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Protein

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4

Gene

Wdr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the formation of N7-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

GO - Biological processi

Keywordsi

Biological processtRNA processing

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4UniRule annotation
Alternative name(s):
WD repeat-containing protein 4UniRule annotation
Gene namesi
Name:Wdr4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1889002 Wdr4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000513492 – 413tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4Add BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei392PhosphoserineBy similarity1
Modified residuei412PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9EP82
MaxQBiQ9EP82
PaxDbiQ9EP82
PRIDEiQ9EP82

PTM databases

iPTMnetiQ9EP82
PhosphoSitePlusiQ9EP82

Expressioni

Gene expression databases

CleanExiMM_WDR4

Interactioni

Subunit structurei

Forms a heterodimer with the catalytic subunit METTL1.UniRule annotation

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126061

Structurei

3D structure databases

ProteinModelPortaliQ9EP82
SMRiQ9EP82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati61 – 100WD 1Add BLAST40
Repeati102 – 141WD 2Add BLAST40
Repeati145 – 185WD 3Add BLAST41
Repeati188 – 228WD 4Add BLAST41
Repeati289 – 329WD 5Add BLAST41

Sequence similaritiesi

Belongs to the WD repeat TRM82 family.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG3914 Eukaryota
ENOG4111WRP LUCA
HOGENOMiHOG000154849
HOVERGENiHBG022880
InParanoidiQ9EP82
KOiK15443
PhylomeDBiQ9EP82

Family and domain databases

Gene3Di2.130.10.101 hit
HAMAPiMF_03056 TRM82, 1 hit
InterProiView protein in InterPro
IPR028884 Trm82
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR16288 PTHR16288, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EP82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSAGLALC AQTLVVRGGS RFLAFSTTGS DDDCVFTYDC STAEKKATPE
60 70 80 90 100
DKGEDGQPAD TGSDSILAST FSKSGRYFAL TDDSKRLILF RTKPWQCLSV
110 120 130 140 150
RMVVRRCTAL TFTASEDRVL VADKSGDVYS FSVLEPDGCG RLELGHLSML
160 170 180 190 200
LDVAVSPDDQ FVLTADRDEK IRVSWAAAPH SIESFCLGHT EFVSRILVVP
210 220 230 240 250
SHPELLLSSS GDGTLRLWEY RSGRQLQCCD LAGLQEPGEQ PGHKGLAASR
260 270 280 290 300
IAFWGQESYV VLLCECVPVV FVFQLDASRQ QLVFRQRLTF PHRVWDVVFE
310 320 330 340 350
EARGLWVLQD CRDAPLVLWR PVGGEWQAAP DGAVSPRLCS HLRESWAMLE
360 370 380 390 400
GSVGTDDSFR SLYKATFDNM TSYLKKKEER LQQQLKKKRQ RSPFPGSPEQ
410
TKKACPGQSA LSC
Length:413
Mass (Da):45,756
Last modified:May 5, 2009 - v2
Checksum:i8EAFB152CFE2884E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28T → A in CAC05584 (PubMed:10950928).Curated1
Sequence conflicti28T → A in CAC05585 (PubMed:10950928).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271893 mRNA Translation: CAC05585.1
AJ271892 mRNA Translation: CAC05584.1
AK144821 mRNA Translation: BAE26082.1
AK152271 mRNA Translation: BAE31087.1
AK153161 mRNA Translation: BAE31771.1
BC039272 mRNA Translation: AAH39272.1
RefSeqiNP_067297.2, NM_021322.2
UniGeneiMm.143771

Genome annotation databases

GeneIDi57773
KEGGimmu:57773
UCSCiuc008bvd.2 mouse

Similar proteinsi

Entry informationi

Entry nameiWDR4_MOUSE
AccessioniPrimary (citable) accession number: Q9EP82
Secondary accession number(s): Q80V01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 5, 2009
Last modified: February 28, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome