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Protein

Dipeptidyl peptidase 2

Gene

Dpp7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the degradation of some oligopeptides.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei172Charge relay systemSequence analysis1
Active sitei428Charge relay systemSequence analysis1
Active sitei453Charge relay systemSequence analysis1

GO - Molecular functioni

  • dipeptidyl-peptidase activity Source: RGD
  • serine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  • proteolysis Source: RGD

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.

Protein family/group databases

ESTHERiratno-dpp2. Prolylcarboxypeptidase.
MEROPSiS28.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 2 (EC:3.4.14.2)
Alternative name(s):
Dipeptidyl aminopeptidase II
Dipeptidyl peptidase 7
Dipeptidyl peptidase II
Short name:
DPP II
Quiescent cell proline dipeptidase
Gene namesi
Name:Dpp7
Synonyms:Dpp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi71073. Dpp7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic vesicle Source: UniProtKB-KW
  • cytosol Source: RGD
  • extracellular exosome Source: Ensembl
  • Golgi apparatus Source: Ensembl
  • lysosome Source: UniProtKB-SubCell
  • vesicle Source: GO_Central

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4352.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
PropeptideiPRO_000002731834 – 363
ChainiPRO_000002731937 – 500Dipeptidyl peptidase 2Add BLAST464

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi325N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi366N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi373N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi438N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9EPB1.
PRIDEiQ9EPB1.

PTM databases

PhosphoSitePlusiQ9EPB1.
UniCarbKBiQ9EPB1.

Expressioni

Tissue specificityi

Predominantly expressed in kidney, but also expressed in a variety of tissues.

Gene expression databases

BgeeiENSRNOG00000012640.
GenevisibleiQ9EPB1. RN.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

IntActiQ9EPB1. 1 interactor.
STRINGi10116.ENSRNOP00000017271.

Chemistry databases

BindingDBiQ9EPB1.

Structurei

3D structure databases

ProteinModelPortaliQ9EPB1.
SMRiQ9EPB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S28 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2183. Eukaryota.
ENOG410Y38A. LUCA.
GeneTreeiENSGT00530000063027.
HOGENOMiHOG000238311.
HOVERGENiHBG005526.
InParanoidiQ9EPB1.
KOiK01276.
OMAiTWGVWPR.
OrthoDBiEOG091G056F.
PhylomeDBiQ9EPB1.
TreeFamiTF314414.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR008758. Peptidase_S28.
PfamiView protein in Pfam
PF05577. Peptidase_S28. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EPB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLHPCSPVD HGVPSWVLVL LLTLGLCSLQ ATADSVLDPD FRENYFEQYM
60 70 80 90 100
DHFNFESFSN KTFGQRFLVS DKFWKMGEGP IFFYTGNEGD IWSLANNSGF
110 120 130 140 150
IVELAAQQEA LLVFAEHRYY GKSLPFGVQS TQRGYTQLLT VEQALADFAV
160 170 180 190 200
LLQALRHNLG VQDAPTIAFG GSYGGMLSAY MRMKYPHLVA GALAASAPVI
210 220 230 240 250
AVAGLGNPDQ FFRDVTADFY GQSPKCAQAV RDAFQQIKDL FLQGAYDTIS
260 270 280 290 300
QNFGTCQSLS SPKDLTQLFG FARNAFTVLA MMDYPYPTNF LGPLPANPVK
310 320 330 340 350
VGCERLLSEG QRIMGLRALA GLVYNSSGME PCFDIYQMYQ SCADPTGCGT
360 370 380 390 400
GSNARAWDYQ ACTEINLTFD SNNVTDMFPE IPFSDELRQQ YCLDTWGVWP
410 420 430 440 450
RPDWLQTSFW GGDLKAASNI IFSNGDLDPW AGGGIQRNLS TSIIAVTIQG
460 470 480 490 500
GAHHLDLRAS NSEDPPSVVE VRKLEATLIR EWVAAARLKQ PAEAQWPGPK
Length:500
Mass (Da):55,114
Last modified:March 1, 2001 - v1
Checksum:i401089D282CE1514
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048711 mRNA. Translation: BAB13500.1.
AB038232 mRNA. Translation: BAB11691.1.
BC078783 mRNA. Translation: AAH78783.1.
PIRiJC7668.
RefSeqiNP_114179.1. NM_031973.1.
UniGeneiRn.3363.

Genome annotation databases

EnsembliENSRNOT00000017271; ENSRNOP00000017271; ENSRNOG00000012640.
GeneIDi83799.
KEGGirno:83799.
UCSCiRGD:71073. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDPP2_RAT
AccessioniPrimary (citable) accession number: Q9EPB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: July 5, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families