Q9EPC2 (FGF23_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor 23
Short name=FGF-23

Gene names

Name:

Fgf23

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulator of phosphate homeostasis By similarity. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels By similarity. Acts directly on the parathyroid to decrease PTH secretion By similarity. Regulator of vitamin-D metabolism By similarity. Negatively regulates osteoblasts differentiation and matrix mineralization By similarity. Upregulates EGR1 expression in the presence of KL. Ref.3
Subunit structure	Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors By similarity. Ref.3
Subcellular location	Secreted By similarity. Note: Secretion is dependent on O-glycosylation By similarity.
Tissue specificity	Mainly expressed in the brain and thymus at low levels. In brain; preferentially expressed in the ventrolateral thalamic nucleus.
Post-translational modification	Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases By similarity. O-glycosylated by GALT3. Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23 By similarity.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Biological process	Differentiation
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW cellular phosphate ion homeostasis Inferred from mutant phenotype. Source: MGI negative regulation of hormone secretion Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of ERK1 and ERK2 cascade Inferred from direct assay Ref.3. Source: UniProtKB positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway Inferred from genetic interaction. Source: MGI positive regulation of transcription, DNA-dependent Inferred from direct assay Ref.3. Source: UniProtKB
Molecular function	growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW type 1 fibroblast growth factor receptor binding Inferred from physical interaction Ref.3. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 251	227	Fibroblast growth factor 23		PRO_0000008999
Amino acid modifications
	Glycosylation	178	1	O-linked (GalNAc) By similarity
	Disulfide bond	95 ↔ 113		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9EPC2 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 110C1F2C735DC360	FASTA	251	27,758
	10 20 30 40 50 60 MLGTCLRLLV GVLCTVCSLG TARAYPDTSP LLGSNWGSLT HLYTATARTS YHLQIHRDGH 70 80 90 100 110 120 VDGTPHQTIY SALMITSEDA GSVVITGAMT RRFLCMDLHG NIFGSLHFSP ENCKFRQWTL 130 140 150 160 170 180 ENGYDVYLSQ KHHYLVSLGR AKRIFQPGTN PPPFSQFLAR RNEVPLLHFY TVRPRRHTRS 190 200 210 220 230 240 AEDPPERDPL NVLKPRPRAT PVPVSCSREL PSAEEGGPAA SDPLGVLRRG RGDARGGAGG 250 ADRCRPFPRF V

References

[1]	"Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain." Yamashita T., Yoshioka M., Itoh N. Biochem. Biophys. Res. Commun. 277:494-498(2000) [PubMed: 11032749] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23." White K.E., Evans W.E., O'Riordan J.L.H., Speer M.C., Econs M.J., Lorenz-Depiereux B., Grabowski M., Meitinger T., Strom T.M. Nat. Genet. 26:345-348(2000) [PubMed: 11062477] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Embryo.
[3]	"Klotho converts canonical FGF receptor into a specific receptor for FGF23." Urakawa I., Yamazaki Y., Shimada T., Iijima K., Hasegawa H., Okawa K., Fujita T., Fukumoto S., Yamashita T. Nature 444:770-774(2006) [PubMed: 17086194] [Abstract] Cited for: FUNCTION, INTERACTION WITH KL AND FGFR1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB037889 mRNA. Translation: BAB13478.1. AF263536 mRNA. Translation: AAG09916.1.
IPI	IPI00109761.
PIR	JC7513.
RefSeq	NP_073148.1. NM_022657.3.
UniGene	Mm.347933.
3D structure databases
ProteinModelPortal	Q9EPC2.
SMR	Q9EPC2. Positions 29-169.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9EPC2.
Proteomic databases
PRIDE	Q9EPC2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000000186; ENSMUSP00000000186; ENSMUSG00000000182.
GeneID	64654.
KEGG	mmu:64654.
Organism-specific databases
CTD	8074.
MGI	MGI:1891427. Fgf23.
Phylogenomic databases
GeneTree	ENSGT00530000063469.
HOGENOM	HBG269053.
HOVERGEN	HBG051613.
InParanoid	Q9EPC2.
OMA	ASCSQEL.
OrthoDB	EOG4MKNH6.
Gene expression databases
ArrayExpress	Q9EPC2.
Bgee	Q9EPC2.
CleanEx	MM_FGF23.
Genevestigator	Q9EPC2.
GermOnline	ENSMUSG00000000182. Mus musculus.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002348. IL1_HBGF. [Graphical view]
KO	K04358.
PANTHER	PTHR11486. IL1_HBGF. 1 hit.
Pfam	PF00167. FGF. 1 hit. [Graphical view]
SMART	SM00442. FGF. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00247. HBGF_FGF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	462088.
SOURCE	Search...

Entry information

Entry name

FGF23_MOUSE

Accession

Primary (citable) accession number: Q9EPC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	March 1, 2001
Last modified:	November 16, 2011
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program