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Protein

Manganese-transporting ATPase 13A1

Gene

Atp13a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei5304-aspartylphosphate intermediateBy similarity1
Metal bindingi861MagnesiumBy similarity1
Metal bindingi865MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Manganese-transporting ATPase 13A1 (EC:3.6.3.-)
Short name:
CATP
Gene namesi
Name:Atp13a1
Synonyms:Atp13a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2180801. Atp13a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 63CytoplasmicSequence analysisAdd BLAST63
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 92ExtracellularSequence analysis8
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Topological domaini114 – 240CytoplasmicSequence analysisAdd BLAST127
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 440ExtracellularSequence analysisAdd BLAST179
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Topological domaini462 – 985CytoplasmicSequence analysisAdd BLAST524
Transmembranei986 – 1006HelicalSequence analysisAdd BLAST21
Topological domaini1007ExtracellularSequence analysis1
Transmembranei1008 – 1028HelicalSequence analysisAdd BLAST21
Topological domaini1029 – 1047CytoplasmicSequence analysisAdd BLAST19
Transmembranei1048 – 1068HelicalSequence analysisAdd BLAST21
Topological domaini1069 – 1092ExtracellularSequence analysisAdd BLAST24
Transmembranei1093 – 1113HelicalSequence analysisAdd BLAST21
Topological domaini1114 – 1128CytoplasmicSequence analysisAdd BLAST15
Transmembranei1129 – 1149HelicalSequence analysisAdd BLAST21
Topological domaini1150 – 1162ExtracellularSequence analysisAdd BLAST13
Transmembranei1163 – 1183HelicalSequence analysisAdd BLAST21
Topological domaini1184 – 1200CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000464221 – 1200Manganese-transporting ATPase 13A1Add BLAST1200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi284N-linked (GlcNAc...)Sequence analysis1
Glycosylationi417N-linked (GlcNAc...)Sequence analysis1
Modified residuei896PhosphoserineCombined sources1
Modified residuei902PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9EPE9.
MaxQBiQ9EPE9.
PaxDbiQ9EPE9.
PeptideAtlasiQ9EPE9.
PRIDEiQ9EPE9.

PTM databases

iPTMnetiQ9EPE9.
PhosphoSitePlusiQ9EPE9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031862.
CleanExiMM_ATP13A1.
GenevisibleiQ9EPE9. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9EPE9. 3 interactors.
MINTiMINT-1850391.
STRINGi10090.ENSMUSP00000034326.

