Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphatidylinositide phosphatase SAC1

Gene

Sacm1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 4-phosphate (PtdIns4P) (By similarity). Has low activity towards PtdIns(3,5)P2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-MMU-1483248. Synthesis of PIPs at the ER membrane.
R-MMU-1660514. Synthesis of PIPs at the Golgi membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositide phosphatase SAC1 (EC:3.1.3.-)
Alternative name(s):
Suppressor of actin mutations 1-like protein
Gene namesi
Name:Sacm1l
Synonyms:Kiaa0851, Sac1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1933169. Sacm1l.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei56 – 7621HelicalSequence analysisAdd
BLAST
Transmembranei521 – 54121HelicalSequence analysisAdd
BLAST
Transmembranei549 – 56921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Phosphatidylinositide phosphatase SAC1PRO_0000317172Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei456 – 4561N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9EP69.
MaxQBiQ9EP69.
PaxDbiQ9EP69.
PeptideAtlasiQ9EP69.
PRIDEiQ9EP69.

PTM databases

iPTMnetiQ9EP69.
PhosphoSiteiQ9EP69.
SwissPalmiQ9EP69.

Expressioni

Tissue specificityi

Detected in brain, lung, liver and kidney, and at lower levels in spleen and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9EP69.
GenevisibleiQ9EP69. MM.

Interactioni

Protein-protein interaction databases

BioGridi219937. 17 interactions.
IntActiQ9EP69. 18 interactions.
MINTiMINT-1844501.
STRINGi10090.ENSMUSP00000026270.

Structurei

3D structure databases

ProteinModelPortaliQ9EP69.
SMRiQ9EP69. Positions 18-453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini122 – 451330SACPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SAC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1889. Eukaryota.
COG5329. LUCA.
GeneTreeiENSGT00530000063393.
HOGENOMiHOG000189112.
HOVERGENiHBG108454.
InParanoidiQ9EP69.
OMAiMMRYIAF.
OrthoDBiEOG73803W.
PhylomeDBiQ9EP69.
TreeFamiTF313543.

Family and domain databases

InterProiIPR002013. SAC_dom.
[Graphical view]
PfamiPF02383. Syja_N. 1 hit.
[Graphical view]
PROSITEiPS50275. SAC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EP69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAYEHLK LHITPEKFYV EACDDGADDV LIIDRVSTEV TLAVKKDVPP
60 70 80 90 100
SAVTRPIFGI LGTIHLVAGN YLVVITKKMK VGECFNHAVW RATDFDVLSY
110 120 130 140 150
KKTMLHLTDI QLQDNKTFLA MLNHVLSMDG FYFSTTYDLT HTLQRLSNTS
160 170 180 190 200
PEFQEMSLLE RADQRFVWNG HLLRELSAQP EVHRFALPVL HGFITMHSCS
210 220 230 240 250
INGKYFDWIL ISRRSCFRAG VRYYVRGIDS EGHAANFVET EQIVHYSGNR
260 270 280 290 300
ASFVQTRGSI PIFWSQRPNL KYKPHPQISK VANHMDGFQR HFDSQVIIYG
310 320 330 340 350
KQVIINLVNH KGSEKPLEQT FANMVSSLGS GMIRYIAFDF HKECKNMRWD
360 370 380 390 400
RLSILLDQVA EMQDELSYFL VDSAGKVVTN QDGVFRSNCM DCLDRTNVIQ
410 420 430 440 450
SLLARRSLQA QLQRLGVLHV GQKLEEQDEF EKTYKNAWAD NANACAKQYA
460 470 480 490 500
GTGALKTDFT RTGKRTQLGL LMDGFNSLLR YYKNNFSDGF RQDSIDLFLG
510 520 530 540 550
NYSVDELESH SPLSVPRDWK FLALPIIMVV AFSMCIICLL MAGDTWTETL
560 570 580
AYVLFWGVAS IGTFFIILYN GKDFVDAPRL VQKEKID
Length:587
Mass (Da):66,944
Last modified:March 1, 2001 - v1
Checksum:iBCC73A3A2B912C98
GO

