Q9EP51 (V1R50_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vomeronasal type-1 receptor 50

Alternative name(s):
Pheromone receptor VN2
Vomeronasal receptor 2
Vomeronasal type-1 receptor A5
Vomeronasal type-1 receptor B1

Gene names

Name:	Vmn1r50
Synonyms:	V1ra5, V1rb1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative pheromone receptor implicated in the regulation of social and reproductive behavior. Ref.5
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed in a subset of sensory neurons located in the apical layer of the vomeronasal organ. Ref.5
Disruption phenotype	Mice lacking all but one V1ra and V1rb gene (12% of the V1r repertoire) show a lack of chemosensory response to a subset of known pheromonal ligands and changes in maternal aggression as well as male reproductive behavior. Ref.5
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Pheromone response
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to pheromone Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of chemical stimulus Traceable author statement Ref.1. Source: MGI
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	pheromone receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Vomeronasal type-1 receptor 50		PRO_0000239973
Regions
	Topological domain	1 – 16	16	Extracellular Potential
	Transmembrane	17 – 37	21	Helical; Name=1; Potential
	Topological domain	38 – 50	13	Cytoplasmic Potential
	Transmembrane	51 – 71	21	Helical; Name=2; Potential
	Topological domain	72 – 93	22	Extracellular Potential
	Transmembrane	94 – 114	21	Helical; Name=3; Potential
	Topological domain	115 – 134	20	Cytoplasmic Potential
	Transmembrane	135 – 155	21	Helical; Name=4; Potential
	Topological domain	156 – 193	38	Extracellular Potential
	Transmembrane	194 – 214	21	Helical; Name=5; Potential
	Topological domain	215 – 237	23	Cytoplasmic Potential
	Transmembrane	238 – 258	21	Helical; Name=6; Potential
	Topological domain	259 – 269	11	Extracellular Potential
	Transmembrane	270 – 290	21	Helical; Name=7; Potential
	Topological domain	291 – 310	20	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	159	1	N-linked (GlcNAc...) Potential
	Disulfide bond	85 ↔ 172		By similarity
Experimental info
	Sequence conflict	115	1	S → N in BAB79219. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9EP51 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: FBC10A7152FD5957	FASTA	310	35,195
	10 20 30 40 50 60 MSKANLLHTD NNMKITLFSE VSVGISANSI LFVVHLCKLL HENKPKPIDL YIAFFSITQL 70 80 90 100 110 120 MLLITMGLIA VDMFMPWGRW DSTTCQSLIY LHRLLRGLTF CATCLLNVLW TITLSPRSSC 130 140 150 160 170 180 LTKFKHKSPH HISGAFLFFC VLYMSFSSHL LVSIIATFNS TSDNFLYVTQ SCSILPVSYS 190 200 210 220 230 240 RTSILSTMMT MREAFLIGLM ALSSGYVVVL LWRHKKQARH LHSTSLSSKA SPEQRATSTI 250 260 270 280 290 300 MLLMGFFVVL YILDTVIFQA RLKFKDVSTF FCVKIIISHS YATFSPFVFI CNDKYMIKFV 310 TSMCGRIVNV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence diversity and genomic organization of vomeronasal receptor genes in the mouse." Del Punta K., Rothman A., Rodriguez I., Mombaerts P. Genome Res. 10:1958-1967(2000) [PubMed: 11116090] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ.
[2]	"Sequence analysis of mouse vomeronasal receptor gene clusters reveals common promoter motifs and a history of recent expansion." Lane R.P., Cutforth T., Axel R., Hood L., Trask B.J. Proc. Natl. Acad. Sci. U.S.A. 99:291-296(2002) [PubMed: 11752409] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Vomeronasal receptor gene diversity in the mammalian genome." Sam M., Matsunami H., Buck L. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes." Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J., Ogawa S., Zufall F., Mombaerts P. Nature 419:70-74(2002) [PubMed: 12214233] [Abstract] Cited for: PUTATIVE FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF291489 Genomic DNA. Translation: AAG42083.1. AF129005 Genomic DNA. Translation: AAG43248.1. AB062902 Genomic DNA. Translation: BAB79219.1. BC107183 mRNA. Translation: AAI07184.1.
IPI	IPI00109171.
RefSeq	NP_444455.1. NM_053225.1.
UniGene	Mm.377149.
3D structure databases
ProteinModelPortal	Q9EP51.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000081706; ENSMUSP00000080407; ENSMUSG00000058595.
GeneID	113852.
KEGG	mmu:113852.
UCSC	uc009cwu.1. mouse.
Organism-specific databases
CTD	113852.
MGI	MGI:2148515. Vmn1r50.
Phylogenomic databases
GeneTree	ENSGT00530000062929.
HOGENOM	HBG283597.
HOVERGEN	HBG101191.
InParanoid	Q9EP51.
OMA	CKLLHEN.
OrthoDB	EOG4CNQS5.
PhylomeDB	Q9EP51.
Gene expression databases
ArrayExpress	Q9EP51.
Bgee	Q9EP51.
CleanEx	MM_V1RA5. MM_V1RB1.
Genevestigator	Q9EP51.
GermOnline	ENSMUSG00000058595. Mus musculus.
Family and domain databases
InterPro	IPR017452. GPCR_Rhodpsn_supfam. IPR004072. Vmron_rcpt_1. [Graphical view]
KO	K04614.
Pfam	PF03402. V1R. 1 hit. [Graphical view]
PRINTS	PR01534. VOMERONASL1R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	367987.
SOURCE	Search...

Entry information

Entry name

V1R50_MOUSE

Accession

Primary (citable) accession number: Q9EP51
Secondary accession number(s): Q8VIC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	March 1, 2001
Last modified:	November 16, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program