Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable G-protein coupled receptor 88

Gene

Gpr88

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function.By similarity1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: MGI
  • motor activity Source: UniProtKB
  • transmembrane signaling receptor activity Source: MGI

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • locomotory behavior Source: MGI
  • motor learning Source: UniProtKB
  • neuromuscular process controlling balance Source: MGI
  • neuronal action potential Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 88
Alternative name(s):
Striatum-specific G-protein coupled receptor
Gene namesi
Name:Gpr88
Synonyms:Strg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1927653. Gpr88.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: During cortical lamination, subcellular location shifts, on the day of birth, from expression at the plasma membrane and in the cytoplasm to the nuclei of neurons. This intranuclear localization remains throughout adulthood.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 56Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini57 – 73CytoplasmicSequence analysisAdd BLAST17
Transmembranei74 – 94Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini95 – 116ExtracellularSequence analysisAdd BLAST22
Transmembranei117 – 136Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini137 – 158CytoplasmicSequence analysisAdd BLAST22
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini180 – 195ExtracellularSequence analysisAdd BLAST16
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 285CytoplasmicSequence analysisAdd BLAST69
Transmembranei286 – 306Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini307 – 310ExtracellularSequence analysis4
Transmembranei311 – 331Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini332 – 384CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice have increased locomotion, increased motor stereotypical behavior, and impaired motor skill learning. Mutant mice also show facilitated hippocampal-mediated behaviors and decreased anxiety. Chronic blockade of delta opioid receptors and mu opioid, but not other Gi/o coupled receptors, using delta opioid receptor antagonist partially improved motor coordination and normalized spatial navigation and anxiety of mutant mice.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695981 – 384Probable G-protein coupled receptor 88Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9EPB7.
PRIDEiQ9EPB7.

PTM databases

PhosphoSitePlusiQ9EPB7.

Expressioni

Tissue specificityi

Expressed predominantly in the striatum.1 Publication

Gene expression databases

BgeeiENSMUSG00000068696.
CleanExiMM_GPR88.
ExpressionAtlasiQ9EPB7. baseline and differential.
GenevisibleiQ9EPB7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087959.

Structurei

3D structure databases

ProteinModelPortaliQ9EPB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000009609.
HOGENOMiHOG000060315.
HOVERGENiHBG051821.
InParanoidiQ9EPB7.
KOiK08422.
OMAiEPPGDWD.
OrthoDBiEOG091G0JWW.
PhylomeDBiQ9EPB7.
TreeFamiTF336499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EPB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNSSSTSTS TTTGGSLLLL CEEEESWAGR RIPVSLLYSG LAIGGTLANG
60 70 80 90 100
MVIYLVSSFR KLQTTSNAFI VNGCAADLSV CALWMPQEAV LGLLPSGSAE
110 120 130 140 150
PPGDWDGGGG SYRLLRGGLL GLGLTVSLLS HCLVALNRYL LITRAPATYQ
160 170 180 190 200
VLYQRRHTVG MLALSWALAL GLVLLLPPWA PKPGAEPPQV HYPALLAAGA
210 220 230 240 250
LLAQTALLLH CYLGIVRRVR VSVKRVSVLN FHLLHQLPGC AAAAAAFPAA
260 270 280 290 300
PHAPGPGGAA HPAQPQPLPA ALQPRRAQRR LSGLSVLLLC CVFLLATQPL
310 320 330 340 350
VWVSLASGFS LPVPWGVQAA SWLLCCALSA LNPLLYTWRN EEFRRSVRSV
360 370 380
LPGVGDAAAA AAAATAVPAM SQAQLGTRAA GQHW
Length:384
Mass (Da):40,240
Last modified:March 1, 2001 - v1
Checksum:i1E5BB8A5B5B3B37D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042408 mRNA. Translation: BAB18245.1.
AB042409 Genomic DNA. Translation: BAB18246.1.
BC051941 mRNA. Translation: AAH51941.1.
CCDSiCCDS38610.1.
RefSeqiNP_071872.1. NM_022427.2.
XP_006501919.1. XM_006501856.1.
XP_006501920.1. XM_006501857.1.
UniGeneiMm.40025.

Genome annotation databases

EnsembliENSMUST00000090473; ENSMUSP00000087959; ENSMUSG00000068696.
GeneIDi64378.
KEGGimmu:64378.
UCSCiuc008rbz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042408 mRNA. Translation: BAB18245.1.
AB042409 Genomic DNA. Translation: BAB18246.1.
BC051941 mRNA. Translation: AAH51941.1.
CCDSiCCDS38610.1.
RefSeqiNP_071872.1. NM_022427.2.
XP_006501919.1. XM_006501856.1.
XP_006501920.1. XM_006501857.1.
UniGeneiMm.40025.

3D structure databases

ProteinModelPortaliQ9EPB7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087959.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ9EPB7.

Proteomic databases

PaxDbiQ9EPB7.
PRIDEiQ9EPB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090473; ENSMUSP00000087959; ENSMUSG00000068696.
GeneIDi64378.
KEGGimmu:64378.
UCSCiuc008rbz.2. mouse.

Organism-specific databases

CTDi54112.
MGIiMGI:1927653. Gpr88.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000009609.
HOGENOMiHOG000060315.
HOVERGENiHBG051821.
InParanoidiQ9EPB7.
KOiK08422.
OMAiEPPGDWD.
OrthoDBiEOG091G0JWW.
PhylomeDBiQ9EPB7.
TreeFamiTF336499.

Miscellaneous databases

PROiQ9EPB7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068696.
CleanExiMM_GPR88.
ExpressionAtlasiQ9EPB7. baseline and differential.
GenevisibleiQ9EPB7. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR88_MOUSE
AccessioniPrimary (citable) accession number: Q9EPB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.