Q9EPB7 (GPR88_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 88

Alternative name(s):
Striatum-specific G-protein coupled receptor

Gene names

Name:	Gpr88
Synonyms:	Strg

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed almost exclusively in striatum. Ref.1
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from sequence or structural similarity Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Probable G-protein coupled receptor 88		PRO_0000069598
Regions
	Topological domain	1 – 35	35	Extracellular Potential
	Transmembrane	36 – 56	21	Helical; Name=1; Potential
	Topological domain	57 – 73	17	Cytoplasmic Potential
	Transmembrane	74 – 94	21	Helical; Name=2; Potential
	Topological domain	95 – 116	22	Extracellular Potential
	Transmembrane	117 – 136	20	Helical; Name=3; Potential
	Topological domain	137 – 158	22	Cytoplasmic Potential
	Transmembrane	159 – 179	21	Helical; Name=4; Potential
	Topological domain	180 – 195	16	Extracellular Potential
	Transmembrane	196 – 216	21	Helical; Name=5; Potential
	Topological domain	217 – 285	69	Cytoplasmic Potential
	Transmembrane	286 – 306	21	Helical; Name=6; Potential
	Topological domain	307 – 310	4	Extracellular Potential
	Transmembrane	311 – 331	21	Helical; Name=7; Potential
	Topological domain	332 – 384	53	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	3	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9EPB7 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 1E5BB8A5B5B3B37D	FASTA	384	40,240
	10 20 30 40 50 60 MTNSSSTSTS TTTGGSLLLL CEEEESWAGR RIPVSLLYSG LAIGGTLANG MVIYLVSSFR 70 80 90 100 110 120 KLQTTSNAFI VNGCAADLSV CALWMPQEAV LGLLPSGSAE PPGDWDGGGG SYRLLRGGLL 130 140 150 160 170 180 GLGLTVSLLS HCLVALNRYL LITRAPATYQ VLYQRRHTVG MLALSWALAL GLVLLLPPWA 190 200 210 220 230 240 PKPGAEPPQV HYPALLAAGA LLAQTALLLH CYLGIVRRVR VSVKRVSVLN FHLLHQLPGC 250 260 270 280 290 300 AAAAAAFPAA PHAPGPGGAA HPAQPQPLPA ALQPRRAQRR LSGLSVLLLC CVFLLATQPL 310 320 330 340 350 360 VWVSLASGFS LPVPWGVQAA SWLLCCALSA LNPLLYTWRN EEFRRSVRSV LPGVGDAAAA 370 380 AAAATAVPAM SQAQLGTRAA GQHW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel G-protein-coupled receptor gene expressed in striatum." Mizushima K., Miyamoto Y., Tsukahara F., Hirai M., Sakaki Y., Ito T. Genomics 69:314-321(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB042408 mRNA. Translation: BAB18245.1. AB042409 Genomic DNA. Translation: BAB18246.1. BC051941 mRNA. Translation: AAH51941.1.
IPI	IPI00109712.
RefSeq	NP_071872.1. NM_022427.2.
UniGene	Mm.40025.
3D structure databases
ProteinModelPortal	Q9EPB7.
SMR	Q9EPB7. Positions 34-177.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9EPB7.
Proteomic databases
PRIDE	Q9EPB7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000090473; ENSMUSP00000087959; ENSMUSG00000068696.
GeneID	64378.
KEGG	mmu:64378.
Organism-specific databases
CTD	54112.
MGI	MGI:1927653. Gpr88.
Phylogenomic databases
eggNOG	NOG253450.
GeneTree	ENSGT00390000009609.
HOGENOM	HOG000060315.
HOVERGEN	HBG051821.
InParanoid	Q9EPB7.
KO	K08422.
OMA	EPPGDWD.
OrthoDB	EOG4M91SM.
Gene expression databases
ArrayExpress	Q9EPB7.
Bgee	Q9EPB7.
CleanEx	MM_GPR88.
Genevestigator	Q9EPB7.
GermOnline	ENSMUSG00000068696. Mus musculus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	320043.
SOURCE	Search...

Entry information

Entry name

GPR88_MOUSE

Accession

Primary (citable) accession number: Q9EPB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program