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Protein

Fibroblast growth factor 23

Gene

Fgf23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator of phosphate homeostasis (By similarity). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism (By similarity). Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity). Upregulates EGR1 expression in the presence of KL.By similarity1 Publication

GO - Molecular functioni

  • growth factor activity Source: UniProtKB-KW
  • type 1 fibroblast growth factor receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGrowth factor
Biological processDifferentiation

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-190322 FGFR4 ligand binding and activation
R-MMU-190372 FGFR3c ligand binding and activation
R-MMU-190373 FGFR1c ligand binding and activation
R-MMU-190374 FGFR1c and Klotho ligand binding and activation
R-MMU-190375 FGFR2c ligand binding and activation
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-5654219 Phospholipase C-mediated cascade: FGFR1
R-MMU-5654221 Phospholipase C-mediated cascade, FGFR2
R-MMU-5654227 Phospholipase C-mediated cascade, FGFR3
R-MMU-5654228 Phospholipase C-mediated cascade, FGFR4
R-MMU-5654687 Downstream signaling of activated FGFR1
R-MMU-5654688 SHC-mediated cascade:FGFR1
R-MMU-5654689 PI-3K cascade:FGFR1
R-MMU-5654693 FRS-mediated FGFR1 signaling
R-MMU-5654695 PI-3K cascade:FGFR2
R-MMU-5654699 SHC-mediated cascade:FGFR2
R-MMU-5654700 FRS-mediated FGFR2 signaling
R-MMU-5654704 SHC-mediated cascade:FGFR3
R-MMU-5654706 FRS-mediated FGFR3 signaling
R-MMU-5654710 PI-3K cascade:FGFR3
R-MMU-5654712 FRS-mediated FGFR4 signaling
R-MMU-5654719 SHC-mediated cascade:FGFR4
R-MMU-5654720 PI-3K cascade:FGFR4
R-MMU-5654726 Negative regulation of FGFR1 signaling
R-MMU-5654727 Negative regulation of FGFR2 signaling
R-MMU-5654732 Negative regulation of FGFR3 signaling
R-MMU-5654733 Negative regulation of FGFR4 signaling
R-MMU-5658623 FGFRL1 modulation of FGFR1 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 23
Short name:
FGF-23
Gene namesi
Name:Fgf23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1891427 Fgf23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000899925 – 251Fibroblast growth factor 23Add BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi95 ↔ 113By similarity
Glycosylationi178O-linked (GalNAc) threonineBy similarity1

Post-translational modificationi

Following secretion this protein is inactivated by cleavage into a N-terminal fragment and a C-terminal fragment. The processing is effected by proprotein convertases (By similarity).By similarity
O-glycosylated by GALT3. Glycosylation is necessary for secretion; it blocks processing by proprotein convertases when the O-glycan is alpha 2,6-sialylated. Competition between proprotein convertase cleavage and block of cleavage by O-glycosylation determines the level of secreted active FGF23 (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9EPC2
PaxDbiQ9EPC2
PRIDEiQ9EPC2

PTM databases

iPTMnetiQ9EPC2
PhosphoSitePlusiQ9EPC2

Expressioni

Tissue specificityi

Mainly expressed in the brain and thymus at low levels. In brain; preferentially expressed in the ventrolateral thalamic nucleus.

Gene expression databases

BgeeiENSMUSG00000000182
CleanExiMM_FGF23
ExpressionAtlasiQ9EPC2 baseline and differential
GenevisibleiQ9EPC2 MM

Interactioni

Subunit structurei

Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).By similarity

GO - Molecular functioni

  • growth factor activity Source: UniProtKB-KW
  • type 1 fibroblast growth factor receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi211090, 3 interactors
STRINGi10090.ENSMUSP00000000186

Structurei

3D structure databases

ProteinModelPortaliQ9EPC2
SMRiQ9EPC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00530000063469
HOGENOMiHOG000112573
HOVERGENiHBG051613
InParanoidiQ9EPC2
KOiK22428
OMAiQIHKDGH
OrthoDBiEOG091G0NAY
PhylomeDBiQ9EPC2
TreeFamiTF335872

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028304 FGF23
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF69 PTHR11486:SF69, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EPC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGTCLRLLV GVLCTVCSLG TARAYPDTSP LLGSNWGSLT HLYTATARTS
60 70 80 90 100
YHLQIHRDGH VDGTPHQTIY SALMITSEDA GSVVITGAMT RRFLCMDLHG
110 120 130 140 150
NIFGSLHFSP ENCKFRQWTL ENGYDVYLSQ KHHYLVSLGR AKRIFQPGTN
160 170 180 190 200
PPPFSQFLAR RNEVPLLHFY TVRPRRHTRS AEDPPERDPL NVLKPRPRAT
210 220 230 240 250
PVPVSCSREL PSAEEGGPAA SDPLGVLRRG RGDARGGAGG ADRCRPFPRF

V
Length:251
Mass (Da):27,758
Last modified:March 1, 2001 - v1
Checksum:i110C1F2C735DC360
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037889 mRNA Translation: BAB13478.1
AF263536 mRNA Translation: AAG09916.1
CCDSiCCDS20562.1
PIRiJC7513
RefSeqiNP_073148.1, NM_022657.4
UniGeneiMm.347933

Genome annotation databases

EnsembliENSMUST00000000186; ENSMUSP00000000186; ENSMUSG00000000182
GeneIDi64654
KEGGimmu:64654
UCSCiuc009dvp.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFGF23_MOUSE
AccessioniPrimary (citable) accession number: Q9EPC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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