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Protein

Solute carrier organic anion transporter family member 1A4

Gene

Slco1a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent transport of organic anions such as taurocholate, cholate, 17-beta-glucuronosyl estradiol, estrone-3-sulfate, the cardiac glycosides ouabain and digoxin and thyroid hormones.By similarity

GO - Molecular functioni

GO - Biological processi

  • anion transport Source: MGI
  • sodium-independent organic anion transport Source: GO_Central

Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-159418 Recycling of bile acids and salts
R-MMU-879518 Transport of organic anions

Protein family/group databases

TCDBi2.A.60.1.6 the organo anion transporter (oat) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1A4
Alternative name(s):
Sodium-independent organic anion-transporting polypeptide 2
Solute carrier family 21 member 5
Gene namesi
Name:Slco1a4
Synonyms:Oatp1a4, Oatp2, Slc21a5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1351896 Slco1a4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 40Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini41 – 59ExtracellularSequence analysisAdd BLAST19
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 86CytoplasmicSequence analysis6
Transmembranei87 – 111Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini112 – 155ExtracellularSequence analysisAdd BLAST44
Transmembranei156 – 184Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini185 – 203CytoplasmicSequence analysisAdd BLAST19
Transmembranei204 – 224Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini225 – 242ExtracellularSequence analysisAdd BLAST18
Transmembranei243 – 267Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini268 – 311CytoplasmicSequence analysisAdd BLAST44
Transmembranei312 – 333Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini334 – 353ExtracellularSequence analysisAdd BLAST20
Transmembranei354 – 377Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini378 – 381CytoplasmicSequence analysis4
Transmembranei382 – 405Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini406 – 513ExtracellularSequence analysisAdd BLAST108
Transmembranei514 – 536Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini537 – 545CytoplasmicSequence analysis9
Transmembranei546 – 571Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini572 – 605ExtracellularSequence analysisAdd BLAST34
Transmembranei606 – 623Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini624 – 670CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2073700

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910461 – 670Solute carrier organic anion transporter family member 1A4Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi439 ↔ 465PROSITE-ProRule annotation
Disulfide bondi443 ↔ 454PROSITE-ProRule annotation
Disulfide bondi445 ↔ 469PROSITE-ProRule annotation
Glycosylationi483N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi492N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei634PhosphoserineBy similarity1
Modified residuei635PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9EP96
PaxDbiQ9EP96
PRIDEiQ9EP96

PTM databases

iPTMnetiQ9EP96
PhosphoSitePlusiQ9EP96

Expressioni

Tissue specificityi

Highly expressed in brain and liver. Detected at very low levels in heart and lung.

Gene expression databases

BgeeiENSMUSG00000030237
ExpressionAtlasiQ9EP96 baseline and differential
GenevisibleiQ9EP96 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032364

Structurei

3D structure databases

ProteinModelPortaliQ9EP96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini433 – 488Kazal-likePROSITE-ProRule annotationAdd BLAST56

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00760000119014
HOGENOMiHOG000231269
HOVERGENiHBG063896
InParanoidiQ9EP96
KOiK03460
OMAiCTRILAG
OrthoDBiEOG091G08QD
PhylomeDBiQ9EP96
TreeFamiTF317540

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 3 hits
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: 3 isoforms are produced.
Isoform 1 (identifier: Q9EP96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKSEKEVAT HGVRCFSKIK AFLLALTCAY VSKSLSGTYM NSMLTQIERQ
60 70 80 90 100
FGIPTSVVGL INGSFEIGNL LLIIFVSYFG TKLHRPIMIG VGCAVMGLGC
110 120 130 140 150
FLISIPHFLM GRYEYETTIL PTSNLSSNSF VCTENRTQTL KPTQDPTECV
160 170 180 190 200
KEMKSLMWIY VLVGNIIRGM GETPIMPLGI SYIEDFAKSE NSPLYIGILE
210 220 230 240 250
TGMTIGPLIG LLLGSSCANI YVDTGSVNTD DLTITPTDTR WVGAWWIGFL
260 270 280 290 300
VCAGVNILTS IPFFFFPKTL LKEGLQDNGD GTENAKEEKH REKIKEENRG
310 320 330 340 350
ITKDFFLFMK SLSCNPIYMI FILISVIQVN AFINSFTFMP KYLEQQYGKS
360 370 380 390 400
TAEIVFLMGL YMLPPICLGY LIGGLIMKKF KITVKKAAYI GFWLSLTEYL
410 420 430 440 450
LSFVSYIMTC DNFPVAGLTT SYEGVQHPLY VENNVLADCN TKCSCLTNTW
460 470 480 490 500
DPVCGDNGLS YMSACLAGCE KSVGTGTNMV FQNCSCIQSS GNASAVLGLC
510 520 530 540 550
DKGPECANKL QYFLIISIIG CFIFSLGAIP GYMVLLRCMK SEEKSLGVGL
560 570 580 590 600
HTFCMRILGG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR MYDINSFRRI
610 620 630 640 650
YLGLPAALRG ASFLPALFIL ILMRKFQFPG DIDSSDTDPA EMKLTAKESK
660 670
CTNVHRSPTM QNDGERKTKL
Length:670
Mass (Da):73,965
Last modified:March 1, 2001 - v1
Checksum:i65EFDD16F641F04F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB043023 Genomic DNA Translation: BAB18305.1
AB031814 mRNA Translation: BAB12445.1
CCDSiCCDS39690.1 [Q9EP96-1]
PIRiJC7616
RefSeqiNP_109612.1, NM_030687.1 [Q9EP96-1]
XP_006507023.1, XM_006506960.3
XP_011239886.1, XM_011241584.2 [Q9EP96-1]
XP_011239887.1, XM_011241585.2 [Q9EP96-1]
XP_011239888.1, XM_011241586.2 [Q9EP96-1]
UniGeneiMm.255586

Genome annotation databases

EnsembliENSMUST00000032364; ENSMUSP00000032364; ENSMUSG00000030237 [Q9EP96-1]
ENSMUST00000165990; ENSMUSP00000130746; ENSMUSG00000030237 [Q9EP96-1]
GeneIDi28250
KEGGimmu:28250
UCSCiuc009eos.1 mouse [Q9EP96-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSO1A4_MOUSE
AccessioniPrimary (citable) accession number: Q9EP96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health