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Q9EPB1

- DPP2_RAT

UniProt

Q9EPB1 - DPP2_RAT

Protein

Dipeptidyl peptidase 2

Gene

Dpp7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Plays an important role in the degradation of some oligopeptides.

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei172 – 1721Charge relay systemSequence Analysis
    Active sitei428 – 4281Charge relay systemSequence Analysis
    Active sitei453 – 4531Charge relay systemSequence Analysis

    GO - Molecular functioni

    1. dipeptidyl-peptidase activity Source: RGD
    2. serine-type peptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. proteolysis Source: RGD

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS28.002.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dipeptidyl peptidase 2 (EC:3.4.14.2)
    Alternative name(s):
    Dipeptidyl aminopeptidase II
    Dipeptidyl peptidase 7
    Dipeptidyl peptidase II
    Short name:
    DPP II
    Quiescent cell proline dipeptidase
    Gene namesi
    Name:Dpp7
    Synonyms:Dpp2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi71073. Dpp7.

    Subcellular locationi

    Lysosome. Cytoplasmic vesicle By similarity. Secreted By similarity

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    2. cytosol Source: RGD
    3. extracellular region Source: UniProtKB-SubCell
    4. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Lysosome, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Sequence AnalysisAdd
    BLAST
    Propeptidei34 – 363PRO_0000027318
    Chaini37 – 500464Dipeptidyl peptidase 2PRO_0000027319Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi366 – 3661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ9EPB1.
    PRIDEiQ9EPB1.

    Expressioni

    Tissue specificityi

    Predominantly expressed in kidney, but also expressed in a variety of tissues.

    Gene expression databases

    GenevestigatoriQ9EPB1.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    IntActiQ9EPB1. 1 interaction.
    STRINGi10116.ENSRNOP00000017271.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EPB1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S28 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG290141.
    GeneTreeiENSGT00530000063027.
    HOGENOMiHOG000238311.
    HOVERGENiHBG005526.
    InParanoidiQ9EPB1.
    KOiK01276.
    OMAiVWPRPDW.
    OrthoDBiEOG78WKRN.
    PhylomeDBiQ9EPB1.
    TreeFamiTF314414.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR008758. Peptidase_S28.
    [Graphical view]
    PANTHERiPTHR11010. PTHR11010. 1 hit.
    PfamiPF05577. Peptidase_S28. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9EPB1-1 [UniParc]FASTAAdd to Basket

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    MGLHPCSPVD HGVPSWVLVL LLTLGLCSLQ ATADSVLDPD FRENYFEQYM    50
    DHFNFESFSN KTFGQRFLVS DKFWKMGEGP IFFYTGNEGD IWSLANNSGF 100
    IVELAAQQEA LLVFAEHRYY GKSLPFGVQS TQRGYTQLLT VEQALADFAV 150
    LLQALRHNLG VQDAPTIAFG GSYGGMLSAY MRMKYPHLVA GALAASAPVI 200
    AVAGLGNPDQ FFRDVTADFY GQSPKCAQAV RDAFQQIKDL FLQGAYDTIS 250
    QNFGTCQSLS SPKDLTQLFG FARNAFTVLA MMDYPYPTNF LGPLPANPVK 300
    VGCERLLSEG QRIMGLRALA GLVYNSSGME PCFDIYQMYQ SCADPTGCGT 350
    GSNARAWDYQ ACTEINLTFD SNNVTDMFPE IPFSDELRQQ YCLDTWGVWP 400
    RPDWLQTSFW GGDLKAASNI IFSNGDLDPW AGGGIQRNLS TSIIAVTIQG 450
    GAHHLDLRAS NSEDPPSVVE VRKLEATLIR EWVAAARLKQ PAEAQWPGPK 500
    Length:500
    Mass (Da):55,114
    Last modified:March 1, 2001 - v1
    Checksum:i401089D282CE1514
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB048711 mRNA. Translation: BAB13500.1.
    AB038232 mRNA. Translation: BAB11691.1.
    BC078783 mRNA. Translation: AAH78783.1.
    PIRiJC7668.
    RefSeqiNP_114179.1. NM_031973.1.
    UniGeneiRn.3363.

    Genome annotation databases

    EnsembliENSRNOT00000017271; ENSRNOP00000017271; ENSRNOG00000012640.
    GeneIDi83799.
    KEGGirno:83799.
    UCSCiRGD:71073. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB048711 mRNA. Translation: BAB13500.1 .
    AB038232 mRNA. Translation: BAB11691.1 .
    BC078783 mRNA. Translation: AAH78783.1 .
    PIRi JC7668.
    RefSeqi NP_114179.1. NM_031973.1.
    UniGenei Rn.3363.

    3D structure databases

    ProteinModelPortali Q9EPB1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9EPB1. 1 interaction.
    STRINGi 10116.ENSRNOP00000017271.

    Chemistry

    BindingDBi Q9EPB1.
    ChEMBLi CHEMBL4352.

    Protein family/group databases

    MEROPSi S28.002.

    Proteomic databases

    PaxDbi Q9EPB1.
    PRIDEi Q9EPB1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000017271 ; ENSRNOP00000017271 ; ENSRNOG00000012640 .
    GeneIDi 83799.
    KEGGi rno:83799.
    UCSCi RGD:71073. rat.

    Organism-specific databases

    CTDi 29952.
    RGDi 71073. Dpp7.

    Phylogenomic databases

    eggNOGi NOG290141.
    GeneTreei ENSGT00530000063027.
    HOGENOMi HOG000238311.
    HOVERGENi HBG005526.
    InParanoidi Q9EPB1.
    KOi K01276.
    OMAi VWPRPDW.
    OrthoDBi EOG78WKRN.
    PhylomeDBi Q9EPB1.
    TreeFami TF314414.

    Miscellaneous databases

    NextBioi 616381.
    PROi Q9EPB1.

    Gene expression databases

    Genevestigatori Q9EPB1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR008758. Peptidase_S28.
    [Graphical view ]
    PANTHERi PTHR11010. PTHR11010. 1 hit.
    Pfami PF05577. Peptidase_S28. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Purification, molecular cloning, and immunohistochemical localization of dipeptidyl peptidase II from the rat kidney and its identity with quiescent cell proline dipeptidase."
      Araki H., Li Y.-H., Yamamoto Y., Haneda M., Nishi K., Kikkawa R., Ohkubo I.
      J. Biochem. 129:279-288(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
      Strain: Wistar.
      Tissue: Kidney.
    2. "Cloning and functional expression of rat kidney dipeptidyl peptidase II."
      Fukasawa K.M., Fukasawa K., Higaki K., Shiina N., Ohno M., Ito S., Otogoto J., Ota N.
      Biochem. J. 353:283-290(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
      Strain: Wistar.
      Tissue: Kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    4. Lubec G., Kang S.U., Lubec S.
      Submitted (SEP-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 67-72; 123-133; 157-184; 214-225; 264-273; 416-437 AND 459-480, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiDPP2_RAT
    AccessioniPrimary (citable) accession number: Q9EPB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3