Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine hydrolase-like protein

Gene

Serhl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable serine hydrolase. May be related to cell muscle hypertrophy.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei102 – 1021Sequence analysis

GO - Molecular functioni

  • hydrolase activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERimouse-SERHL. AlphaBeta_hydrolase.
MEROPSiS33.012.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine hydrolase-like protein (EC:3.1.-.-)
Short name:
SHL
Gene namesi
Name:Serhl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1890404. Serhl.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: MGI
  • mitochondrion Source: MGI
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
  • peroxisome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Peroxisome

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3259500.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Serine hydrolase-like proteinPRO_0000097693Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei210 – 2101PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9EPB5.
MaxQBiQ9EPB5.
PaxDbiQ9EPB5.
PRIDEiQ9EPB5.

PTM databases

iPTMnetiQ9EPB5.
PhosphoSiteiQ9EPB5.

Expressioni

Tissue specificityi

Ubiquitous. High protein expression in skeletal and cardiac muscle.

Developmental stagei

Present in both unfused and recently fused myotubes, but not thereafter.

Inductioni

Induced by passive stretch of skeletal muscle.

Gene expression databases

BgeeiQ9EPB5.
CleanExiMM_SERHL.
ExpressionAtlasiQ9EPB5. baseline and differential.
GenevisibleiQ9EPB5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077345.

Structurei

3D structure databases

ProteinModelPortaliQ9EPB5.
SMRiQ9EPB5. Positions 15-167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Phylogenomic databases

eggNOGiKOG1454. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00530000063960.
HOVERGENiHBG023947.
InParanoidiQ9EPB5.
PhylomeDBiQ9EPB5.
TreeFamiTF326547.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Serhl-1 (identifier: Q9EPB5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLHSELKLA VPWGHIALKV WGSQKNPPVL CLHGWLDNAN SFDRLIPLLP
60 70 80 90 100
QDFCYMAMDF GGHGLSSHYN PGLPYYQQNF VSEVRRVATA FKWNQFTLLG
110 120 130 140 150
HSFGGCVGGT FACMFPEMVD KLILLDSTPF FLDSNEMENI LTYRRRNIEH
160 170 180 190 200
TLQVEASQKK SLRAVSPEEM LQGFLNNNSH LDKDCGELIL QRGTTKVDAG
210 220 230 240 250
LVLNRDRRIS WPENSFDFVS KEMFVHSAKS LQASVLMIKA LQGYYDVRRA
260 270 280 290 300
NDADKAPMHF MVDTLRSTLK ERFQFVEVPG NHYIHMNKPQ VVAGVVGPFL
310
QGLQRMTSAR L
Length:311
Mass (Da):35,311
Last modified:March 1, 2001 - v1
Checksum:i273404E85F07556E
GO
Isoform Serhl-2 (identifier: Q9EPB5-2)

Also known as: short

Sequence is not available
Note: No experimental confirmation available.
Length:
Mass (Da):

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131W → R in BAB22007 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251200 mRNA. Translation: CAC20674.1.
AJ245737 mRNA. Translation: CAC20673.1.
AK002313 mRNA. Translation: BAB22007.1.
AK003827 mRNA. Translation: BAB23023.1.
BC055431 mRNA. Translation: AAH55431.1.
CCDSiCCDS49682.1. [Q9EPB5-1]
RefSeqiNP_075964.1. NM_023475.3. [Q9EPB5-1]
UniGeneiMm.30056.

Genome annotation databases

EnsembliENSMUST00000078218; ENSMUSP00000077345; ENSMUSG00000058586. [Q9EPB5-1]
GeneIDi68607.
KEGGimmu:68607.
UCSCiuc011zwz.1. mouse. [Q9EPB5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251200 mRNA. Translation: CAC20674.1.
AJ245737 mRNA. Translation: CAC20673.1.
AK002313 mRNA. Translation: BAB22007.1.
AK003827 mRNA. Translation: BAB23023.1.
BC055431 mRNA. Translation: AAH55431.1.
CCDSiCCDS49682.1. [Q9EPB5-1]
RefSeqiNP_075964.1. NM_023475.3. [Q9EPB5-1]
UniGeneiMm.30056.

3D structure databases

ProteinModelPortaliQ9EPB5.
SMRiQ9EPB5. Positions 15-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077345.

Chemistry

ChEMBLiCHEMBL3259500.

Protein family/group databases

ESTHERimouse-SERHL. AlphaBeta_hydrolase.
MEROPSiS33.012.

PTM databases

iPTMnetiQ9EPB5.
PhosphoSiteiQ9EPB5.

Proteomic databases

EPDiQ9EPB5.
MaxQBiQ9EPB5.
PaxDbiQ9EPB5.
PRIDEiQ9EPB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078218; ENSMUSP00000077345; ENSMUSG00000058586. [Q9EPB5-1]
GeneIDi68607.
KEGGimmu:68607.
UCSCiuc011zwz.1. mouse. [Q9EPB5-1]

Organism-specific databases

CTDi94009.
MGIiMGI:1890404. Serhl.

Phylogenomic databases

eggNOGiKOG1454. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00530000063960.
HOVERGENiHBG023947.
InParanoidiQ9EPB5.
PhylomeDBiQ9EPB5.
TreeFamiTF326547.

Miscellaneous databases

PROiQ9EPB5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EPB5.
CleanExiMM_SERHL.
ExpressionAtlasiQ9EPB5. baseline and differential.
GenevisibleiQ9EPB5. MM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PRINTSiPR00111. ABHYDROLASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of Serhl, a new member of the serine hydrolase family induced by passive stretch of skeletal muscle in vivo."
    Sadusky T.J., Kemp T.J., Simon M., Carey N., Coulton G.R.
    Genomics 73:38-49(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/10.
    Tissue: Muscle.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-210, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Kidney, Liver, Lung and Testis.

Entry informationi

Entry nameiSERHL_MOUSE
AccessioniPrimary (citable) accession number: Q9EPB5
Secondary accession number(s): Q9DCZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.