Q9E6P5 (KITH_GAHVM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:

MDV036

Organism

Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) [Reference proteome]

Taxonomic identifier

10389 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Mardivirus › Gallid herpesvirus 2

Virus host

Gallus gallus (Chicken) [TaxID: 9031]

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.
Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the herpesviruses thymidine kinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	TMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thymidine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	Thymidine kinase		PRO_0000406521
Regions
	Nucleotide binding	26 – 33	8	ATP By similarity
	Compositional bias	76 – 79	4	Poly-Arg
Sites
	Active site	54	1	Proton acceptor Potential
	Binding site	95	1	Substrate By similarity
	Binding site	140	1	Substrate By similarity
	Binding site	185	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9E6P5 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 34A65B16BB0F67A2	FASTA	352	40,410
	10 20 30 40 50 60 MSEPQSWSVM ASQMTSAQLI RVYLDGSMGI GKTSMLNEIP THSLMGVPVL KVFEPMKYWR 70 80 90 100 110 120 YYFTDLVTTV NDTCDRRRRG EFSLFQSSMI VTALQSKFAD PYLVFHERLS SKCHRITGTR 130 140 150 160 170 180 GNPSLILILD RHPISATVCF PIARHLTGDC SLEMLISMII RLPQEPPGCN LVIVDLHDEK 190 200 210 220 230 240 EHVSRLSSRN RTGEKTDLLM LRALNAVYSC LVDTIMYANH ICPYSKDEWE SEWLDLPWFD 250 260 270 280 290 300 TSLATTFINE PRTDYRGSRV SLHHTLLAIF KRRELCAEDG SLSTTHAWIL WGLLMKLRNI 310 320 330 340 350 NVERFNITGL STTKCVESFM DTMSERLVTH MSWNDAFEIE ADVLAYNKEM AM

References

[1]	"The genome of a very virulent Marek's disease virus." Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F. J. Virol. 74:7980-7988(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF243438 Genomic DNA. Translation: AAG14216.1.
RefSeq	YP_001033951.1. NC_002229.3.
3D structure databases
HSSP	HSSP built from PDB template 1OSN based on UniProtKB P14344.
ProteinModelPortal	Q9E6P5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4811496.
Phylogenomic databases
ProtClustDB	PHA3135.
Family and domain databases
InterPro	IPR001889. Herpes_TK. [Graphical view]
Pfam	PF00693. Herpes_TK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_GAHVM

Accession

Primary (citable) accession number: Q9E6P5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 5, 2011
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program