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Protein

Dystrophin-related protein 2

Gene

Drp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri604 – 651ZZ-typePROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

GO - Biological processi

  • central nervous system development Source: InterPro
  • synapse organization Source: RGD
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Dystrophin-related protein 2
Short name:
DRP-2
Gene namesi
Name:Drp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi621750. Drp2.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • dendrite Source: RGD
  • membrane Source: RGD
  • perikaryon Source: UniProtKB-SubCell
  • postsynaptic density Source: UniProtKB-SubCell
  • postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003450161 – 957Dystrophin-related protein 2Add BLAST957

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei748PhosphoserineBy similarity1
Modified residuei910PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9EPA0.

PTM databases

iPTMnetiQ9EPA0.
PhosphoSitePlusiQ9EPA0.

Expressioni

Tissue specificityi

Detected in trigeminal nerve Schwann cells (PubMed:11430802). Detected in brain cortex and hippocampus. Detected in brain membrane fractions and highly enriched in the postsynaptic density (at protein level).2 Publications

Gene expression databases

BgeeiENSRNOG00000026704.

Interactioni

Subunit structurei

Interacts with PRX; this enhances phosphorylation (PubMed:11430802). Identified in a dystroglycan complex that contains at least PRX, DRP2, UTRN, DMD and DAG1 (By similarity).By similarity1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9EPA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati102 – 179Spectrin 1Add BLAST78
Repeati231 – 337Spectrin 2Add BLAST107
Domaini358 – 383WWPROSITE-ProRule annotationAdd BLAST26

Sequence similaritiesi

Contains 2 spectrin repeats.Curated
Contains 1 WW domain.PROSITE-ProRule annotation
Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri604 – 651ZZ-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410KCP3. Eukaryota.
ENOG410XQUI. LUCA.
GeneTreeiENSGT00760000119237.
HOGENOMiHOG000231175.
HOVERGENiHBG053790.
InParanoidiQ9EPA0.
OMAiYINHQAQ.
OrthoDBiEOG091G001Y.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR017433. Dystrophin-related_2.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
IPR001202. WW_dom.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00435. Spectrin. 1 hit.
PF00397. WW. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
PIRSFiPIRSF038205. Dystrophin-related_p2. 1 hit.
SMARTiSM00150. SPEC. 2 hits.
SM00456. WW. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF51045. SSF51045. 1 hit.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EPA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPLVMQGCP YTLPRCHEWH AADRFHHSSS LRNTCPQPQV RAAVTIPAPP
60 70 80 90 100
WDGAGDPCLS PKLLNGSVGA VGPLEPSAMN LCWNEIKKKS HNLRARLEAF
110 120 130 140 150
SDHSGKLQLP LQEIIDWLSQ KDEELSAQLP LQGDVALVQQ EKETHAAFME
160 170 180 190 200
EVKSKGPYIY SVLESAQAFL SQHPFEELEE SHSESKDTSP RQRIQNLSRF
210 220 230 240 250
VWKQATVASE LWEKLTARCV DQHRHIEHTL EHLLEIQGAM EELSSTLTQA
260 270 280 290 300
EGVRATWEPI GDLFIDSLPE HIQAIKLFKE EFSPVKDGVK LVNDLAHQLA
310 320 330 340 350
ISDVHLSMEN SRALEQINVR WKQLQVSVAE RLKQLQDAHR DFGPGSQHFL
360 370 380 390 400
STSVQVPWER AISPNKVPYY INHQAQTTCW DHPKMTELYQ TLADLNNIKF
410 420 430 440 450
SAYRTAMKLR RVQKALRLDL VTLTTALEIF NEHDLQASEH VMDVVEVIHC
460 470 480 490 500
LTALYERLEE ERGILVNVPL CVDMSLNWLL NVFDSGRSGK MRALSFKTGI
510 520 530 540 550
ACLCGTEVKE KLQYLFSQVA NSGSQCDQRH LGALLHEAIQ VPRQLGEVAA
560 570 580 590 600
FGGSNVEPSV RSCFRFSTGK PVIEASQFLE WVNLEPQSMV WLAVLHRVTV
610 620 630 640 650
AEQVKHQTKC SICRQCPIKG FRYRSLKQFN VDICQTCFLT GKASKGNKLH
660 670 680 690 700
YPIMEYYTPT TSSENMRDFA TTLKNKFRSK QYFSKHPQRG YLPVQSVLES
710 720 730 740 750
DCSETPASSP MLPHADTHSR IEHFASRLAE MESQNCSFFN DSLSPDDSID
760 770 780 790 800
EDQYLLRHSS PITDREPAFG QQAPCSMATE SKGELEKILA HLEDENRILQ
810 820 830 840 850
GELRRLKWQH EEAVEAPTLA EGSAEATPDH RNEELLAEAR ILRQHKSRLE
860 870 880 890 900
TRMQILEDHN KQLESQLQRL RELLLQPPTE SDGNGSAGSS LASSPRQSEG
910 920 930 940 950
SHPREKGQTT PDTEAADDVG SKSQDVSLCL EDIMEKLRHA FPSVRSSDVT

