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Q9EP82

- WDR4_MOUSE

UniProt

Q9EP82 - WDR4_MOUSE

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Protein

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4

Gene

Wdr4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: Ensembl

GO - Biological processi

  1. tRNA modification Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4UniRule annotation
Alternative name(s):
WD repeat-containing protein 4UniRule annotation
Gene namesi
Name:Wdr4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1889002. Wdr4.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleoplasm Source: Ensembl
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 413412tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4PRO_0000051349Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei392 – 3921PhosphoserineBy similarity
Modified residuei412 – 4121PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9EP82.
PaxDbiQ9EP82.
PRIDEiQ9EP82.

PTM databases

PhosphoSiteiQ9EP82.

Expressioni

Gene expression databases

BgeeiQ9EP82.
CleanExiMM_WDR4.
ExpressionAtlasiQ9EP82. baseline and differential.
GenevestigatoriQ9EP82.

Interactioni

Subunit structurei

Forms a heterodimer with the catalytic subunit METTL1.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9EP82.
SMRiQ9EP82. Positions 72-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati61 – 10040WD 1Add
BLAST
Repeati102 – 14140WD 2Add
BLAST
Repeati145 – 18541WD 3Add
BLAST
Repeati188 – 22841WD 4Add
BLAST
Repeati289 – 32941WD 5Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat TRM82 family.UniRule annotation
Contains 5 WD repeats.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOGENOMiHOG000154849.
HOVERGENiHBG022880.
InParanoidiQ9EP82.
KOiK15443.
PhylomeDBiQ9EP82.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03056. TRM82.
InterProiIPR028884. Trm82.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EP82-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASSAGLALC AQTLVVRGGS RFLAFSTTGS DDDCVFTYDC STAEKKATPE
60 70 80 90 100
DKGEDGQPAD TGSDSILAST FSKSGRYFAL TDDSKRLILF RTKPWQCLSV
110 120 130 140 150
RMVVRRCTAL TFTASEDRVL VADKSGDVYS FSVLEPDGCG RLELGHLSML
160 170 180 190 200
LDVAVSPDDQ FVLTADRDEK IRVSWAAAPH SIESFCLGHT EFVSRILVVP
210 220 230 240 250
SHPELLLSSS GDGTLRLWEY RSGRQLQCCD LAGLQEPGEQ PGHKGLAASR
260 270 280 290 300
IAFWGQESYV VLLCECVPVV FVFQLDASRQ QLVFRQRLTF PHRVWDVVFE
310 320 330 340 350
EARGLWVLQD CRDAPLVLWR PVGGEWQAAP DGAVSPRLCS HLRESWAMLE
360 370 380 390 400
GSVGTDDSFR SLYKATFDNM TSYLKKKEER LQQQLKKKRQ RSPFPGSPEQ
410
TKKACPGQSA LSC
Length:413
Mass (Da):45,756
Last modified:May 5, 2009 - v2
Checksum:i8EAFB152CFE2884E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281T → A in CAC05584. (PubMed:10950928)Curated
Sequence conflicti28 – 281T → A in CAC05585. (PubMed:10950928)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ271893 mRNA. Translation: CAC05585.1.
AJ271892 mRNA. Translation: CAC05584.1.
AK144821 mRNA. Translation: BAE26082.1.
AK152271 mRNA. Translation: BAE31087.1.
AK153161 mRNA. Translation: BAE31771.1.
BC039272 mRNA. Translation: AAH39272.1.
RefSeqiNP_067297.2. NM_021322.2.
UniGeneiMm.143771.

Genome annotation databases

GeneIDi57773.
KEGGimmu:57773.
UCSCiuc008bvd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ271893 mRNA. Translation: CAC05585.1 .
AJ271892 mRNA. Translation: CAC05584.1 .
AK144821 mRNA. Translation: BAE26082.1 .
AK152271 mRNA. Translation: BAE31087.1 .
AK153161 mRNA. Translation: BAE31771.1 .
BC039272 mRNA. Translation: AAH39272.1 .
RefSeqi NP_067297.2. NM_021322.2.
UniGenei Mm.143771.

3D structure databases

ProteinModelPortali Q9EP82.
SMRi Q9EP82. Positions 72-294.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9EP82.

Proteomic databases

MaxQBi Q9EP82.
PaxDbi Q9EP82.
PRIDEi Q9EP82.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 57773.
KEGGi mmu:57773.
UCSCi uc008bvd.2. mouse.

Organism-specific databases

CTDi 10785.
MGIi MGI:1889002. Wdr4.

Phylogenomic databases

eggNOGi COG2319.
HOGENOMi HOG000154849.
HOVERGENi HBG022880.
InParanoidi Q9EP82.
KOi K15443.
PhylomeDBi Q9EP82.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Miscellaneous databases

NextBioi 313940.
PROi Q9EP82.
SOURCEi Search...

Gene expression databases

Bgeei Q9EP82.
CleanExi MM_WDR4.
ExpressionAtlasi Q9EP82. baseline and differential.
Genevestigatori Q9EP82.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
HAMAPi MF_03056. TRM82.
InterProi IPR028884. Trm82.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 2 hits.
[Graphical view ]
SMARTi SM00320. WD40. 4 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein."
    Michaud J., Kudoh J., Berry A., Bonne-Tamir B., Lalioti M.D., Rossier C., Shibuya K., Kawasaki K., Asakawa S., Minoshima S., Shimizu N., Antonarakis S.E., Scott H.S.
    Genomics 68:71-79(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiWDR4_MOUSE
AccessioniPrimary (citable) accession number: Q9EP82
Secondary accession number(s): Q80V01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3