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Protein

Serine beta-lactamase-like protein LACTB, mitochondrial

Gene

Lactb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei162 – 1621Acyl-ester intermediateBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

MEROPSiS12.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine beta-lactamase-like protein LACTB, mitochondrial (EC:3.4.-.-)
Gene namesi
Name:Lactb
Synonyms:Lact1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1933395. Lactb.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3259498.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 113113MitochondrionSequence analysisAdd
BLAST
Chaini114 – 551438Serine beta-lactamase-like protein LACTB, mitochondrialPRO_0000195477Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei287 – 2871N6-succinyllysineCombined sources
Modified residuei288 – 2881N6-succinyllysineCombined sources
Modified residuei301 – 3011N6-acetyllysineCombined sources
Modified residuei346 – 3461N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9EP89.
MaxQBiQ9EP89.
PaxDbiQ9EP89.
PRIDEiQ9EP89.

PTM databases

iPTMnetiQ9EP89.
PhosphoSiteiQ9EP89.

Expressioni

Tissue specificityi

Expressed predominantly in liver.

Gene expression databases

BgeeiQ9EP89.
CleanExiMM_LACTB.
ExpressionAtlasiQ9EP89. baseline and differential.
GenevisibleiQ9EP89. MM.

Interactioni

Protein-protein interaction databases

BioGridi219844. 1 interaction.
IntActiQ9EP89. 1 interaction.
STRINGi10090.ENSMUSP00000034929.

Structurei

3D structure databases

ProteinModelPortaliQ9EP89.
SMRiQ9EP89. Positions 91-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S12 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IHHD. Eukaryota.
COG1680. LUCA.
GeneTreeiENSGT00390000001062.
HOGENOMiHOG000060285.
HOVERGENiHBG052296.
InParanoidiQ9EP89.
KOiK17382.
OMAiQVGLFKN.
OrthoDBiEOG7353WG.
PhylomeDBiQ9EP89.
TreeFamiTF315050.

Family and domain databases

Gene3Di3.40.710.10. 2 hits.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
[Graphical view]
PfamiPF00144. Beta-lactamase. 2 hits.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EP89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRLLSSVTA RAAATAGPAW DGGRRGAHRR PGLPVLGLGW AGGLGLGLGL
60 70 80 90 100
ALGAKLVVGL RGAVPIQSPA DPEASGTTEL SHEQALSPGS PHTPAPPAAR
110 120 130 140 150
GFSRAIESSR DLLHRIKDEV GAPGIVVGVS VDGKEVWSEG LGYADVENRV
160 170 180 190 200
PCKPETVMRI ASISKSLTMV ALAKLWEAGK LDLDLPVQHY VPEFPEKEYE
210 220 230 240 250
GEKVSVTTRL LISHLSGIRH YEKDIKKVKE EKAYKALKMV KGTPPPSDQE
260 270 280 290 300
KELKEKGGKN NEKSDAPKAK VEQDSEARCR SAKPGKKKND FEQGELYLKE
310 320 330 340 350
KFENSIESLR LFKNDPLFFK PGSQFLYSTF GYTLLAAIVE RASGYKYLDY
360 370 380 390 400
MQKIFHDLDM LTTVQEENEP VIYNRARFYV YNKKKRLVNT PYVDNSYKWA
410 420 430 440 450
GGGFLSTVGD LLKFGNAMLY GYQVGQFKNS NENLLPGYLK PETMVMMWTP
460 470 480 490 500
VPNTEMSWDK EGKYAMAWGV VEKKQTYGSC RKQRHYASHT GGAVGASSVL
510 520 530 540 550
LVLPEELDSE AVNNKVPPRG IIVSIICNMQ SVGLNSTALK IALEFDKDRA

D
Length:551
Mass (Da):60,705
Last modified:March 1, 2001 - v1
Checksum:i816C1EE94B1D6009
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317900 mRNA. Translation: AAG37910.1.
AF317901 Genomic DNA. Translation: AAG37911.1.
CCDSiCCDS40674.1.
RefSeqiNP_109642.1. NM_030717.1.
UniGeneiMm.157882.

Genome annotation databases

EnsembliENSMUST00000034929; ENSMUSP00000034929; ENSMUSG00000032370.
GeneIDi80907.
KEGGimmu:80907.
UCSCiuc009qfn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317900 mRNA. Translation: AAG37910.1.
AF317901 Genomic DNA. Translation: AAG37911.1.
CCDSiCCDS40674.1.
RefSeqiNP_109642.1. NM_030717.1.
UniGeneiMm.157882.

3D structure databases

ProteinModelPortaliQ9EP89.
SMRiQ9EP89. Positions 91-506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219844. 1 interaction.
IntActiQ9EP89. 1 interaction.
STRINGi10090.ENSMUSP00000034929.

Chemistry

ChEMBLiCHEMBL3259498.

Protein family/group databases

MEROPSiS12.004.

PTM databases

iPTMnetiQ9EP89.
PhosphoSiteiQ9EP89.

Proteomic databases

EPDiQ9EP89.
MaxQBiQ9EP89.
PaxDbiQ9EP89.
PRIDEiQ9EP89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034929; ENSMUSP00000034929; ENSMUSG00000032370.
GeneIDi80907.
KEGGimmu:80907.
UCSCiuc009qfn.1. mouse.

Organism-specific databases

CTDi114294.
MGIiMGI:1933395. Lactb.

Phylogenomic databases

eggNOGiENOG410IHHD. Eukaryota.
COG1680. LUCA.
GeneTreeiENSGT00390000001062.
HOGENOMiHOG000060285.
HOVERGENiHBG052296.
InParanoidiQ9EP89.
KOiK17382.
OMAiQVGLFKN.
OrthoDBiEOG7353WG.
PhylomeDBiQ9EP89.
TreeFamiTF315050.

Miscellaneous databases

PROiQ9EP89.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EP89.
CleanExiMM_LACTB.
ExpressionAtlasiQ9EP89. baseline and differential.
GenevisibleiQ9EP89. MM.

Family and domain databases

Gene3Di3.40.710.10. 2 hits.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
[Graphical view]
PfamiPF00144. Beta-lactamase. 2 hits.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification, genomic organization, and mRNA expression of LACTB, encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain."
    Smith T.S., Southan C., Ellington K., Campbell D., Tew D.G., Debouck C.
    Genomics 78:12-14(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: 129/Sv and BALB/c.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Kidney, Liver and Testis.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-287 AND LYS-288, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast and Liver.
  4. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiLACTB_MOUSE
AccessioniPrimary (citable) accession number: Q9EP89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.