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Protein

Solute carrier organic anion transporter family member 1A4

Gene

Slco1a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent transport of organic anions such as taurocholate, cholate, 17-beta-glucuronosyl estradiol, estrone-3-sulfate, the cardiac glycosides ouabain and digoxin and thyroid hormones.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-159418. Recycling of bile acids and salts.
R-MMU-879518. Transport of organic anions.

Protein family/group databases

TCDBi2.A.60.1.6. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1A4
Alternative name(s):
Sodium-independent organic anion-transporting polypeptide 2
Solute carrier family 21 member 5
Gene namesi
Name:Slco1a4
Synonyms:Oatp1a4, Oatp2, Slc21a5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1351896. Slco1a4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence analysisAdd
BLAST
Transmembranei21 – 4020Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini41 – 5919ExtracellularSequence analysisAdd
BLAST
Transmembranei60 – 8021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini81 – 866CytoplasmicSequence analysis
Transmembranei87 – 11125Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini112 – 15544ExtracellularSequence analysisAdd
BLAST
Transmembranei156 – 18429Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini185 – 20319CytoplasmicSequence analysisAdd
BLAST
Transmembranei204 – 22421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini225 – 24218ExtracellularSequence analysisAdd
BLAST
Transmembranei243 – 26725Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini268 – 31144CytoplasmicSequence analysisAdd
BLAST
Transmembranei312 – 33322Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini334 – 35320ExtracellularSequence analysisAdd
BLAST
Transmembranei354 – 37724Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini378 – 3814CytoplasmicSequence analysis
Transmembranei382 – 40524Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini406 – 513108ExtracellularSequence analysisAdd
BLAST
Transmembranei514 – 53623Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini537 – 5459CytoplasmicSequence analysis
Transmembranei546 – 57126Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini572 – 60534ExtracellularSequence analysisAdd
BLAST
Transmembranei606 – 62318Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini624 – 67047CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2073700.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Solute carrier organic anion transporter family member 1A4PRO_0000191046Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence analysis
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence analysis
Disulfide bondi439 ↔ 465PROSITE-ProRule annotation
Disulfide bondi443 ↔ 454PROSITE-ProRule annotation
Disulfide bondi445 ↔ 469PROSITE-ProRule annotation
Glycosylationi483 – 4831N-linked (GlcNAc...)Sequence analysis
Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence analysis
Modified residuei634 – 6341PhosphoserineBy similarity
Modified residuei635 – 6351PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9EP96.
PaxDbiQ9EP96.
PRIDEiQ9EP96.

PTM databases

iPTMnetiQ9EP96.
PhosphoSiteiQ9EP96.

Expressioni

Tissue specificityi

Highly expressed in brain and liver. Detected at very low levels in heart and lung.

Gene expression databases

BgeeiQ9EP96.
ExpressionAtlasiQ9EP96. baseline and differential.
GenevisibleiQ9EP96. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032364.

Structurei

3D structure databases

ProteinModelPortaliQ9EP96.
SMRiQ9EP96. Positions 437-470.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini433 – 48856Kazal-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ9EP96.
KOiK03460.
OMAiCHAGCKE.
OrthoDBiEOG7GFB4C.
PhylomeDBiQ9EP96.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: 3 isoforms are produced.

