAPP
410 420 430 440 450
FSGSASSEPL ELRINGPAPK PRLEALWKGK VPLGHEAIFQ CHGHVPRVSM
460 470 480 490 500
ELVREGFKTP FWMASTTSTS AFLKLSFVGP QHTGNYSCRY TALSPFTFES
510
GISDPVEVVV EGS
Length:513
Mass (Da):56,479
Last modified:December 20, 2005 - v2
Checksum:i9CFA96A8BBC2ED1D
GO
Isoform 21 Publication (identifier: Q9EPH1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     417-473: PAPKPRLEAL...ASTTSTSAFL → ELRRTMTEEG...TWKSGLFRIL
     474-513: Missing.

Show »
Length:473
Mass (Da):52,497
Checksum:i829180C7E33F92BD
GO

Sequence cautioni

The sequence AAF68963.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241D → N in CAC19029 (PubMed:11356721).Curated
Sequence conflicti204 – 2041K → E in CAC19029 (PubMed:11356721).Curated
Sequence conflicti239 – 2391T → A in AAF68963 (PubMed:11097837).Curated
Sequence conflicti242 – 2421T → M in AAF68963 (PubMed:11097837).Curated
Sequence conflicti283 – 2831E → K in AAF68963 (PubMed:11097837).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei417 – 47357PAPKP…TSAFL → ELRRTMTEEGTERYSLRNQG SCAVISQLYLNEVLGFENLE EISLRCETWKSGLFRIL in isoform 2. 1 PublicationVSP_051640Add
BLAST
Alternative sequencei474 – 51340Missing in isoform 2. 1 PublicationVSP_051641Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302031 mRNA. Translation: CAC19029.1.
BC089771 mRNA. Translation: AAH89771.1.
AF236054 mRNA. Translation: AAF68963.1. Different initiation.
RefSeqiNP_071594.2. NM_022258.2.
UniGeneiRn.53990.

Genome annotation databases

EnsembliENSRNOT00000006273; ENSRNOP00000006273; ENSRNOG00000004692. [Q9EPH1-1]
GeneIDi140656.
KEGGirno:140656.
UCSCiRGD:69417. rat. [Q9EPH1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302031 mRNA. Translation: CAC19029.1.
BC089771 mRNA. Translation: AAH89771.1.
AF236054 mRNA. Translation: AAF68963.1. Different initiation.
RefSeqiNP_071594.2. NM_022258.2.
UniGeneiRn.53990.

3D structure databases

ProteinModelPortaliQ9EPH1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006273.

Protein family/group databases

MEROPSiI43.950.

Proteomic databases

PaxDbiQ9EPH1.
PRIDEiQ9EPH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006273; ENSRNOP00000006273; ENSRNOG00000004692. [Q9EPH1-1]
GeneIDi140656.
KEGGirno:140656.
UCSCiRGD:69417. rat. [Q9EPH1-1]

Organism-specific databases

CTDi1.
RGDi69417. A1bg.

Phylogenomic databases

eggNOGiENOG410IY79. Eukaryota.
ENOG4111984. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000152502.
HOVERGENiHBG000037.
InParanoidiQ9EPH1.
OMAiTHETLAC.
OrthoDBiEOG78SQGZ.
PhylomeDBiQ9EPH1.
TreeFamiTF336644.

Enzyme and pathway databases

ReactomeiR-RNO-114608. Platelet degranulation.

Miscellaneous databases

PROiQ9EPH1.

Gene expression databases

GenevisibleiQ9EPH1. RN.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00409. IG. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel growth hormone-regulated rat complementary deoxyribonucleic acid with homology to the human alpha1B-glycoprotein, characterizing a new protein family."
    Gardmo C., Persson B., Mode A.
    Endocrinology 142:2695-2701(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
    Strain: Sprague-DawleyImported.
    Tissue: LiverImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.
  3. "Identification and characterization of differentially expressed genes in the early response phase during liver regeneration."
    Xu W., Wang S., Wang G., Wei H., He F., Yang X.
    Biochem. Biophys. Res. Commun. 278:318-325(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 219-513 (ISOFORM 2), TISSUE SPECIFICITY.
    Strain: Wistar1 Publication.
    Tissue: LiverImported.

Entry informationi

Entry nameiA1BG_RAT
AccessioniPrimary (citable) accession number: Q9EPH1
Secondary accession number(s): Q5EBD6, Q9JKL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: December 20, 2005
Last modified: June 8, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.