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Q9EPB7

- GPR88_MOUSE

UniProt

Q9EPB7 - GPR88_MOUSE

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Protein

Probable G-protein coupled receptor 88

Gene

Gpr88

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: MGI
  2. transmembrane signaling receptor activity Source: MGI

GO - Biological processi

  1. locomotory behavior Source: MGI
  2. neuromuscular process controlling balance Source: MGI
  3. neuronal action potential Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 88
Alternative name(s):
Striatum-specific G-protein coupled receptor
Gene namesi
Name:Gpr88
Synonyms:Strg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1927653. Gpr88.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
BLAST
Transmembranei36 – 5621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini57 – 7317CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei74 – 9421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini95 – 11622ExtracellularSequence AnalysisAdd
BLAST
Transmembranei117 – 13620Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini137 – 15822CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei159 – 17921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini180 – 19516ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini217 – 28569CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei286 – 30621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini307 – 3104ExtracellularSequence Analysis
Transmembranei311 – 33121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini332 – 38453CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Probable G-protein coupled receptor 88PRO_0000069598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9EPB7.

PTM databases

PhosphoSiteiQ9EPB7.

Expressioni

Tissue specificityi

Expressed almost exclusively in striatum.1 Publication

Gene expression databases

BgeeiQ9EPB7.
CleanExiMM_GPR88.
ExpressionAtlasiQ9EPB7. baseline.
GenevestigatoriQ9EPB7.

Structurei

3D structure databases

ProteinModelPortaliQ9EPB7.
SMRiQ9EPB7. Positions 34-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253450.
GeneTreeiENSGT00390000009609.
HOGENOMiHOG000060315.
HOVERGENiHBG051821.
InParanoidiQ9EPB7.
KOiK08422.
OMAiEPPGDWD.
OrthoDBiEOG7ZD1WN.
PhylomeDBiQ9EPB7.
TreeFamiTF336499.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EPB7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNSSSTSTS TTTGGSLLLL CEEEESWAGR RIPVSLLYSG LAIGGTLANG
60 70 80 90 100
MVIYLVSSFR KLQTTSNAFI VNGCAADLSV CALWMPQEAV LGLLPSGSAE
110 120 130 140 150
PPGDWDGGGG SYRLLRGGLL GLGLTVSLLS HCLVALNRYL LITRAPATYQ
160 170 180 190 200
VLYQRRHTVG MLALSWALAL GLVLLLPPWA PKPGAEPPQV HYPALLAAGA
210 220 230 240 250
LLAQTALLLH CYLGIVRRVR VSVKRVSVLN FHLLHQLPGC AAAAAAFPAA
260 270 280 290 300
PHAPGPGGAA HPAQPQPLPA ALQPRRAQRR LSGLSVLLLC CVFLLATQPL
310 320 330 340 350
VWVSLASGFS LPVPWGVQAA SWLLCCALSA LNPLLYTWRN EEFRRSVRSV
360 370 380
LPGVGDAAAA AAAATAVPAM SQAQLGTRAA GQHW
Length:384
Mass (Da):40,240
Last modified:March 1, 2001 - v1
Checksum:i1E5BB8A5B5B3B37D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042408 mRNA. Translation: BAB18245.1.
AB042409 Genomic DNA. Translation: BAB18246.1.
BC051941 mRNA. Translation: AAH51941.1.
CCDSiCCDS38610.1.
RefSeqiNP_071872.1. NM_022427.2.
XP_006501919.1. XM_006501856.1.
XP_006501920.1. XM_006501857.1.
XP_006501921.1. XM_006501858.1.
UniGeneiMm.40025.

Genome annotation databases

EnsembliENSMUST00000090473; ENSMUSP00000087959; ENSMUSG00000068696.
GeneIDi64378.
KEGGimmu:64378.
UCSCiuc008rbz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042408 mRNA. Translation: BAB18245.1 .
AB042409 Genomic DNA. Translation: BAB18246.1 .
BC051941 mRNA. Translation: AAH51941.1 .
CCDSi CCDS38610.1.
RefSeqi NP_071872.1. NM_022427.2.
XP_006501919.1. XM_006501856.1.
XP_006501920.1. XM_006501857.1.
XP_006501921.1. XM_006501858.1.
UniGenei Mm.40025.

3D structure databases

ProteinModelPortali Q9EPB7.
SMRi Q9EPB7. Positions 34-177.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9EPB7.

Proteomic databases

PRIDEi Q9EPB7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000090473 ; ENSMUSP00000087959 ; ENSMUSG00000068696 .
GeneIDi 64378.
KEGGi mmu:64378.
UCSCi uc008rbz.2. mouse.

Organism-specific databases

CTDi 54112.
MGIi MGI:1927653. Gpr88.

Phylogenomic databases

eggNOGi NOG253450.
GeneTreei ENSGT00390000009609.
HOGENOMi HOG000060315.
HOVERGENi HBG051821.
InParanoidi Q9EPB7.
KOi K08422.
OMAi EPPGDWD.
OrthoDBi EOG7ZD1WN.
PhylomeDBi Q9EPB7.
TreeFami TF336499.

Miscellaneous databases

NextBioi 320043.
PROi Q9EPB7.
SOURCEi Search...

Gene expression databases

Bgeei Q9EPB7.
CleanExi MM_GPR88.
ExpressionAtlasi Q9EPB7. baseline.
Genevestigatori Q9EPB7.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel G-protein-coupled receptor gene expressed in striatum."
    Mizushima K., Miyamoto Y., Tsukahara F., Hirai M., Sakaki Y., Ito T.
    Genomics 69:314-321(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiGPR88_MOUSE
AccessioniPrimary (citable) accession number: Q9EPB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3