Isoform 1 (identifier: Q9EP96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKSEKEVAT HGVRCFSKIK AFLLALTCAY VSKSLSGTYM NSMLTQIERQ
60 70 80 90 100
FGIPTSVVGL INGSFEIGNL LLIIFVSYFG TKLHRPIMIG VGCAVMGLGC
110 120 130 140 150
FLISIPHFLM GRYEYETTIL PTSNLSSNSF VCTENRTQTL KPTQDPTECV
160 170 180 190 200
KEMKSLMWIY VLVGNIIRGM GETPIMPLGI SYIEDFAKSE NSPLYIGILE
210 220 230 240 250
TGMTIGPLIG LLLGSSCANI YVDTGSVNTD DLTITPTDTR WVGAWWIGFL
260 270 280 290 300
VCAGVNILTS IPFFFFPKTL LKEGLQDNGD GTENAKEEKH REKIKEENRG
310 320 330 340 350
ITKDFFLFMK SLSCNPIYMI FILISVIQVN AFINSFTFMP KYLEQQYGKS
360 370 380 390 400
TAEIVFLMGL YMLPPICLGY LIGGLIMKKF KITVKKAAYI GFWLSLTEYL
410 420 430 440 450
LSFVSYIMTC DNFPVAGLTT SYEGVQHPLY VENNVLADCN TKCSCLTNTW
460 470 480 490 500
DPVCGDNGLS YMSACLAGCE KSVGTGTNMV FQNCSCIQSS GNASAVLGLC
510 520 530 540 550
DKGPECANKL QYFLIISIIG CFIFSLGAIP GYMVLLRCMK SEEKSLGVGL
560 570 580 590 600
HTFCMRILGG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR MYDINSFRRI
610 620 630 640 650
YLGLPAALRG ASFLPALFIL ILMRKFQFPG DIDSSDTDPA EMKLTAKESK
660 670
CTNVHRSPTM QNDGERKTKL
Length:670
Mass (Da):73,965
Last modified:March 1, 2001 - v1
Checksum:i65EFDD16F641F04F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043023 Genomic DNA. Translation: BAB18305.1.
AB031814 mRNA. Translation: BAB12445.1.
CCDSiCCDS39690.1. [Q9EP96-1]
PIRiJC7616.
RefSeqiNP_109612.1. NM_030687.1. [Q9EP96-1]
XP_006507023.1. XM_006506960.2. [Q9EP96-1]
XP_011239886.1. XM_011241584.1. [Q9EP96-1]
XP_011239887.1. XM_011241585.1. [Q9EP96-1]
XP_011239888.1. XM_011241586.1. [Q9EP96-1]
UniGeneiMm.255586.

Genome annotation databases

EnsembliENSMUST00000032364; ENSMUSP00000032364; ENSMUSG00000030237. [Q9EP96-1]
ENSMUST00000165990; ENSMUSP00000130746; ENSMUSG00000030237. [Q9EP96-1]
GeneIDi28250.
KEGGimmu:28250.
UCSCiuc009eos.1. mouse. [Q9EP96-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043023 Genomic DNA. Translation: BAB18305.1.
AB031814 mRNA. Translation: BAB12445.1.
CCDSiCCDS39690.1. [Q9EP96-1]
PIRiJC7616.
RefSeqiNP_109612.1. NM_030687.1. [Q9EP96-1]
XP_006507023.1. XM_006506960.2. [Q9EP96-1]
XP_011239886.1. XM_011241584.1. [Q9EP96-1]
XP_011239887.1. XM_011241585.1. [Q9EP96-1]
XP_011239888.1. XM_011241586.1. [Q9EP96-1]
UniGeneiMm.255586.

3D structure databases

ProteinModelPortaliQ9EP96.
SMRiQ9EP96. Positions 437-470.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032364.

Chemistry

ChEMBLiCHEMBL2073700.

Protein family/group databases

TCDBi2.A.60.1.6. the organo anion transporter (oat) family.

PTM databases

iPTMnetiQ9EP96.
PhosphoSiteiQ9EP96.

Proteomic databases

MaxQBiQ9EP96.
PaxDbiQ9EP96.
PRIDEiQ9EP96.

Protocols and materials databases

DNASUi28250.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032364; ENSMUSP00000032364; ENSMUSG00000030237. [Q9EP96-1]
ENSMUST00000165990; ENSMUSP00000130746; ENSMUSG00000030237. [Q9EP96-1]
GeneIDi28250.
KEGGimmu:28250.
UCSCiuc009eos.1. mouse. [Q9EP96-1]

Organism-specific databases

CTDi28250.
MGIiMGI:1351896. Slco1a4.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ9EP96.
KOiK03460.
OMAiCHAGCKE.
OrthoDBiEOG7GFB4C.
PhylomeDBiQ9EP96.
TreeFamiTF317540.

Enzyme and pathway databases

ReactomeiR-MMU-159418. Recycling of bile acids and salts.
R-MMU-879518. Transport of organic anions.

Miscellaneous databases

PROiQ9EP96.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EP96.
ExpressionAtlasiQ9EP96. baseline and differential.
GenevisibleiQ9EP96. MM.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization and tissue-specific expression of splice variants of mouse organic anion transporting polypeptide 2."
    Ogura K., Choudhuri S., Klaassen C.D.
    Biochem. Biophys. Res. Commun. 281:431-439(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING.
    Strain: 129/SvJ and BALB/c.
    Tissue: Liver.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSO1A4_MOUSE
AccessioniPrimary (citable) accession number: Q9EP96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.