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Q9E6P5

- KITH_GAHVM

UniProt

Q9E6P5 - KITH_GAHVM

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Protein

Thymidine kinase

Gene

MDV036

Organism
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei54 – 541Proton acceptorSequence Analysis
Binding sitei95 – 951SubstrateBy similarity
Binding sitei140 – 1401SubstrateBy similarity
Binding sitei185 – 1851ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 338ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:MDV036
OrganismiGallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
Taxonomic identifieri10389 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
ProteomesiUP000008072: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Thymidine kinasePRO_0000406521Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9E6P5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi76 – 794Poly-Arg

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9E6P5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEPQSWSVM ASQMTSAQLI RVYLDGSMGI GKTSMLNEIP THSLMGVPVL
60 70 80 90 100
KVFEPMKYWR YYFTDLVTTV NDTCDRRRRG EFSLFQSSMI VTALQSKFAD
110 120 130 140 150
PYLVFHERLS SKCHRITGTR GNPSLILILD RHPISATVCF PIARHLTGDC
160 170 180 190 200
SLEMLISMII RLPQEPPGCN LVIVDLHDEK EHVSRLSSRN RTGEKTDLLM
210 220 230 240 250
LRALNAVYSC LVDTIMYANH ICPYSKDEWE SEWLDLPWFD TSLATTFINE
260 270 280 290 300
PRTDYRGSRV SLHHTLLAIF KRRELCAEDG SLSTTHAWIL WGLLMKLRNI
310 320 330 340 350
NVERFNITGL STTKCVESFM DTMSERLVTH MSWNDAFEIE ADVLAYNKEM

AM
Length:352
Mass (Da):40,410
Last modified:March 1, 2001 - v1
Checksum:i34A65B16BB0F67A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF243438 Genomic DNA. Translation: AAG14216.1.
RefSeqiYP_001033951.1. NC_002229.3.

Genome annotation databases

GeneIDi4811496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF243438 Genomic DNA. Translation: AAG14216.1 .
RefSeqi YP_001033951.1. NC_002229.3.

3D structure databases

ProteinModelPortali Q9E6P5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4811496.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00693. Herpes_TK. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of a very virulent Marek's disease virus."
    Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.
    J. Virol. 74:7980-7988(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKITH_GAHVM
AccessioniPrimary (citable) accession number: Q9E6P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: March 1, 2001
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3