ID   Q9EPF7_MOUSE            Unreviewed;       316 AA.
AC   Q9EPF7;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 158.
DE   SubName: Full=Olfactory receptor family 2 subfamily AG member 1 {ECO:0000313|Ensembl:ENSMUSP00000050694.6};
DE   SubName: Full=T2 olfactory receptor {ECO:0000313|EMBL:AAG45196.1};
GN   Name=Or2ag1 {ECO:0000313|Ensembl:ENSMUSP00000050694.6,
GN   ECO:0000313|MGI:MGI:3030539};
GN   Synonyms=Olfr705 {ECO:0000313|MGI:MGI:3030539};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAG45196.1};
RN   [1] {ECO:0000313|EMBL:AAG45196.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:AAG45196.1};
RX   PubMed=11416212; DOI=10.1073/pnas.131215398;
RA   Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L.,
RA   Evans G., Axel R., Hood L., Trask B.J.;
RT   "Genomic analysis of orthologous mouse and human olfactory receptor loci.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000050694.6, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000050694.6,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000050694.6}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000050694.6};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF321234; AAG45196.1; -; Genomic_DNA.
DR   RefSeq; NP_667243.2; NM_147032.2.
DR   STRING; 10090.ENSMUSP00000150853; -.
DR   PaxDb; 10090-ENSMUSP00000050694; -.
DR   DNASU; 259034; -.
DR   Ensembl; ENSMUST00000060879.6; ENSMUSP00000050694.6; ENSMUSG00000109058.4.
DR   Ensembl; ENSMUST00000213721.2; ENSMUSP00000149585.2; ENSMUSG00000109058.4.
DR   Ensembl; ENSMUST00000216009.2; ENSMUSP00000150853.2; ENSMUSG00000109058.4.
DR   GeneID; 259034; -.
DR   KEGG; mmu:259034; -.
DR   UCSC; uc009jaj.1; mouse.
DR   AGR; MGI:3030539; -.
DR   CTD; 144125; -.
DR   MGI; MGI:3030539; Or2ag1.
DR   VEuPathDB; HostDB:ENSMUSG00000109058; -.
DR   eggNOG; ENOG502SIEP; Eukaryota.
DR   GeneTree; ENSGT01090000259995; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   OMA; YELFVYV; -.
DR   OrthoDB; 3784606at2759; -.
DR   BioGRID-ORCS; 259034; 1 hit in 40 CRISPR screens.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000109058; Expressed in respiratory tract epithelium and 2 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; ISA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR   GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR   CDD; cd15421; 7tmA_OR2T-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF183; OLFACTORY RECEPTOR 2AG1; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Olfaction {ECO:0000256|ARBA:ARBA00022725};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AAG45196.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        29..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        60..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        99..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        140..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        197..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        237..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        273..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          41..290
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
SQ   SEQUENCE   316 AA;  35252 MW;  B50299F55D161A1E CRC64;
     MEPWNSTLGT DFNLVGILDD SGSPELLCAT FTALYMLALI SNGLLILVIT MDARLHVPMY
     FLLGQLSLMD LLFTSVVTPK AVIDFLLRDN TISFEGCSLQ MFLALTLGGA EDLLLAFMAY
     DRYVAICHPL NYMIFMRPSI CWLMVATSWV LASLMALGYT TYTMQYSYCK SRKIRHLLCE
     IPPLLKLACA DTSKYELMVY VMGVTFLIPP LAAILASYSL ILFTVLHMPS NEGRKKALVT
     CSSHLTVVGM FYGAATFMYV LPNSFHSPRQ DNIISVFYTI VTPALNPLIY SLRNKEVTGA
     LIRVLGRYIV PAHPTL
//