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Q9E6P5 (KITH_GAHVM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processTMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 352352Thymidine kinase
PRO_0000406521

Regions

Nucleotide binding26 – 338ATP By similarity
Compositional bias76 – 794Poly-Arg

Sites

Active site541Proton acceptor Potential
Binding site951Substrate By similarity
Binding site1401Substrate By similarity
Binding site1851ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9E6P5 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 34A65B16BB0F67A2

FASTA35240,410
        10         20         30         40         50         60 
MSEPQSWSVM ASQMTSAQLI RVYLDGSMGI GKTSMLNEIP THSLMGVPVL KVFEPMKYWR 

        70         80         90        100        110        120 
YYFTDLVTTV NDTCDRRRRG EFSLFQSSMI VTALQSKFAD PYLVFHERLS SKCHRITGTR 

       130        140        150        160        170        180 
GNPSLILILD RHPISATVCF PIARHLTGDC SLEMLISMII RLPQEPPGCN LVIVDLHDEK 

       190        200        210        220        230        240 
EHVSRLSSRN RTGEKTDLLM LRALNAVYSC LVDTIMYANH ICPYSKDEWE SEWLDLPWFD 

       250        260        270        280        290        300 
TSLATTFINE PRTDYRGSRV SLHHTLLAIF KRRELCAEDG SLSTTHAWIL WGLLMKLRNI 

       310        320        330        340        350 
NVERFNITGL STTKCVESFM DTMSERLVTH MSWNDAFEIE ADVLAYNKEM AM 

« Hide

References

[1]"The genome of a very virulent Marek's disease virus."
Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.
J. Virol. 74:7980-7988(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF243438 Genomic DNA. Translation: AAG14216.1.
RefSeqYP_001033951.1. NC_002229.3.

3D structure databases

ProteinModelPortalQ9E6P5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4811496.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_GAHVM
AccessionPrimary (citable) accession number: Q9E6P5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: March 1, 2001
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families