Structurei

3D structure databases

ProteinModelPortaliQ9EPE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0209. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00550000075064.
HOGENOMiHOG000199432.
HOVERGENiHBG050602.
InParanoidiQ9EPE9.
KOiK14950.
OMAiYLYSEAQ.
OrthoDBiEOG091G00UD.
TreeFamiTF300725.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF82. PTHR24093:SF82. 3 hits.
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EPE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVVGNAVPC GARPGGARDN GSPQPGSRLR PGLAAGPALI ANGDELVAAV
60 70 80 90 100
WPYRRLALLR RLTVLPFAGL LYPAWLGAAA SGCWGWGSSW TQIPEAALLA
110 120 130 140 150
LATICLAHAL TVLSGHWSVH AHCALTCTPE YDPNKVTFVK VVPTPNNGST
160 170 180 190 200
ELVALHRDKG EDGLEVLSFE FQKIKYSYDA LEKKQFLPVA FPVGNAFSYY
210 220 230 240 250
QSNRGFQEDS EIRAAEKKFG SNKAEMVVPD FSELFKERAT APFFVFQVFC
260 270 280 290 300
VGLWCLDEYW YYSVFTLSML VAFEASLVQQ QMRNMSEIRK MGNKPHMIQV
310 320 330 340 350
YRSRKWRPVA SDDIVPGDIV SIGRSPQENL VPCDVLLLRG RCIVDEAMLT
360 370 380 390 400
GESVPQMKEP IEDLSPDRVL DLQADARLHV IFGGTKVVQH IPPQKATSGL
410 420 430 440 450
KPVDNGCVAF VLRTGFNTSQ GRLLRTILFG VKRVTANNLE TFIFILFLLV
460 470 480 490 500
FAIAAAAYVW VEGTKDPSRN RYKLFLECTL ILTSVVPPEL PIELSLAVNT
510 520 530 540 550
SLIALAKLYM YCTEPFRIPF AGKVEVCCFD KTGTLTSDSL VVRGVAGLRD
560 570 580 590 600
GKEVTPVSSI PIETHRALAS CHSLMQLDDG TLVGDPLEKA MLTAVDWTLT
610 620 630 640 650
KDEKVFPRSI KTQGLKIHQR FHFASALKRM SVLASYEKLG STDLCYIAAV
660 670 680 690 700
KGAPETLHSM FSQCPPDYHH IHTEISREGA RVLALGYKEL GHLTHQQARE
710 720 730 740 750
IKREALECSL KFVGFIVVSC PLKADSKAVI REIQNASHRV VMITGDNPLT
760 770 780 790 800
ACHVAQELHF IDKAHTLILH PPSEKGQPCE WRSIDSSIVL PLTLGSPKAL
810 820 830 840 850
ALEHALCLTG DGLAHLQAVD PQQLLCLIPH VQVFARVAPK QKEFVITSLK
860 870 880 890 900
ELGYVTLMCG DGTNDVGALK HADVGVALLA NAPERVVERR RRPRDSPVLS
910 920 930 940 950
NSGPRVSRST KQKSALLSPE EPPASHRDRL SQVLRDLEEE STPIVKLGDA
960 970 980 990 1000
SIAAPFTSKL SSIQCICHVI KQGRCTLVTT LQMFKILALN ALILAYSQSV
1010 1020 1030 1040 1050
LYLEGVKFSD FQATLQGLLL AGCFLFISRS KPLKTLSRER PLPNIFNLYT
1060 1070 1080 1090 1100
ILTVMLQFSV HFLSLVYLYR EAQARSPEKQ EQFVDLYKEF EPSLVNSTVY
1110 1120 1130 1140 1150
IMAMAMQMAT FAINYKGPPF MESLPENKPL VWSLAVSLLA IIGLLLGSSP
1160 1170 1180 1190 1200
DFNSQFGLVD IPVEFKLVIG QVLALDFCLA LLADRVLQFF LGTPKLRVPS
Length:1,200
Mass (Da):132,388
Last modified:July 27, 2011 - v2
Checksum:i059C366D63030B82
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188P → S in BAB20095 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035381 mRNA. Translation: BAB20095.1.
CH466569 Genomic DNA. Translation: EDL28752.1.
BC138721 mRNA. Translation: AAI38722.1.
BC138722 mRNA. Translation: AAI38723.1.
CCDSiCCDS22349.1.
RefSeqiNP_573487.2. NM_133224.2.
UniGeneiMm.186066.

Genome annotation databases

EnsembliENSMUST00000034326; ENSMUSP00000034326; ENSMUSG00000031862.
GeneIDi170759.
KEGGimmu:170759.
UCSCiuc009lxr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035381 mRNA. Translation: BAB20095.1.
CH466569 Genomic DNA. Translation: EDL28752.1.
BC138721 mRNA. Translation: AAI38722.1.
BC138722 mRNA. Translation: AAI38723.1.
CCDSiCCDS22349.1.
RefSeqiNP_573487.2. NM_133224.2.
UniGeneiMm.186066.

3D structure databases

ProteinModelPortaliQ9EPE9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9EPE9. 3 interactors.
MINTiMINT-1850391.
STRINGi10090.ENSMUSP00000034326.

PTM databases

iPTMnetiQ9EPE9.
PhosphoSitePlusiQ9EPE9.

Proteomic databases

EPDiQ9EPE9.
MaxQBiQ9EPE9.
PaxDbiQ9EPE9.
PeptideAtlasiQ9EPE9.
PRIDEiQ9EPE9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034326; ENSMUSP00000034326; ENSMUSG00000031862.
GeneIDi170759.
KEGGimmu:170759.
UCSCiuc009lxr.2. mouse.

Organism-specific databases

CTDi57130.
MGIiMGI:2180801. Atp13a1.

Phylogenomic databases

eggNOGiKOG0209. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00550000075064.
HOGENOMiHOG000199432.
HOVERGENiHBG050602.
InParanoidiQ9EPE9.
KOiK14950.
OMAiYLYSEAQ.
OrthoDBiEOG091G00UD.
TreeFamiTF300725.

Enzyme and pathway databases

ReactomeiR-MMU-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiQ9EPE9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031862.
CleanExiMM_ATP13A1.
GenevisibleiQ9EPE9. MM.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF82. PTHR24093:SF82. 3 hits.
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT131_MOUSE
AccessioniPrimary (citable) accession number: Q9EPE9
Secondary accession number(s): B2RS54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.