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Q9EPB7

- GPR88_MOUSE

UniProt

Q9EPB7 - GPR88_MOUSE

Protein

Probable G-protein coupled receptor 88

Gene

Gpr88

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: MGI
    2. transmembrane signaling receptor activity Source: MGI

    GO - Biological processi

    1. locomotory behavior Source: MGI
    2. neuromuscular process controlling balance Source: MGI
    3. neuronal action potential Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 88
    Alternative name(s):
    Striatum-specific G-protein coupled receptor
    Gene namesi
    Name:Gpr88
    Synonyms:Strg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1927653. Gpr88.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384Probable G-protein coupled receptor 88PRO_0000069598Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9EPB7.

    PTM databases

    PhosphoSiteiQ9EPB7.

    Expressioni

    Tissue specificityi

    Expressed almost exclusively in striatum.1 Publication

    Gene expression databases

    ArrayExpressiQ9EPB7.
    BgeeiQ9EPB7.
    CleanExiMM_GPR88.
    GenevestigatoriQ9EPB7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EPB7.
    SMRiQ9EPB7. Positions 34-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini57 – 7317CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini95 – 11622ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini137 – 15822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 19516ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini217 – 28569CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini307 – 3104ExtracellularSequence Analysis
    Topological domaini332 – 38453CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei74 – 9421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei117 – 13620Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei286 – 30621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei311 – 33121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253450.
    GeneTreeiENSGT00390000009609.
    HOGENOMiHOG000060315.
    HOVERGENiHBG051821.
    InParanoidiQ9EPB7.
    KOiK08422.
    OMAiEPPGDWD.
    OrthoDBiEOG7ZD1WN.
    PhylomeDBiQ9EPB7.
    TreeFamiTF336499.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9EPB7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNSSSTSTS TTTGGSLLLL CEEEESWAGR RIPVSLLYSG LAIGGTLANG    50
    MVIYLVSSFR KLQTTSNAFI VNGCAADLSV CALWMPQEAV LGLLPSGSAE 100
    PPGDWDGGGG SYRLLRGGLL GLGLTVSLLS HCLVALNRYL LITRAPATYQ 150
    VLYQRRHTVG MLALSWALAL GLVLLLPPWA PKPGAEPPQV HYPALLAAGA 200
    LLAQTALLLH CYLGIVRRVR VSVKRVSVLN FHLLHQLPGC AAAAAAFPAA 250
    PHAPGPGGAA HPAQPQPLPA ALQPRRAQRR LSGLSVLLLC CVFLLATQPL 300
    VWVSLASGFS LPVPWGVQAA SWLLCCALSA LNPLLYTWRN EEFRRSVRSV 350
    LPGVGDAAAA AAAATAVPAM SQAQLGTRAA GQHW 384
    Length:384
    Mass (Da):40,240
    Last modified:March 1, 2001 - v1
    Checksum:i1E5BB8A5B5B3B37D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB042408 mRNA. Translation: BAB18245.1.
    AB042409 Genomic DNA. Translation: BAB18246.1.
    BC051941 mRNA. Translation: AAH51941.1.
    CCDSiCCDS38610.1.
    RefSeqiNP_071872.1. NM_022427.2.
    XP_006501919.1. XM_006501856.1.
    XP_006501920.1. XM_006501857.1.
    XP_006501921.1. XM_006501858.1.
    UniGeneiMm.40025.

    Genome annotation databases

    EnsembliENSMUST00000090473; ENSMUSP00000087959; ENSMUSG00000068696.
    GeneIDi64378.
    KEGGimmu:64378.
    UCSCiuc008rbz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB042408 mRNA. Translation: BAB18245.1 .
    AB042409 Genomic DNA. Translation: BAB18246.1 .
    BC051941 mRNA. Translation: AAH51941.1 .
    CCDSi CCDS38610.1.
    RefSeqi NP_071872.1. NM_022427.2.
    XP_006501919.1. XM_006501856.1.
    XP_006501920.1. XM_006501857.1.
    XP_006501921.1. XM_006501858.1.
    UniGenei Mm.40025.

    3D structure databases

    ProteinModelPortali Q9EPB7.
    SMRi Q9EPB7. Positions 34-177.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9EPB7.

    Proteomic databases

    PRIDEi Q9EPB7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000090473 ; ENSMUSP00000087959 ; ENSMUSG00000068696 .
    GeneIDi 64378.
    KEGGi mmu:64378.
    UCSCi uc008rbz.2. mouse.

    Organism-specific databases

    CTDi 54112.
    MGIi MGI:1927653. Gpr88.

    Phylogenomic databases

    eggNOGi NOG253450.
    GeneTreei ENSGT00390000009609.
    HOGENOMi HOG000060315.
    HOVERGENi HBG051821.
    InParanoidi Q9EPB7.
    KOi K08422.
    OMAi EPPGDWD.
    OrthoDBi EOG7ZD1WN.
    PhylomeDBi Q9EPB7.
    TreeFami TF336499.

    Miscellaneous databases

    NextBioi 320043.
    PROi Q9EPB7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9EPB7.
    Bgeei Q9EPB7.
    CleanExi MM_GPR88.
    Genevestigatori Q9EPB7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel G-protein-coupled receptor gene expressed in striatum."
      Mizushima K., Miyamoto Y., Tsukahara F., Hirai M., Sakaki Y., Ito T.
      Genomics 69:314-321(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiGPR88_MOUSE
    AccessioniPrimary (citable) accession number: Q9EPB7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3