Q9EP89 (LACTB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine beta-lactamase-like protein LACTB, mitochondrial
EC=3.4.-.-

Gene names

Name:	Lactb
Synonyms:	Lact1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	551 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion By similarity.
Tissue specificity	Expressed predominantly in liver.
Sequence similarities	Belongs to the peptidase S12 family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Hydrolase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	mitochondrion Inferred from direct assay. Source: MGI
Molecular function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 113	113	Mitochondrion Potential
	Chain	114 – 551	438	Serine beta-lactamase-like protein LACTB, mitochondrial		PRO_0000195477
Sites
	Active site	162	1	Acyl-ester intermediate By similarity
Amino acid modifications
	Modified residue	6	1	Phosphoserine By similarity
	Modified residue	162	1	Phosphoserine Ref.3
	Modified residue	264	1	Phosphoserine Ref.3
	Modified residue	268	1	N6-acetyllysine By similarity
	Modified residue	346	1	N6-acetyllysine By similarity
	Modified residue	463	1	N6-acetyllysine Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9EP89 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 816C1EE94B1D6009	FASTA	551	60,705
	10 20 30 40 50 60 MYRLLSSVTA RAAATAGPAW DGGRRGAHRR PGLPVLGLGW AGGLGLGLGL ALGAKLVVGL 70 80 90 100 110 120 RGAVPIQSPA DPEASGTTEL SHEQALSPGS PHTPAPPAAR GFSRAIESSR DLLHRIKDEV 130 140 150 160 170 180 GAPGIVVGVS VDGKEVWSEG LGYADVENRV PCKPETVMRI ASISKSLTMV ALAKLWEAGK 190 200 210 220 230 240 LDLDLPVQHY VPEFPEKEYE GEKVSVTTRL LISHLSGIRH YEKDIKKVKE EKAYKALKMV 250 260 270 280 290 300 KGTPPPSDQE KELKEKGGKN NEKSDAPKAK VEQDSEARCR SAKPGKKKND FEQGELYLKE 310 320 330 340 350 360 KFENSIESLR LFKNDPLFFK PGSQFLYSTF GYTLLAAIVE RASGYKYLDY MQKIFHDLDM 370 380 390 400 410 420 LTTVQEENEP VIYNRARFYV YNKKKRLVNT PYVDNSYKWA GGGFLSTVGD LLKFGNAMLY 430 440 450 460 470 480 GYQVGQFKNS NENLLPGYLK PETMVMMWTP VPNTEMSWDK EGKYAMAWGV VEKKQTYGSC 490 500 510 520 530 540 RKQRHYASHT GGAVGASSVL LVLPEELDSE AVNNKVPPRG IIVSIICNMQ SVGLNSTALK 550 IALEFDKDRA D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification, genomic organization, and mRNA expression of LACTB, encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain." Smith T.S., Southan C., Ellington K., Campbell D., Tew D.G., Debouck C. Genomics 78:12-14(2001) [PubMed: 11707067] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: 129/Sv and BALB/c.
[2]	"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey." Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y. Mol. Cell 23:607-618(2006) [PubMed: 16916647] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-463, MASS SPECTROMETRY. Tissue: Liver.
[3]	"Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS." Lee J., Xu Y., Chen Y., Sprung R., Kim S.C., Xie S., Zhao Y. Mol. Cell. Proteomics 6:669-676(2007) [PubMed: 17208939] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162 AND SER-264, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF317900 mRNA. Translation: AAG37910.1. AF317901 Genomic DNA. Translation: AAG37911.1.
IPI	IPI00109293.
RefSeq	NP_109642.1. NM_030717.1.
UniGene	Mm.157882.
3D structure databases
ProteinModelPortal	Q9EP89.
SMR	Q9EP89. Positions 153-187.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9EP89. 1 interaction.
STRING	Q9EP89.
Protein family/group databases
MEROPS	S12.004.
PTM databases
PhosphoSite	Q9EP89.
Proteomic databases
PRIDE	Q9EP89.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000034929; ENSMUSP00000034929; ENSMUSG00000032370. ENSMUST00000116554; ENSMUSP00000112253; ENSMUSG00000032370.
GeneID	80907.
KEGG	mmu:80907.
Organism-specific databases
CTD	114294.
MGI	MGI:1933395. Lactb.
Phylogenomic databases
GeneTree	ENSGT00390000001062.
HOGENOM	HBG713681.
HOVERGEN	HBG052296.
InParanoid	Q9EP89.
OMA	YKALKMM.
OrthoDB	EOG4GQQ58.
PhylomeDB	Q9EP89.
Gene expression databases
ArrayExpress	Q9EP89.
Bgee	Q9EP89.
CleanEx	MM_LACTB.
Genevestigator	Q9EP89.
GermOnline	ENSMUSG00000032370. Mus musculus.
Family and domain databases
InterPro	IPR001466. Beta-lactam-related. IPR012338. Beta-lactam/transpept-like. [Graphical view]
Gene3D	G3DSA:3.40.710.10. G3DSA:3.40.710.10. 2 hits.
Pfam	PF00144. Beta-lactamase. 2 hits. [Graphical view]
SUPFAM	SSF56601. PBP_transp_fold. 1 hit.
ProtoNet	Search...
Other
NextBio	438861.
SOURCE	Search...

Entry information

Entry name

LACTB_MOUSE

Accession

Primary (citable) accession number: Q9EP89

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	March 1, 2001
Last modified:	November 16, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program