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Q9EPB1

- DPP2_RAT

UniProt

Q9EPB1 - DPP2_RAT

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Protein

Dipeptidyl peptidase 2

Gene

Dpp7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays an important role in the degradation of some oligopeptides.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei172 – 1721Charge relay systemSequence Analysis
Active sitei428 – 4281Charge relay systemSequence Analysis
Active sitei453 – 4531Charge relay systemSequence Analysis

GO - Molecular functioni

  1. dipeptidyl-peptidase activity Source: RGD
  2. serine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. proteolysis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS28.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 2 (EC:3.4.14.2)
Alternative name(s):
Dipeptidyl aminopeptidase II
Dipeptidyl peptidase 7
Dipeptidyl peptidase II
Short name:
DPP II
Quiescent cell proline dipeptidase
Gene namesi
Name:Dpp7
Synonyms:Dpp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi71073. Dpp7.

Subcellular locationi

Lysosome. Cytoplasmic vesicle By similarity. Secreted By similarity

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. cytosol Source: RGD
  3. extracellular vesicular exosome Source: Ensembl
  4. lysosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence AnalysisAdd
BLAST
Propeptidei34 – 363PRO_0000027318
Chaini37 – 500464Dipeptidyl peptidase 2PRO_0000027319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi366 – 3661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9EPB1.
PRIDEiQ9EPB1.

Expressioni

Tissue specificityi

Predominantly expressed in kidney, but also expressed in a variety of tissues.

Gene expression databases

GenevestigatoriQ9EPB1.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

IntActiQ9EPB1. 1 interaction.
STRINGi10116.ENSRNOP00000017271.

Structurei

3D structure databases

ProteinModelPortaliQ9EPB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S28 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG290141.
GeneTreeiENSGT00530000063027.
HOGENOMiHOG000238311.
HOVERGENiHBG005526.
InParanoidiQ9EPB1.
KOiK01276.
OMAiVWPRPDW.
OrthoDBiEOG78WKRN.
PhylomeDBiQ9EPB1.
TreeFamiTF314414.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR008758. Peptidase_S28.
[Graphical view]
PANTHERiPTHR11010. PTHR11010. 1 hit.
PfamiPF05577. Peptidase_S28. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EPB1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLHPCSPVD HGVPSWVLVL LLTLGLCSLQ ATADSVLDPD FRENYFEQYM
60 70 80 90 100
DHFNFESFSN KTFGQRFLVS DKFWKMGEGP IFFYTGNEGD IWSLANNSGF
110 120 130 140 150
IVELAAQQEA LLVFAEHRYY GKSLPFGVQS TQRGYTQLLT VEQALADFAV
160 170 180 190 200
LLQALRHNLG VQDAPTIAFG GSYGGMLSAY MRMKYPHLVA GALAASAPVI
210 220 230 240 250
AVAGLGNPDQ FFRDVTADFY GQSPKCAQAV RDAFQQIKDL FLQGAYDTIS
260 270 280 290 300
QNFGTCQSLS SPKDLTQLFG FARNAFTVLA MMDYPYPTNF LGPLPANPVK
310 320 330 340 350
VGCERLLSEG QRIMGLRALA GLVYNSSGME PCFDIYQMYQ SCADPTGCGT
360 370 380 390 400
GSNARAWDYQ ACTEINLTFD SNNVTDMFPE IPFSDELRQQ YCLDTWGVWP
410 420 430 440 450
RPDWLQTSFW GGDLKAASNI IFSNGDLDPW AGGGIQRNLS TSIIAVTIQG
460 470 480 490 500
GAHHLDLRAS NSEDPPSVVE VRKLEATLIR EWVAAARLKQ PAEAQWPGPK
Length:500
Mass (Da):55,114
Last modified:March 1, 2001 - v1
Checksum:i401089D282CE1514
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048711 mRNA. Translation: BAB13500.1.
AB038232 mRNA. Translation: BAB11691.1.
BC078783 mRNA. Translation: AAH78783.1.
PIRiJC7668.
RefSeqiNP_114179.1. NM_031973.1.
UniGeneiRn.3363.

Genome annotation databases

EnsembliENSRNOT00000017271; ENSRNOP00000017271; ENSRNOG00000012640.
GeneIDi83799.
KEGGirno:83799.
UCSCiRGD:71073. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048711 mRNA. Translation: BAB13500.1 .
AB038232 mRNA. Translation: BAB11691.1 .
BC078783 mRNA. Translation: AAH78783.1 .
PIRi JC7668.
RefSeqi NP_114179.1. NM_031973.1.
UniGenei Rn.3363.

3D structure databases

ProteinModelPortali Q9EPB1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9EPB1. 1 interaction.
STRINGi 10116.ENSRNOP00000017271.

Chemistry

BindingDBi Q9EPB1.
ChEMBLi CHEMBL4352.

Protein family/group databases

MEROPSi S28.002.

Proteomic databases

PaxDbi Q9EPB1.
PRIDEi Q9EPB1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000017271 ; ENSRNOP00000017271 ; ENSRNOG00000012640 .
GeneIDi 83799.
KEGGi rno:83799.
UCSCi RGD:71073. rat.

Organism-specific databases

CTDi 29952.
RGDi 71073. Dpp7.

Phylogenomic databases

eggNOGi NOG290141.
GeneTreei ENSGT00530000063027.
HOGENOMi HOG000238311.
HOVERGENi HBG005526.
InParanoidi Q9EPB1.
KOi K01276.
OMAi VWPRPDW.
OrthoDBi EOG78WKRN.
PhylomeDBi Q9EPB1.
TreeFami TF314414.

Miscellaneous databases

NextBioi 616381.
PROi Q9EPB1.

Gene expression databases

Genevestigatori Q9EPB1.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR008758. Peptidase_S28.
[Graphical view ]
PANTHERi PTHR11010. PTHR11010. 1 hit.
Pfami PF05577. Peptidase_S28. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Purification, molecular cloning, and immunohistochemical localization of dipeptidyl peptidase II from the rat kidney and its identity with quiescent cell proline dipeptidase."
    Araki H., Li Y.-H., Yamamoto Y., Haneda M., Nishi K., Kikkawa R., Ohkubo I.
    J. Biochem. 129:279-288(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
    Strain: Wistar.
    Tissue: Kidney.
  2. "Cloning and functional expression of rat kidney dipeptidyl peptidase II."
    Fukasawa K.M., Fukasawa K., Higaki K., Shiina N., Ohno M., Ito S., Otogoto J., Ota N.
    Biochem. J. 353:283-290(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
    Strain: Wistar.
    Tissue: Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 67-72; 123-133; 157-184; 214-225; 264-273; 416-437 AND 459-480, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiDPP2_RAT
AccessioniPrimary (citable) accession number: Q9EPB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3