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Q9EPB7 (GPR88_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 88
Alternative name(s):
Striatum-specific G-protein coupled receptor
Gene names
Name:Gpr88
Synonyms:Strg
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed almost exclusively in striatum. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Probable G-protein coupled receptor 88
PRO_0000069598

Regions

Topological domain1 – 3535Extracellular Potential
Transmembrane36 – 5621Helical; Name=1; Potential
Topological domain57 – 7317Cytoplasmic Potential
Transmembrane74 – 9421Helical; Name=2; Potential
Topological domain95 – 11622Extracellular Potential
Transmembrane117 – 13620Helical; Name=3; Potential
Topological domain137 – 15822Cytoplasmic Potential
Transmembrane159 – 17921Helical; Name=4; Potential
Topological domain180 – 19516Extracellular Potential
Transmembrane196 – 21621Helical; Name=5; Potential
Topological domain217 – 28569Cytoplasmic Potential
Transmembrane286 – 30621Helical; Name=6; Potential
Topological domain307 – 3104Extracellular Potential
Transmembrane311 – 33121Helical; Name=7; Potential
Topological domain332 – 38453Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9EPB7 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 1E5BB8A5B5B3B37D

FASTA38440,240
        10         20         30         40         50         60 
MTNSSSTSTS TTTGGSLLLL CEEEESWAGR RIPVSLLYSG LAIGGTLANG MVIYLVSSFR 

        70         80         90        100        110        120 
KLQTTSNAFI VNGCAADLSV CALWMPQEAV LGLLPSGSAE PPGDWDGGGG SYRLLRGGLL 

       130        140        150        160        170        180 
GLGLTVSLLS HCLVALNRYL LITRAPATYQ VLYQRRHTVG MLALSWALAL GLVLLLPPWA 

       190        200        210        220        230        240 
PKPGAEPPQV HYPALLAAGA LLAQTALLLH CYLGIVRRVR VSVKRVSVLN FHLLHQLPGC 

       250        260        270        280        290        300 
AAAAAAFPAA PHAPGPGGAA HPAQPQPLPA ALQPRRAQRR LSGLSVLLLC CVFLLATQPL 

       310        320        330        340        350        360 
VWVSLASGFS LPVPWGVQAA SWLLCCALSA LNPLLYTWRN EEFRRSVRSV LPGVGDAAAA 

       370        380 
AAAATAVPAM SQAQLGTRAA GQHW 

« Hide

References

« Hide 'large scale' references
[1]"A novel G-protein-coupled receptor gene expressed in striatum."
Mizushima K., Miyamoto Y., Tsukahara F., Hirai M., Sakaki Y., Ito T.
Genomics 69:314-321(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB042408 mRNA. Translation: BAB18245.1.
AB042409 Genomic DNA. Translation: BAB18246.1.
BC051941 mRNA. Translation: AAH51941.1.
RefSeqNP_071872.1. NM_022427.2.
XP_006501919.1. XM_006501856.1.
XP_006501920.1. XM_006501857.1.
XP_006501921.1. XM_006501858.1.
UniGeneMm.40025.

3D structure databases

ProteinModelPortalQ9EPB7.
SMRQ9EPB7. Positions 32-354.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9EPB7.

Proteomic databases

PRIDEQ9EPB7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000090473; ENSMUSP00000087959; ENSMUSG00000068696.
GeneID64378.
KEGGmmu:64378.
UCSCuc008rbz.2. mouse.

Organism-specific databases

CTD54112.
MGIMGI:1927653. Gpr88.

Phylogenomic databases

eggNOGNOG253450.
GeneTreeENSGT00390000009609.
HOGENOMHOG000060315.
HOVERGENHBG051821.
InParanoidQ9EPB7.
KOK08422.
OMAEPPGDWD.
OrthoDBEOG7ZD1WN.
PhylomeDBQ9EPB7.
TreeFamTF336499.

Gene expression databases

ArrayExpressQ9EPB7.
BgeeQ9EPB7.
CleanExMM_GPR88.
GenevestigatorQ9EPB7.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio320043.
PROQ9EPB7.
SOURCESearch...

Entry information

Entry nameGPR88_MOUSE
AccessionPrimary (citable) accession number: Q9EPB7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries