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Protein

Serine beta-lactamase-like protein LACTB, mitochondrial

Gene

Lactb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (By similarity). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (By similarity). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (By similarity). Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei162Acyl-ester intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease
Biological processLipid metabolism

Protein family/group databases

MEROPSiS12.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine beta-lactamase-like protein LACTB, mitochondrialCurated (EC:3.4.-.-By similarity)
Gene namesi
Name:LactbImported
Synonyms:Lact1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1933395. Lactb.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Chemistry databases

ChEMBLiCHEMBL3259498.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 113MitochondrionSequence analysisAdd BLAST113
ChainiPRO_0000195477114 – 551Serine beta-lactamase-like protein LACTB, mitochondrialAdd BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei287N6-succinyllysineCombined sources1
Modified residuei288N6-succinyllysineCombined sources1
Modified residuei301N6-acetyllysineCombined sources1
Modified residuei346N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9EP89.
MaxQBiQ9EP89.
PaxDbiQ9EP89.
PRIDEiQ9EP89.

PTM databases

iPTMnetiQ9EP89.
PhosphoSitePlusiQ9EP89.

Expressioni

Tissue specificityi

Expressed predominantly in liver.1 Publication

Inductioni

Down-regulated in a number of cancer cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000032370.
CleanExiMM_LACTB.
ExpressionAtlasiQ9EP89. baseline and differential.
GenevisibleiQ9EP89. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi219844. 2 interactors.
IntActiQ9EP89. 1 interactor.
STRINGi10090.ENSMUSP00000034929.

Structurei

3D structure databases

ProteinModelPortaliQ9EP89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S12 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IHHD. Eukaryota.
COG1680. LUCA.
GeneTreeiENSGT00390000001062.
HOGENOMiHOG000060285.
HOVERGENiHBG052296.
InParanoidiQ9EP89.
KOiK17382.
OMAiTFLYSTH.
OrthoDBiEOG091G0BW6.
PhylomeDBiQ9EP89.
TreeFamiTF315050.

Family and domain databases

InterProiView protein in InterPro
IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
PfamiView protein in Pfam
PF00144. Beta-lactamase. 2 hits.
SUPFAMiSSF56601. SSF56601. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EP89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRLLSSVTA RAAATAGPAW DGGRRGAHRR PGLPVLGLGW AGGLGLGLGL
60 70 80 90 100
ALGAKLVVGL RGAVPIQSPA DPEASGTTEL SHEQALSPGS PHTPAPPAAR
110 120 130 140 150
GFSRAIESSR DLLHRIKDEV GAPGIVVGVS VDGKEVWSEG LGYADVENRV
160 170 180 190 200
PCKPETVMRI ASISKSLTMV ALAKLWEAGK LDLDLPVQHY VPEFPEKEYE
210 220 230 240 250
GEKVSVTTRL LISHLSGIRH YEKDIKKVKE EKAYKALKMV KGTPPPSDQE
260 270 280 290 300
KELKEKGGKN NEKSDAPKAK VEQDSEARCR SAKPGKKKND FEQGELYLKE
310 320 330 340 350
KFENSIESLR LFKNDPLFFK PGSQFLYSTF GYTLLAAIVE RASGYKYLDY
360 370 380 390 400
MQKIFHDLDM LTTVQEENEP VIYNRARFYV YNKKKRLVNT PYVDNSYKWA
410 420 430 440 450
GGGFLSTVGD LLKFGNAMLY GYQVGQFKNS NENLLPGYLK PETMVMMWTP
460 470 480 490 500
VPNTEMSWDK EGKYAMAWGV VEKKQTYGSC RKQRHYASHT GGAVGASSVL
510 520 530 540 550
LVLPEELDSE AVNNKVPPRG IIVSIICNMQ SVGLNSTALK IALEFDKDRA

D
Length:551
Mass (Da):60,705
Last modified:March 1, 2001 - v1
Checksum:i816C1EE94B1D6009
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317900 mRNA. Translation: AAG37910.1.
AF317901 Genomic DNA. Translation: AAG37911.1.
CCDSiCCDS40674.1.
RefSeqiNP_109642.1. NM_030717.1.
UniGeneiMm.157882.

Genome annotation databases

EnsembliENSMUST00000034929; ENSMUSP00000034929; ENSMUSG00000032370.
GeneIDi80907.
KEGGimmu:80907.
UCSCiuc009qfn.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiLACTB_MOUSE
AccessioniPrimary (citable) accession number: Q9EP89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families