ANTLLAS
Length:957
Mass (Da):108,045
Last modified:December 9, 2015 - v2
Checksum:i1C245F6C90EB26BC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti525Q → K in AAG28484 (PubMed:11083927).Curated1
Sequence conflicti525Q → K in AAG28485 (PubMed:11083927).Curated1
Sequence conflicti642K → R in AAG28484 (PubMed:11083927).Curated1
Sequence conflicti642K → R in AAG28485 (PubMed:11083927).Curated1
Sequence conflicti928 – 929LC → HS in AAG28484 (PubMed:11083927).Curated2
Sequence conflicti928 – 929LC → HS in AAG28485 (PubMed:11083927).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195787 mRNA. Translation: AAG28484.1.
AF195788 mRNA. Translation: AAG28485.1.
AC094684 Genomic DNA. No translation available.
CH473969 Genomic DNA. Translation: EDM07026.1.
CH473969 Genomic DNA. Translation: EDM07027.1.
CH473969 Genomic DNA. Translation: EDM07028.1.
RefSeqiNP_076461.1. NM_023971.1.
XP_008771655.1. XM_008773433.2.
UniGeneiRn.162341.

Genome annotation databases

EnsembliENSRNOT00000039864; ENSRNOP00000037371; ENSRNOG00000026704.
ENSRNOT00000085693; ENSRNOP00000070220; ENSRNOG00000026704.
GeneIDi66027.
KEGGirno:66027.
UCSCiRGD:621750. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195787 mRNA. Translation: AAG28484.1.
AF195788 mRNA. Translation: AAG28485.1.
AC094684 Genomic DNA. No translation available.
CH473969 Genomic DNA. Translation: EDM07026.1.
CH473969 Genomic DNA. Translation: EDM07027.1.
CH473969 Genomic DNA. Translation: EDM07028.1.
RefSeqiNP_076461.1. NM_023971.1.
XP_008771655.1. XM_008773433.2.
UniGeneiRn.162341.

3D structure databases

ProteinModelPortaliQ9EPA0.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9EPA0.
PhosphoSitePlusiQ9EPA0.

Proteomic databases

PaxDbiQ9EPA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000039864; ENSRNOP00000037371; ENSRNOG00000026704.
ENSRNOT00000085693; ENSRNOP00000070220; ENSRNOG00000026704.
GeneIDi66027.
KEGGirno:66027.
UCSCiRGD:621750. rat.

Organism-specific databases

CTDi1821.
RGDi621750. Drp2.

Phylogenomic databases

eggNOGiENOG410KCP3. Eukaryota.
ENOG410XQUI. LUCA.
GeneTreeiENSGT00760000119237.
HOGENOMiHOG000231175.
HOVERGENiHBG053790.
InParanoidiQ9EPA0.
OMAiYINHQAQ.
OrthoDBiEOG091G001Y.

Miscellaneous databases

PROiQ9EPA0.

Gene expression databases

BgeeiENSRNOG00000026704.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR017433. Dystrophin-related_2.
IPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
IPR001202. WW_dom.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00435. Spectrin. 1 hit.
PF00397. WW. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
PIRSFiPIRSF038205. Dystrophin-related_p2. 1 hit.
SMARTiSM00150. SPEC. 2 hits.
SM00456. WW. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF51045. SSF51045. 1 hit.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRP2_RAT
AccessioniPrimary (citable) accession number: Q9EPA0
Secondary accession number(s): G3V971
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: December 9, 2015
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.