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Protein

Probable G-protein coupled receptor 88

Gene

Gpr88

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: MGI
  • transmembrane signaling receptor activity Source: MGI

GO - Biological processi

  • locomotory behavior Source: MGI
  • neuromuscular process controlling balance Source: MGI
  • neuronal action potential Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 88
Alternative name(s):
Striatum-specific G-protein coupled receptor
Gene namesi
Name:Gpr88
Synonyms:Strg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1927653. Gpr88.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence AnalysisAdd
BLAST
Transmembranei36 – 5621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini57 – 7317CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei74 – 9421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini95 – 11622ExtracellularSequence AnalysisAdd
BLAST
Transmembranei117 – 13620Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini137 – 15822CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei159 – 17921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini180 – 19516ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini217 – 28569CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei286 – 30621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini307 – 3104ExtracellularSequence Analysis
Transmembranei311 – 33121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini332 – 38453CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Probable G-protein coupled receptor 88PRO_0000069598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9EPB7.

PTM databases

PhosphoSiteiQ9EPB7.

Expressioni

Tissue specificityi

Expressed almost exclusively in striatum.1 Publication

Gene expression databases

BgeeiQ9EPB7.
CleanExiMM_GPR88.
ExpressionAtlasiQ9EPB7. baseline and differential.
GenevisibleiQ9EPB7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087959.

Structurei

3D structure databases

ProteinModelPortaliQ9EPB7.
SMRiQ9EPB7. Positions 34-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253450.
GeneTreeiENSGT00390000009609.
HOGENOMiHOG000060315.
HOVERGENiHBG051821.
InParanoidiQ9EPB7.
KOiK08422.
OMAiEPPGDWD.
OrthoDBiEOG7ZD1WN.
PhylomeDBiQ9EPB7.
TreeFamiTF336499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EPB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNSSSTSTS TTTGGSLLLL CEEEESWAGR RIPVSLLYSG LAIGGTLANG
60 70 80 90 100
MVIYLVSSFR KLQTTSNAFI VNGCAADLSV CALWMPQEAV LGLLPSGSAE
110 120 130 140 150
PPGDWDGGGG SYRLLRGGLL GLGLTVSLLS HCLVALNRYL LITRAPATYQ
160 170 180 190 200
VLYQRRHTVG MLALSWALAL GLVLLLPPWA PKPGAEPPQV HYPALLAAGA
210 220 230 240 250
LLAQTALLLH CYLGIVRRVR VSVKRVSVLN FHLLHQLPGC AAAAAAFPAA
260 270 280 290 300
PHAPGPGGAA HPAQPQPLPA ALQPRRAQRR LSGLSVLLLC CVFLLATQPL
310 320 330 340 350
VWVSLASGFS LPVPWGVQAA SWLLCCALSA LNPLLYTWRN EEFRRSVRSV
360 370 380
LPGVGDAAAA AAAATAVPAM SQAQLGTRAA GQHW
Length:384
Mass (Da):40,240
Last modified:March 1, 2001 - v1
Checksum:i1E5BB8A5B5B3B37D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042408 mRNA. Translation: BAB18245.1.
AB042409 Genomic DNA. Translation: BAB18246.1.
BC051941 mRNA. Translation: AAH51941.1.
CCDSiCCDS38610.1.
RefSeqiNP_071872.1. NM_022427.2.
XP_006501919.1. XM_006501856.1.
XP_006501920.1. XM_006501857.1.
XP_006501921.1. XM_006501858.2.
UniGeneiMm.40025.

Genome annotation databases

EnsembliENSMUST00000090473; ENSMUSP00000087959; ENSMUSG00000068696.
GeneIDi64378.
KEGGimmu:64378.
UCSCiuc008rbz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042408 mRNA. Translation: BAB18245.1.
AB042409 Genomic DNA. Translation: BAB18246.1.
BC051941 mRNA. Translation: AAH51941.1.
CCDSiCCDS38610.1.
RefSeqiNP_071872.1. NM_022427.2.
XP_006501919.1. XM_006501856.1.
XP_006501920.1. XM_006501857.1.
XP_006501921.1. XM_006501858.2.
UniGeneiMm.40025.

3D structure databases

ProteinModelPortaliQ9EPB7.
SMRiQ9EPB7. Positions 34-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087959.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9EPB7.

Proteomic databases

PRIDEiQ9EPB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090473; ENSMUSP00000087959; ENSMUSG00000068696.
GeneIDi64378.
KEGGimmu:64378.
UCSCiuc008rbz.2. mouse.

Organism-specific databases

CTDi54112.
MGIiMGI:1927653. Gpr88.

Phylogenomic databases

eggNOGiNOG253450.
GeneTreeiENSGT00390000009609.
HOGENOMiHOG000060315.
HOVERGENiHBG051821.
InParanoidiQ9EPB7.
KOiK08422.
OMAiEPPGDWD.
OrthoDBiEOG7ZD1WN.
PhylomeDBiQ9EPB7.
TreeFamiTF336499.

Miscellaneous databases

NextBioi320043.
PROiQ9EPB7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EPB7.
CleanExiMM_GPR88.
ExpressionAtlasiQ9EPB7. baseline and differential.
GenevisibleiQ9EPB7. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel G-protein-coupled receptor gene expressed in striatum."
    Mizushima K., Miyamoto Y., Tsukahara F., Hirai M., Sakaki Y., Ito T.
    Genomics 69:314-321(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiGPR88_MOUSE
AccessioniPrimary (citable) accession number: Q9EPB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 1, 2001
Last modified: June 24, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.