Sequence cautioni

The sequence BAC65672.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297526 mRNA. Translation: CAC01937.1.
AJ245720 mRNA. Translation: CAC20672.1.
AK122390 mRNA. Translation: BAC65672.1. Different initiation.
AK089174 mRNA. Translation: BAC40778.1.
AK161111 mRNA. Translation: BAE36196.1.
AK171080 mRNA. Translation: BAE42234.1.
BC005489 mRNA. Translation: AAH05489.1.
BC117752 mRNA. Translation: AAI17753.1.
BC117753 mRNA. Translation: AAI17754.1.
CCDSiCCDS40816.1.
RefSeqiNP_109617.1. NM_030692.4.
UniGeneiMm.273671.

Genome annotation databases

EnsembliENSMUST00000026270; ENSMUSP00000026270; ENSMUSG00000025240.
GeneIDi83493.
KEGGimmu:83493.
UCSCiuc009sgh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297526 mRNA. Translation: CAC01937.1.
AJ245720 mRNA. Translation: CAC20672.1.
AK122390 mRNA. Translation: BAC65672.1. Different initiation.
AK089174 mRNA. Translation: BAC40778.1.
AK161111 mRNA. Translation: BAE36196.1.
AK171080 mRNA. Translation: BAE42234.1.
BC005489 mRNA. Translation: AAH05489.1.
BC117752 mRNA. Translation: AAI17753.1.
BC117753 mRNA. Translation: AAI17754.1.
CCDSiCCDS40816.1.
RefSeqiNP_109617.1. NM_030692.4.
UniGeneiMm.273671.

3D structure databases

ProteinModelPortaliQ9EP69.
SMRiQ9EP69. Positions 18-453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219937. 17 interactions.
IntActiQ9EP69. 18 interactions.
MINTiMINT-1844501.
STRINGi10090.ENSMUSP00000026270.

PTM databases

iPTMnetiQ9EP69.
PhosphoSiteiQ9EP69.
SwissPalmiQ9EP69.

Proteomic databases

EPDiQ9EP69.
MaxQBiQ9EP69.
PaxDbiQ9EP69.
PeptideAtlasiQ9EP69.
PRIDEiQ9EP69.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026270; ENSMUSP00000026270; ENSMUSG00000025240.
GeneIDi83493.
KEGGimmu:83493.
UCSCiuc009sgh.1. mouse.

Organism-specific databases

CTDi22908.
MGIiMGI:1933169. Sacm1l.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1889. Eukaryota.
COG5329. LUCA.
GeneTreeiENSGT00530000063393.
HOGENOMiHOG000189112.
HOVERGENiHBG108454.
InParanoidiQ9EP69.
OMAiMMRYIAF.
OrthoDBiEOG73803W.
PhylomeDBiQ9EP69.
TreeFamiTF313543.

Enzyme and pathway databases

ReactomeiR-MMU-1483248. Synthesis of PIPs at the ER membrane.
R-MMU-1660514. Synthesis of PIPs at the Golgi membrane.

Miscellaneous databases

PROiQ9EP69.
SOURCEiSearch...

Gene expression databases

BgeeiQ9EP69.
GenevisibleiQ9EP69. MM.

Family and domain databases

InterProiIPR002013. SAC_dom.
[Graphical view]
PfamiPF02383. Syja_N. 1 hit.
[Graphical view]
PROSITEiPS50275. SAC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3."
    Kiss H., Kedra D., Kiss C., Kost-Alimova M., Yang Y., Klein G., Imreh S., Dumanski J.P.
    Genomics 73:10-19(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Cloning and characterization of the murine homolog of S.cerevisiae SAC1 (suppressor of actin mutations)."
    Boehmelt G., Tsang E., Smith C., Mak T.W.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Skin.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Mammary tumor.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiSAC1_MOUSE
AccessioniPrimary (citable) accession number: Q9EP69
Secondary accession number(s): Q80TQ1, Q99K33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.